3b4d - Revision history

OCA at 14:03, 13 March 2024

OCA — Wed, 13 Mar 2024 14:03:33 GMT

←Older revision		Revision as of 14:03, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='3b4d' size='340' side='right'caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3b4d' size='340' side='right'caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4D FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3b4m\|3b4m]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.001Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [https://pdbe.org/3b4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [https://www.ebi.ac.uk/pdbsum/3b4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [https://pdbe.org/3b4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [https://www.ebi.ac.uk/pdbsum/3b4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[https://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>	+	[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[https://omim.org/entry/164300 164300]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref> <ref>PMID:11371506</ref>	+	[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref> <ref>PMID:11371506</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ge, H]]	+	[[Category: Ge H]]
-	[[Category: Niu, L]]	+	[[Category: Niu L]]
-	[[Category: Teng, M]]	+	[[Category: Teng M]]
-	[[Category: Tong, S]]	+	[[Category: Tong S]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Alpha-beta sandwich structure]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Methylation]]~~	+
-	~~[[Category: Mrna processing]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Rna binding domain]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna recognition motif]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Rrm fold]]~~	+
-	~~[[Category: Triplet repeat expansion~~]]	+

OCA at 11:23, 5 January 2022

OCA — Wed, 05 Jan 2022 11:23:08 GMT

←Older revision		Revision as of 11:23, 5 January 2022
Line 1:		Line 1:

	==Crystal Structure of Human PABPN1 RRM==		==Crystal Structure of Human PABPN1 RRM==
-	<StructureSection load='3b4d' size='340' side='right' caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3b4d' size='340' side='right'caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3B4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4D FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b4m\|3b4m]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [~~http~~://pdbe.org/3b4d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3b4d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [https://pdbe.org/3b4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [https://www.ebi.ac.uk/pdbsum/3b4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[~~http~~://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>	+	[[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[https://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref> <ref>PMID:11371506</ref>	+	[[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref> <ref>PMID:11371506</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ge, H]]		[[Category: Ge, H]]
	[[Category: Niu, L]]		[[Category: Niu, L]]

OCA at 07:31, 31 October 2018

OCA — Wed, 31 Oct 2018 07:31:04 GMT

←Older revision		Revision as of 07:31, 31 October 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Human PABPN1 RRM==		==Crystal Structure of Human PABPN1 RRM==
	<StructureSection load='3b4d' size='340' side='right' caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3b4d' size='340' side='right' caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [http://pdbe.org/3b4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [http://www.ebi.ac.uk/pdbsum/3b4d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [http://pdbe.org/3b4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [http://www.ebi.ac.uk/pdbsum/3b4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/3b4d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/3b4d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	[[Category: Teng, M]]		[[Category: Teng, M]]
	[[Category: Tong, S]]		[[Category: Tong, S]]
		+	[[Category: Acetylation]]
	[[Category: Alpha-beta sandwich structure]]		[[Category: Alpha-beta sandwich structure]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Methylation]]		[[Category: Methylation]]
	[[Category: Mrna processing]]		[[Category: Mrna processing]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
		+	[[Category: Polymorphism]]
	[[Category: Rna binding domain]]		[[Category: Rna binding domain]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
Line 40:		Line 46:
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Rrm fold]]		[[Category: Rrm fold]]
		+	[[Category: Triplet repeat expansion]]

OCA at 16:11, 7 February 2016

OCA — Sun, 07 Feb 2016 16:11:25 GMT

←Older revision		Revision as of 16:11, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3b4d' size='340' side='right' caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3b4d' size='340' side='right' caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B4D FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [http://www.ebi.ac.uk/pdbsum/3b4d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [http://pdbe.org/3b4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [http://www.ebi.ac.uk/pdbsum/3b4d PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b4d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ge, H]]		[[Category: Ge, H]]
	[[Category: Niu, L]]		[[Category: Niu, L]]

OCA at 11:03, 20 January 2015

OCA — Tue, 20 Jan 2015 11:03:57 GMT

←Older revision		Revision as of 11:03, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B4D FirstGlance]. <br>		<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B4D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [http://www.ebi.ac.uk/pdbsum/3b4d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [http://www.ebi.ac.uk/pdbsum/3b4d PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[http://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>		[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[http://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ge, H.]]	+	[[Category: Ge, H]]
-	[[Category: Niu, L.]]	+	[[Category: Niu, L]]
-	[[Category: Teng, M.]]	+	[[Category: Teng, M]]
-	[[Category: Tong, S.]]	+	[[Category: Tong, S]]
	[[Category: Alpha-beta sandwich structure]]		[[Category: Alpha-beta sandwich structure]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 05:17, 2 October 2014

OCA — Thu, 02 Oct 2014 05:17:18 GMT

←Older revision		Revision as of 05:17, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3b4d\| PDB~~=3b4d \| ~~SCENE~~= }}	+	==Crystal Structure of Human PABPN1 RRM==
-	===~~Crystal Structure of Human~~ PABPN1 ~~RRM~~===	+	<StructureSection load='3b4d' size='340' side='right' caption='[[3b4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B4D FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[http://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref><ref>PMID:12673802</ref>	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b4m\|3b4m]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PABPN1, PAB2, PABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==Function==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [http://www.ebi.ac.uk/pdbsum/3b4d PDBsum]</span></td></tr>
-	[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref><ref>PMID:11371506</ref>	+	<table>
-		+	== Disease ==
-	==~~About this Structure~~==	+	[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[http://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>
-	[[~~3b4d~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~3B4D OCA~~].	+	== Function ==
-		+	[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref> <ref>PMID:11371506</ref>
-	~~==Reference==~~	+	== Evolutionary Conservation ==
-	<~~ref group~~="~~xtra~~">~~PMID:018275081~~</~~ref~~><references ~~group="xtra"~~/><~~references~~/>	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/3b4d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ge, H.]]		[[Category: Ge, H.]]

OCA at 21:39, 24 March 2013

OCA — Sun, 24 Mar 2013 21:39:20 GMT

←Older revision		Revision as of 21:39, 24 March 2013
Line 1:		Line 1:
-	[[Image:3b4d.png\|left\|200px]]
-
	{{STRUCTURE_3b4d\| PDB=3b4d \| SCENE= }}		{{STRUCTURE_3b4d\| PDB=3b4d \| SCENE= }}
		+	===Crystal Structure of Human PABPN1 RRM===

-	===~~Crystal Structure~~ of ~~Human PABPN1 RRM===~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[http://omim.org/entry/164300 164300]]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref><ref>PMID:12673802</ref>

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN]] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref><ref>PMID:11371506</ref>

	==About this Structure==		==About this Structure==
Line 10:		Line 12:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018275081</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018275081</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ge, H.]]		[[Category: Ge, H.]]

OCA: Protected "3b4d" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:42:57 GMT

Protected "3b4d" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:42, 7 January 2013

OCA at 22:42, 7 January 2013

OCA — Mon, 07 Jan 2013 22:42:50 GMT

←Older revision		Revision as of 22:42, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3b4d.png\|left\|200px]]		[[Image:3b4d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3b4d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3b4d\| PDB=3b4d \| SCENE= }}		{{STRUCTURE_3b4d\| PDB=3b4d \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~3B4D~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA].	+	[[3b4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18275081~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018275081</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ge, H.]]		[[Category: Ge, H.]]
Line 23:		Line 16:
	[[Category: Teng, M.]]		[[Category: Teng, M.]]
	[[Category: Tong, S.]]		[[Category: Tong, S.]]
-	[[Category: Acetylation]]
	[[Category: Alpha-beta sandwich structure]]		[[Category: Alpha-beta sandwich structure]]
-	[[Category: Alternative splicing]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Methylation]]		[[Category: Methylation]]
	[[Category: Mrna processing]]		[[Category: Mrna processing]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
-	[[Category: Polymorphism]]
	[[Category: Rna binding domain]]		[[Category: Rna binding domain]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
Line 38:		Line 26:
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Rrm fold]]		[[Category: Rrm fold]]
-	[[Category: Triplet repeat expansion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:00:57 2009''

OCA at 13:00, 16 February 2009

OCA — Mon, 16 Feb 2009 13:00:57 GMT

←Older revision		Revision as of 13:00, 16 February 2009
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	3B4D is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA].	+	3B4D is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA].

	==Reference==		==Reference==
-	~~Crystal structure and possible dimerization of the single RRM of human PABPN1., Ge H, Zhou D, Tong S, Gao Y, Teng M, Niu L, Proteins. 2008 May 15;71(3):1539-45.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18275081 18275081]~~	+	<ref group="xtra">PMID:18275081</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Ge, H.]]		[[Category: Ge, H.]]
	[[Category: Niu, L.]]		[[Category: Niu, L.]]
Line 41:		Line 40:
	[[Category: Triplet repeat expansion]]		[[Category: Triplet repeat expansion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 17~~:47:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:00:57 2009''