3b9j - Revision history

OCA at 12:05, 30 August 2023

OCA — Wed, 30 Aug 2023 12:05:09 GMT

←Older revision		Revision as of 12:05, 30 August 2023
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	<StructureSection load='3b9j' size='340' side='right'caption='[[3b9j]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3b9j' size='340' side='right'caption='[[3b9j]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b9j]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3B9J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b9j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B9J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [~~http~~://pdbe.org/3b9j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3b9j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3b9j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [https://pdbe.org/3b9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [https://www.ebi.ac.uk/pdbsum/3b9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b9j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/XDH_BOVIN XDH_BOVIN]] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.	+	[https://www.uniprot.org/uniprot/XDH_BOVIN XDH_BOVIN] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Xanthine dehydrogenase\|Xanthine dehydrogenase]]	+	*[[Xanthine dehydrogenase 3D structures\|Xanthine dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Xanthine oxidase]]~~	+	[[Category: Bell CE]]
-	[[Category: Bell~~, C E~~]]	+	[[Category: Hille R]]
-	[[Category: Hille, R]]	+	[[Category: Pauff JM]]
-	[[Category: Pauff~~, J M~~]]	+	[[Category: Zhang J]]
-	[[Category: Zhang, J]]	+
-	~~[[Category: Catalysis]]~~	+
-	~~[[Category: Intermediate]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Peroxisome]]~~	+
-	~~[[Category: Substrate orientation~~]]	+

OCA at 06:16, 5 August 2020

OCA — Wed, 05 Aug 2020 06:16:05 GMT

←Older revision		Revision as of 06:16, 5 August 2020
Line 1:		Line 1:

	==Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine==		==Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine==
-	<StructureSection load='3b9j' size='340' side='right' caption='[[3b9j]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3b9j' size='340' side='right'caption='[[3b9j]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3B9J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3B9J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://pdbe.org/3b9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b9j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://pdbe.org/3b9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b9j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Xanthine oxidase]]		[[Category: Xanthine oxidase]]
	[[Category: Bell, C E]]		[[Category: Bell, C E]]

OCA at 08:02, 31 October 2018

OCA — Wed, 31 Oct 2018 08:02:16 GMT

←Older revision		Revision as of 08:02, 31 October 2018
Line 1:		Line 1:
		+
	==Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine==		==Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine==
	<StructureSection load='3b9j' size='340' side='right' caption='[[3b9j]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3b9j' size='340' side='right' caption='[[3b9j]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://pdbe.org/3b9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://pdbe.org/3b9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b9j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b9j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b9j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:33, 10 February 2016

OCA — Wed, 10 Feb 2016 06:33:35 GMT

←Older revision		Revision as of 06:33, 10 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://pdbe.org/3b9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b9j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3b9j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:28, 25 December 2014

OCA — Thu, 25 Dec 2014 12:28:18 GMT

←Older revision		Revision as of 12:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3b9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B9J FirstGlance]. <br>		<table><tr><td colspan='2'>[[3b9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B9J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/XDH_BOVIN XDH_BOVIN]] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Xanthine oxidase]]		[[Category: Xanthine oxidase]]
-	[[Category: Bell, C E.]]	+	[[Category: Bell, C E]]
-	[[Category: Hille, R.]]	+	[[Category: Hille, R]]
-	[[Category: Pauff, J M.]]	+	[[Category: Pauff, J M]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
	[[Category: Catalysis]]		[[Category: Catalysis]]
	[[Category: Intermediate]]		[[Category: Intermediate]]

OCA at 09:04, 29 September 2014

OCA — Mon, 29 Sep 2014 09:04:40 GMT

←Older revision		Revision as of 09:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:3b9j.~~png\|left~~\|200px]]	+	==Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine==
		+	<StructureSection load='3b9j' size='340' side='right' caption='[[3b9j]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3b9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B9J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=290:6-METHYL-3,9-DIHYDRO-2H-PURIN-2-ONE'>290</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_oxidase Xanthine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.3.2 1.17.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b9j RCSB], [http://www.ebi.ac.uk/pdbsum/3b9j PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b9j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Xanthine oxidoreductase catalyzes the final two steps of purine catabolism and is involved in a variety of pathological states ranging from hyperuricemia to ischemia-reperfusion injury. The human enzyme is expressed primarily in its dehydrogenase form utilizing NAD+ as the final electron acceptor from the enzyme's flavin site but can exist as an oxidase that utilizes O2 for this purpose. Central to an understanding of the enzyme's function is knowledge of purine substrate orientation in the enzyme's molybdenum-containing active site. We report here the crystal structure of xanthine oxidase, trapped at the stage of a critical intermediate in the course of reaction with the slow substrate 2-hydroxy-6-methylpurine at 2.3A. This is the first crystal structure of a reaction intermediate with a purine substrate that is hydroxylated at its C8 position as is xanthine and confirms the structure predicted to occur in the course of the presently favored reaction mechanism. The structure also corroborates recent work suggesting that 2-hydroxy-6-methylpurine orients in the active site with its C2 carbonyl group interacting with Arg-880 and extends our hypothesis that xanthine binds opposite this orientation, with its C6 carbonyl positioned to interact with Arg-880 in stabilizing the MoV transition state.

-	~~{{STRUCTURE_3b9j\| PDB=3b9j \| SCENE= }}~~	+	Substrate orientation in xanthine oxidase: crystal structure of enzyme in reaction with 2-hydroxy-6-methylpurine.,Pauff JM, Zhang J, Bell CE, Hille R J Biol Chem. 2008 Feb 22;283(8):4818-24. Epub 2007 Dec 6. PMID:18063585<ref>PMID:18063585</ref>

-	~~===Structure~~ of ~~Xanthine Oxidase with 2-hydroxy-6-methylpurine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18063585}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3b9j]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA].~~	+

	==See Also==		==See Also==
	*[[Xanthine dehydrogenase\|Xanthine dehydrogenase]]		*[[Xanthine dehydrogenase\|Xanthine dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018063585<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Xanthine oxidase]]		[[Category: Xanthine oxidase]]

OCA at 16:40, 20 October 2012

OCA — Sat, 20 Oct 2012 16:40:12 GMT

←Older revision		Revision as of 16:40, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3b9j]] is a 6 chain structure ~~of [[Xanthine dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA].	+	[[3b9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA].

	==See Also==		==See Also==

OCA: Protected "3b9j" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 22:27:08 GMT

Protected "3b9j" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:27, 26 July 2012

OCA at 22:27, 26 July 2012

OCA — Thu, 26 Jul 2012 22:27:06 GMT

←Older revision		Revision as of 22:27, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3b9j.png\|left\|200px]]		[[Image:3b9j.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3b9j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3b9j\| PDB=3b9j \| SCENE= }}		{{STRUCTURE_3b9j\| PDB=3b9j \| SCENE= }}

	===Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine===		===Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18063585}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18063585 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18063585}}		{{ABSTRACT_PUBMED_18063585}}

	==About this Structure==		==About this Structure==
-	~~3B9J~~ is a 6 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA].	+	[[3b9j]] is a 6 chain structure of [[Xanthine dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA].
		+
		+	==See Also==
		+	*[[Xanthine dehydrogenase\|Xanthine dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18063585~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018063585</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Xanthine oxidase]]		[[Category: Xanthine oxidase]]
Line 35:		Line 26:
	[[Category: Peroxisome]]		[[Category: Peroxisome]]
	[[Category: Substrate orientation]]		[[Category: Substrate orientation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:21:27 2009''

OCA at 06:21, 15 April 2009

OCA — Wed, 15 Apr 2009 06:21:28 GMT

←Older revision		Revision as of 06:21, 15 April 2009
Line 12:		Line 12:
	===Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine===		===Structure of Xanthine Oxidase with 2-hydroxy-6-methylpurine===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18063585}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18063585 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18063585}}

	==About this Structure==		==About this Structure==
	3B9J is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA].		3B9J is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9J OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:18063585</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Xanthine oxidase]]		[[Category: Xanthine oxidase]]
Line 27:		Line 36:
	[[Category: Substrate orientation]]		[[Category: Substrate orientation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Feb 17 16~~:10:46 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:21:27 2009''