3bex - Revision history

OCA at 12:08, 30 August 2023

OCA — Wed, 30 Aug 2023 12:08:26 GMT

←Older revision		Revision as of 12:08, 30 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bex]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bex]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.51Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3bf1\|3bf1]], [[3bf3\|3bf3]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>coaX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~2336 Thermotoga maritima])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [https://pdbe.org/3bex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [https://www.ebi.ac.uk/pdbsum/3bex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bex ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [https://pdbe.org/3bex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [https://www.ebi.ac.uk/pdbsum/3bex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bex ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/COAX_THEMA COAX_THEMA]] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16855243</ref>	+	[https://www.uniprot.org/uniprot/COAX_THEMA COAX_THEMA] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16855243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pantothenate kinase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Huerta, C]]	+	[[Category: Huerta C]]
-	[[Category: Strauss, E]]	+	[[Category: Strauss E]]
-	[[Category: Yang, K]]	+	[[Category: Yang K]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Actin-like fold]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Coenzyme a biosynthesis]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Potassium]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:33, 5 January 2022

OCA — Wed, 05 Jan 2022 11:33:23 GMT

←Older revision		Revision as of 11:33, 5 January 2022
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	==Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate==		==Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate==
-	<StructureSection load='3bex' size='340' side='right' caption='[[3bex]], [[Resolution\|resolution]] 1.51Å' scene=''>	+	<StructureSection load='3bex' size='340' side='right'caption='[[3bex]], [[Resolution\|resolution]] 1.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bex]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BEX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bex]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bf1\|3bf1]], [[3bf3\|3bf3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bf1\|3bf1]], [[3bf3\|3bf3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaX ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [~~http~~://pdbe.org/3bex PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bex PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bex ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [https://pdbe.org/3bex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [https://www.ebi.ac.uk/pdbsum/3bex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bex ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/COAX_THEMA COAX_THEMA]] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16855243</ref>	+	[[https://www.uniprot.org/uniprot/COAX_THEMA COAX_THEMA]] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16855243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Pantothenate kinase\|Pantothenate kinase]]	+	*[[Pantothenate kinase 3D structures\|Pantothenate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]

OCA at 08:12, 31 October 2018

OCA — Wed, 31 Oct 2018 08:12:01 GMT

←Older revision		Revision as of 08:12, 31 October 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bex_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bex_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 47:		Line 47:
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Coenzyme a biosynthesis]]		[[Category: Coenzyme a biosynthesis]]
		+	[[Category: Cytoplasm]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]

OCA at 03:31, 5 August 2016

OCA — Fri, 05 Aug 2016 03:31:00 GMT

←Older revision		Revision as of 03:31, 5 August 2016
Line 1:		Line 1:
		+
	==Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate==		==Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate==
	<StructureSection load='3bex' size='340' side='right' caption='[[3bex]], [[Resolution\|resolution]] 1.51Å' scene=''>		<StructureSection load='3bex' size='340' side='right' caption='[[3bex]], [[Resolution\|resolution]] 1.51Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [http://www.ebi.ac.uk/pdbsum/3bex PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [http://pdbe.org/3bex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [http://www.ebi.ac.uk/pdbsum/3bex PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bex ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bex ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3bex" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:31, 25 December 2014

OCA — Thu, 25 Dec 2014 15:31:00 GMT

←Older revision		Revision as of 15:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bex]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bex]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BEX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bf1\|3bf1]], [[3bf3\|3bf3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bf1\|3bf1]], [[3bf3\|3bf3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [http://www.ebi.ac.uk/pdbsum/3bex PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [http://www.ebi.ac.uk/pdbsum/3bex PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/COAX_THEMA COAX_THEMA]] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16855243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Huerta, C.]]	+	[[Category: Huerta, C]]
-	[[Category: Strauss, E.]]	+	[[Category: Strauss, E]]
-	[[Category: Yang, K.]]	+	[[Category: Yang, K]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
	[[Category: Actin-like fold]]		[[Category: Actin-like fold]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 21:27, 2 October 2014

OCA — Thu, 02 Oct 2014 21:27:31 GMT

←Older revision		Revision as of 21:27, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3bex.~~png~~\|~~left~~\|200px]]	+	==Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate==
		+	<StructureSection load='3bex' size='340' side='right' caption='[[3bex]], [[Resolution\|resolution]] 1.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3bex]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BEX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bf1\|3bf1]], [[3bf3\|3bf3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bex RCSB], [http://www.ebi.ac.uk/pdbsum/3bex PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bex_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pantothenate kinase (PanK) catalyzes the first step of the universal five-step coenzyme A (CoA) biosynthetic pathway. The recently characterized type III PanK (PanK-III, encoded by the coaX gene) is distinct in sequence, structure and enzymatic properties from both the long-known bacterial type I PanK (PanK-I, exemplified by the Escherichia coli CoaA protein) and the predominantly eukaryotic type II PanK (PanK-II). PanK-III enzymes have an unusually high Km for ATP, are resistant to feedback inhibition by CoA, and are unable to utilize the N-alkylpantothenamide family of pantothenate analogues as alternative substrates, thus making type III PanK ineffective in generating CoA analogues as antimetabolites in vivo. Previously, we reported the crystal structure of the PanK-III from Thermotoga maritima and identified it as a member of the "acetate and sugar kinase/heat shock protein 70/actin" (ASKHA) superfamily. Here we report the crystal structures of the same PanK-III in complex with one of its substrates (pantothenate), its product (phosphopantothenate) as well as a ternary complex structure of PanK-III with pantothenate and ADP. These results are combined with isothermal titration calorimetry experiments to present a detailed structural and thermodynamic characterization of the interactions between PanK-III and its substrates ATP and pantothenate. Comparison of substrate binding and catalytic sites of PanK-III with that of eukaryotic PanK-II revealed drastic differences in the binding modes for both ATP and pantothenate substrates, and suggests that these differences may be exploited in the development of new inhibitors specifically targeting PanK-III.

-	~~{{STRUCTURE_3bex\| PDB=3bex \| SCENE= }}~~	+	Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.,Yang K, Strauss E, Huerta C, Zhang H Biochemistry. 2008 Feb 5;47(5):1369-80. Epub 2008 Jan 11. PMID:18186650<ref>PMID:18186650</ref>

-	~~===Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18186650}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3bex]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermotoga_maritima Thermotoga maritima]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA].~~	+

	==See Also==		==See Also==
	*[[Pantothenate kinase\|Pantothenate kinase]]		*[[Pantothenate kinase\|Pantothenate kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018186650<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]

OCA: Protected "3bex" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:18:04 GMT

Protected "3bex" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:18, 7 January 2013

OCA at 18:18, 7 January 2013

OCA — Mon, 07 Jan 2013 18:18:02 GMT

←Older revision		Revision as of 18:18, 7 January 2013
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-	{{Seed}}
	[[Image:3bex.png\|left\|200px]]		[[Image:3bex.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bex", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bex\| PDB=3bex \| SCENE= }}		{{STRUCTURE_3bex\| PDB=3bex \| SCENE= }}

	===Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate===		===Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18186650}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18186650 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18186650}}		{{ABSTRACT_PUBMED_18186650}}

	==About this Structure==		==About this Structure==
-	~~3BEX~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA].	+	[[3bex]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA].
		+
		+	==See Also==
		+	*[[Pantothenate kinase\|Pantothenate kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18186650~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018186650</ref><references group="xtra"/>
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
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	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Coenzyme a biosynthesis]]		[[Category: Coenzyme a biosynthesis]]
-	[[Category: Cytoplasm]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
Line 39:		Line 29:
	[[Category: Potassium]]		[[Category: Potassium]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:25:13 2009''

OCA at 18:25, 17 February 2009

OCA — Tue, 17 Feb 2009 18:25:15 GMT

←Older revision		Revision as of 18:25, 17 February 2009
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	==About this Structure==		==About this Structure==
-	3BEX is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA].	+	3BEX is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA].

	==Reference==		==Reference==
-	~~Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase., Yang K, Strauss E, Huerta C, Zhang H, Biochemistry. 2008 Feb 5;47(5):1369-80. Epub 2008 Jan 11.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18186650 18186650]~~	+	<ref group="xtra">PMID:18186650</ref><references group="xtra"/>
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
-	[[Category: Single protein]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Huerta, C.]]		[[Category: Huerta, C.]]
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	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 22~~:00:~~57 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:25:13 2009''

OCA at 19:00, 2 July 2008

OCA — Wed, 02 Jul 2008 19:00:57 GMT

←Older revision		Revision as of 19:00, 2 July 2008
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-	[[Image:3bex.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3bex.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3bex\| PDB=3bex \| SCENE= }}		{{STRUCTURE_3bex\| PDB=3bex \| SCENE= }}

-	~~'''~~Type III pantothenate kinase from Thermotoga maritima complexed with ~~panothenate'''~~	+	===Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate===


-	{{~~ABSTRACT_18186650~~}}	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18186650}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18186650 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18186650}}

	==About this Structure==		==About this Structure==
	3BEX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA].		3BEX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEX OCA].
		+
		+	==Reference==
		+	Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase., Yang K, Strauss E, Huerta C, Zhang H, Biochemistry. 2008 Feb 5;47(5):1369-80. Epub 2008 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18186650 18186650]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Single protein]]		[[Category: Single protein]]
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	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 25 18~~:57:53 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:00:57 2008''