3bgg - Revision history

OCA at 12:08, 30 August 2023

OCA — Wed, 30 Aug 2023 12:08:40 GMT

←Older revision		Revision as of 12:08, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3bgg' size='340' side='right'caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3bgg' size='340' side='right'caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMP:6~~-~~HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>UMPS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Orotidine~~-5'-~~phosphate_decarboxylase Orotidine-5~~'~~-phosphate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [https://pdbe.org/3bgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [https://www.ebi.ac.uk/pdbsum/3bgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [https://pdbe.org/3bgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [https://www.ebi.ac.uk/pdbsum/3bgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>	+	[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Orotidine-5'-phosphate decarboxylase]]~~	+	[[Category: Kotra LP]]
-	[[Category: Kotra~~, L P~~]]	+	[[Category: Liu Y]]
-	[[Category: Liu, Y]]	+	[[Category: Pai EF]]
-	[[Category: Pai~~, E F~~]]	+	[[Category: Tang HL]]
-	[[Category: Tang~~, H L~~]]	+	[[Category: Wang XY]]
-	[[Category: Wang~~, X Y]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Bmp]]~~	+
-	~~[[Category: C-terminal domain]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Orotidine 5'-monophosphate decarboxylase]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Pyrimidine biosynthesis]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Ump synthase~~]]	+

OCA at 10:40, 12 January 2022

OCA — Wed, 12 Jan 2022 10:40:34 GMT

←Older revision		Revision as of 10:40, 12 January 2022
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	==Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP==		==Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP==
-	<StructureSection load='3bgg' size='340' side='right' caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>	+	<StructureSection load='3bgg' size='340' side='right'caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BGG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [~~http~~://pdbe.org/3bgg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bgg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [https://pdbe.org/3bgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [https://www.ebi.ac.uk/pdbsum/3bgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[~~http~~://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>	+	[[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 22:		Line 22:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Uridine 5'-monophosphate synthase 3D structures\|Uridine 5'-monophosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Kotra, L P]]		[[Category: Kotra, L P]]

OCA at 08:02, 25 October 2017

OCA — Wed, 25 Oct 2017 08:02:35 GMT

←Older revision		Revision as of 08:02, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP==		==Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP==
	<StructureSection load='3bgg' size='340' side='right' caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3bgg' size='340' side='right' caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [http://pdbe.org/3bgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [http://www.ebi.ac.uk/pdbsum/3bgg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [http://pdbe.org/3bgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [http://www.ebi.ac.uk/pdbsum/3bgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 33:
	[[Category: Tang, H L]]		[[Category: Tang, H L]]
	[[Category: Wang, X Y]]		[[Category: Wang, X Y]]
		+	[[Category: Alternative splicing]]
	[[Category: Bmp]]		[[Category: Bmp]]
	[[Category: C-terminal domain]]		[[Category: C-terminal domain]]
Line 42:		Line 41:
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
	[[Category: Orotidine 5'-monophosphate decarboxylase]]		[[Category: Orotidine 5'-monophosphate decarboxylase]]
		+	[[Category: Polymorphism]]
	[[Category: Pyrimidine biosynthesis]]		[[Category: Pyrimidine biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Ump synthase]]		[[Category: Ump synthase]]

OCA at 15:38, 9 February 2016

OCA — Tue, 09 Feb 2016 15:38:40 GMT

←Older revision		Revision as of 15:38, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3bgg' size='340' side='right' caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3bgg' size='340' side='right' caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BGG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BGG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [http://www.ebi.ac.uk/pdbsum/3bgg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [http://pdbe.org/3bgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [http://www.ebi.ac.uk/pdbsum/3bgg PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/~~PYR5_HUMAN PYR5_HUMAN~~]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>	+	[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Kotra, L P]]		[[Category: Kotra, L P]]
Line 39:		Line 39:
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
-	[[Category: Human]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]

OCA at 07:47, 25 December 2014

OCA — Thu, 25 Dec 2014 07:47:55 GMT

←Older revision		Revision as of 07:47, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BGG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BGG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [http://www.ebi.ac.uk/pdbsum/3bgg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [http://www.ebi.ac.uk/pdbsum/3bgg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>		[[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
-	== Function ==
-
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 30:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
-	[[Category: Kotra, L P.]]	+	[[Category: Kotra, L P]]
-	[[Category: Liu, Y.]]	+	[[Category: Liu, Y]]
-	[[Category: Pai, E F.]]	+	[[Category: Pai, E F]]
-	[[Category: Tang, H L.]]	+	[[Category: Tang, H L]]
-	[[Category: Wang, X Y.]]	+	[[Category: Wang, X Y]]
	[[Category: Bmp]]		[[Category: Bmp]]
	[[Category: C-terminal domain]]		[[Category: C-terminal domain]]

OCA at 21:27, 2 October 2014

OCA — Thu, 02 Oct 2014 21:27:12 GMT

←Older revision		Revision as of 21:27, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3bgg\| PDB=3bgg \| SCENE= }}~~	+	==Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP==
-	===Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP===	+	<StructureSection load='3bgg' size='340' side='right' caption='[[3bgg]], [[Resolution\|resolution]] 1.93Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BGG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1f\|2p1f]], [[2eaw\|2eaw]], [[3bgj\|3bgj]], [[3bk0\|3bk0]], [[3bvj\|3bvj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [http://www.ebi.ac.uk/pdbsum/3bgg PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
		+	== Function ==

-	==~~Disease~~==	+	== Evolutionary Conservation ==
-	[[~~http~~://~~www~~.~~uniprot.org~~/~~uniprot~~/~~PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http:~~//~~omim.org~~/~~entry~~/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<~~ref~~>~~PMID:9042911~~</~~ref~~>	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-		+	Check<jmol>
-	~~==About this Structure==~~	+	<jmolCheckbox>
-	~~[[3bgg]] is a 1 chain structure with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~3BGG OCA~~].	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]		*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]

OCA at 11:37, 24 March 2013

OCA — Sun, 24 Mar 2013 11:37:02 GMT

←Older revision		Revision as of 11:37, 24 March 2013
Line 1:		Line 1:
-	[[Image:3bgg.png\|left\|200px]]
-
	{{STRUCTURE_3bgg\| PDB=3bgg \| SCENE= }}		{{STRUCTURE_3bgg\| PDB=3bgg \| SCENE= }}
-
	===Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP===		===Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 10:
	==See Also==		==See Also==
	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]		*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]

OCA: Protected "3bgg" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:58:30 GMT

Protected "3bgg" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:58, 7 January 2013

OCA at 18:58, 7 January 2013

OCA — Mon, 07 Jan 2013 18:58:25 GMT

←Older revision		Revision as of 18:58, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3bgg.png\|left\|200px]]		[[Image:3bgg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bgg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bgg\| PDB=3bgg \| SCENE= }}		{{STRUCTURE_3bgg\| PDB=3bgg \| SCENE= }}

	===Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP===		===Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP===

-
-	==Disease==
-	Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]

	==About this Structure==		==About this Structure==
-	~~3BGG~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA].	+	[[3bgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA].
		+
		+	==See Also==
		+	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
Line 25:		Line 18:
	[[Category: Tang, H L.]]		[[Category: Tang, H L.]]
	[[Category: Wang, X Y.]]		[[Category: Wang, X Y.]]
-	[[Category: Alternative splicing]]
	[[Category: Bmp]]		[[Category: Bmp]]
	[[Category: C-terminal domain]]		[[Category: C-terminal domain]]
Line 34:		Line 26:
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
	[[Category: Orotidine 5'-monophosphate decarboxylase]]		[[Category: Orotidine 5'-monophosphate decarboxylase]]
-	[[Category: Polymorphism]]
	[[Category: Pyrimidine biosynthesis]]		[[Category: Pyrimidine biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Ump synthase]]		[[Category: Ump synthase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:54:14 2008''

OCA at 05:54, 20 November 2008

OCA — Thu, 20 Nov 2008 05:54:17 GMT

←Older revision		Revision as of 05:54, 20 November 2008
Line 17:		Line 17:

	==About this Structure==		==About this Structure==
-	3BGG is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA].	+	3BGG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
-	[[Category: Single protein]]
	[[Category: Kotra, L P.]]		[[Category: Kotra, L P.]]
	[[Category: Liu, Y.]]		[[Category: Liu, Y.]]
Line 40:		Line 39:
	[[Category: Ump synthase]]		[[Category: Ump synthase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Nov 19 20:46:19 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:54:14 2008''