3bk8 - Revision history

OCA at 14:47, 1 November 2023

OCA — Wed, 01 Nov 2023 14:47:26 GMT

←Older revision		Revision as of 14:47, 1 November 2023
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	<StructureSection load='3bk8' size='340' side='right'caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3bk8' size='340' side='right'caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aspfl Aspfl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AZA:8~~-~~AZAXANTHINE'>AZA</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [https://pdbe.org/3bk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3bk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bk8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [https://pdbe.org/3bk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3bk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bk8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.	+	[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 32:
	==See Also==		==See Also==
	*[[Urate Oxidase\|Urate Oxidase]]		*[[Urate Oxidase\|Urate Oxidase]]
		+	*[[Urate oxidase 3D structures\|Urate oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspfl]]~~	+	[[Category: Aspergillus flavus]]
-	~~[[Category: Factor independent urate hydroxylase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Castro, B]]	+	[[Category: Castro B]]
-	[[Category: Chiadmi, M]]	+	[[Category: Chiadmi M]]
-	[[Category: ~~Gabison, L~~]]	+	[[Category: Colloc'h N]]
-	[[Category: Hajji, M El]]	+	[[Category: El Hajji M]]
-	[[Category: ~~Prange, T~~]]	+	[[Category: Gabison L]]
-	[[Category: ~~H, N Colloc]]~~	+	[[Category: Prange T]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Cyanide]]~~	+
-	~~[[Category: Degradation mechanism]]~~	+
-	~~[[Category: Inhibition]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Peroxisome]]~~	+
-	~~[[Category: Purine metabolism]]~~	+
-	~~[[Category: Uric acid~~]]	+

OCA at 10:45, 12 January 2022

OCA — Wed, 12 Jan 2022 10:45:04 GMT

←Older revision		Revision as of 10:45, 12 January 2022
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	<StructureSection load='3bk8' size='340' side='right'caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3bk8' size='340' side='right'caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [~~http~~://pdbe.org/3bk8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bk8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bk8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [https://pdbe.org/3bk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3bk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bk8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.	+	[[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:31, 31 July 2019

OCA — Wed, 31 Jul 2019 07:31:28 GMT

←Older revision		Revision as of 07:31, 31 July 2019
Line 1:		Line 1:

	==Urate oxidase aza-xanthine complex in cyanide==		==Urate oxidase aza-xanthine complex in cyanide==
-	<StructureSection load='3bk8' size='340' side='right' caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3bk8' size='340' side='right'caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/3bk8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/3bk8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3bk8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3bk8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Aspfl]]		[[Category: Aspfl]]
	[[Category: Factor independent urate hydroxylase]]		[[Category: Factor independent urate hydroxylase]]
		+	[[Category: Large Structures]]
	[[Category: Castro, B]]		[[Category: Castro, B]]
	[[Category: Chiadmi, M]]		[[Category: Chiadmi, M]]

OCA at 08:05, 25 October 2017

OCA — Wed, 25 Oct 2017 08:05:08 GMT

←Older revision		Revision as of 08:05, 25 October 2017
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3bk8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3bk8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>
Line 45:		Line 42:
	[[Category: Prange, T]]		[[Category: Prange, T]]
	[[Category: H, N Colloc]]		[[Category: H, N Colloc]]
		+	[[Category: Acetylation]]
	[[Category: Cyanide]]		[[Category: Cyanide]]
	[[Category: Degradation mechanism]]		[[Category: Degradation mechanism]]

OCA at 21:40, 4 August 2016

OCA — Thu, 04 Aug 2016 21:40:03 GMT

←Older revision		Revision as of 21:40, 4 August 2016
Line 1:		Line 1:
		+
	==Urate oxidase aza-xanthine complex in cyanide==		==Urate oxidase aza-xanthine complex in cyanide==
	<StructureSection load='3bk8' size='340' side='right' caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3bk8' size='340' side='right' caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aspergillus_flavus Aspergillus flavus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Urate_oxidase Urate oxidase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3bk8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [http://pdbe.org/3bk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3bk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bk8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bk8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3bk8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspergillus flavus~~]]	+	[[Category: Aspfl]]
-	[[Category: ~~Urate oxidase~~]]	+	[[Category: Factor independent urate hydroxylase]]
	[[Category: Castro, B]]		[[Category: Castro, B]]
	[[Category: Chiadmi, M]]		[[Category: Chiadmi, M]]

OCA at 13:22, 25 December 2014

OCA — Thu, 25 Dec 2014 13:22:53 GMT

←Older revision		Revision as of 13:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3bk8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3bk8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Aspergillus flavus]]		[[Category: Aspergillus flavus]]
	[[Category: Urate oxidase]]		[[Category: Urate oxidase]]
-	[[Category: Castro, B.]]	+	[[Category: Castro, B]]
-	[[Category: Chiadmi, M.]]	+	[[Category: Chiadmi, M]]
-	[[Category: Gabison, L.]]	+	[[Category: Gabison, L]]
-	[[Category: Hajji, M El.]]	+	[[Category: Hajji, M El]]
-	[[Category: Prange, T.]]	+	[[Category: Prange, T]]
-	[[Category: H, N Colloc.]]	+	[[Category: H, N Colloc]]
	[[Category: Cyanide]]		[[Category: Cyanide]]
	[[Category: Degradation mechanism]]		[[Category: Degradation mechanism]]

OCA at 06:35, 29 September 2014

OCA — Mon, 29 Sep 2014 06:35:51 GMT

←Older revision		Revision as of 06:35, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3bk8.~~png~~\|~~left~~\|200px]]	+	==Urate oxidase aza-xanthine complex in cyanide==
		+	<StructureSection load='3bk8' size='340' side='right' caption='[[3bk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BK8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bjp\|3bjp]], [[1r51\|1r51]], [[2iba\|2iba]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3bk8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/3bk8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric interfaces. RESULTS: The catalytic mechanism was investigated through a ternary complex formed between the enzyme, uric acid, and cyanide that stabilizes an intermediate state of the reaction. When uric acid is replaced by a competitive inhibitor, no complex with cyanide is formed. CONCLUSION: The X-ray structure of this compulsory ternary complex led to a number of mechanistic evidences that support a sequential mechanism in which the two reagents, dioxygen and a water molecule, process through a common site located 3.3 A above the mean plane of the ligand. This site is built by the side chains of Asn 254, and Thr 57, two conserved residues belonging to two different subunits of the homo-tetramer. The absence of a ternary complex between the enzyme, a competitive inhibitor, and cyanide suggests that cyanide inhibits the hydroxylation step of the reaction, after the initial formation of a hydroperoxyde type intermediate.

-	~~{{STRUCTURE_3bk8\| PDB=3bk8 \| SCENE= }}~~	+	Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: mechanistic implications.,Gabison L, Prange T, Colloc'h N, El Hajji M, Castro B, Chiadmi M BMC Struct Biol. 2008 Jul 20;8:32. PMID:18638417<ref>PMID:18638417</ref>

-	~~===Urate oxidase aza-xanthine complex in cyanide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18638417}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3bk8]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aspergillus_flavus Aspergillus flavus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA].~~	+

	==See Also==		==See Also==
	*[[Urate Oxidase\|Urate Oxidase]]		*[[Urate Oxidase\|Urate Oxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018638417<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aspergillus flavus]]		[[Category: Aspergillus flavus]]
	[[Category: Urate oxidase]]		[[Category: Urate oxidase]]

OCA at 17:11, 20 October 2012

OCA — Sat, 20 Oct 2012 17:11:17 GMT

←Older revision		Revision as of 17:11, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3bk8]] is a 1 chain structure ~~of [[Urate Oxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA].	+	[[3bk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA].

	==See Also==		==See Also==

OCA: Protected "3bk8" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 00:05:29 GMT

Protected "3bk8" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:05, 27 July 2012

OCA at 00:05, 27 July 2012

OCA — Fri, 27 Jul 2012 00:05:27 GMT

←Older revision		Revision as of 00:05, 27 July 2012
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-	{{Seed}}
	[[Image:3bk8.png\|left\|200px]]		[[Image:3bk8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bk8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bk8\| PDB=3bk8 \| SCENE= }}		{{STRUCTURE_3bk8\| PDB=3bk8 \| SCENE= }}

	===Urate oxidase aza-xanthine complex in cyanide===		===Urate oxidase aza-xanthine complex in cyanide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18638417}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18638417 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18638417}}		{{ABSTRACT_PUBMED_18638417}}

	==About this Structure==		==About this Structure==
-	~~3BK8~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA].	+	[[3bk8]] is a 1 chain structure of [[Urate Oxidase]] with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK8 OCA].
		+
		+	==See Also==
		+	*[[Urate Oxidase\|Urate Oxidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18638417~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018638417</ref><references group="xtra"/>
	[[Category: Aspergillus flavus]]		[[Category: Aspergillus flavus]]
	[[Category: Urate oxidase]]		[[Category: Urate oxidase]]
Line 32:		Line 23:
	[[Category: Prange, T.]]		[[Category: Prange, T.]]
	[[Category: H, N Colloc.]]		[[Category: H, N Colloc.]]
-	[[Category: Acetylation]]
	[[Category: Cyanide]]		[[Category: Cyanide]]
	[[Category: Degradation mechanism]]		[[Category: Degradation mechanism]]
Line 40:		Line 30:
	[[Category: Purine metabolism]]		[[Category: Purine metabolism]]
	[[Category: Uric acid]]		[[Category: Uric acid]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:18:03 2009''