3blx - Revision history

OCA at 12:10, 30 August 2023

OCA — Wed, 30 Aug 2023 12:10:48 GMT

←Older revision		Revision as of 12:10, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3blx' size='340' side='right'caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3blx' size='340' side='right'caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3blx]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3blx]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BLX FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3blv\|3blv]], [[3blw\|3blw]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">IDH1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824]), IDH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [https://pdbe.org/3blx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [https://www.ebi.ac.uk/pdbsum/3blx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3blx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [https://pdbe.org/3blx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [https://www.ebi.ac.uk/pdbsum/3blx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3blx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IDH1_YEAST IDH1_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs. [[https://www.uniprot.org/uniprot/IDH2_YEAST IDH2_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.	+	[https://www.uniprot.org/uniprot/IDH1_YEAST IDH1_YEAST] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hart~~, P J~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Hu, G]]	+	[[Category: Hart PJ]]
-	[[Category: McAlister-Henn, L]]	+	[[Category: Hu G]]
-	[[Category: Taylor~~, A B]]~~	+	[[Category: McAlister-Henn L]]
-	~~[[Category: Allosteric enzyme]]~~	+	[[Category: Taylor AB]]
-	~~[[Category: Allostery]]~~	+
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Magnesium]]~~	+
-	~~[[Category: Manganese]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Mitochondrion]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Oxidative metabolism]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Tca cycle]]~~	+
-	~~[[Category: Transit peptide]]~~	+
-	~~[[Category: Tricarboxylic acid cycle~~]]	+

OCA at 10:46, 12 January 2022

OCA — Wed, 12 Jan 2022 10:46:27 GMT

←Older revision		Revision as of 10:46, 12 January 2022
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	==Yeast Isocitrate Dehydrogenase (Apo Form)==		==Yeast Isocitrate Dehydrogenase (Apo Form)==
-	<StructureSection load='3blx' size='340' side='right' caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3blx' size='340' side='right'caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3blx]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3blx]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BLX FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3blv\|3blv]], [[3blw\|3blw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3blv\|3blv]], [[3blw\|3blw]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDH1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), IDH2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), IDH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [~~http~~://pdbe.org/3blx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3blx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3blx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [https://pdbe.org/3blx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [https://www.ebi.ac.uk/pdbsum/3blx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3blx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IDH1_YEAST IDH1_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs. [[~~http~~://www.uniprot.org/uniprot/IDH2_YEAST IDH2_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.	+	[[https://www.uniprot.org/uniprot/IDH1_YEAST IDH1_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs. [[https://www.uniprot.org/uniprot/IDH2_YEAST IDH2_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]	+	*[[Isocitrate dehydrogenase 3D structures\|Isocitrate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Hart, P J]]		[[Category: Hart, P J]]
	[[Category: Hu, G]]		[[Category: Hu, G]]

OCA at 08:06, 31 October 2018

OCA — Wed, 31 Oct 2018 08:06:03 GMT

←Older revision		Revision as of 08:06, 31 October 2018
Line 1:		Line 1:
		+
	==Yeast Isocitrate Dehydrogenase (Apo Form)==		==Yeast Isocitrate Dehydrogenase (Apo Form)==
	<StructureSection load='3blx' size='340' side='right' caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3blx' size='340' side='right' caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), IDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), IDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [http://pdbe.org/3blx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [http://www.ebi.ac.uk/pdbsum/3blx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [http://pdbe.org/3blx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [http://www.ebi.ac.uk/pdbsum/3blx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3blx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/3blx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/3blx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:27, 7 February 2016

OCA — Sun, 07 Feb 2016 13:27:10 GMT

←Older revision		Revision as of 13:27, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3blx' size='340' side='right' caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3blx' size='340' side='right' caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3blx]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3blx]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BLX FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3blv\|3blv]], [[3blw\|3blw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3blv\|3blv]], [[3blw\|3blw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), IDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), IDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [http://www.ebi.ac.uk/pdbsum/3blx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [http://pdbe.org/3blx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [http://www.ebi.ac.uk/pdbsum/3blx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3blx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3blx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Hart, P J]]		[[Category: Hart, P J]]
	[[Category: Hu, G]]		[[Category: Hu, G]]

OCA at 15:25, 24 December 2014

OCA — Wed, 24 Dec 2014 15:25:04 GMT

←Older revision		Revision as of 15:25, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [http://www.ebi.ac.uk/pdbsum/3blx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [http://www.ebi.ac.uk/pdbsum/3blx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IDH1_YEAST IDH1_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs. [[http://www.uniprot.org/uniprot/IDH2_YEAST IDH2_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Hart, P J.]]	+	[[Category: Hart, P J]]
-	[[Category: Hu, G.]]	+	[[Category: Hu, G]]
-	[[Category: McAlister-Henn, L.]]	+	[[Category: McAlister-Henn, L]]
-	[[Category: Taylor, A B.]]	+	[[Category: Taylor, A B]]
	[[Category: Allosteric enzyme]]		[[Category: Allosteric enzyme]]
	[[Category: Allostery]]		[[Category: Allostery]]

OCA at 06:42, 10 October 2014

OCA — Fri, 10 Oct 2014 06:42:42 GMT

←Older revision		Revision as of 06:42, 10 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3blx.~~png~~\|~~left~~\|200px]]	+	==Yeast Isocitrate Dehydrogenase (Apo Form)==
		+	<StructureSection load='3blx' size='340' side='right' caption='[[3blx]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3blx]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BLX FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3blv\|3blv]], [[3blw\|3blw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), IDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3blx RCSB], [http://www.ebi.ac.uk/pdbsum/3blx PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/3blx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitochondrial NAD(+)-specific isocitrate dehydrogenases (IDHs) are key regulators of flux through biosynthetic and oxidative pathways in response to cellular energy levels. Here we present the first structures of a eukaryotic member of this enzyme family, the allosteric, hetero-octameric, NAD(+)-specific IDH from yeast in three forms: 1) without ligands, 2) with bound analog citrate, and 3) with bound citrate + AMP. The structures reveal the molecular basis for ligand binding to homologous but distinct regulatory and catalytic sites positioned at the interfaces between IDH1 and IDH2 subunits and define pathways of communication between heterodimers and heterotetramers in the hetero-octamer. Disulfide bonds observed at the heterotetrameric interfaces in the unliganded IDH hetero-octamer are reduced in the ligand-bound forms, suggesting a redox regulatory mechanism that may be analogous to the "on-off" regulation of non-allosteric bacterial IDHs via phosphorylation. The results strongly suggest that eukaryotic IDH enzymes are exquisitely tuned to ensure that allosteric activation occurs only when concentrations of isocitrate are elevated.

-	~~{{STRUCTURE_3blx\| PDB=3blx \| SCENE= }}~~	+	Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase.,Taylor AB, Hu G, Hart PJ, McAlister-Henn L J Biol Chem. 2008 Apr 18;283(16):10872-80. Epub 2008 Feb 6. PMID:18256028<ref>PMID:18256028</ref>

-	~~===Yeast Isocitrate Dehydrogenase (Apo Form)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18256028}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3blx]] is~~ a ~~16 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA].~~	+

	==See Also==		==See Also==
-	*[[Ferguson sandbox 1\|Ferguson sandbox 1]]
	*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]		*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018256028<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Hart, P J.]]		[[Category: Hart, P J.]]

OCA at 06:46, 20 October 2012

OCA — Sat, 20 Oct 2012 06:46:53 GMT

←Older revision		Revision as of 06:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3blx]] is a 16 chain structure ~~of [[Ferguson sandbox 1]] and [[Isocitrate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA].	+	[[3blx]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA].

	==See Also==		==See Also==

OCA at 14:16, 25 July 2012

OCA — Wed, 25 Jul 2012 14:16:16 GMT

←Older revision		Revision as of 14:16, 25 July 2012
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	[[Image:3blx.png\|left\|200px]]		[[Image:3blx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3blx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3blx\| PDB=3blx \| SCENE= }}		{{STRUCTURE_3blx\| PDB=3blx \| SCENE= }}

	===Yeast Isocitrate Dehydrogenase (Apo Form)===		===Yeast Isocitrate Dehydrogenase (Apo Form)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18256028}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18256028 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18256028}}		{{ABSTRACT_PUBMED_18256028}}

	==About this Structure==		==About this Structure==
-	[[3blx]] is a 16 chain structure of [[Isocitrate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA].	+	[[3blx]] is a 16 chain structure of [[Ferguson sandbox 1]] and [[Isocitrate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA].

	==See Also==		==See Also==
-	*[[Isocitrate dehydrogenase]]	+	*[[Ferguson sandbox 1\|Ferguson sandbox 1]]
		+	*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18256028~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018256028</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Hart, P J.]]		[[Category: Hart, P J.]]

OCA: Protected "3blx" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 01:41:29 GMT

Protected "3blx" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:41, 27 December 2010

OCA at 01:41, 27 December 2010

OCA — Mon, 27 Dec 2010 01:41:28 GMT

←Older revision		Revision as of 01:41, 27 December 2010
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3blx.png\|left\|200px]]		[[Image:3blx.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3BLX~~ is a 16 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA].	+	[[3blx]] is a 16 chain structure of [[Isocitrate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLX OCA].
		+
		+	==See Also==
		+	*[[Isocitrate dehydrogenase]]

	==Reference==		==Reference==
Line 45:		Line 47:
	[[Category: Transit peptide]]		[[Category: Transit peptide]]
	[[Category: Tricarboxylic acid cycle]]		[[Category: Tricarboxylic acid cycle]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:06:42 2009''