3br5 - Revision history

OCA at 12:13, 30 August 2023

OCA — Wed, 30 Aug 2023 12:13:16 GMT

←Older revision		Revision as of 12:13, 30 August 2023
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	<StructureSection load='3br5' size='340' side='right'caption='[[3br5]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3br5' size='340' side='right'caption='[[3br5]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3br5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BR5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3br5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BR5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">qacR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [https://pdbe.org/3br5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [https://www.ebi.ac.uk/pdbsum/3br5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3br5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [https://pdbe.org/3br5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [https://www.ebi.ac.uk/pdbsum/3br5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3br5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).	+	[https://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]		*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brooks, B E~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Dna-binding]]~~	+	[[Category: Brooks BE]]
-	~~[[Category: Multidrug resistance]]~~	+
-	~~[[Category: Plasmid]]~~	+
-	~~[[Category: Qacr]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Rhodamine 6g]]~~	+
-	~~[[Category: Tetr]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 19:01, 20 October 2021

OCA — Wed, 20 Oct 2021 19:01:09 GMT

←Older revision		Revision as of 19:01, 20 October 2021
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	==Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor==		==Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor==
-	<StructureSection load='3br5' size='340' side='right' caption='[[3br5]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3br5' size='340' side='right'caption='[[3br5]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3br5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BR5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3br5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BR5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [~~http~~://pdbe.org/3br5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3br5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3br5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [https://pdbe.org/3br5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [https://www.ebi.ac.uk/pdbsum/3br5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3br5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).	+	[[https://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3br5 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3br5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brooks, B E]]		[[Category: Brooks, B E]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA at 07:53, 31 October 2018

OCA — Wed, 31 Oct 2018 07:53:39 GMT

←Older revision		Revision as of 07:53, 31 October 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor==		==Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor==
	<StructureSection load='3br5' size='340' side='right' caption='[[3br5]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3br5' size='340' side='right' caption='[[3br5]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://pdbe.org/3br5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://pdbe.org/3br5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3br5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/3br5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/3br5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Multidrug resistance]]		[[Category: Multidrug resistance]]
		+	[[Category: Plasmid]]
	[[Category: Qacr]]		[[Category: Qacr]]
	[[Category: Repressor]]		[[Category: Repressor]]

OCA at 08:02, 10 February 2016

OCA — Wed, 10 Feb 2016 08:02:42 GMT

←Older revision		Revision as of 08:02, 10 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://pdbe.org/3br5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3br5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__

OCA at 12:53, 25 December 2014

OCA — Thu, 25 Dec 2014 12:53:03 GMT

←Older revision		Revision as of 12:53, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Brooks, B E.]]	+	[[Category: Brooks, B E]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Multidrug resistance]]		[[Category: Multidrug resistance]]

OCA at 06:35, 10 October 2014

OCA — Fri, 10 Oct 2014 06:35:10 GMT

←Older revision		Revision as of 06:35, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3br5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BR5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3br5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BR5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 03:18, 4 September 2014

OCA — Thu, 04 Sep 2014 03:18:28 GMT

←Older revision		Revision as of 03:18, 4 September 2014
Line 1:		Line 1:
-	~~[[Image:3br5.png\|left\|200px]]~~	+	==Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor==
-		+	<StructureSection load='3br5' size='340' side='right' caption='[[3br5]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~{{STRUCTURE_3br5\| PDB=3br5 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3br5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BR5 FirstGlance]. <br>
-	===Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jup\|1jup]], [[1jus\|1jus]], [[1jty\|1jty]], [[1jt6\|1jt6]], [[3bqz\|3bqz]], [[3br0\|3br0]], [[3br1\|3br1]], [[3br2\|3br2]], [[3br3\|3br3]], [[3br4\|3br4]], [[3br6\|3br6]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3br5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3br5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3br5 RCSB], [http://www.ebi.ac.uk/pdbsum/3br5 PDBsum]</span></td></tr>
-	[[3br5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA].	+	<table>
-	[[~~Category~~: ~~Staphylococcus~~ aureus]]	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/3br5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Brooks, B E.]]		[[Category: Brooks, B E.]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA: Protected "3br5" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:09:40 GMT

Protected "3br5" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:09, 7 January 2013

OCA at 20:09, 7 January 2013

OCA — Mon, 07 Jan 2013 20:09:32 GMT

←Older revision		Revision as of 20:09, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3br5.png\|left\|200px]]
-	[[Image:3br5.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3br5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3br5\| PDB=3br5 \| SCENE= }}		{{STRUCTURE_3br5\| PDB=3br5 \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~3BR5~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA].	+	[[3br5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA].
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Brooks, B E.]]		[[Category: Brooks, B E.]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Multidrug resistance]]		[[Category: Multidrug resistance]]
-	[[Category: Plasmid]]
	[[Category: Qacr]]		[[Category: Qacr]]
	[[Category: Repressor]]		[[Category: Repressor]]
Line 26:		Line 18:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:28:55 2008''

OCA at 09:28, 24 December 2008

OCA — Wed, 24 Dec 2008 09:28:57 GMT

←Older revision		Revision as of 09:28, 24 December 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3br5.jpg\|left\|200px]]

-	The ~~entry 3br5~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3br5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3br5\| PDB=3br5 \| SCENE= }}

-	~~Authors: Brooks~~, ~~B.E.~~	+	===Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor===

-	Description: Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor

		+	==About this Structure==
		+	3BR5 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BR5 OCA].
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Brooks, B E.]]
		+	[[Category: Dna-binding]]
		+	[[Category: Multidrug resistance]]
		+	[[Category: Plasmid]]
		+	[[Category: Qacr]]
		+	[[Category: Repressor]]
		+	[[Category: Rhodamine 6g]]
		+	[[Category: Tetr]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun~~ 11 09:27:44 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:28:55 2008''