3c2h - Revision history

OCA at 09:32, 21 February 2024

OCA — Wed, 21 Feb 2024 09:32:33 GMT

←Older revision		Revision as of 09:32, 21 February 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q9XVI2_CAEEL Q9XVI2_CAEEL]		[https://www.uniprot.org/uniprot/Q9XVI2_CAEEL Q9XVI2_CAEEL]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
-
-	The C. elegans SYS-1 protein is a bona fide beta-catenin.,Liu J, Phillips BT, Amaya MF, Kimble J, Xu W Dev Cell. 2008 May;14(5):751-61. PMID:18477457<ref>PMID:18477457</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3c2h" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:09, 1 November 2023

OCA — Wed, 01 Nov 2023 18:09:49 GMT

←Older revision		Revision as of 18:09, 1 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3c2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C2H FirstGlance]. <br>		<table><tr><td colspan='2'>[[3c2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C2H FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3c2g\|3c2g]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">sys-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [https://pdbe.org/3c2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [https://www.ebi.ac.uk/pdbsum/3c2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [https://pdbe.org/3c2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [https://www.ebi.ac.uk/pdbsum/3c2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2h ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9XVI2_CAEEL Q9XVI2_CAEEL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amaya~~, M F~~]]	+	[[Category: Amaya MF]]
-	[[Category: Kimble, J]]	+	[[Category: Kimble J]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Phillips~~, B T~~]]	+	[[Category: Phillips BT]]
-	[[Category: Xu, W]]	+	[[Category: Xu W]]
-	~~[[Category: Beta-catenin]]~~	+
-	~~[[Category: Caenorhabditis elegan]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Sys-1]]~~	+
-	~~[[Category: Wnt~~]]	+

OCA at 07:40, 27 January 2022

OCA — Thu, 27 Jan 2022 07:40:42 GMT

←Older revision		Revision as of 07:40, 27 January 2022
Line 1:		Line 1:

	==Crystal Structure of SYS-1 at 2.6A resolution==		==Crystal Structure of SYS-1 at 2.6A resolution==
-	<StructureSection load='3c2h' size='340' side='right' caption='[[3c2h]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3c2h' size='340' side='right'caption='[[3c2h]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3c2h]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3C2H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3c2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C2H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c2g\|3c2g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c2g\|3c2g]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sys-1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sys-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [~~http~~://pdbe.org/3c2h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3c2h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [https://pdbe.org/3c2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [https://www.ebi.ac.uk/pdbsum/3c2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2h ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
		+	[[Category: Large Structures]]
	[[Category: Amaya, M F]]		[[Category: Amaya, M F]]
	[[Category: Kimble, J]]		[[Category: Kimble, J]]

OCA at 15:44, 11 August 2016

OCA — Thu, 11 Aug 2016 15:44:43 GMT

←Older revision		Revision as of 15:44, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of SYS-1 at 2.6A resolution==		==Crystal Structure of SYS-1 at 2.6A resolution==
	<StructureSection load='3c2h' size='340' side='right' caption='[[3c2h]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3c2h' size='340' side='right' caption='[[3c2h]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c2g\|3c2g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c2g\|3c2g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sys-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sys-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [http://www.ebi.ac.uk/pdbsum/3c2h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [http://pdbe.org/3c2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [http://www.ebi.ac.uk/pdbsum/3c2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2h ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3c2h" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 25 January 2015

OCA — Sun, 25 Jan 2015 10:03:16 GMT

←Older revision		Revision as of 10:03, 25 January 2015
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: Amaya, M F.]]	+	[[Category: Amaya, M F]]
-	[[Category: Kimble, J.]]	+	[[Category: Kimble, J]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Phillips, B T.]]	+	[[Category: Phillips, B T]]
-	[[Category: Xu, W.]]	+	[[Category: Xu, W]]
	[[Category: Beta-catenin]]		[[Category: Beta-catenin]]
	[[Category: Caenorhabditis elegan]]		[[Category: Caenorhabditis elegan]]

OCA at 09:29, 5 November 2014

OCA — Wed, 05 Nov 2014 09:29:12 GMT

←Older revision		Revision as of 09:29, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3c2h.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of SYS-1 at 2.6A resolution==
		+	<StructureSection load='3c2h' size='340' side='right' caption='[[3c2h]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3c2h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C2H FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c2g\|3c2g]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sys-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [http://www.ebi.ac.uk/pdbsum/3c2h PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.

-	~~{{STRUCTURE_3c2h\| PDB=3c2h \| SCENE= }}~~	+	The C. elegans SYS-1 protein is a bona fide beta-catenin.,Liu J, Phillips BT, Amaya MF, Kimble J, Xu W Dev Cell. 2008 May;14(5):751-61. PMID:18477457<ref>PMID:18477457</ref>

-	~~===Crystal Structure~~ of ~~SYS-1 at 2~~.~~6A resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18477457}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3c2h]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA].~~	+	</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Amaya, M F.]]		[[Category: Amaya, M F.]]

OCA: Protected "3c2h" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:02:21 GMT

Protected "3c2h" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:02, 7 January 2013

OCA at 19:02, 7 January 2013

OCA — Mon, 07 Jan 2013 19:02:19 GMT

←Older revision		Revision as of 19:02, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3c2h.png\|left\|200px]]		[[Image:3c2h.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3c2h", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3c2h\| PDB=3c2h \| SCENE= }}		{{STRUCTURE_3c2h\| PDB=3c2h \| SCENE= }}

	===Crystal Structure of SYS-1 at 2.6A resolution===		===Crystal Structure of SYS-1 at 2.6A resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18477457}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18477457 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18477457}}		{{ABSTRACT_PUBMED_18477457}}

	==About this Structure==		==About this Structure==
-	~~3C2H is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA].	+	[[3c2h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA].
-		+
-	~~==Reference==~~	+
-	~~The C. elegans SYS-1 protein is a bona fide beta-catenin., Liu J, Phillips BT, Amaya MF, Kimble J, Xu W, Dev Cell. 2008 May;14(5):751-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18477457 18477457]~~	+
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: Single protein]]
	[[Category: Amaya, M F.]]		[[Category: Amaya, M F.]]
	[[Category: Kimble, J.]]		[[Category: Kimble, J.]]
Line 36:		Line 20:
	[[Category: Sys-1]]		[[Category: Sys-1]]
	[[Category: Wnt]]		[[Category: Wnt]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:31:36 2008''

OCA at 18:31, 28 July 2008

OCA — Mon, 28 Jul 2008 18:31:40 GMT

←Older revision		Revision as of 18:31, 28 July 2008
Line 1:		Line 1:
-	[[Image:3c2h.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3c2h.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_3c2h\| PDB=3c2h \| SCENE= }}		{{STRUCTURE_3c2h\| PDB=3c2h \| SCENE= }}

-	~~'''~~Crystal Structure of SYS-1 at 2.6A resolution~~'''~~	+	===Crystal Structure of SYS-1 at 2.6A resolution===


-	~~==Overview==~~	+	<!--
-	~~C. elegans SYS~~-~~1 has key functional characteristics of a canonical beta~~-~~catenin~~, ~~but no significant sequence similarity. Here~~, ~~we report~~ the ~~SYS-1 crystal structure, both~~ on ~~its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin~~/~~TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1~~/~~POP-1 interface is anchored by a conserved salt-bridge, the "charged button~~.~~" We also modeled structures for three other C~~. ~~elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally~~, ~~we generated a phylogenetic tree, using~~ the ~~region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade~~. ~~We conclude that the SYS~~-~~1 protein belongs to the beta~~-~~catenin family and suggest that additional divergent beta-catenins await discovery.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18477457}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18477457 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18477457}}

	==About this Structure==		==About this Structure==
Line 32:		Line 36:
	[[Category: Sys-1]]		[[Category: Sys-1]]
	[[Category: Wnt]]		[[Category: Wnt]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu May 22~~ 21:54:11 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:31:36 2008''