3c5f - Revision history

OCA at 19:06, 20 October 2021

OCA — Wed, 20 Oct 2021 19:06:22 GMT

←Older revision		Revision as of 19:06, 20 October 2021
Line 1:		Line 1:

	==Structure of a binary complex of the R517A Pol lambda mutant==		==Structure of a binary complex of the R517A Pol lambda mutant==
-	<StructureSection load='3c5f' size='340' side='right' caption='[[3c5f]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='3c5f' size='340' side='right'caption='[[3c5f]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3c5f]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3C5F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3c5f]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c5g\|3c5g]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [~~http~~://pdbe.org/3c5f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3c5f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [https://pdbe.org/3c5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [https://www.ebi.ac.uk/pdbsum/3c5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN]] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>	+	[[https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN]] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5f_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Bebenek, K]]		[[Category: Bebenek, K]]
	[[Category: Foley, M C]]		[[Category: Foley, M C]]

OCA at 08:18, 25 October 2017

OCA — Wed, 25 Oct 2017 08:18:08 GMT

←Older revision		Revision as of 08:18, 25 October 2017
Line 1:		Line 1:
		+
	==Structure of a binary complex of the R517A Pol lambda mutant==		==Structure of a binary complex of the R517A Pol lambda mutant==
	<StructureSection load='3c5f' size='340' side='right' caption='[[3c5f]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3c5f' size='340' side='right' caption='[[3c5f]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [http://pdbe.org/3c5f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [http://www.ebi.ac.uk/pdbsum/3c5f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [http://pdbe.org/3c5f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [http://www.ebi.ac.uk/pdbsum/3c5f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3c5f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3c5f" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>
Line 57:		Line 55:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 03:44, 10 February 2016

OCA — Wed, 10 Feb 2016 03:44:57 GMT

←Older revision		Revision as of 03:44, 10 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [http://www.ebi.ac.uk/pdbsum/3c5f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [http://pdbe.org/3c5f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [http://www.ebi.ac.uk/pdbsum/3c5f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3c5f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:33, 25 December 2014

OCA — Thu, 25 Dec 2014 11:33:29 GMT

←Older revision		Revision as of 11:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3c5f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5F FirstGlance]. <br>		<table><tr><td colspan='2'>[[3c5f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [http://www.ebi.ac.uk/pdbsum/3c5f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [http://www.ebi.ac.uk/pdbsum/3c5f PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN]] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bebenek, K.]]	+	[[Category: Bebenek, K]]
-	[[Category: Foley, M C.]]	+	[[Category: Foley, M C]]
-	[[Category: Garcia-Diaz, M.]]	+	[[Category: Garcia-Diaz, M]]
-	[[Category: Kunkel, T A.]]	+	[[Category: Kunkel, T A]]
-	[[Category: Pedersen, L C.]]	+	[[Category: Pedersen, L C]]
-	[[Category: Schlick, T.]]	+	[[Category: Schlick, T]]
	[[Category: Dna damage]]		[[Category: Dna damage]]
	[[Category: Dna repair]]		[[Category: Dna repair]]

OCA at 07:06, 29 September 2014

OCA — Mon, 29 Sep 2014 07:06:58 GMT

←Older revision		Revision as of 07:06, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3c5f.~~png~~\|~~left~~\|200px]]	+	==Structure of a binary complex of the R517A Pol lambda mutant==
		+	<StructureSection load='3c5f' size='340' side='right' caption='[[3c5f]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3c5f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5F FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c5g\|3c5g]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5f RCSB], [http://www.ebi.ac.uk/pdbsum/3c5f PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5f_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The simple deletion of nucleotides is common in many organisms. It can be advantageous when it activates genes beneficial to microbial survival in adverse environments, and deleterious when it mutates genes relevant to survival, cancer or degenerative diseases. The classical idea is that simple deletions arise by strand slippage. A prime opportunity for slippage occurs during DNA synthesis, but it remains unclear how slippage is controlled during a polymerization cycle. Here, we report crystal structures and molecular dynamics simulations of mutant derivatives of DNA polymerase lambda bound to a primer-template during strand slippage. Relative to the primer strand, the template strand is in multiple conformations, indicating intermediates on the pathway to deletion mutagenesis. Consistent with these intermediates, the mutant polymerases generate single-base deletions at high rates. The results indicate that dNTP-induced template strand repositioning during conformational rearrangements in the catalytic cycle is crucial to controlling the rate of strand slippage.

-	~~{{STRUCTURE_3c5f\| PDB=3c5f \| SCENE= }}~~	+	Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda.,Bebenek K, Garcia-Diaz M, Foley MC, Pedersen LC, Schlick T, Kunkel TA EMBO Rep. 2008 May;9(5):459-64. Epub 2008 Mar 28. PMID:18369368<ref>PMID:18369368</ref>

-	~~===Structure of~~ a ~~binary complex~~ of the ~~R517A Pol lambda mutant===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18369368}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3c5f]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].~~	+

	==See Also==		==See Also==
	*[[DNA polymerase\|DNA polymerase]]		*[[DNA polymerase\|DNA polymerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018369368<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bebenek, K.]]		[[Category: Bebenek, K.]]

OCA at 16:12, 20 October 2012

OCA — Sat, 20 Oct 2012 16:12:58 GMT

←Older revision		Revision as of 16:12, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3c5f]] is a 8 chain structure ~~of [[DNA polymerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].	+	[[3c5f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].

	==See Also==		==See Also==

OCA: Protected "3c5f" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 20:57:35 GMT

Protected "3c5f" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:57, 26 July 2012

OCA at 20:57, 26 July 2012

OCA — Thu, 26 Jul 2012 20:57:34 GMT

←Older revision		Revision as of 20:57, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3c5f.png\|left\|200px]]		[[Image:3c5f.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3c5f", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3c5f\| PDB=3c5f \| SCENE= }}		{{STRUCTURE_3c5f\| PDB=3c5f \| SCENE= }}

	===Structure of a binary complex of the R517A Pol lambda mutant===		===Structure of a binary complex of the R517A Pol lambda mutant===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18369368}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18369368 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18369368}}		{{ABSTRACT_PUBMED_18369368}}

	==About this Structure==		==About this Structure==
-	~~3C5F~~ is a 8 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].	+	[[3c5f]] is a 8 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].
		+
		+	==See Also==
		+	*[[DNA polymerase\|DNA polymerase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18369368~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018369368</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bebenek, K.]]		[[Category: Bebenek, K.]]
Line 39:		Line 30:
	[[Category: Helix hairpin helix]]		[[Category: Helix hairpin helix]]
	[[Category: Lyase]]		[[Category: Lyase]]
-	[[Category: Lyase/dna complex]]	+	[[Category: Lyase-dna complex]]
	[[Category: Manganese]]		[[Category: Manganese]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
Line 45:		Line 36:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:10:29 2009''

OCA at 13:10, 17 February 2009

OCA — Tue, 17 Feb 2009 13:10:30 GMT

←Older revision		Revision as of 13:10, 17 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3c5f.~~jpg~~\|left\|200px]]	+	[[Image:3c5f.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3C5F is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].	+	3C5F is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].

	==Reference==		==Reference==
-	Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda., Bebenek K, Garcia-Diaz M, Foley MC, Pedersen LC, Schlick T, Kunkel TA, EMBO Rep. 2008 May;9(5):459-64. Epub 2008 Mar 28. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18369368 18369368]~~	+	<ref group="xtra">PMID:18369368</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Bebenek, K.]]		[[Category: Bebenek, K.]]
	[[Category: Foley, M C.]]		[[Category: Foley, M C.]]
Line 49:		Line 48:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 3 13~~:10:~~33 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:10:29 2009''

OCA at 10:10, 3 September 2008

OCA — Wed, 03 Sep 2008 10:10:34 GMT

←Older revision		Revision as of 10:10, 3 September 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3c5f.jpg\|left\|200px]]

-	The ~~entry 3c5f~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3c5f", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3c5f\| PDB=3c5f \| SCENE= }}

-	~~Authors: Garcia-Diaz, M., Bebenek, K., Foley, M.C., Pedersen, L.C., Schlick, T., Kunkel, T.A.~~	+	===Structure of a binary complex of the R517A Pol lambda mutant===

-	Description: Structure of a binary complex of the R517A Pol lambda mutant

		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18369368}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18369368 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18369368}}

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 09~~:29:56 2008''	+	==About this Structure==
		+	3C5F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5F OCA].
		+
		+	==Reference==
		+	Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda., Bebenek K, Garcia-Diaz M, Foley MC, Pedersen LC, Schlick T, Kunkel TA, EMBO Rep. 2008 May;9(5):459-64. Epub 2008 Mar 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18369368 18369368]
		+	[[Category: Homo sapiens]]
		+	[[Category: Protein complex]]
		+	[[Category: Bebenek, K.]]
		+	[[Category: Foley, M C.]]
		+	[[Category: Garcia-Diaz, M.]]
		+	[[Category: Kunkel, T A.]]
		+	[[Category: Pedersen, L C.]]
		+	[[Category: Schlick, T.]]
		+	[[Category: Dna damage]]
		+	[[Category: Dna repair]]
		+	[[Category: Dna replication]]
		+	[[Category: Dna synthesis]]
		+	[[Category: Dna-binding]]
		+	[[Category: Dna-directed dna polymerase]]
		+	[[Category: Helix hairpin helix]]
		+	[[Category: Lyase]]
		+	[[Category: Lyase/dna complex]]
		+	[[Category: Manganese]]
		+	[[Category: Metal-binding]]
		+	[[Category: Nucleotidyltransferase]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 3 13:10:33 2008''