3c5x - Revision history

OCA at 13:12, 26 July 2023

OCA — Wed, 26 Jul 2023 13:12:15 GMT

←Older revision		Revision as of 13:12, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='3c5x' size='340' side='right'caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3c5x' size='340' side='right'caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Den26 Den26~~] and [https://en.wikipedia.org/wiki/~~Dengue_virus_2~~ Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Dengue_virus_2_Thailand/16681/84 Dengue virus 2 Thailand/16681/84]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c6e\|3c6e]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [https://pdbe.org/3c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [https://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [https://pdbe.org/3c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [https://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/O09234_DEN26 O09234_DEN26]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]	+	[https://www.uniprot.org/uniprot/Q6H1E5_9FLAV Q6H1E5_9FLAV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Den26]]
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
		+	[[Category: Dengue virus 2 Thailand/16681/84]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, L]]	+	[[Category: Li L]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Helicase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Prm-e protein complex]]~~	+
-	~~[[Category: Rna replication]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 19:06, 20 October 2021

OCA — Wed, 20 Oct 2021 19:06:26 GMT

←Older revision		Revision as of 19:06, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='3c5x' size='340' side='right'caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3c5x' size='340' side='right'caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Den26 Den26] and [~~http~~://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3C5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Den26 Den26] and [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c6e\|3c6e]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [~~http~~://pdbe.org/3c5x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [https://pdbe.org/3c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [https://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/O09234_DEN26 O09234_DEN26]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]	+	[[https://www.uniprot.org/uniprot/O09234_DEN26 O09234_DEN26]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:24, 12 August 2020

OCA — Wed, 12 Aug 2020 10:24:17 GMT

←Older revision		Revision as of 10:24, 12 August 2020
Line 1:		Line 1:

	==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH==		==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH==
-	<StructureSection load='3c5x' size='340' side='right' caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3c5x' size='340' side='right'caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26] and [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3C5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26] and [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://pdbe.org/3c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://pdbe.org/3c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 26:
	[[Category: Den26]]		[[Category: Den26]]
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
		+	[[Category: Large Structures]]
	[[Category: Li, L]]		[[Category: Li, L]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]

OCA at 13:45, 7 November 2018

OCA — Wed, 07 Nov 2018 13:45:14 GMT

←Older revision		Revision as of 13:45, 7 November 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26] and [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5X FirstGlance]. <br>		<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26] and [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA~~</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://pdbe.org/3c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://pdbe.org/3c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>

OCA at 22:01, 4 August 2016

OCA — Thu, 04 Aug 2016 22:01:20 GMT

←Older revision		Revision as of 22:01, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH==		==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH==
	<StructureSection load='3c5x' size='340' side='right' caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3c5x' size='340' side='right' caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dengue_virus_2 Dengue virus 2~~] and [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26] and [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://pdbe.org/3c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3c5x" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Den26]]
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
-	[[Category: Viruses]]
	[[Category: Li, L]]		[[Category: Li, L]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]

OCA at 13:30, 25 December 2014

OCA — Thu, 25 Dec 2014 13:30:30 GMT

←Older revision		Revision as of 13:30, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5X FirstGlance]. <br>		<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/O09234_DEN26 O09234_DEN26]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	The flavivirus precursor membrane-envelope protein complex: structure and maturation.,Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG Science. 2008 Mar 28;319(5871):1830-4. PMID:18369147<ref>PMID:18369147</ref>		The flavivirus precursor membrane-envelope protein complex: structure and maturation.,Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG Science. 2008 Mar 28;319(5871):1830-4. PMID:18369147<ref>PMID:18369147</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Viruses]]		[[Category: Viruses]]
-	[[Category: Li, L.]]	+	[[Category: Li, L]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Helicase]]		[[Category: Helicase]]

OCA at 09:41, 21 May 2014

OCA — Wed, 21 May 2014 09:41:29 GMT

←Older revision		Revision as of 09:41, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3c5x.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH==
		+	<StructureSection load='3c5x' size='340' side='right' caption='[[3c5x]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6e\|3c6e]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [http://www.ebi.ac.uk/pdbsum/3c5x PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the proteolytic cleavage of the precursor membrane protein (prM), turning inert virus into infectious particles. We have determined the 2.2 angstrom resolution crystal structure of a recombinant protein in which the dengue virus prM is linked to the envelope glycoprotein E. The structure represents the prM-E heterodimer and fits well into the cryo-electron microscopy density of immature virus at neutral pH. The pr peptide beta-barrel structure covers the fusion loop in E, preventing fusion with host cell membranes. The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host.

-	~~<!--~~	+	The flavivirus precursor membrane-envelope protein complex: structure and maturation.,Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG Science. 2008 Mar 28;319(5871):1830-4. PMID:18369147<ref>PMID:18369147</ref>
-	The ~~line below this paragraph~~, ~~containing "STRUCTURE_3c5x"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3c5x\| PDB=3c5x \| SCENE= }}~~	+

-	~~===Crystal structure~~ of the ~~precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_18369147}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 18369147 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_18369147}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3c5x]] is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018369147<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Viruses]]		[[Category: Viruses]]

OCA: Protected "3c5x" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 06:08:39 GMT

Protected "3c5x" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:08, 24 August 2011

OCA at 06:08, 24 August 2011

OCA — Wed, 24 Aug 2011 06:08:38 GMT

←Older revision		Revision as of 06:08, 24 August 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3c5x.png\|left\|200px]]		[[Image:3c5x.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3C5X is a~~ [[~~Protein complex~~]] structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA].	+	[[3c5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA].

	==Reference==		==Reference==
-	~~The flavivirus precursor membrane-envelope protein complex: structure and maturation., Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG, Science. 2008 Mar 28;319(5871):1830-4.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18369147 18369147]~~	+	<ref group="xtra">PMID:018369147</ref><references group="xtra"/>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
-	[[Category: ~~Protein complex~~]]	+	[[Category: Viruses]]
	[[Category: Li, L.]]		[[Category: Li, L.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
Line 35:		Line 34:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:25:47 2008''

OCA at 21:25, 28 July 2008

OCA — Mon, 28 Jul 2008 21:25:50 GMT

←Older revision		Revision as of 21:25, 28 July 2008
Line 1:		Line 1:
-	[[Image:3c5x.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3c5x.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_3c5x\| PDB=3c5x \| SCENE= }}		{{STRUCTURE_3c5x\| PDB=3c5x \| SCENE= }}

-	~~'''~~Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH~~'''~~	+	===Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH===


-	~~==Overview==~~	+	<!--
-	~~Many viruses go through a maturation step in~~ the ~~final stages of assembly before being transmitted~~ to ~~another host. The maturation process of flaviviruses is directed by~~ the ~~proteolytic cleavage of the precursor membrane protein~~ (~~prM~~), ~~turning inert virus into infectious particles. We have determined the 2.2 angstrom resolution crystal structure of a recombinant protein in which the dengue virus prM~~ is ~~linked to~~ the ~~envelope glycoprotein E~~. ~~The structure represents the prM~~-~~E heterodimer and fits well into the cryo~~-electron microscopy density of immature virus at neutral pH. The pr peptide beta-barrel structure covers the fusion loop in E, preventing fusion with host cell membranes. The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18369147}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18369147 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18369147}}

	==About this Structure==		==About this Structure==
Line 31:		Line 35:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:25:47 2008''