3cbk - Revision history

OCA at 14:57, 1 November 2023

OCA — Wed, 01 Nov 2023 14:57:00 GMT

←Older revision		Revision as of 14:57, 1 November 2023
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	<StructureSection load='3cbk' size='340' side='right'caption='[[3cbk]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='3cbk' size='340' side='right'caption='[[3cbk]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBK FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2nqd\|2nqd]], [[2nnr\|2nnr]], [[1huc\|1huc]], [[3pbh\|3pbh]], [[3cbj\|3cbj]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.67Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CTSB, CPSB ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), cha ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [https://pdbe.org/3cbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [https://www.ebi.ac.uk/pdbsum/3cbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cbk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [https://pdbe.org/3cbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [https://www.ebi.ac.uk/pdbsum/3cbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cbk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	+	[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cathepsin B]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trycr~~]]	+	[[Category: Trypanosoma cruzi]]
-	[[Category: Abrahamson, M]]	+	[[Category: Abrahamson M]]
-	[[Category: Bujacz~~, G D~~]]	+	[[Category: Bujacz GD]]
-	[[Category: Jaskolski, M]]	+	[[Category: Jaskolski M]]
-	[[Category: Ljunggren, A]]	+	[[Category: Ljunggren A]]
-	[[Category: Mort~~, J S~~]]	+	[[Category: Mort JS]]
-	[[Category: Redzynia, I]]	+	[[Category: Redzynia I]]
-	~~[[Category: Cathepsin b]]~~	+
-	~~[[Category: Chagas disease]]~~	+
-	~~[[Category: Chagasin]]~~	+
-	~~[[Category: Cytoplasmic vesicle]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Lysosome]]~~	+
-	~~[[Category: Occluding loop]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Protease inhibitor]]~~	+
-	~~[[Category: Thiol protease]]~~	+
-	~~[[Category: Thiol protease inhibitor]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 07:29, 10 November 2021

OCA — Wed, 10 Nov 2021 07:29:26 GMT

←Older revision		Revision as of 07:29, 10 November 2021
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	==chagasin-cathepsin B==		==chagasin-cathepsin B==
-	<StructureSection load='3cbk' size='340' side='right' caption='[[3cbk]], [[Resolution\|resolution]] 2.67Å' scene=''>	+	<StructureSection load='3cbk' size='340' side='right'caption='[[3cbk]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cbk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CBK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBK FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nqd\|2nqd]], [[2nnr\|2nnr]], [[1huc\|1huc]], [[3pbh\|3pbh]], [[3cbj\|3cbj]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nqd\|2nqd]], [[2nnr\|2nnr]], [[1huc\|1huc]], [[3pbh\|3pbh]], [[3cbj\|3cbj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSB, CPSB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cha ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSB, CPSB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cha ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [~~http~~://pdbe.org/3cbk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cbk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cbk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [https://pdbe.org/3cbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [https://www.ebi.ac.uk/pdbsum/3cbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cbk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	+	[[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Cathepsin\|Cathepsin]]	+	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Cathepsin B]]		[[Category: Cathepsin B]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Trycr]]		[[Category: Trycr]]
	[[Category: Abrahamson, M]]		[[Category: Abrahamson, M]]

OCA at 07:33, 23 May 2018

OCA — Wed, 23 May 2018 07:33:31 GMT

←Older revision		Revision as of 07:33, 23 May 2018
Line 1:		Line 1:
		+
	==chagasin-cathepsin B==		==chagasin-cathepsin B==
	<StructureSection load='3cbk' size='340' side='right' caption='[[3cbk]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='3cbk' size='340' side='right' caption='[[3cbk]], [[Resolution\|resolution]] 2.67Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSB, CPSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSB, CPSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [http://pdbe.org/3cbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [http://www.ebi.ac.uk/pdbsum/3cbk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [http://pdbe.org/3cbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [http://www.ebi.ac.uk/pdbsum/3cbk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cbk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cbk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cbk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:58, 7 February 2016

OCA — Sun, 07 Feb 2016 15:58:49 GMT

←Older revision		Revision as of 15:58, 7 February 2016
Line 6:		Line 6:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSB, CPSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSB, CPSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [http://www.ebi.ac.uk/pdbsum/3cbk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [http://pdbe.org/3cbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [http://www.ebi.ac.uk/pdbsum/3cbk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cbk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cbk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:28, 24 December 2014

OCA — Wed, 24 Dec 2014 16:28:22 GMT

←Older revision		Revision as of 16:28, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [http://www.ebi.ac.uk/pdbsum/3cbk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [http://www.ebi.ac.uk/pdbsum/3cbk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Human]]		[[Category: Human]]
	[[Category: Trycr]]		[[Category: Trycr]]
-	[[Category: Abrahamson, M.]]	+	[[Category: Abrahamson, M]]
-	[[Category: Bujacz, G D.]]	+	[[Category: Bujacz, G D]]
-	[[Category: Jaskolski, M.]]	+	[[Category: Jaskolski, M]]
-	[[Category: Ljunggren, A.]]	+	[[Category: Ljunggren, A]]
-	[[Category: Mort, J S.]]	+	[[Category: Mort, J S]]
-	[[Category: Redzynia, I.]]	+	[[Category: Redzynia, I]]
	[[Category: Cathepsin b]]		[[Category: Cathepsin b]]
	[[Category: Chagas disease]]		[[Category: Chagas disease]]

OCA at 06:19, 10 October 2014

OCA — Fri, 10 Oct 2014 06:19:26 GMT

←Older revision		Revision as of 06:19, 10 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3cbk\| PDB~~=3cbk \| ~~SCENE~~= }}	+	==chagasin-cathepsin B==
-	===~~chagasin~~-~~cathepsin~~ B===	+	<StructureSection load='3cbk' size='340' side='right' caption='[[3cbk]], [[Resolution\|resolution]] 2.67Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18515357}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cbk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CBK FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nqd\|2nqd]], [[2nnr\|2nnr]], [[1huc\|1huc]], [[3pbh\|3pbh]], [[3cbj\|3cbj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSB, CPSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cbk RCSB], [http://www.ebi.ac.uk/pdbsum/3cbk PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cbk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cathepsin B is a papain-like cysteine protease showing both endo- and exopeptidase activity, the latter due to a unique occluding loop that restricts access to the active site cleft. To clarify the mode by which natural protein inhibitors manage to overcome this obstacle, we have analyzed the structure and function of cathepsin B in complexes with the Trypanosoma cruzi inhibitor, chagasin. Kinetic analysis revealed that substitution of His-110e, which anchors the loop in occluding position, results in 3-fold increased chagasin affinity (Ki for H110A cathepsin B, 0.35 nm) due to an improved association rate (kon, 5 x 10(5) m(-1)s(-1)). The structure of chagasin in complex with cathepsin B was solved in two crystal forms (1.8 and 2.67 angstroms resolution), demonstrating that the occluding loop is displaced to allow chagasin binding with its three loops, L4, L2, and L6, spanning the entire active site cleft. The occluding loop is differently displaced in the two structures, indicating a large range of movement and adoption of conformations forced by the inhibitor. The area of contact is slightly larger than in chagasin complexes with the endopeptidase, cathepsin L. However, residues important for high affinity to both enzymes are mainly found in the outer loops L4 and L6 of chagasin. The chagasin-cathepsin B complex provides a structural framework for modeling and design of inhibitors for cruzipain, the parasite cysteine protease and a virulence factor in Chagas disease.

-	~~==Function==~~	+	Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B.,Redzynia I, Ljunggren A, Abrahamson M, Mort JS, Krupa JC, Jaskolski M, Bujacz G J Biol Chem. 2008 Aug 15;283(33):22815-25. Epub 2008 May 30. PMID:18515357<ref>PMID:18515357</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3cbk]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3CBK OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Cathepsin\|Cathepsin]]		*[[Cathepsin\|Cathepsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018515357</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cathepsin B]]		[[Category: Cathepsin B]]
		+	[[Category: Human]]
		+	[[Category: Trycr]]
	[[Category: Abrahamson, M.]]		[[Category: Abrahamson, M.]]
	[[Category: Bujacz, G D.]]		[[Category: Bujacz, G D.]]

OCA at 09:14, 19 March 2014

OCA — Wed, 19 Mar 2014 09:14:38 GMT

←Older revision		Revision as of 09:14, 19 March 2014
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-	[[Image:3cbk.png\|left\|200px]]
-
	{{STRUCTURE_3cbk\| PDB=3cbk \| SCENE= }}		{{STRUCTURE_3cbk\| PDB=3cbk \| SCENE= }}
-
	===chagasin-cathepsin B===		===chagasin-cathepsin B===
		+	{{ABSTRACT_PUBMED_18515357}}

-	~~{{ABSTRACT_PUBMED_018515357}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

	==About this Structure==		==About this Structure==
-	[[3cbk]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA].	+	[[3cbk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018515357</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018515357</ref><references group="xtra"/><references/>
	[[Category: Cathepsin B]]		[[Category: Cathepsin B]]
-	[[Category: Homo sapiens]]
-	[[Category: Trypanosoma cruzi]]
	[[Category: Abrahamson, M.]]		[[Category: Abrahamson, M.]]
	[[Category: Bujacz, G D.]]		[[Category: Bujacz, G D.]]

OCA at 07:09, 20 October 2012

OCA — Sat, 20 Oct 2012 07:09:16 GMT

←Older revision		Revision as of 07:09, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3cbk]] is a 2 chain structure ~~of [[Cathepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA].	+	[[3cbk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA].

	==See Also==		==See Also==

OCA: Protected "3cbk" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 15:26:18 GMT

Protected "3cbk" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:26, 25 July 2012

OCA at 15:26, 25 July 2012

OCA — Wed, 25 Jul 2012 15:26:15 GMT

←Older revision		Revision as of 15:26, 25 July 2012
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-	{{Seed}}
	[[Image:3cbk.png\|left\|200px]]		[[Image:3cbk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cbk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cbk\| PDB=3cbk \| SCENE= }}		{{STRUCTURE_3cbk\| PDB=3cbk \| SCENE= }}

	===chagasin-cathepsin B===		===chagasin-cathepsin B===

		+	{{ABSTRACT_PUBMED_018515357}}

	==About this Structure==		==About this Structure==
-	~~3CBK~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA].	+	[[3cbk]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBK OCA].
		+
		+	==See Also==
		+	*[[Cathepsin\|Cathepsin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:018515357</ref><references group="xtra"/>
	[[Category: Cathepsin B]]		[[Category: Cathepsin B]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 30:		Line 30:
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Hydrolase/hydrolase inhibitor complex]]	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Lysosome]]		[[Category: Lysosome]]
	[[Category: Occluding loop]]		[[Category: Occluding loop]]
-	[[Category: Polymorphism]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Protease inhibitor]]		[[Category: Protease inhibitor]]
Line 39:		Line 38:
	[[Category: Thiol protease inhibitor]]		[[Category: Thiol protease inhibitor]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:56:51 2009''