3cby - Revision history

OCA at 12:25, 30 August 2023

OCA — Wed, 30 Aug 2023 12:25:46 GMT

←Older revision		Revision as of 12:25, 30 August 2023
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	<StructureSection load='3cby' size='340' side='right'caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3cby' size='340' side='right'caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [https://pdbe.org/3cby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [https://www.ebi.ac.uk/pdbsum/3cby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cby ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [https://pdbe.org/3cby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [https://www.ebi.ac.uk/pdbsum/3cby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>	+	[https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Appleton~~, B A~~]]	+	[[Category: Appleton BA]]
-	[[Category: Wiesmann, C]]	+	[[Category: Wiesmann C]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Phage derived high affinity ligand]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Wnt signaling pathway~~]]	+

OCA at 19:08, 20 October 2021

OCA — Wed, 20 Oct 2021 19:08:37 GMT

←Older revision		Revision as of 19:08, 20 October 2021
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	==The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide==		==The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide==
-	<StructureSection load='3cby' size='340' side='right' caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3cby' size='340' side='right'caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [~~http~~://pdbe.org/3cby PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cby PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cby ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [https://pdbe.org/3cby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [https://www.ebi.ac.uk/pdbsum/3cby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>	+	[[https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cby_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cby_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Appleton, B A]]		[[Category: Appleton, B A]]
	[[Category: Wiesmann, C]]		[[Category: Wiesmann, C]]

OCA at 08:22, 25 October 2017

OCA — Wed, 25 Oct 2017 08:22:36 GMT

←Older revision		Revision as of 08:22, 25 October 2017
Line 1:		Line 1:
		+
	==The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide==		==The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide==
	<StructureSection load='3cby' size='340' side='right' caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3cby' size='340' side='right' caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [http://pdbe.org/3cby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [http://www.ebi.ac.uk/pdbsum/3cby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [http://pdbe.org/3cby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [http://www.ebi.ac.uk/pdbsum/3cby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	[[Category: Appleton, B A]]		[[Category: Appleton, B A]]
	[[Category: Wiesmann, C]]		[[Category: Wiesmann, C]]
		+	[[Category: Cytoplasm]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]

OCA at 14:45, 9 February 2016

OCA — Tue, 09 Feb 2016 14:45:47 GMT

←Older revision		Revision as of 14:45, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3cby' size='340' side='right' caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3cby' size='340' side='right' caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CBY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [http://www.ebi.ac.uk/pdbsum/3cby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [http://pdbe.org/3cby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [http://www.ebi.ac.uk/pdbsum/3cby PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cby ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cby" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Appleton, B A]]		[[Category: Appleton, B A]]
	[[Category: Wiesmann, C]]		[[Category: Wiesmann, C]]

OCA at 07:28, 25 December 2014

OCA — Thu, 25 Dec 2014 07:28:26 GMT

←Older revision		Revision as of 07:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CBY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [http://www.ebi.ac.uk/pdbsum/3cby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [http://www.ebi.ac.uk/pdbsum/3cby PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Appleton, B A.]]	+	[[Category: Appleton, B A]]
-	[[Category: Wiesmann, C.]]	+	[[Category: Wiesmann, C]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]

OCA at 20:59, 2 October 2014

OCA — Thu, 02 Oct 2014 20:59:22 GMT

←Older revision		Revision as of 20:59, 2 October 2014
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-	[[~~Image:~~3cby.~~png~~\|~~left~~\|200px]]	+	==The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide==
		+	<StructureSection load='3cby' size='340' side='right' caption='[[3cby]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CBY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cbx\|3cbx]], [[3cbz\|3cbz]], [[3cc0\|3cc0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cby RCSB], [http://www.ebi.ac.uk/pdbsum/3cby PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cby_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dishevelled proteins are key regulators of Wnt signaling pathways that have been implicated in the progression of human cancers. We found that the binding cleft of the Dishevelled PDZ domain is more flexible than those of canonical PDZ domains and enables recognition of both C-terminal and internal peptides. These peptide ligands inhibit Wnt/beta-catenin signaling in cells, showing that Dishevelled PDZ domains are potential targets for small-molecule cancer therapeutics.

-	~~{{STRUCTURE_3cby\| PDB=3cby \| SCENE= }}~~	+	Inhibition of Wnt signaling by Dishevelled PDZ peptides.,Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS Nat Chem Biol. 2009 Apr;5(4):217-9. Epub 2009 Mar 1. PMID:19252499<ref>PMID:19252499</ref>

-	~~===The Dvl2 PDZ Domain in Complex with~~ the ~~N1 Inhibitory Peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19252499}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cby]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019252499<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Appleton, B A.]]		[[Category: Appleton, B A.]]

OCA: Protected "3cby" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:37:23 GMT

Protected "3cby" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:37, 7 January 2013

OCA at 18:37, 7 January 2013

OCA — Mon, 07 Jan 2013 18:37:22 GMT

←Older revision		Revision as of 18:37, 7 January 2013
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-	{{Seed}}
	[[Image:3cby.png\|left\|200px]]		[[Image:3cby.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cby", creates the "Structure Box" on the page.
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	{{STRUCTURE_3cby\| PDB=3cby \| SCENE= }}		{{STRUCTURE_3cby\| PDB=3cby \| SCENE= }}

	===The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide===		===The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19252499}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19252499 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19252499}}		{{ABSTRACT_PUBMED_19252499}}

	==About this Structure==		==About this Structure==
-	~~3CBY~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA].	+	[[3cby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19252499~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019252499</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Appleton, B A.]]		[[Category: Appleton, B A.]]
	[[Category: Wiesmann, C.]]		[[Category: Wiesmann, C.]]
-	[[Category: Cytoplasm]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
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	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:29:36 2009''

OCA at 08:29, 22 March 2009

OCA — Sun, 22 Mar 2009 08:29:37 GMT

←Older revision		Revision as of 08:29, 22 March 2009
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	==About this Structure==		==About this Structure==
-	3CBY is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA].	+	3CBY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA].

	==Reference==		==Reference==
-	~~Inhibition of Wnt signaling by Dishevelled PDZ peptides., Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS, Nat Chem Biol. 2009 Mar 1.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19252499 19252499]~~	+	<ref group="xtra">PMID:19252499</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Appleton, B A.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx:audit_author~~.]]	+	[[Category: Wiesmann, C.]]
	[[Category: Cytoplasm]]		[[Category: Cytoplasm]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
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	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Mar ~~18 20~~:06:53 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:29:36 2009''

OCA at 18:06, 18 March 2009

OCA — Wed, 18 Mar 2009 18:06:54 GMT

←Older revision		Revision as of 18:06, 18 March 2009
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	===The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide===		===The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19252499}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19252499 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19252499}}

	==About this Structure==		==About this Structure==
-	3CBY is a ~~2 chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA].	+	3CBY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBY OCA].
		+
		+	==Reference==
		+	Inhibition of Wnt signaling by Dishevelled PDZ peptides., Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS, Nat Chem Biol. 2009 Mar 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19252499 19252499]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Appleton, B A.~~]]	+	[[Category: Single protein]]
-	[[Category: ~~Wiesmann~~, C.]]	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
	[[Category: Cytoplasm]]		[[Category: Cytoplasm]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
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	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 18 20:05:18 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 18 20:06:53 2009''