3cge - Revision history

OCA at 12:28, 30 August 2023

OCA — Wed, 30 Aug 2023 12:28:17 GMT

←Older revision		Revision as of 12:28, 30 August 2023
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	<StructureSection load='3cge' size='340' side='right'caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3cge' size='340' side='right'caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bacillus_anthracis_(strain_ames)~~ Bacillus anthracis ~~(strain ames)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CGE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CGE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.262Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow: auto; max-height~~: ~~3em;~~'>~~[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [https://pdbe.org/3cge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [https://www.ebi.ac.uk/pdbsum/3cge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cge ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [https://pdbe.org/3cge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [https://www.ebi.ac.uk/pdbsum/3cge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cge ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A6L7HMK7_BACAN A0A6L7HMK7_BACAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus anthracis str. Ames]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wallen~~, J R]]~~	+	[[Category: Wallen JR]]
-	~~[[Category: Coenzyme some]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Flavin adenine dinucleotide]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Nicotinamide adenine dinucleotide phosphate]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:55, 27 January 2022

OCA — Thu, 27 Jan 2022 07:55:02 GMT

←Older revision		Revision as of 07:55, 27 January 2022
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	==Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity==		==Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity==
-	<StructureSection load='3cge' size='340' side='right' caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='3cge' size='340' side='right'caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CGE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CGE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [~~http~~://pdbe.org/3cge PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cge PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cge ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [https://pdbe.org/3cge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [https://www.ebi.ac.uk/pdbsum/3cge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cge ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Wallen, J R]]		[[Category: Wallen, J R]]
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]

OCA at 13:30, 7 November 2018

OCA — Wed, 07 Nov 2018 13:30:37 GMT

←Older revision		Revision as of 13:30, 7 November 2018
Line 1:		Line 1:
		+
	==Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity==		==Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity==
	<StructureSection load='3cge' size='340' side='right' caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3cge' size='340' side='right' caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [http://pdbe.org/3cge PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [http://www.ebi.ac.uk/pdbsum/3cge PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [http://pdbe.org/3cge PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [http://www.ebi.ac.uk/pdbsum/3cge PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cge ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/3cge_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/3cge_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:04, 9 February 2016

OCA — Tue, 09 Feb 2016 22:04:08 GMT

←Older revision		Revision as of 22:04, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3cge' size='340' side='right' caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3cge' size='340' side='right' caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_anthracis_str._ames~~ Bacillus anthracis ~~str.~~ ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CGE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CGE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis ~~str.~~ Ames])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [http://www.ebi.ac.uk/pdbsum/3cge PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [http://pdbe.org/3cge PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [http://www.ebi.ac.uk/pdbsum/3cge PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cge ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cge" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus anthracis str. ames]]
	[[Category: Wallen, J R]]		[[Category: Wallen, J R]]
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]

OCA at 09:11, 20 January 2015

OCA — Tue, 20 Jan 2015 09:11:58 GMT

←Older revision		Revision as of 09:11, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_str._ames Bacillus anthracis str. ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CGE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_str._ames Bacillus anthracis str. ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CGE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis str. Ames])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis str. Ames])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [http://www.ebi.ac.uk/pdbsum/3cge PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [http://www.ebi.ac.uk/pdbsum/3cge PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus anthracis str. ames]]		[[Category: Bacillus anthracis str. ames]]
-	[[Category: Wallen, J R.]]	+	[[Category: Wallen, J R]]
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]
	[[Category: Fad]]		[[Category: Fad]]

OCA at 07:40, 29 September 2014

OCA — Mon, 29 Sep 2014 07:40:33 GMT

←Older revision		Revision as of 07:40, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3cge.~~png~~\|~~left~~\|200px]]	+	==Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity==
		+	<StructureSection load='3cge' size='340' side='right' caption='[[3cge]], [[Resolution\|resolution]] 2.26Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cge]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_str._ames Bacillus anthracis str. ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CGE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cgb\|3cgb]], [[3cgc\|3cgc]], [[3cgd\|3cgd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pyridine nucleotide-disulfide oxidoreductase, class I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis str. Ames])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cge RCSB], [http://www.ebi.ac.uk/pdbsum/3cge PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/3cge_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have recently reported that CoASH is the major low-molecular weight thiol in Bacillus anthracis [ Nicely, N. I. , Parsonage, D. , Paige, C. , Newton, G. L. , Fahey, R. C. , Leonardi, R. , Jackowski, S. , Mallett, T. C. , and Claiborne, A. ( 2007) Biochemistry , -3245 ], and we have now characterized the kinetic and redox properties of the B. anthracis coenzyme A-disulfide reductase (CoADR, BACoADR) and determined the crystal structure at 2.30 A resolution. While the Staphylococcus aureus and Borrelia burgdorferi CoADRs exhibit strong preferences for NADPH and NADH, respectively, B. anthracis CoADR can use either pyridine nucleotide equally well. Sequence elements within the respective NAD(P)H-binding motifs correctly reflect the preferences for S. aureus and Bo. burgdorferi CoADRs, but leave questions as to how BACoADR can interact with both pyridine nucleotides. The structures of the NADH and NADPH complexes at ca. 2.3 A resolution reveal that a loop consisting of residues Glu180-Thr187 becomes ordered and changes conformation on NAD(P)H binding. NADH and NADPH interact with nearly identical conformations of this loop; the latter interaction, however, involves a novel binding mode in which the 2'-phosphate of NADPH points out toward solvent. In addition, the NAD(P)H-reduced BACoADR structures provide the first view of the reduced form (Cys42-SH/CoASH) of the Cys42-SSCoA redox center. The Cys42-SH side chain adopts a new conformation in which the conserved Tyr367'-OH and Tyr425'-OH interact with the nascent thiol(ate) on the flavin si-face. Kinetic data with Y367F, Y425F, and Y367,425F BACoADR mutants indicate that Tyr425' is the primary proton donor in catalysis, with Tyr367' functioning as a cryptic alternate donor in the absence of Tyr425'.

-	~~{{STRUCTURE_3cge\| PDB=3cge \| SCENE= }}~~	+	Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity.,Wallen JR, Paige C, Mallett TC, Karplus PA, Claiborne A Biochemistry. 2008 Apr 10;. PMID:18399646<ref>PMID:18399646</ref>

-	~~===Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis~~ of ~~Dual NAD(P)H Specificity===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18399646}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3cge]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_anthracis_str~~.~~_ames Bacillus anthracis str. ames]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA].~~	+

	==See Also==		==See Also==
	*[[Coenzyme A-Disulfide Reductase\|Coenzyme A-Disulfide Reductase]]		*[[Coenzyme A-Disulfide Reductase\|Coenzyme A-Disulfide Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018399646<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus anthracis str. ames]]		[[Category: Bacillus anthracis str. ames]]
	[[Category: Wallen, J R.]]		[[Category: Wallen, J R.]]

OCA at 15:17, 20 October 2012

OCA — Sat, 20 Oct 2012 15:17:56 GMT

←Older revision		Revision as of 15:17, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3cge]] is a 2 chain structure ~~of [[Coenzyme A-Disulfide Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_str. Bacillus anthracis str.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA].	+	[[3cge]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_str._ames Bacillus anthracis str. ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:018399646</ref><references group="xtra"/>		<ref group="xtra">PMID:018399646</ref><references group="xtra"/>
-	[[Category: Bacillus anthracis str.]]	+	[[Category: Bacillus anthracis str. ames]]
	[[Category: Wallen, J R.]]		[[Category: Wallen, J R.]]
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]

OCA: Protected "3cge" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 17:56:02 GMT

Protected "3cge" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:56, 26 July 2012

OCA at 17:56, 26 July 2012

OCA — Thu, 26 Jul 2012 17:56:01 GMT

←Older revision		Revision as of 17:56, 26 July 2012
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-	{{Seed}}
	[[Image:3cge.png\|left\|200px]]		[[Image:3cge.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cge", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cge\| PDB=3cge \| SCENE= }}		{{STRUCTURE_3cge\| PDB=3cge \| SCENE= }}

	===Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity===		===Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18399646}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18399646 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18399646}}		{{ABSTRACT_PUBMED_18399646}}

	==About this Structure==		==About this Structure==
-	~~3CGE~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/~~Bacillus_anthracis~~ Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA].	+	[[3cge]] is a 2 chain structure of [[Coenzyme A-Disulfide Reductase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_str. Bacillus anthracis str.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA].
		+
		+	==See Also==
		+	*[[Coenzyme A-Disulfide Reductase\|Coenzyme A-Disulfide Reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18399646~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018399646</ref><references group="xtra"/>
-	[[Category: Bacillus anthracis]]	+	[[Category: Bacillus anthracis str.]]
	[[Category: Wallen, J R.]]		[[Category: Wallen, J R.]]
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]
Line 32:		Line 23:
	[[Category: Nicotinamide adenine dinucleotide phosphate]]		[[Category: Nicotinamide adenine dinucleotide phosphate]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:05:48 2009''

OCA at 11:05, 17 February 2009

OCA — Tue, 17 Feb 2009 11:05:50 GMT

←Older revision		Revision as of 11:05, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CGE is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA].	+	3CGE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CGE OCA].

	==Reference==		==Reference==
-	Pyridine Nucleotide Complexes with Bacillus anthracis Coenzyme A-Disulfide Reductase: A Structural Analysis of Dual NAD(P)H Specificity., Wallen JR, Paige C, Mallett TC, Karplus PA, Claiborne A, Biochemistry. 2008 Apr 10;. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18399646 18399646]~~	+	<ref group="xtra">PMID:18399646</ref><references group="xtra"/>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
-	[[Category: Single protein]]
	[[Category: Wallen, J R.]]		[[Category: Wallen, J R.]]
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]
Line 34:		Line 33:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28~~ 17:35:~~16 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:05:48 2009''