3ch9 - Revision history

OCA at 12:28, 30 August 2023

OCA — Wed, 30 Aug 2023 12:28:32 GMT

←Older revision		Revision as of 12:28, 30 August 2023
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	<StructureSection load='3ch9' size='340' side='right'caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ch9' size='340' side='right'caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~, ~~<scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~3~~.2.1.14 3.2.1.14]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [https://pdbe.org/3ch9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ch9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [~~http~~://pdbe.org/3ch9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ch9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CHIB1_ASPFM CHIB1_ASPFM]] Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis (By similarity).	+	[https://www.uniprot.org/uniprot/CHIB1_ASPFM CHIB1_ASPFM] Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chitinase~~]]	+	[[Category: Aspergillus fumigatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Aalten, D M.F van]]~~	+	[[Category: Andersen OA]]
-	[[Category: Andersen~~, O A~~]]	+	[[Category: Van Aalten DMF]]
-	[[Category: ~~Glycosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Peptide inhibitor~~]]	+

OCA at 10:27, 12 August 2020

OCA — Wed, 12 Aug 2020 10:27:19 GMT

←Older revision		Revision as of 10:27, 12 August 2020
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	==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea==		==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea==
-	<StructureSection load='3ch9' size='340' side='right' caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3ch9' size='340' side='right'caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://pdbe.org/3ch9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://pdbe.org/3ch9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
-	*[[Chitinase\|Chitinase]]	+	*[[Chitinase 3D structures\|Chitinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Chitinase]]		[[Category: Chitinase]]
		+	[[Category: Large Structures]]
	[[Category: Aalten, D M.F van]]		[[Category: Aalten, D M.F van]]
	[[Category: Andersen, O A]]		[[Category: Andersen, O A]]

OCA at 13:48, 7 November 2018

OCA — Wed, 07 Nov 2018 13:48:18 GMT

←Older revision		Revision as of 13:48, 7 November 2018
Line 1:		Line 1:
		+
	==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea==		==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea==
	<StructureSection load='3ch9' size='340' side='right' caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ch9' size='340' side='right' caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://pdbe.org/3ch9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://pdbe.org/3ch9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3ch9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3ch9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:12, 7 February 2016

OCA — Sun, 07 Feb 2016 21:12:47 GMT

←Older revision		Revision as of 21:12, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3ch9' size='340' side='right' caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ch9' size='340' side='right' caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chiB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=746128 Aspergillus fumigatus])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://pdbe.org/3ch9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHIB1_ASPFM CHIB1_ASPFM]] Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ch9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ch9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Aalten, D M.F van]]		[[Category: Aalten, D M.F van]]

OCA at 09:34, 20 January 2015

OCA — Tue, 20 Jan 2015 09:34:15 GMT

←Older revision		Revision as of 09:34, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chiB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=746128 Aspergillus fumigatus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chiB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=746128 Aspergillus fumigatus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
-	[[Category: Aalten, D M.F van.]]	+	[[Category: Aalten, D M.F van]]
-	[[Category: Andersen, O A~~.]]~~	+	[[Category: Andersen, O A]]
-	~~[[Category: Chitinase~~]]	+
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Peptide inhibitor]]		[[Category: Peptide inhibitor]]

OCA at 07:54, 29 September 2014

OCA — Mon, 29 Sep 2014 07:54:58 GMT

←Older revision		Revision as of 07:54, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3ch9.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea==
		+	<StructureSection load='3ch9' size='340' side='right' caption='[[3ch9]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ch9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CH9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRG:1-METHYL-3-(N-METHYLCARBAMIMIDOYL)UREA'>XRG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9v\|1w9v]], [[1w9p\|1w9p]], [[3chc\|3chc]], [[3chd\|3chd]], [[3che\|3che]], [[3chf\|3chf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chiB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=746128 Aspergillus fumigatus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ch9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ch9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ch9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3ch9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chitinase inhibitors have chemotherapeutic potential as fungicides, pesticides, and antiasthmatics. Argifin, a natural product cyclopentapeptide, competitively inhibits family 18 chitinases in the nanomolar to micromolar range and shows extensive substrate mimicry. In an attempt to map the active fragments of this large natural product, the cyclopentapeptide was progressively dissected down to four linear peptides and dimethylguanylurea, synthesized using a combination of solution and solid phase peptide synthesis. The peptide fragments inhibit chitinase B1 from Aspergillus fumigatus (AfChiB1), the human chitotriosidase, and chitinase activity in lung homogenates from a murine model of chronic asthma, with potencies ranging from high nanomolar to high micromolar inhibition. X-ray crystallographic analysis of the chitinase-inhibitor complexes revealed that the conformations of the linear peptides were remarkably similar to that of the natural product. Strikingly, the dimethylguanylurea fragment, representing only a quarter of the natural product mass, was found to harbor all significant interactions with the protein and binds with unusually high efficiency. The data provide useful information that could lead to the generation of drug-like, natural product-based chitinase inhibitors.

-	~~{{STRUCTURE_3ch9\| PDB=3ch9 \| SCENE= }}~~	+	Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.,Andersen OA, Nathubhai A, Dixon MJ, Eggleston IM, van Aalten DM Chem Biol. 2008 Mar;15(3):295-301. PMID:18355729<ref>PMID:18355729</ref>

-	~~===Crystal structure~~ of ~~Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18355729}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ch9]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA].~~	+

	==See Also==		==See Also==
	*[[Chitinase\|Chitinase]]		*[[Chitinase\|Chitinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018355729<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]

OCA at 07:52, 20 October 2012

OCA — Sat, 20 Oct 2012 07:52:58 GMT

←Older revision		Revision as of 07:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ch9]] is a 2 chain structure ~~of [[Chitinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA].	+	[[3ch9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA].

	==See Also==		==See Also==

OCA: Protected "3ch9" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 17:45:34 GMT

Protected "3ch9" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:45, 25 July 2012

OCA at 17:45, 25 July 2012

OCA — Wed, 25 Jul 2012 17:45:32 GMT

←Older revision		Revision as of 17:45, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ch9.png\|left\|200px]]		[[Image:3ch9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ch9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ch9\| PDB=3ch9 \| SCENE= }}		{{STRUCTURE_3ch9\| PDB=3ch9 \| SCENE= }}

	===Crystal structure of Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea===		===Crystal structure of Aspergillus fumigatus chitinase B1 in complex with dimethylguanylurea===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18355729}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18355729 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18355729}}		{{ABSTRACT_PUBMED_18355729}}

	==About this Structure==		==About this Structure==
-	~~3CH9~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA].	+	[[3ch9]] is a 2 chain structure of [[Chitinase]] with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA].
		+
		+	==See Also==
		+	*[[Chitinase\|Chitinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18355729~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018355729</ref><references group="xtra"/>
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
Line 31:		Line 22:
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Peptide inhibitor]]		[[Category: Peptide inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:33:09 2009''

OCA at 14:33, 16 February 2009

OCA — Mon, 16 Feb 2009 14:33:09 GMT

←Older revision		Revision as of 14:33, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CH9 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA].	+	3CH9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH9 OCA].

	==Reference==		==Reference==
-	~~Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin., Andersen OA, Nathubhai A, Dixon MJ, Eggleston IM, van Aalten DM, Chem Biol. 2008 Mar;15(3):295-301.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18355729 18355729]~~	+	<ref group="xtra">PMID:18355729</ref><references group="xtra"/>
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
-	[[Category: Single protein]]
	[[Category: Aalten, D M.F van.]]		[[Category: Aalten, D M.F van.]]
	[[Category: Andersen, O A.]]		[[Category: Andersen, O A.]]
Line 34:		Line 33:
	[[Category: Peptide inhibitor]]		[[Category: Peptide inhibitor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 19~~:45:~~23 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:33:09 2009''