3cjt - Revision history

OCA at 12:29, 30 August 2023

OCA — Wed, 30 Aug 2023 12:29:24 GMT

←Older revision		Revision as of 12:29, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3cjt' size='340' side='right'caption='[[3cjt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3cjt' size='340' side='right'caption='[[3cjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cjt]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thermus_thermophilus~~ Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CJT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cjt]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CJT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MM:N,N-DIMETHYL-L-METHIONINE'>2MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MM:N,N-DIMETHYL-L-METHIONINE'>2MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [https://pdbe.org/3cjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [https://www.ebi.ac.uk/pdbsum/3cjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [https://pdbe.org/3cjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [https://www.ebi.ac.uk/pdbsum/3cjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRMA_THET8 PRMA_THET8]] Methylates ribosomal protein L11; this reaction probably occurs before the protein is assembled into the ribosome. This function is dispensable for growth and thermostability~~. [[https://www.uniprot.org/uniprot/RL11_THETH RL11_THETH]] This protein binds directly to 23S ribosomal RNA (By similarity)~~.	+	[https://www.uniprot.org/uniprot/PRMA_THET8 PRMA_THET8] Methylates ribosomal protein L11; this reaction probably occurs before the protein is assembled into the ribosome. This function is dispensable for growth and thermostability.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 31:

	==See Also==		==See Also==
-	*[[Ribosomal protein L11\|Ribosomal protein L11]]	+	*[[Ribosomal protein L11 3D structures\|Ribosomal protein L11 3D structures]]
	*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]		*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]
	== References ==		== References ==
Line 39:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Thermus thermophilus]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Dahlberg~~, A E~~]]	+	[[Category: Dahlberg AE]]
-	[[Category: Demirci, H]]	+	[[Category: Demirci H]]
-	[[Category: Gregory~~, S T~~]]	+	[[Category: Gregory ST]]
-	[[Category: Jogl, G]]	+	[[Category: Jogl G]]
-	~~[[Category: Multi-specific trimethylation]]~~	+
-	~~[[Category: Post-translational modification]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Ribosomal protein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Rrna-binding]]~~	+
-	~~[[Category: S-adenosyl-l-methionine dependent methyltransferase]]~~	+
-	~~[[Category: Transferase-ribosomal protein complex~~]]	+

OCA at 19:10, 20 October 2021

OCA — Wed, 20 Oct 2021 19:10:37 GMT

←Older revision		Revision as of 19:10, 20 October 2021
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	==Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11==		==Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11==
-	<StructureSection load='3cjt' size='340' side='right' caption='[[3cjt]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3cjt' size='340' side='right'caption='[[3cjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cjt]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CJT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cjt]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CJT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MM:N,N-DIMETHYL-L-METHIONINE'>2MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MM:N,N-DIMETHYL-L-METHIONINE'>2MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [~~http~~://pdbe.org/3cjt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cjt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [https://pdbe.org/3cjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [https://www.ebi.ac.uk/pdbsum/3cjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRMA_THET8 PRMA_THET8]] Methylates ribosomal protein L11; this reaction probably occurs before the protein is assembled into the ribosome. This function is dispensable for growth and thermostability. [[~~http~~://www.uniprot.org/uniprot/RL11_THETH RL11_THETH]] This protein binds directly to 23S ribosomal RNA (By similarity).	+	[[https://www.uniprot.org/uniprot/PRMA_THET8 PRMA_THET8]] Methylates ribosomal protein L11; this reaction probably occurs before the protein is assembled into the ribosome. This function is dispensable for growth and thermostability. [[https://www.uniprot.org/uniprot/RL11_THETH RL11_THETH]] This protein binds directly to 23S ribosomal RNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Dahlberg, A E]]		[[Category: Dahlberg, A E]]

OCA at 14:07, 7 November 2018

OCA — Wed, 07 Nov 2018 14:07:07 GMT

←Older revision		Revision as of 14:07, 7 November 2018
Line 1:		Line 1:
		+
	==Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11==		==Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11==
	<StructureSection load='3cjt' size='340' side='right' caption='[[3cjt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3cjt' size='340' side='right' caption='[[3cjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [http://pdbe.org/3cjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [http://www.ebi.ac.uk/pdbsum/3cjt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [http://pdbe.org/3cjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [http://www.ebi.ac.uk/pdbsum/3cjt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cjt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cjt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:57, 8 February 2016

OCA — Mon, 08 Feb 2016 06:57:33 GMT

←Older revision		Revision as of 06:57, 8 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [http://www.ebi.ac.uk/pdbsum/3cjt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [http://pdbe.org/3cjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [http://www.ebi.ac.uk/pdbsum/3cjt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cjt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cjt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Ribosomal protein L11\|Ribosomal protein L11]]
	*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]		*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]
	== References ==		== References ==

OCA at 21:28, 24 December 2014

OCA — Wed, 24 Dec 2014 21:28:46 GMT

←Older revision		Revision as of 21:28, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cjt]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cjt]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MM:N,N-DIMETHYL-L-METHIONINE'>2MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MM:N,N-DIMETHYL-L-METHIONINE'>2MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [http://www.ebi.ac.uk/pdbsum/3cjt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [http://www.ebi.ac.uk/pdbsum/3cjt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRMA_THET8 PRMA_THET8]] Methylates ribosomal protein L11; this reaction probably occurs before the protein is assembled into the ribosome. This function is dispensable for growth and thermostability. [[http://www.uniprot.org/uniprot/RL11_THETH RL11_THETH]] This protein binds directly to 23S ribosomal RNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:

	==See Also==		==See Also==
-	*[[Ribosomal protein L11\|Ribosomal protein L11]]
	*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]		*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]
	== References ==		== References ==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Dahlberg, A E.]]	+	[[Category: Dahlberg, A E]]
-	[[Category: Demirci, H.]]	+	[[Category: Demirci, H]]
-	[[Category: Gregory, S T.]]	+	[[Category: Gregory, S T]]
-	[[Category: Jogl, G.]]	+	[[Category: Jogl, G]]
	[[Category: Multi-specific trimethylation]]		[[Category: Multi-specific trimethylation]]
	[[Category: Post-translational modification]]		[[Category: Post-translational modification]]

OCA at 09:24, 29 September 2014

OCA — Mon, 29 Sep 2014 09:24:16 GMT

←Older revision		Revision as of 09:24, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3cjt.~~png~~\|~~left~~\|200px]]	+	==Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11==
		+	<StructureSection load='3cjt' size='340' side='right' caption='[[3cjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cjt]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MM:N,N-DIMETHYL-L-METHIONINE'>2MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nxc\|2nxc]], [[2nxe\|2nxe]], [[2nxj\|2nxj]], [[2nxn\|2nxn]], [[1ufk\|1ufk]], [[3cjq\|3cjq]], [[3cjr\|3cjr]], [[3cjs\|3cjs]], [[3cju\|3cju]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), rplK, rpl11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cjt RCSB], [http://www.ebi.ac.uk/pdbsum/3cjt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cjt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribosomal protein L11 is a universally conserved component of the large subunit, and plays a significant role during initiation, elongation, and termination of protein synthesis. In Escherichia coli, the lysine methyltransferase PrmA trimethylates the N-terminal alpha-amino group and the epsilon-amino groups of Lys3 and Lys39. Here, we report four PrmA-L11 complex structures in different orientations with respect to the PrmA active site. Two structures capture the L11 N-terminal alpha-amino group in the active site in a trimethylated post-catalytic state and in a dimethylated state with bound S-adenosyl-L-homocysteine. Two other structures show L11 in a catalytic orientation to modify Lys39 and in a noncatalytic orientation. The comparison of complex structures in different orientations with a minimal substrate recognition complex shows that the binding mode remains conserved in all L11 orientations, and that substrate orientation is brought about by the unusual interdomain flexibility of PrmA.

-	~~{{STRUCTURE_3cjt\| PDB=3cjt \| SCENE= }}~~	+	Multiple-site trimethylation of ribosomal protein L11 by the PrmA methyltransferase.,Demirci H, Gregory ST, Dahlberg AE, Jogl G Structure. 2008 Jul;16(7):1059-66. PMID:18611379<ref>PMID:18611379</ref>

-	~~===Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18611379}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3cjt]] is~~ a ~~16 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA].~~	+

	==See Also==		==See Also==
	*[[Ribosomal protein L11\|Ribosomal protein L11]]		*[[Ribosomal protein L11\|Ribosomal protein L11]]
	*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]		*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018611379<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Dahlberg, A E.]]		[[Category: Dahlberg, A E.]]

OCA at 09:19, 20 October 2012

OCA — Sat, 20 Oct 2012 09:19:06 GMT

←Older revision		Revision as of 09:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3cjt]] is a 16 chain structure ~~of [[Ribosomal protein L11]] and [[Ribosomal protein L11 methyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA].	+	[[3cjt]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA].

	==See Also==		==See Also==

OCA: Protected "3cjt" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 22:26:32 GMT

Protected "3cjt" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:26, 25 July 2012

OCA at 22:26, 25 July 2012

OCA — Wed, 25 Jul 2012 22:26:30 GMT

←Older revision		Revision as of 22:26, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3cjt.png\|left\|200px]]		[[Image:3cjt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cjt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cjt\| PDB=3cjt \| SCENE= }}		{{STRUCTURE_3cjt\| PDB=3cjt \| SCENE= }}

	===Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11===		===Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18611379}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18611379 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18611379}}		{{ABSTRACT_PUBMED_18611379}}

	==About this Structure==		==About this Structure==
-	~~3CJT~~ is a 16 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA].	+	[[3cjt]] is a 16 chain structure of [[Ribosomal protein L11]] and [[Ribosomal protein L11 methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA].
		+
		+	==See Also==
		+	*[[Ribosomal protein L11\|Ribosomal protein L11]]
		+	*[[Ribosomal protein L11 methyltransferase\|Ribosomal protein L11 methyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18611379~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018611379</ref><references group="xtra"/>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Dahlberg, A E.]]		[[Category: Dahlberg, A E.]]
Line 29:		Line 21:
	[[Category: Gregory, S T.]]		[[Category: Gregory, S T.]]
	[[Category: Jogl, G.]]		[[Category: Jogl, G.]]
-	[[Category: Cytoplasm]]
	[[Category: Multi-specific trimethylation]]		[[Category: Multi-specific trimethylation]]
	[[Category: Post-translational modification]]		[[Category: Post-translational modification]]
Line 37:		Line 28:
	[[Category: Rrna-binding]]		[[Category: Rrna-binding]]
	[[Category: S-adenosyl-l-methionine dependent methyltransferase]]		[[Category: S-adenosyl-l-methionine dependent methyltransferase]]
-	[[Category: Transferase/ribosomal protein complex]]	+	[[Category: Transferase-ribosomal protein complex]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:00:06 2009''~~	+

OCA at 18:00, 16 February 2009

OCA — Mon, 16 Feb 2009 18:00:07 GMT

←Older revision		Revision as of 18:00, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CJT is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA].	+	3CJT is a 16 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJT OCA].

	==Reference==		==Reference==
-	~~Multiple-Site Trimethylation of Ribosomal Protein L11 by the PrmA Methyltransferase., Demirci H, Gregory ST, Dahlberg AE, Jogl G, Structure. 2008 Jul;16(7):1059-66.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18611379 18611379]~~	+	<ref group="xtra">PMID:18611379</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Dahlberg, A E.]]		[[Category: Dahlberg, A E.]]
Line 40:		Line 39:
	[[Category: Transferase/ribosomal protein complex]]		[[Category: Transferase/ribosomal protein complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 23 10~~:14:~~26 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:00:06 2009''