3cpi - Revision history

OCA at 14:59, 1 November 2023

OCA — Wed, 01 Nov 2023 14:59:17 GMT

←Older revision		Revision as of 14:59, 1 November 2023
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	<StructureSection load='3cpi' size='340' side='right'caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3cpi' size='340' side='right'caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPI FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[3cph\|3cph]]~~, [[~~3cpj~~\|~~3cpj~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [https://pdbe.org/3cpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [https://www.ebi.ac.uk/pdbsum/3cpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [https://pdbe.org/3cpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [https://www.ebi.ac.uk/pdbsum/3cpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GDI1_YEAST GDI1_YEAST]] Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway.<ref>PMID:8157010</ref>	+	[https://www.uniprot.org/uniprot/GDI1_YEAST GDI1_YEAST] Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway.<ref>PMID:8157010</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Goody~~, R S~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Ignatev, A]]	+	[[Category: Goody RS]]
-	[[Category: Kravchenko, S]]	+	[[Category: Ignatev A]]
-	[[Category: Pylypenko, O]]	+	[[Category: Kravchenko S]]
-	[[Category: Rak, A]]	+	[[Category: Pylypenko O]]
-	~~[[Category: Cytoplasm]]~~	+	[[Category: Rak A]]
-	~~[[Category: Gdi]]~~	+
-	~~[[Category: Gtpase activation]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Rab]]~~	+
-	~~[[Category: Vesicular transport~~]]	+

OCA at 07:41, 2 February 2022

OCA — Wed, 02 Feb 2022 07:41:17 GMT

←Older revision		Revision as of 07:41, 2 February 2022
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	<StructureSection load='3cpi' size='340' side='right'caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3cpi' size='340' side='right'caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPI FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cph\|3cph]], [[3cpj\|3cpj]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cph\|3cph]], [[3cpj\|3cpj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [~~http~~://pdbe.org/3cpi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cpi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [https://pdbe.org/3cpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [https://www.ebi.ac.uk/pdbsum/3cpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GDI1_YEAST GDI1_YEAST]] Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway.<ref>PMID:8157010</ref>	+	[[https://www.uniprot.org/uniprot/GDI1_YEAST GDI1_YEAST]] Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway.<ref>PMID:8157010</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:21, 31 July 2019

OCA — Wed, 31 Jul 2019 07:21:31 GMT

←Older revision		Revision as of 07:21, 31 July 2019
Line 1:		Line 1:

	==Crystal structure of yeast Rab-GDI==		==Crystal structure of yeast Rab-GDI==
-	<StructureSection load='3cpi' size='340' side='right' caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3cpi' size='340' side='right'caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPI FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Goody, R S]]		[[Category: Goody, R S]]
	[[Category: Ignatev, A]]		[[Category: Ignatev, A]]

OCA at 08:32, 25 October 2017

OCA — Wed, 25 Oct 2017 08:32:33 GMT

←Older revision		Revision as of 08:32, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of yeast Rab-GDI==		==Crystal structure of yeast Rab-GDI==
	<StructureSection load='3cpi' size='340' side='right' caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3cpi' size='340' side='right' caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cph\|3cph]], [[3cpj\|3cpj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cph\|3cph]], [[3cpj\|3cpj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [http://pdbe.org/3cpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [http://www.ebi.ac.uk/pdbsum/3cpi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [http://pdbe.org/3cpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [http://www.ebi.ac.uk/pdbsum/3cpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 37:		Line 38:
	[[Category: Pylypenko, O]]		[[Category: Pylypenko, O]]
	[[Category: Rak, A]]		[[Category: Rak, A]]
		+	[[Category: Cytoplasm]]
	[[Category: Gdi]]		[[Category: Gdi]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]

OCA at 18:00, 8 February 2016

OCA — Mon, 08 Feb 2016 18:00:20 GMT

←Older revision		Revision as of 18:00, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3cpi' size='340' side='right' caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3cpi' size='340' side='right' caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cph\|3cph]], [[3cpj\|3cpj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cph\|3cph]], [[3cpj\|3cpj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [http://www.ebi.ac.uk/pdbsum/3cpi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [http://pdbe.org/3cpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [http://www.ebi.ac.uk/pdbsum/3cpi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cpi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cpi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Goody, R S]]		[[Category: Goody, R S]]
	[[Category: Ignatev, A]]		[[Category: Ignatev, A]]

OCA at 01:10, 25 December 2014

OCA — Thu, 25 Dec 2014 01:10:09 GMT

←Older revision		Revision as of 01:10, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [http://www.ebi.ac.uk/pdbsum/3cpi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [http://www.ebi.ac.uk/pdbsum/3cpi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GDI1_YEAST GDI1_YEAST]] Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway.<ref>PMID:8157010</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Goody, R S.]]	+	[[Category: Goody, R S]]
-	[[Category: Ignatev, A.]]	+	[[Category: Ignatev, A]]
-	[[Category: Kravchenko, S.]]	+	[[Category: Kravchenko, S]]
-	[[Category: Pylypenko, O.]]	+	[[Category: Pylypenko, O]]
-	[[Category: Rak, A.]]	+	[[Category: Rak, A]]
	[[Category: Gdi]]		[[Category: Gdi]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]

OCA at 06:26, 10 October 2014

OCA — Fri, 10 Oct 2014 06:26:23 GMT

←Older revision		Revision as of 06:26, 10 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3cpi~~\| ~~PDB~~=3cpi \| ~~SCENE~~= }}	+	==Crystal structure of yeast Rab-GDI==
-	===~~Crystal~~ structure of ~~yeast Rab~~-~~GDI~~===	+	<StructureSection load='3cpi' size='340' side='right' caption='[[3cpi]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18426803}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPI FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cph\|3cph]], [[3cpj\|3cpj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cpi RCSB], [http://www.ebi.ac.uk/pdbsum/3cpi PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rab GDP dissociation inhibitors (GDI)-facilitated extraction of prenylated Rab proteins from membranes plays an important role in vesicular membrane trafficking. The investigated thermodynamic properties of yeast Rab.GDI and Rab.MRS6 complexes demonstrated differences in the Rab binding properties of the closely related Rab GDI and MRS6 proteins, consistent with their functional diversity. The importance of the Rab C terminus and its prenylation for GDI/MRS6 binding was demonstrated using both biochemical and structural data. The presented structures of the apo-form yeast Rab GDI and its two complexes with unprenylated Rab proteins, together with the earlier published structures of the prenylated Ypt1.GDI, provide evidence of allosteric regulation of the GDI lipid binding site opening, which plays a key role in the proposed mechanism of GDI-mediated Rab extraction. We suggest a model for the interaction of GDI with prenylated Rab proteins that incorporates a stepwise increase in affinity as the three different partial interactions are successively formed.

-	~~==About this Structure==~~	+	A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.,Ignatev A, Kravchenko S, Rak A, Goody RS, Pylypenko O J Biol Chem. 2008 Jun 27;283(26):18377-84. Epub 2008 Apr 20. PMID:18426803<ref>PMID:18426803</ref>
-	~~[[3cpi]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3CPI OCA].~~	+

-	~~==See Also==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	*[[Introduction to Evolutionary Conservation\|Introduction to Evolutionary Conservation]]	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018426803<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Goody, R S.]]		[[Category: Goody, R S.]]

OCA: Protected "3cpi" [edit=sysop:move=sysop]

OCA — Mon, 11 Mar 2013 09:44:43 GMT

Protected "3cpi" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:44, 11 March 2013

OCA at 09:44, 11 March 2013

OCA — Mon, 11 Mar 2013 09:44:41 GMT

←Older revision		Revision as of 09:44, 11 March 2013
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-	{{Seed}}
-	[[Image:3cpi.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cpi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3cpi\| PDB=3cpi \| SCENE= }}		{{STRUCTURE_3cpi\| PDB=3cpi \| SCENE= }}
-
	===Crystal structure of yeast Rab-GDI===		===Crystal structure of yeast Rab-GDI===
-
-
-	<!--
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	{{ABSTRACT_PUBMED_18426803}}		{{ABSTRACT_PUBMED_18426803}}

	==About this Structure==		==About this Structure==
-	~~3CPI~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA].	+	[[3cpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA].
		+
		+	==See Also==
		+	*[[Introduction to Evolutionary Conservation\|Introduction to Evolutionary Conservation]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18426803~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018426803</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Goody, R S.]]		[[Category: Goody, R S.]]
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	[[Category: Pylypenko, O.]]		[[Category: Pylypenko, O.]]
	[[Category: Rak, A.]]		[[Category: Rak, A.]]
-	[[Category: Cytoplasm]]
	[[Category: Gdi]]		[[Category: Gdi]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]
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	[[Category: Rab]]		[[Category: Rab]]
	[[Category: Vesicular transport]]		[[Category: Vesicular transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:58:13 2009''

OCA at 22:58, 16 February 2009

OCA — Mon, 16 Feb 2009 22:58:14 GMT

←Older revision		Revision as of 22:58, 16 February 2009
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	==About this Structure==		==About this Structure==
-	3CPI is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA].	+	3CPI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPI OCA].

	==Reference==		==Reference==
-	~~A structural model of the GDI rab membrane extraction mechanism., Ignatev A, Kravchenko S, Rak A, Goody RS, Pylypenko O, J Biol Chem. 2008 Apr 20;.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18426803 18426803]~~	+	<ref group="xtra">PMID:18426803</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Goody, R S.]]		[[Category: Goody, R S.]]
	[[Category: Ignatev, A.]]		[[Category: Ignatev, A.]]
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	[[Category: Vesicular transport]]		[[Category: Vesicular transport]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 16 08~~:53:~~50 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:58:13 2009''