3cre - Revision history

OCA at 09:37, 21 February 2024

OCA — Wed, 21 Feb 2024 09:37:35 GMT

←Older revision		Revision as of 09:37, 21 February 2024
Line 9:		Line 9:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q8ZRK4_SALTY Q8ZRK4_SALTY]		[https://www.uniprot.org/uniprot/Q8ZRK4_SALTY Q8ZRK4_SALTY]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Bacterial pili are important virulence factors involved in host cell attachment and/or biofilm formation, key steps in establishing and maintaining successful infection. Here we studied Salmonella atypical fimbriae (or Saf pili), formed by the conserved chaperone/usher pathway. In contrast to the well-established quaternary structure of typical/FGS-chaperone assembled, rod-shaped, chaperone/usher pili, little is known about the supramolecular organisation in atypical/FGL-chaperone assembled fimbriae. In our study, we have used negative stain electron microscopy and single-particle image analysis to determine the three-dimensional structure of the Salmonella typhimurium Saf pilus. Our results show atypical/FGL-chaperone assembled fimbriae are composed of highly flexible linear multi-subunit fibres that are formed by globular subunits connected to each other by short links giving a "beads on a string"-like appearance. Quantitative fitting of the atomic structure of the SafA pilus subunit into the electron density maps, in combination with linker modelling and energy minimisation, has enabled analysis of subunit arrangement and intersubunit interactions in the Saf pilus. Short intersubunit linker regions provide the molecular basis for flexibility of the Saf pilus by acting as molecular hinges allowing a large range of movement between consecutive subunits in the fibre.
-
-	Structural analysis of the Saf pilus by electron microscopy and image processing.,Salih O, Remaut H, Waksman G, Orlova EV J Mol Biol. 2008 May 23;379(1):174-87. Epub 2008 Apr 3. PMID:18448124<ref>PMID:18448124</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3cre" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>

OCA at 17:29, 8 November 2023

OCA — Wed, 08 Nov 2023 17:29:16 GMT

←Older revision		Revision as of 17:29, 8 November 2023
Line 3:		Line 3:
	<SX load='3cre' size='340' side='right' viewer='molstar' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>		<SX load='3cre' size='340' side='right' viewer='molstar' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Salmonella_typhimurium~~ Salmonella ~~typhimurium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2co4\|2co4]], [[3crf\|3crf]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 17Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">safA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=90371 Salmonella typhimurium])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [https://pdbe.org/3cre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [https://www.ebi.ac.uk/pdbsum/3cre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [https://pdbe.org/3cre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [https://www.ebi.ac.uk/pdbsum/3cre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZRK4_SALTY Q8ZRK4_SALTY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Salmonella ~~typhimurium~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: Orlova~~, E V~~]]	+	[[Category: Orlova EV]]
-	[[Category: Remaut, H]]	+	[[Category: Remaut H]]
-	[[Category: Salih, O]]	+	[[Category: Salih O]]
-	[[Category: Waksman, G]]	+	[[Category: Waksman G]]
-	~~[[Category: Fibril protein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Safa protein polymer]]~~	+
-	~~[[Category: Type a saf pilus~~]]	+

OCA at 07:42, 2 February 2022

OCA — Wed, 02 Feb 2022 07:42:47 GMT

←Older revision		Revision as of 07:42, 2 February 2022
Line 3:		Line 3:
	<SX load='3cre' size='340' side='right' viewer='molstar' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>		<SX load='3cre' size='340' side='right' viewer='molstar' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3CRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2co4\|2co4]], [[3crf\|3crf]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella typhimurium])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella typhimurium])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [~~http~~://pdbe.org/3cre PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cre PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [https://pdbe.org/3cre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [https://www.ebi.ac.uk/pdbsum/3cre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:15, 10 April 2020

OCA — Fri, 10 Apr 2020 17:15:45 GMT

←Older revision		Revision as of 17:15, 10 April 2020
Line 3:		Line 3:
	<SX load='3cre' size='340' side='right' viewer='molstar' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>		<SX load='3cre' size='340' side='right' viewer='molstar' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CRE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella typhimurium])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella typhimurium])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [http://pdbe.org/3cre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [http://www.ebi.ac.uk/pdbsum/3cre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [http://pdbe.org/3cre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [http://www.ebi.ac.uk/pdbsum/3cre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:05, 6 March 2020

OCA — Fri, 06 Mar 2020 17:05:52 GMT

←Older revision		Revision as of 17:05, 6 March 2020
Line 1:		Line 1:

	==Electron Microscopy model of the Saf Pilus- Type A==		==Electron Microscopy model of the Saf Pilus- Type A==
-	<~~StructureSection~~ load='3cre' size='340' side='right' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>	+	<SX load='3cre' size='340' side='right' viewer='molstar' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CRE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CRE FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Salmonella typhimurium]]		[[Category: Salmonella typhimurium]]
	[[Category: Orlova, E V]]		[[Category: Orlova, E V]]

OCA at 07:55, 18 July 2018

OCA — Wed, 18 Jul 2018 07:55:03 GMT

←Older revision		Revision as of 07:55, 18 July 2018
Line 3:		Line 3:
	<StructureSection load='3cre' size='340' side='right' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>		<StructureSection load='3cre' size='340' side='right' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmonella_enterica_subsp._enterica_serovar_typhimurium~~ Salmonella ~~enterica subsp. enterica serovar~~ typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CRE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella ~~enterica subsp. enterica serovar Typhimurium~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella typhimurium])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [http://pdbe.org/3cre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [http://www.ebi.ac.uk/pdbsum/3cre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [http://pdbe.org/3cre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [http://www.ebi.ac.uk/pdbsum/3cre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Salmonella ~~enterica subsp. enterica serovar~~ typhimurium]]	+	[[Category: Salmonella typhimurium]]
	[[Category: Orlova, E V]]		[[Category: Orlova, E V]]
	[[Category: Remaut, H]]		[[Category: Remaut, H]]

OCA at 15:46, 11 August 2016

OCA — Thu, 11 Aug 2016 15:46:11 GMT

←Older revision		Revision as of 15:46, 11 August 2016
Line 1:		Line 1:
		+
	==Electron Microscopy model of the Saf Pilus- Type A==		==Electron Microscopy model of the Saf Pilus- Type A==
	<StructureSection load='3cre' size='340' side='right' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>		<StructureSection load='3cre' size='340' side='right' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [http://www.ebi.ac.uk/pdbsum/3cre PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [http://pdbe.org/3cre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [http://www.ebi.ac.uk/pdbsum/3cre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cre ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cre" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:04, 25 January 2015

OCA — Sun, 25 Jan 2015 10:04:03 GMT

←Older revision		Revision as of 10:04, 25 January 2015
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Orlova, E V.]]	+	[[Category: Orlova, E V]]
-	[[Category: Remaut, H.]]	+	[[Category: Remaut, H]]
-	[[Category: Salih, O.]]	+	[[Category: Salih, O]]
-	[[Category: Waksman, G.]]	+	[[Category: Waksman, G]]
	[[Category: Fibril protein]]		[[Category: Fibril protein]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Safa protein polymer]]		[[Category: Safa protein polymer]]
	[[Category: Type a saf pilus]]		[[Category: Type a saf pilus]]

OCA at 09:29, 5 November 2014

OCA — Wed, 05 Nov 2014 09:29:51 GMT

←Older revision		Revision as of 09:29, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3cre.~~png~~\|~~left~~\|~~200px~~]]	+	==Electron Microscopy model of the Saf Pilus- Type A==
		+	<StructureSection load='3cre' size='340' side='right' caption='[[3cre]], [[Resolution\|resolution]] 17.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cre]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CRE FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2co4\|2co4]], [[3crf\|3crf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">safA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cre RCSB], [http://www.ebi.ac.uk/pdbsum/3cre PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial pili are important virulence factors involved in host cell attachment and/or biofilm formation, key steps in establishing and maintaining successful infection. Here we studied Salmonella atypical fimbriae (or Saf pili), formed by the conserved chaperone/usher pathway. In contrast to the well-established quaternary structure of typical/FGS-chaperone assembled, rod-shaped, chaperone/usher pili, little is known about the supramolecular organisation in atypical/FGL-chaperone assembled fimbriae. In our study, we have used negative stain electron microscopy and single-particle image analysis to determine the three-dimensional structure of the Salmonella typhimurium Saf pilus. Our results show atypical/FGL-chaperone assembled fimbriae are composed of highly flexible linear multi-subunit fibres that are formed by globular subunits connected to each other by short links giving a "beads on a string"-like appearance. Quantitative fitting of the atomic structure of the SafA pilus subunit into the electron density maps, in combination with linker modelling and energy minimisation, has enabled analysis of subunit arrangement and intersubunit interactions in the Saf pilus. Short intersubunit linker regions provide the molecular basis for flexibility of the Saf pilus by acting as molecular hinges allowing a large range of movement between consecutive subunits in the fibre.

-	~~{{STRUCTURE_3cre\| PDB=3cre \| SCENE= }}~~	+	Structural analysis of the Saf pilus by electron microscopy and image processing.,Salih O, Remaut H, Waksman G, Orlova EV J Mol Biol. 2008 May 23;379(1):174-87. Epub 2008 Apr 3. PMID:18448124<ref>PMID:18448124</ref>

-	~~===Electron Microscopy model~~ of the ~~Saf Pilus- Type A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18448124}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3cre]] is a 3 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRE OCA].	+	</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Orlova, E V.]]		[[Category: Orlova, E V.]]

OCA: Protected "3cre" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:03:44 GMT

Protected "3cre" [edit=sysop:move=sysop]

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Revision as of 19:03, 7 January 2013