3ctt - Revision history

OCA at 12:33, 30 August 2023

OCA — Wed, 30 Aug 2023 12:33:12 GMT

←Older revision		Revision as of 12:33, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ctt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CTT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ctt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CTT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=3CU:CASUARINE'>3CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2qly\|2qly]], [[2qmj\|2qmj]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3CU:CASUARINE'>3CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~MGAM~~, ~~MGA, MGAML ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [https://pdbe.org/3ctt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [https://www.ebi.ac.uk/pdbsum/3ctt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ctt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [https://pdbe.org/3ctt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [https://www.ebi.ac.uk/pdbsum/3ctt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ctt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MGA_HUMAN MGA_HUMAN]] May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.	+	[https://www.uniprot.org/uniprot/MGA_HUMAN MGA_HUMAN] May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alpha-glucosidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rose~~, D R~~]]	+	[[Category: Rose DR]]
-	[[Category: Sim, L]]	+	[[Category: Sim L]]
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Glycosyl hydrolase family 31]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Signal-anchor]]~~	+
-	~~[[Category: Sulfation]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 07:44, 2 February 2022

OCA — Wed, 02 Feb 2022 07:44:39 GMT

←Older revision		Revision as of 07:44, 2 February 2022
Line 1:		Line 1:

	==Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine==		==Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine==
-	<StructureSection load='3ctt' size='340' side='right' caption='[[3ctt]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3ctt' size='340' side='right'caption='[[3ctt]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ctt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CTT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ctt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CTT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3CU:CASUARINE'>3CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3CU:CASUARINE'>3CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qly\|2qly]], [[2qmj\|2qmj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qly\|2qly]], [[2qmj\|2qmj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGAM, MGA, MGAML ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGAM, MGA, MGAML ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [~~http~~://pdbe.org/3ctt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ctt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ctt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [https://pdbe.org/3ctt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [https://www.ebi.ac.uk/pdbsum/3ctt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ctt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MGA_HUMAN MGA_HUMAN]] May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.	+	[[https://www.uniprot.org/uniprot/MGA_HUMAN MGA_HUMAN]] May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/3ctt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/3ctt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3ctt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ctt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Alpha-glucosidase 3D structures\|Alpha-glucosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Rose, D R]]		[[Category: Rose, D R]]
	[[Category: Sim, L]]		[[Category: Sim, L]]

OCA at 08:34, 25 October 2017

OCA — Wed, 25 Oct 2017 08:34:55 GMT

←Older revision		Revision as of 08:34, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine==		==Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine==
	<StructureSection load='3ctt' size='340' side='right' caption='[[3ctt]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ctt' size='340' side='right' caption='[[3ctt]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGAM, MGA, MGAML ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGAM, MGA, MGAML ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [http://pdbe.org/3ctt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [http://www.ebi.ac.uk/pdbsum/3ctt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [http://pdbe.org/3ctt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [http://www.ebi.ac.uk/pdbsum/3ctt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ctt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:14, 9 February 2016

OCA — Tue, 09 Feb 2016 05:14:41 GMT

←Older revision		Revision as of 05:14, 9 February 2016
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGAM, MGA, MGAML ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGAM, MGA, MGAML ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [http://www.ebi.ac.uk/pdbsum/3ctt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [http://pdbe.org/3ctt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [http://www.ebi.ac.uk/pdbsum/3ctt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ctt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ctt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:41, 25 December 2014

OCA — Thu, 25 Dec 2014 04:41:07 GMT

←Older revision		Revision as of 04:41, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [http://www.ebi.ac.uk/pdbsum/3ctt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [http://www.ebi.ac.uk/pdbsum/3ctt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MGA_HUMAN MGA_HUMAN]] May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Rose, D R.]]	+	[[Category: Rose, D R]]
-	[[Category: Sim, L~~.]]~~	+	[[Category: Sim, L]]
-	~~[[Category: Alpha-glucosidase~~]]	+
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]

OCA at 06:54, 10 October 2014

OCA — Fri, 10 Oct 2014 06:54:18 GMT

←Older revision		Revision as of 06:54, 10 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3ctt.~~png~~\|~~left~~\|200px]]	+	==Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine==
		+	<StructureSection load='3ctt' size='340' side='right' caption='[[3ctt]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ctt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CTT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3CU:CASUARINE'>3CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qly\|2qly]], [[2qmj\|2qmj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGAM, MGA, MGAML ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ctt RCSB], [http://www.ebi.ac.uk/pdbsum/3ctt PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/3ctt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Total synthesis of naturally occurring casuarine (1) and the first total synthesis of casuarine 6-O-alpha-glucoside (2) were achieved through complete stereoselective nitrone cycloaddition, Tamao-Fleming oxidation and selective alpha-glucosylation as key steps. Biological assays of the two compounds proved their strong and selective inhibitory properties towards glucoamylase NtMGAM and trehalase Tre37A, respectively, which place them among the most powerful inhibitors of these enzymes. The structural determination of the complexes of NtMGAM with 1 and of Tre37A with 2 revealed interesting similarities in the catalytic sites of these two enzymes which belong to different families and clans.

-	~~{{STRUCTURE_3ctt\| PDB=3ctt \| SCENE= }}~~	+	Total Syntheses of Casuarine and Its 6-O-alpha-Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families.,Cardona F, Parmeggiani C, Faggi E, Bonaccini C, Gratteri P, Sim L, Gloster TM, Roberts S, Davies GJ, Rose DR, Goti A Chemistry. 2009 Jan 2. PMID:19123216<ref>PMID:19123216</ref>

-	~~===Crystal complex~~ of ~~N-terminal Human Maltase-Glucoamylase with Casuarine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19123216}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3ctt]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019123216<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "3ctt" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:29:53 GMT

Protected "3ctt" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:29, 7 January 2013

OCA at 20:29, 7 January 2013

OCA — Mon, 07 Jan 2013 20:29:49 GMT

←Older revision		Revision as of 20:29, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3ctt.png\|left\|200px]]
-	[[Image:3ctt.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ctt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ctt\| PDB=3ctt \| SCENE= }}		{{STRUCTURE_3ctt\| PDB=3ctt \| SCENE= }}

	===Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine===		===Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19123216}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19123216 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19123216}}		{{ABSTRACT_PUBMED_19123216}}

	==About this Structure==		==About this Structure==
-	~~3CTT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA].	+	[[3ctt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19123216~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019123216</ref><references group="xtra"/>
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 32:		Line 20:
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Glycosyl hydrolase family 31]]		[[Category: Glycosyl hydrolase family 31]]
		+	[[Category: Hydrolase]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
Line 37:		Line 26:
	[[Category: Sulfation]]		[[Category: Sulfation]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:28:31 2009''

OCA at 07:28, 25 February 2009

OCA — Wed, 25 Feb 2009 07:28:33 GMT

←Older revision		Revision as of 07:28, 25 February 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ctt.jpg\|left\|200px]]

-	The ~~entry 3ctt~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ctt", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ctt\| PDB=3ctt \| SCENE= }}

-	~~Authors: Sim, L., Rose, D.R.~~	+	===Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine===

-	Description: Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri Jul 11 13~~:04:~~11 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19123216}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19123216 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19123216}}
		+
		+	==About this Structure==
		+	3CTT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19123216</ref><references group="xtra"/>
		+	[[Category: Alpha-glucosidase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Rose, D R.]]
		+	[[Category: Sim, L.]]
		+	[[Category: Alpha-glucosidase]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Glycosidase]]
		+	[[Category: Glycosyl hydrolase family 31]]
		+	[[Category: Membrane]]
		+	[[Category: Multifunctional enzyme]]
		+	[[Category: Signal-anchor]]
		+	[[Category: Sulfation]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:28:31 2009''

OCA at 10:04, 11 July 2008

OCA — Fri, 11 Jul 2008 10:04:11 GMT

←Older revision		Revision as of 10:04, 11 July 2008
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ctt is ON HOLD	+	The entry 3ctt is ON HOLD until Paper Publication

	Authors: Sim, L., Rose, D.R.		Authors: Sim, L., Rose, D.R.
Line 7:		Line 7:
	Description: Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine		Description: Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine

-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:04:11 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun~~ 11 09:34:07 2008''	+