3cva - Revision history

OCA at 15:00, 1 November 2023

OCA — Wed, 01 Nov 2023 15:00:39 GMT

←Older revision		Revision as of 15:00, 1 November 2023
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	<StructureSection load='3cva' size='340' side='right'caption='[[3cva]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3cva' size='340' side='right'caption='[[3cva]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVA FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~bcl~~-~~xl (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [https://pdbe.org/3cva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [https://www.ebi.ac.uk/pdbsum/3cva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cva ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [https://pdbe.org/3cva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [https://www.ebi.ac.uk/pdbsum/3cva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cva ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>	+	[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, K]]	+	[[Category: Chen K]]
-	[[Category: Feng, Y]]	+	[[Category: Feng Y]]
-	[[Category: Hu, T]]	+	[[Category: Hu T]]
-	[[Category: Jiang, H]]	+	[[Category: Jiang H]]
-	[[Category: Liu, D]]	+	[[Category: Liu D]]
-	[[Category: Shen, X]]	+	[[Category: Shen X]]
-	[[Category: Zhang, L]]	+	[[Category: Zhang L]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mitochondrion]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 07:30, 10 November 2021

OCA — Wed, 10 Nov 2021 07:30:10 GMT

←Older revision		Revision as of 07:30, 10 November 2021
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	==Human Bcl-xL containing a Trp to Ala mutation at position 137==		==Human Bcl-xL containing a Trp to Ala mutation at position 137==
-	<StructureSection load='3cva' size='340' side='right' caption='[[3cva]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3cva' size='340' side='right'caption='[[3cva]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cva]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVA FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bcl-xl ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bcl-xl ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [~~http~~://pdbe.org/3cva PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cva PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cva ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [https://pdbe.org/3cva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [https://www.ebi.ac.uk/pdbsum/3cva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cva ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>	+	[[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cva_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cva_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3cva" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3cva" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, K]]		[[Category: Chen, K]]
	[[Category: Feng, Y]]		[[Category: Feng, Y]]

OCA at 08:35, 25 October 2017

OCA — Wed, 25 Oct 2017 08:35:45 GMT

←Older revision		Revision as of 08:35, 25 October 2017
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3cva" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3cva" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Bcl-2\|Bcl-2]]
	== References ==		== References ==
	<references/>		<references/>
Line 43:		Line 40:
	[[Category: Shen, X]]		[[Category: Shen, X]]
	[[Category: Zhang, L]]		[[Category: Zhang, L]]
		+	[[Category: Alternative splicing]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 21:22, 5 August 2016

OCA — Fri, 05 Aug 2016 21:22:53 GMT

←Older revision		Revision as of 21:22, 5 August 2016
Line 1:		Line 1:
		+
	==Human Bcl-xL containing a Trp to Ala mutation at position 137==		==Human Bcl-xL containing a Trp to Ala mutation at position 137==
	<StructureSection load='3cva' size='340' side='right' caption='[[3cva]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3cva' size='340' side='right' caption='[[3cva]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVA FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bcl-xl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bcl-xl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [http://www.ebi.ac.uk/pdbsum/3cva PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [http://pdbe.org/3cva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [http://www.ebi.ac.uk/pdbsum/3cva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cva ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~BCLX_HUMAN BCLX_HUMAN~~]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>	+	[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cva ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cva" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, K]]		[[Category: Chen, K]]
	[[Category: Feng, Y]]		[[Category: Feng, Y]]

OCA at 22:00, 25 December 2014

OCA — Thu, 25 Dec 2014 22:00:21 GMT

←Older revision		Revision as of 22:00, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [http://www.ebi.ac.uk/pdbsum/3cva PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [http://www.ebi.ac.uk/pdbsum/3cva PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BCLX_HUMAN BCLX_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, K.]]	+	[[Category: Chen, K]]
-	[[Category: Feng, Y.]]	+	[[Category: Feng, Y]]
-	[[Category: Hu, T.]]	+	[[Category: Hu, T]]
-	[[Category: Jiang, H.]]	+	[[Category: Jiang, H]]
-	[[Category: Liu, D.]]	+	[[Category: Liu, D]]
-	[[Category: Shen, X.]]	+	[[Category: Shen, X]]
-	[[Category: Zhang, L.]]	+	[[Category: Zhang, L]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 05:59, 10 October 2014

OCA — Fri, 10 Oct 2014 05:59:17 GMT

←Older revision		Revision as of 05:59, 10 October 2014
Line 1:		Line 1:
-	[[~~Image~~:3cva.~~png\|left~~\|200px]]	+	==Human Bcl-xL containing a Trp to Ala mutation at position 137==
		+	<StructureSection load='3cva' size='340' side='right' caption='[[3cva]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVA FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bcl-xl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cva RCSB], [http://www.ebi.ac.uk/pdbsum/3cva PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cva_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bcl-2 family proteins regulate apoptosis through their homo- and heterodimerization. By protein sequence analysis and structural comparison, we have identified a conserved hydrophobic core at the BH1 and BH2 domains of Bcl-2 family proteins. The hydrophobic core is stabilized by hydrophobic interactions among the residues of Trp137, Ile140, Trp181, Ile182, Trp188 and Phe191 in Bcl-x(L). Destabilization of the hydrophobic core can promote the protein unfolding and pore formation in synthetic lipid vesicles. Interestingly, though the hydrophobic core does not participate in binding with BH3 domain of pro-apoptotic proteins, disruption of the hydrophobic core can reduce the affinity of Bcl-x(L) with BH3-domain peptide by changing the conformation of Bcl-x(L) C-terminal residues that are involved in the peptide interaction. The BH3-domain peptide binding affinity and pore forming propensity of Bcl-x(L) were correlated to its death-repressor activity, which provides new information to help study the regulatory mechanism of anti-apoptotic proteins. Meanwhile, as the tryptophans are conserved in the hydrophobic core, in vitro binding assay based on FRET of "Trp-->AEDANS" can be devised to screen for new modulators targeting anti-apoptotic proteins as well as "multi-BH domains" pro-apoptotic proteins.

-	~~{{STRUCTURE_3cva\| PDB=3cva \| SCENE= }}~~	+	A conserved hydrophobic core at Bcl-xL mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein.,Feng Y, Zhang L, Hu T, Shen X, Ding J, Chen K, Jiang H, Liu D Arch Biochem Biophys. 2009 Apr 1;484(1):46-54. Epub 2009 Jan 10. PMID:19161970<ref>PMID:19161970</ref>

-	~~===Human Bcl-xL containing~~ a ~~Trp to Ala mutation at position 137===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19161970}}~~	+	==See Also==
-		+	*[[Bcl-2\|Bcl-2]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3cva~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019161970<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, K.]]		[[Category: Chen, K.]]

OCA: Protected "3cva" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:03:39 GMT

Protected "3cva" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:03, 7 January 2013

OCA at 22:03, 7 January 2013

OCA — Mon, 07 Jan 2013 22:03:37 GMT

←Older revision		Revision as of 22:03, 7 January 2013
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-	{{Seed}}
	[[Image:3cva.png\|left\|200px]]		[[Image:3cva.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cva", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cva\| PDB=3cva \| SCENE= }}		{{STRUCTURE_3cva\| PDB=3cva \| SCENE= }}

	===Human Bcl-xL containing a Trp to Ala mutation at position 137===		===Human Bcl-xL containing a Trp to Ala mutation at position 137===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19161970}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19161970 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19161970}}		{{ABSTRACT_PUBMED_19161970}}

	==About this Structure==		==About this Structure==
-	~~3CVA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA].	+	[[3cva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19161970~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019161970</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, K.]]		[[Category: Chen, K.]]
Line 32:		Line 20:
	[[Category: Shen, X.]]		[[Category: Shen, X.]]
	[[Category: Zhang, L.]]		[[Category: Zhang, L.]]
-	[[Category: Alternative splicing]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Membrane]]		[[Category: Membrane]]
Line 38:		Line 25:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:21:49 2009''

OCA at 13:21, 2 April 2009

OCA — Thu, 02 Apr 2009 13:21:50 GMT

←Older revision		Revision as of 13:21, 2 April 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3cva.~~jpg~~\|left\|200px]]	+	[[Image:3cva.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Mar 25 12~~:24:04 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:21:49 2009''

OCA at 10:24, 25 March 2009

OCA — Wed, 25 Mar 2009 10:24:06 GMT

←Older revision		Revision as of 10:24, 25 March 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3cva.jpg\|left\|200px]]

-	The ~~entry 3cva~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3cva", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3cva\| PDB=3cva \| SCENE= }}

-	~~Authors: Feng, Y., Zhang, L., Hu, T., Shen, X., Chen, K., Jiang, H., Liu, D~~	+	===Human Bcl-xL containing a Trp to Ala mutation at position 137===

-	Description: Human Bcl-xL containing a Trp to Ala mutation at position 137

		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19161970}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19161970 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19161970}}

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 09~~:34:~~30 2008~~''	+	==About this Structure==
		+	3CVA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19161970</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, K.]]
		+	[[Category: Feng, Y.]]
		+	[[Category: Hu, T.]]
		+	[[Category: Jiang, H.]]
		+	[[Category: Liu, D.]]
		+	[[Category: Shen, X.]]
		+	[[Category: Zhang, L.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Apoptosis]]
		+	[[Category: Membrane]]
		+	[[Category: Mitochondrion]]
		+	[[Category: Nucleus]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:24:04 2009''