3cvf - Revision history

OCA at 14:56, 20 September 2023

OCA — Wed, 20 Sep 2023 14:56:20 GMT

←Older revision		Revision as of 14:56, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [https://pdbe.org/3cvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [https://www.ebi.ac.uk/pdbsum/3cvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [https://pdbe.org/3cvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [https://www.ebi.ac.uk/pdbsum/3cvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:59, 21 December 2022

OCA — Wed, 21 Dec 2022 09:59:42 GMT

←Older revision		Revision as of 09:59, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='3cvf' size='340' side='right'caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3cvf' size='340' side='right'caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVF FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cve\|3cve]]</div></td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [https://pdbe.org/3cvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [https://www.ebi.ac.uk/pdbsum/3cvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [https://pdbe.org/3cvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [https://www.ebi.ac.uk/pdbsum/3cvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.	+	[https://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Giannini, V]]	+	[[Category: Giannini V]]
-	[[Category: Hayashi~~, M K~~]]	+	[[Category: Hayashi MK]]
-	[[Category: Hayashi, Y]]	+	[[Category: Hayashi Y]]
-	[[Category: Sala, C]]	+	[[Category: Sala C]]
-	[[Category: Stearns~~, M H~~]]	+	[[Category: Stearns MH]]
-	[[Category: Xu, R M]]	+	[[Category: Xu R-M]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Postsynaptic cell membrane]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Synapse~~]]	+

OCA at 07:46, 2 February 2022

OCA — Wed, 02 Feb 2022 07:46:09 GMT

←Older revision		Revision as of 07:46, 2 February 2022
Line 1:		Line 1:

	==Crystal Structure of the carboxy terminus of Homer3==		==Crystal Structure of the carboxy terminus of Homer3==
-	<StructureSection load='3cvf' size='340' side='right' caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3cvf' size='340' side='right'caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CVF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVF FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cve\|3cve]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cve\|3cve]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [~~http~~://pdbe.org/3cvf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cvf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [https://pdbe.org/3cvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [https://www.ebi.ac.uk/pdbsum/3cvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.	+	[[https://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Giannini, V]]		[[Category: Giannini, V]]
	[[Category: Hayashi, M K]]		[[Category: Hayashi, M K]]

OCA at 08:35, 25 October 2017

OCA — Wed, 25 Oct 2017 08:35:47 GMT

←Older revision		Revision as of 08:35, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the carboxy terminus of Homer3==		==Crystal Structure of the carboxy terminus of Homer3==
	<StructureSection load='3cvf' size='340' side='right' caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3cvf' size='340' side='right' caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cve\|3cve]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cve\|3cve]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [http://pdbe.org/3cvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [http://www.ebi.ac.uk/pdbsum/3cvf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [http://pdbe.org/3cvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [http://www.ebi.ac.uk/pdbsum/3cvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 40:		Line 41:
	[[Category: Stearns, M H]]		[[Category: Stearns, M H]]
	[[Category: Xu, R M]]		[[Category: Xu, R M]]
		+	[[Category: Alternative splicing]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Postsynaptic cell membrane]]		[[Category: Postsynaptic cell membrane]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Synapse]]		[[Category: Synapse]]

OCA at 21:26, 8 February 2016

OCA — Mon, 08 Feb 2016 21:26:37 GMT

←Older revision		Revision as of 21:26, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3cvf' size='340' side='right' caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3cvf' size='340' side='right' caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVF FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cve\|3cve]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cve\|3cve]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [http://www.ebi.ac.uk/pdbsum/3cvf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [http://pdbe.org/3cvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [http://www.ebi.ac.uk/pdbsum/3cvf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cvf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cvf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Giannini, V]]		[[Category: Giannini, V]]
	[[Category: Hayashi, M K]]		[[Category: Hayashi, M K]]

OCA at 02:16, 25 December 2014

OCA — Thu, 25 Dec 2014 02:16:09 GMT

←Older revision		Revision as of 02:16, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [http://www.ebi.ac.uk/pdbsum/3cvf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [http://www.ebi.ac.uk/pdbsum/3cvf PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Giannini, V.]]	+	[[Category: Giannini, V]]
-	[[Category: Hayashi, M K.]]	+	[[Category: Hayashi, M K]]
-	[[Category: Hayashi, Y.]]	+	[[Category: Hayashi, Y]]
-	[[Category: Sala, C.]]	+	[[Category: Sala, C]]
-	[[Category: Stearns, M H.]]	+	[[Category: Stearns, M H]]
-	[[Category: Xu, R M.]]	+	[[Category: Xu, R M]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 06:27, 10 October 2014

OCA — Fri, 10 Oct 2014 06:27:37 GMT

←Older revision		Revision as of 06:27, 10 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3cvf.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the carboxy terminus of Homer3==
		+	<StructureSection load='3cvf' size='340' side='right' caption='[[3cvf]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVF FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cve\|3cve]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvf RCSB], [http://www.ebi.ac.uk/pdbsum/3cvf PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The postsynaptic density (PSD) is crucial for synaptic functions, but the molecular architecture retaining its structure and components remains elusive. Homer and Shank are among the most abundant scaffolding proteins in the PSD, working synergistically for maturation of dendritic spines. Here, we demonstrate that Homer and Shank, together, form a mesh-like matrix structure. Crystallographic analysis of this region revealed a pair of parallel dimeric coiled coils intercalated in a tail-to-tail fashion to form a tetramer, giving rise to the unique configuration of a pair of N-terminal EVH1 domains at each end of the coiled coil. In neurons, the tetramerization is required for structural integrity of the dendritic spines and recruitment of proteins to synapses. We propose that the Homer-Shank complex serves as a structural framework and as an assembly platform for other PSD proteins.

-	~~{{STRUCTURE_3cvf\| PDB=3cvf \| SCENE= }}~~	+	The postsynaptic density proteins Homer and Shank form a polymeric network structure.,Hayashi MK, Tang C, Verpelli C, Narayanan R, Stearns MH, Xu RM, Li H, Sala C, Hayashi Y Cell. 2009 Apr 3;137(1):159-71. PMID:19345194<ref>PMID:19345194</ref>

-	~~===Crystal Structure~~ of the ~~carboxy terminus of Homer3===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19345194}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cvf]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019345194<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Giannini, V.]]		[[Category: Giannini, V.]]

OCA: Protected "3cvf" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:47:42 GMT

Protected "3cvf" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:47, 7 January 2013

OCA at 22:47, 7 January 2013

OCA — Mon, 07 Jan 2013 22:47:41 GMT

←Older revision		Revision as of 22:47, 7 January 2013
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-	{{Seed}}
	[[Image:3cvf.png\|left\|200px]]		[[Image:3cvf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cvf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cvf\| PDB=3cvf \| SCENE= }}		{{STRUCTURE_3cvf\| PDB=3cvf \| SCENE= }}

	===Crystal Structure of the carboxy terminus of Homer3===		===Crystal Structure of the carboxy terminus of Homer3===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19345194}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19345194 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19345194}}		{{ABSTRACT_PUBMED_19345194}}

	==About this Structure==		==About this Structure==
-	~~3CVF~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA].	+	[[3cvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19345194~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019345194</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Giannini, V.]]		[[Category: Giannini, V.]]
Line 31:		Line 19:
	[[Category: Stearns, M H.]]		[[Category: Stearns, M H.]]
	[[Category: Xu, R M.]]		[[Category: Xu, R M.]]
-	[[Category: Alternative splicing]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Postsynaptic cell membrane]]		[[Category: Postsynaptic cell membrane]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Synapse]]		[[Category: Synapse]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 29 20:58:47 2009''

OCA at 17:58, 29 April 2009

OCA — Wed, 29 Apr 2009 17:58:48 GMT

←Older revision		Revision as of 17:58, 29 April 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3cvf.png\|left\|200px]]

-	The ~~entry 3cvf~~ is ~~ON HOLD~~ ~~until Mar 31 2010~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3cvf", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3cvf\| PDB=3cvf \| SCENE= }}

-	~~Authors: Hayashi, M.K., Stearns, M.H., Giannini, V., Xu, R.-M., Sala, C., Hayashi, Y.~~	+	===Crystal Structure of the carboxy terminus of Homer3===

-	Description: Crystal Structure of the carboxy terminus of Homer3

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Apr ~~9 12~~:15:31 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19345194}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19345194 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19345194}}
		+
		+	==About this Structure==
		+	3CVF is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19345194</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Giannini, V.]]
		+	[[Category: Hayashi, M K.]]
		+	[[Category: Hayashi, Y.]]
		+	[[Category: Sala, C.]]
		+	[[Category: Stearns, M H.]]
		+	[[Category: Xu, R M.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cell junction]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Membrane]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Postsynaptic cell membrane]]
		+	[[Category: Signaling protein]]
		+	[[Category: Synapse]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 29 20:58:47 2009''