3cvl - Revision history

OCA at 12:33, 30 August 2023

OCA — Wed, 30 Aug 2023 12:33:40 GMT

←Older revision		Revision as of 12:33, 30 August 2023
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	<StructureSection load='3cvl' size='340' side='right'caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3cvl' size='340' side='right'caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei] and [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVL FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PEX5 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [https://pdbe.org/3cvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [https://www.ebi.ac.uk/pdbsum/3cvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [https://pdbe.org/3cvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [https://www.ebi.ac.uk/pdbsum/3cvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186~~]	+	[https://www.uniprot.org/uniprot/Q9U7C3_9TRYP Q9U7C3_9TRYP]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hol, W G.J~~]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: ~~Michels, P A.M~~]]	+	[[Category: Trypanosoma brucei brucei]]
-	[[Category: ~~Roach, C~~]]	+	[[Category: Hol WGJ]]
-	[[Category: ~~Sampathkumar, P~~]]	+	[[Category: Michels PAM]]
-	[[Category: ~~Peroxin 5~~]]	+	[[Category: Roach C]]
-	[[Category: ~~Pex5]]~~	+	[[Category: Sampathkumar P]]
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Pts1 binding domain]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Tpr motif]]~~	+
-	~~[[Category: Tpr protein]]~~	+
-	~~[[Category: Tpr repeat]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 19:14, 20 October 2021

OCA — Wed, 20 Oct 2021 19:14:58 GMT

←Older revision		Revision as of 19:14, 20 October 2021
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	==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide==		==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide==
-	<StructureSection load='3cvl' size='340' side='right' caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='3cvl' size='340' side='right'caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVL FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [~~http~~://pdbe.org/3cvl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cvl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [https://pdbe.org/3cvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [https://www.ebi.ac.uk/pdbsum/3cvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]	+	[[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Michels, P A.M]]		[[Category: Michels, P A.M]]

OCA at 19:13, 24 January 2018

OCA — Wed, 24 Jan 2018 19:13:04 GMT

←Older revision		Revision as of 19:13, 24 January 2018
Line 1:		Line 1:
		+
	==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide==		==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide==
	<StructureSection load='3cvl' size='340' side='right' caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3cvl' size='340' side='right' caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [http://pdbe.org/3cvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [http://www.ebi.ac.uk/pdbsum/3cvl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [http://pdbe.org/3cvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [http://www.ebi.ac.uk/pdbsum/3cvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:48, 7 February 2016

OCA — Sun, 07 Feb 2016 19:48:18 GMT

←Older revision		Revision as of 19:48, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3cvl' size='340' side='right' caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3cvl' size='340' side='right' caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [http://www.ebi.ac.uk/pdbsum/3cvl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [http://pdbe.org/3cvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [http://www.ebi.ac.uk/pdbsum/3cvl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 15:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cvl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cvl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Trypanosoma brucei]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Michels, P A.M]]		[[Category: Michels, P A.M]]

OCA at 08:41, 20 January 2015

OCA — Tue, 20 Jan 2015 08:41:21 GMT

←Older revision		Revision as of 08:41, 20 January 2015
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
-	[[Category: Hol, W G.J.]]	+	[[Category: Hol, W G.J]]
	[[Category: Michels, P A.M]]		[[Category: Michels, P A.M]]
-	[[Category: Roach, C.]]	+	[[Category: Roach, C]]
-	[[Category: Sampathkumar, P.]]	+	[[Category: Sampathkumar, P]]
	[[Category: Peroxin 5]]		[[Category: Peroxin 5]]
	[[Category: Pex5]]		[[Category: Pex5]]

OCA at 06:16, 10 October 2014

OCA — Fri, 10 Oct 2014 06:16:33 GMT

←Older revision		Revision as of 06:16, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [http://www.ebi.ac.uk/pdbsum/3cvl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [http://www.ebi.ac.uk/pdbsum/3cvl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:
	Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.,Sampathkumar P, Roach C, Michels PA, Hol WG J Mol Biol. 2008 Sep 12;381(4):867-80. Epub 2008 Jun 21. PMID:18598704<ref>PMID:18598704</ref>		Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.,Sampathkumar P, Roach C, Michels PA, Hol WG J Mol Biol. 2008 Sep 12;381(4):867-80. Epub 2008 Jun 21. PMID:18598704<ref>PMID:18598704</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:50, 21 May 2014

OCA — Wed, 21 May 2014 09:50:47 GMT

←Older revision		Revision as of 09:50, 21 May 2014
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-	[[~~Image:~~3cvl.~~png~~\|~~left~~\|200px]]	+	==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide==
		+	<StructureSection load='3cvl' size='340' side='right' caption='[[3cvl]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvn\|3cvn]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvl RCSB], [http://www.ebi.ac.uk/pdbsum/3cvl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycosomes are peroxisome-like organelles essential for trypanosomatid parasites. Glycosome biogenesis is mediated by proteins called "peroxins," which are considered to be promising drug targets in pathogenic Trypanosomatidae. The first step during protein translocation across the glycosomal membrane of peroxisomal targeting signal 1 (PTS1)-harboring proteins is signal recognition by the cytosolic receptor peroxin 5 (PEX5). The C-terminal PTS1 motifs interact with the PTS1 binding domain (P1BD) of PEX5, which is made up of seven tetratricopeptide repeats. Obtaining diffraction-quality crystals of the P1BD of Trypanosoma brucei PEX5 (TbPEX5) required surface entropy reduction mutagenesis. Each of the seven tetratricopeptide repeats appears to have a residue in the alpha(L) conformation in the loop connecting helices A and B. Five crystal structures of the P1BD of TbPEX5 were determined, each in complex with a hepta- or decapeptide corresponding to a natural or nonnatural PTS1 sequence. The PTS1 peptides are bound between the two subdomains of the P1BD. These structures indicate precise recognition of the C-terminal Leu of the PTS1 motif and important interactions between the PTS1 peptide main chain and up to five invariant Asn side chains of PEX5. The TbPEX5 structures reported here reveal a unique hydrophobic pocket in the subdomain interface that might be explored to obtain compounds that prevent relative motions of the subdomains and interfere selectively with PTS1 motif binding or release in trypanosomatids, and would therefore disrupt glycosome biogenesis and prevent parasite growth.

-	~~<!--~~	+	Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.,Sampathkumar P, Roach C, Michels PA, Hol WG J Mol Biol. 2008 Sep 12;381(4):867-80. Epub 2008 Jun 21. PMID:18598704<ref>PMID:18598704</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3cvl"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3cvl\| PDB=3cvl \| SCENE= }}~~	+

-	~~===Structure~~ of ~~Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_18598704}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 18598704 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_18598704}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3cvl]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVL OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018598704<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J.]]

OCA: Protected "3cvl" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:49:47 GMT

Protected "3cvl" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:49, 2 June 2012