3cvn - Revision history

OCA at 12:33, 30 August 2023

OCA — Wed, 30 Aug 2023 12:33:46 GMT

←Older revision		Revision as of 12:33, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3cvn' size='340' side='right'caption='[[3cvn]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3cvn' size='340' side='right'caption='[[3cvn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei] and [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [https://pdbe.org/3cvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [https://www.ebi.ac.uk/pdbsum/3cvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [https://pdbe.org/3cvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [https://www.ebi.ac.uk/pdbsum/3cvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9U7C3_9TRYP Q9U7C3_9TRYP]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 35:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
-	[[Category: ~~Hol, W G.J~~]]	+	[[Category: Trypanosoma brucei brucei]]
-	[[Category: ~~Michels, P A.M~~]]	+	[[Category: Hol WGJ]]
-	[[Category: ~~Roach, C~~]]	+	[[Category: Michels PAM]]
-	[[Category: ~~Sampathkumar, P~~]]	+	[[Category: Roach C]]
-	[[Category: ~~Peroxin 5]]~~	+	[[Category: Sampathkumar P]]
-	~~[[Category: Pex5]]~~	+
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Pts1 binding domain]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Tpr motif]]~~	+
-	~~[[Category: Tpr protein]]~~	+
-	~~[[Category: Tpr repeat]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 19:15, 20 October 2021

OCA — Wed, 20 Oct 2021 19:15:07 GMT

←Older revision		Revision as of 19:15, 20 October 2021
Line 1:		Line 1:

	==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) PTS1 peptide==		==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) PTS1 peptide==
-	<StructureSection load='3cvn' size='340' side='right' caption='[[3cvn]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3cvn' size='340' side='right'caption='[[3cvn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cvn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [~~http~~://pdbe.org/3cvn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cvn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [https://pdbe.org/3cvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [https://www.ebi.ac.uk/pdbsum/3cvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvn ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]

OCA at 19:13, 24 January 2018

OCA — Wed, 24 Jan 2018 19:13:04 GMT

←Older revision		Revision as of 19:13, 24 January 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:24, 11 August 2016

OCA — Thu, 11 Aug 2016 16:24:06 GMT

←Older revision		Revision as of 16:24, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) PTS1 peptide==		==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) PTS1 peptide==
	<StructureSection load='3cvn' size='340' side='right' caption='[[3cvn]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3cvn' size='340' side='right' caption='[[3cvn]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [http://www.ebi.ac.uk/pdbsum/3cvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [http://pdbe.org/3cvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [http://www.ebi.ac.uk/pdbsum/3cvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvn ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cvn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cvn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:34, 20 January 2015

OCA — Tue, 20 Jan 2015 10:34:14 GMT

←Older revision		Revision as of 10:34, 20 January 2015
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
-	[[Category: Hol, W G.J.]]	+	[[Category: Hol, W G.J]]
	[[Category: Michels, P A.M]]		[[Category: Michels, P A.M]]
-	[[Category: Roach, C.]]	+	[[Category: Roach, C]]
-	[[Category: Sampathkumar, P.]]	+	[[Category: Sampathkumar, P]]
	[[Category: Peroxin 5]]		[[Category: Peroxin 5]]
	[[Category: Pex5]]		[[Category: Pex5]]

OCA at 06:03, 10 October 2014

OCA — Fri, 10 Oct 2014 06:03:28 GMT

←Older revision		Revision as of 06:03, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cvn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cvn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [http://www.ebi.ac.uk/pdbsum/3cvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [http://www.ebi.ac.uk/pdbsum/3cvn PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.,Sampathkumar P, Roach C, Michels PA, Hol WG J Mol Biol. 2008 Sep 12;381(4):867-80. Epub 2008 Jun 21. PMID:18598704<ref>PMID:18598704</ref>		Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.,Sampathkumar P, Roach C, Michels PA, Hol WG J Mol Biol. 2008 Sep 12;381(4):867-80. Epub 2008 Jun 21. PMID:18598704<ref>PMID:18598704</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:41, 21 May 2014

OCA — Wed, 21 May 2014 09:41:05 GMT

←Older revision		Revision as of 09:41, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3cvn.~~png~~\|~~left~~\|200px]]	+	==Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) PTS1 peptide==
		+	<StructureSection load='3cvn' size='340' side='right' caption='[[3cvn]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cvn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CVN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cv0\|3cv0]], [[3cvl\|3cvl]], [[3cvp\|3cvp]], [[3cvq\|3cvq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cvn RCSB], [http://www.ebi.ac.uk/pdbsum/3cvn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycosomes are peroxisome-like organelles essential for trypanosomatid parasites. Glycosome biogenesis is mediated by proteins called "peroxins," which are considered to be promising drug targets in pathogenic Trypanosomatidae. The first step during protein translocation across the glycosomal membrane of peroxisomal targeting signal 1 (PTS1)-harboring proteins is signal recognition by the cytosolic receptor peroxin 5 (PEX5). The C-terminal PTS1 motifs interact with the PTS1 binding domain (P1BD) of PEX5, which is made up of seven tetratricopeptide repeats. Obtaining diffraction-quality crystals of the P1BD of Trypanosoma brucei PEX5 (TbPEX5) required surface entropy reduction mutagenesis. Each of the seven tetratricopeptide repeats appears to have a residue in the alpha(L) conformation in the loop connecting helices A and B. Five crystal structures of the P1BD of TbPEX5 were determined, each in complex with a hepta- or decapeptide corresponding to a natural or nonnatural PTS1 sequence. The PTS1 peptides are bound between the two subdomains of the P1BD. These structures indicate precise recognition of the C-terminal Leu of the PTS1 motif and important interactions between the PTS1 peptide main chain and up to five invariant Asn side chains of PEX5. The TbPEX5 structures reported here reveal a unique hydrophobic pocket in the subdomain interface that might be explored to obtain compounds that prevent relative motions of the subdomains and interfere selectively with PTS1 motif binding or release in trypanosomatids, and would therefore disrupt glycosome biogenesis and prevent parasite growth.

-	~~<!--~~	+	Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.,Sampathkumar P, Roach C, Michels PA, Hol WG J Mol Biol. 2008 Sep 12;381(4):867-80. Epub 2008 Jun 21. PMID:18598704<ref>PMID:18598704</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3cvn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3cvn\| PDB=3cvn \| SCENE= }}~~	+

-	~~===Structure~~ of ~~Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) PTS1 peptide===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_18598704}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 18598704 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_18598704}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3cvn]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018598704<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J.]]

OCA: Protected "3cvn" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:04:28 GMT

Protected "3cvn" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:04, 2 June 2012