3cwg - Revision history

OCA at 12:34, 30 August 2023

OCA — Wed, 30 Aug 2023 12:34:00 GMT

←Older revision		Revision as of 12:34, 30 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWG FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Stat3~~, ~~Aprf (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 Mus musculus])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [https://pdbe.org/3cwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [https://www.ebi.ac.uk/pdbsum/3cwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [https://pdbe.org/3cwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [https://www.ebi.ac.uk/pdbsum/3cwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>	+	[https://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Krishnaraj, R]]	+	[[Category: Krishnaraj R]]
-	[[Category: Mandal~~, P K~~]]	+	[[Category: Mandal PK]]
-	[[Category: Mao, X]]	+	[[Category: Mao X]]
-	[[Category: McMurray~~, J S~~]]	+	[[Category: McMurray JS]]
-	[[Category: Mertens, C]]	+	[[Category: Mertens C]]
-	[[Category: Qin, J]]	+	[[Category: Qin J]]
-	[[Category: Ren, Z]]	+	[[Category: Ren Z]]
-	[[Category: Romanowshi~~, M J]]~~	+	[[Category: Romanowshi MJ]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Acute phase]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Stat3]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 07:47, 2 February 2022

OCA — Wed, 02 Feb 2022 07:47:01 GMT

←Older revision		Revision as of 07:47, 2 February 2022
Line 1:		Line 1:

	==Unphosphorylated mouse STAT3 core fragment==		==Unphosphorylated mouse STAT3 core fragment==
-	<StructureSection load='3cwg' size='340' side='right' caption='[[3cwg]], [[Resolution\|resolution]] 3.05Å' scene=''>	+	<StructureSection load='3cwg' size='340' side='right'caption='[[3cwg]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CWG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWG FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stat3, Aprf ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stat3, Aprf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [~~http~~://pdbe.org/3cwg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cwg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [https://pdbe.org/3cwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [https://www.ebi.ac.uk/pdbsum/3cwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>	+	[[https://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Krishnaraj, R]]		[[Category: Krishnaraj, R]]

OCA at 13:44, 7 November 2018

OCA — Wed, 07 Nov 2018 13:44:30 GMT

←Older revision		Revision as of 13:44, 7 November 2018
Line 1:		Line 1:
		+
	==Unphosphorylated mouse STAT3 core fragment==		==Unphosphorylated mouse STAT3 core fragment==
	<StructureSection load='3cwg' size='340' side='right' caption='[[3cwg]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='3cwg' size='340' side='right' caption='[[3cwg]], [[Resolution\|resolution]] 3.05Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWG FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stat3, Aprf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stat3, Aprf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [http://pdbe.org/3cwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [http://www.ebi.ac.uk/pdbsum/3cwg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [http://pdbe.org/3cwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [http://www.ebi.ac.uk/pdbsum/3cwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cwg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cwg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 42:		Line 43:
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Acute phase]]		[[Category: Acute phase]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Nucleus]]		[[Category: Nucleus]]

OCA at 08:23, 10 February 2016

OCA — Wed, 10 Feb 2016 08:23:02 GMT

←Older revision		Revision as of 08:23, 10 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWG FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stat3, Aprf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stat3, Aprf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [http://www.ebi.ac.uk/pdbsum/3cwg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [http://pdbe.org/3cwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [http://www.ebi.ac.uk/pdbsum/3cwg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cwg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cwg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:58, 25 December 2014

OCA — Thu, 25 Dec 2014 12:58:33 GMT

←Older revision		Revision as of 12:58, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [http://www.ebi.ac.uk/pdbsum/3cwg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [http://www.ebi.ac.uk/pdbsum/3cwg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Krishnaraj, R.]]	+	[[Category: Krishnaraj, R]]
-	[[Category: Mandal, P K.]]	+	[[Category: Mandal, P K]]
-	[[Category: Mao, X.]]	+	[[Category: Mao, X]]
-	[[Category: McMurray, J S.]]	+	[[Category: McMurray, J S]]
-	[[Category: Mertens, C.]]	+	[[Category: Mertens, C]]
-	[[Category: Qin, J.]]	+	[[Category: Qin, J]]
-	[[Category: Ren, Z.]]	+	[[Category: Ren, Z]]
-	[[Category: Romanowshi, M J.]]	+	[[Category: Romanowshi, M J]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Acute phase]]		[[Category: Acute phase]]

OCA at 09:21, 5 November 2014

OCA — Wed, 05 Nov 2014 09:21:22 GMT

←Older revision		Revision as of 09:21, 5 November 2014
Line 1:		Line 1:
-	[[~~Image~~:3cwg.~~png\|left~~\|200px]]	+	==Unphosphorylated mouse STAT3 core fragment==
		+	<StructureSection load='3cwg' size='340' side='right' caption='[[3cwg]], [[Resolution\|resolution]] 3.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWG FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stat3, Aprf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwg RCSB], [http://www.ebi.ac.uk/pdbsum/3cwg PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cwg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcriptional factors that play an important role in cytokine and growth factor signaling. Here we report a 3.05 A-resolution crystal structure of an unphosphorylated STAT3 core fragment. The overall monomeric structure is very similar to that of the phosphorylated STAT3 core fragment. However, the dimer interface observed in the unphosphorylated STAT1 core fragment structure is absent in the STAT3 structure. Solution studies further demonstrate that the core fragment of STAT3 is primarily monomeric. Mutations corresponding to those in STAT1, which lead to disruption of the core fragment interface and prolonged tyrosine phosphorylation, show little or no effect on the tyrosine phosphorylation kinetics of STAT3. These results highlight the structural and biochemical differences between STAT3 and STAT1, and suggest different regulation mechanisms of these two proteins.

-	~~{{STRUCTURE_3cwg\| PDB=3cwg \| SCENE= }}~~	+	Crystal structure of unphosphorylated STAT3 core fragment.,Ren Z, Mao X, Mertens C, Krishnaraj R, Qin J, Mandal PK, Romanowski MJ, McMurray JS, Chen X Biochem Biophys Res Commun. 2008 Sep 12;374(1):1-5. Epub 2008 Apr 21. PMID:18433722<ref>PMID:18433722</ref>

-	~~===Unphosphorylated mouse STAT3 core fragment===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18433722}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cwg]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018433722<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Krishnaraj, R.]]		[[Category: Krishnaraj, R.]]

OCA: Protected "3cwg" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:16:01 GMT

Protected "3cwg" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:16, 7 January 2013

OCA at 20:15, 7 January 2013

OCA — Mon, 07 Jan 2013 20:15:58 GMT

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	[[Image:3cwg.png\|left\|200px]]		[[Image:3cwg.png\|left\|200px]]

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	{{STRUCTURE_3cwg\| PDB=3cwg \| SCENE= }}		{{STRUCTURE_3cwg\| PDB=3cwg \| SCENE= }}

	===Unphosphorylated mouse STAT3 core fragment===		===Unphosphorylated mouse STAT3 core fragment===

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	{{ABSTRACT_PUBMED_18433722}}		{{ABSTRACT_PUBMED_18433722}}

	==About this Structure==		==About this Structure==
-	~~3CWG~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA].	+	[[3cwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18433722~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018433722</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Krishnaraj, R.]]		[[Category: Krishnaraj, R.]]
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	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Acute phase]]		[[Category: Acute phase]]
-	[[Category: Alternative splicing]]
-	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
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OCA at 14:48, 17 February 2009

OCA — Tue, 17 Feb 2009 14:48:19 GMT

←Older revision		Revision as of 14:48, 17 February 2009
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	==About this Structure==		==About this Structure==
-	3CWG is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA].	+	3CWG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWG OCA].

	==Reference==		==Reference==
-	~~Crystal structure of unphosphorylated STAT3 core fragment., Ren Z, Mao X, Mertens C, Krishnaraj R, Qin J, Mandal PK, Romanowski MJ, McMurray JS, Chen X, Biochem Biophys Res Commun. 2008 Apr 18;.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18433722 18433722]~~	+	<ref group="xtra">PMID:18433722</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Krishnaraj, R.]]		[[Category: Krishnaraj, R.]]
	[[Category: Mandal, P K.]]		[[Category: Mandal, P K.]]
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OCA at 20:34, 28 July 2008

OCA — Mon, 28 Jul 2008 20:34:06 GMT

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