3cwz - Revision history

OCA at 09:39, 21 February 2024

OCA — Wed, 21 Feb 2024 09:39:17 GMT

←Older revision		Revision as of 09:39, 21 February 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.		[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Small GTPase Rab6 regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors. The crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 was solved at 3.2 angstroms resolution. This Rab6IP1 region encompasses an all alpha-helical RUN domain followed in tandem by a PLAT domain that adopts a beta sandwich fold. The structure reveals that the first and last alpha helices of the RUN domain mediate binding to switch I, switch II, and the interswitch region of Rab6. It represents the largest Rab-effector complex determined to date. Comparisons with the recent structure of Rab6 in complex with an unrelated effector, human golgin GCC185, reveals significant conformational changes in the conserved hydrophobic triad of Rab6. Flexibility in the switch and interswitch regions of Rab6 mediates recognition of compositionally distinct alpha-helical coiled coils, thereby contributing to Rab6 promiscuity in effector recruitment.
-
-	Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain.,Recacha R, Boulet A, Jollivet F, Monier S, Houdusse A, Goud B, Khan AR Structure. 2009 Jan 14;17(1):21-30. PMID:19141279<ref>PMID:19141279</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3cwz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ras-related protein Rab 3D structures\|Ras-related protein Rab 3D structures]]		*[[Ras-related protein Rab 3D structures\|Ras-related protein Rab 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:12, 26 July 2023

OCA — Wed, 26 Jul 2023 13:12:26 GMT

←Older revision		Revision as of 13:12, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='3cwz' size='340' side='right'caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3cwz' size='340' side='right'caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GTP:GUANOSINE~~-~~5-TRIPHOSPHATE'>GTP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">RAB6A, RAB6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Rab6ip1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [https://pdbe.org/3cwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [https://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [https://pdbe.org/3cwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [https://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. [[https://www.uniprot.org/uniprot/DEN5A_MOUSE DEN5A_MOUSE]] Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).	+	[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Goud, B]]	+	[[Category: Goud B]]
-	[[Category: Houdusse, A]]	+	[[Category: Houdusse A]]
-	[[Category: Khan~~, A R~~]]	+	[[Category: Khan AR]]
-	[[Category: Recacha, R]]	+	[[Category: Recacha R]]
-	~~[[Category: Er-golgi transport]]~~	+
-	~~[[Category: Golgi]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Guanosine 5' triphosphate]]~~	+
-	~~[[Category: Lipase]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Lipoxygenase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Methylation]]~~	+
-	~~[[Category: Nesca plat]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Prenylation]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Rab small gtpase]]~~	+
-	~~[[Category: Rab-binding domain]]~~	+
-	~~[[Category: Rab6 interacting protein 1]]~~	+
-	~~[[Category: Rpip8]]~~	+
-	~~[[Category: Run]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Unc-14~~]]	+

OCA at 19:15, 20 October 2021

OCA — Wed, 20 Oct 2021 19:15:41 GMT

←Older revision		Revision as of 19:15, 20 October 2021
Line 1:		Line 1:

	==Structure of RAB6(GTP)-R6IP1 complex==		==Structure of RAB6(GTP)-R6IP1 complex==
-	<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='3cwz' size='340' side='right'caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Rab6ip1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Rab6ip1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [~~http~~://pdbe.org/3cwz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [https://pdbe.org/3cwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [https://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. [[~~http~~://www.uniprot.org/uniprot/DEN5A_MOUSE DEN5A_MOUSE]] Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).	+	[[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. [[https://www.uniprot.org/uniprot/DEN5A_MOUSE DEN5A_MOUSE]] Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3cwz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3cwz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ras-related protein Rab 3D structures\|Ras-related protein Rab 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Goud, B]]		[[Category: Goud, B]]

OCA at 13:18, 7 November 2018

OCA — Wed, 07 Nov 2018 13:18:29 GMT

←Older revision		Revision as of 13:18, 7 November 2018
Line 3:		Line 3:
	<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Rab6ip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://pdbe.org/3cwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://pdbe.org/3cwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Goud, B]]		[[Category: Goud, B]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA at 11:16, 15 December 2016

OCA — Thu, 15 Dec 2016 11:16:03 GMT

←Older revision		Revision as of 11:16, 15 December 2016
Line 1:		Line 1:

-	==~~Strucure~~ of RAB6(GTP)-R6IP1 complex==	+	==Structure of RAB6(GTP)-R6IP1 complex==
	<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Rab6ip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://pdbe.org/3cwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://pdbe.org/3cwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
-	[[Category: Lk3 transgenic mice]]
	[[Category: Goud, B]]		[[Category: Goud, B]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA at 22:25, 5 August 2016

OCA — Fri, 05 Aug 2016 22:25:01 GMT

←Older revision		Revision as of 22:25, 5 August 2016
Line 1:		Line 1:
		+
	==Strucure of RAB6(GTP)-R6IP1 complex==		==Strucure of RAB6(GTP)-R6IP1 complex==
	<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), Rab6ip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Rab6ip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://pdbe.org/3cwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.	+	[[http://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. [[http://www.uniprot.org/uniprot/DEN5A_MOUSE DEN5A_MOUSE]] Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cwz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Goud, B]]		[[Category: Goud, B]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA at 22:26, 25 December 2014

OCA — Thu, 25 Dec 2014 22:26:31 GMT

←Older revision		Revision as of 22:26, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Goud, B.]]	+	[[Category: Goud, B]]
-	[[Category: Houdusse, A.]]	+	[[Category: Houdusse, A]]
-	[[Category: Khan, A R.]]	+	[[Category: Khan, A R]]
-	[[Category: Recacha, R.]]	+	[[Category: Recacha, R]]
	[[Category: Er-golgi transport]]		[[Category: Er-golgi transport]]
	[[Category: Golgi]]		[[Category: Golgi]]

OCA at 09:23, 5 November 2014

OCA — Wed, 05 Nov 2014 09:23:01 GMT

←Older revision		Revision as of 09:23, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3cwz.~~png~~\|~~left~~\|~~200px~~]]	+	==Strucure of RAB6(GTP)-R6IP1 complex==
		+	<StructureSection load='3cwz' size='340' side='right' caption='[[3cwz]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bbp\|3bbp]], [[2gil\|2gil]], [[1d5c\|1d5c]], [[2dwk\|2dwk]], [[1lox\|1lox]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Rab6ip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small GTPase Rab6 regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors. The crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 was solved at 3.2 angstroms resolution. This Rab6IP1 region encompasses an all alpha-helical RUN domain followed in tandem by a PLAT domain that adopts a beta sandwich fold. The structure reveals that the first and last alpha helices of the RUN domain mediate binding to switch I, switch II, and the interswitch region of Rab6. It represents the largest Rab-effector complex determined to date. Comparisons with the recent structure of Rab6 in complex with an unrelated effector, human golgin GCC185, reveals significant conformational changes in the conserved hydrophobic triad of Rab6. Flexibility in the switch and interswitch regions of Rab6 mediates recognition of compositionally distinct alpha-helical coiled coils, thereby contributing to Rab6 promiscuity in effector recruitment.

-	~~{{STRUCTURE_3cwz\| PDB=3cwz \| SCENE= }}~~	+	Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain.,Recacha R, Boulet A, Jollivet F, Monier S, Houdusse A, Goud B, Khan AR Structure. 2009 Jan 14;17(1):21-30. PMID:19141279<ref>PMID:19141279</ref>

-	~~===Strucure~~ of ~~RAB6(GTP)-R6IP1 complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19141279}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cwz]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019141279<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA: Protected "3cwz" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:45:07 GMT

Protected "3cwz" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:45, 7 January 2013

OCA at 22:45, 7 January 2013

OCA — Mon, 07 Jan 2013 22:45:05 GMT

←Older revision		Revision as of 22:45, 7 January 2013
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-	{{Seed}}
	[[Image:3cwz.png\|left\|200px]]		[[Image:3cwz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cwz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cwz\| PDB=3cwz \| SCENE= }}		{{STRUCTURE_3cwz\| PDB=3cwz \| SCENE= }}

	===Strucure of RAB6(GTP)-R6IP1 complex===		===Strucure of RAB6(GTP)-R6IP1 complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19141279}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19141279 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19141279}}		{{ABSTRACT_PUBMED_19141279}}

	==About this Structure==		==About this Structure==
-	~~3CWZ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA].	+	[[3cwz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19141279~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019141279</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 30:		Line 18:
	[[Category: Khan, A R.]]		[[Category: Khan, A R.]]
	[[Category: Recacha, R.]]		[[Category: Recacha, R.]]
-	[[Category: Acetylation]]
-	[[Category: Alternative splicing]]
	[[Category: Er-golgi transport]]		[[Category: Er-golgi transport]]
	[[Category: Golgi]]		[[Category: Golgi]]
Line 55:		Line 41:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Unc-14]]		[[Category: Unc-14]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 08:57:45 2009''