3cx6 - Revision history

OCA at 12:34, 30 August 2023

OCA — Wed, 30 Aug 2023 12:34:23 GMT

←Older revision		Revision as of 12:34, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3cx6' size='340' side='right'caption='[[3cx6]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3cx6' size='340' side='right'caption='[[3cx6]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CX6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GDP:GUANOSINE~~-5~~-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1shz\|1shz]], [[3cx7\|3cx7]], [[3cx8\|3cx8]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">Gna13, Gna-13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Arhgef11 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [https://pdbe.org/3cx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [https://www.ebi.ac.uk/pdbsum/3cx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cx6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [https://pdbe.org/3cx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [https://www.ebi.ac.uk/pdbsum/3cx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GNA13_MOUSE GNA13_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.	+	[https://www.uniprot.org/uniprot/GNA13_MOUSE GNA13_MOUSE] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Chen, Z~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Sprang, S R~~]]	+	[[Category: Chen Z]]
-	[[Category: ~~Coiled coil]]~~	+	[[Category: Sprang SR]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Gtpase activation]]~~	+
-	~~[[Category: Guanine-nucleotide releasing factor]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein complex]]~~	+
-	~~[[Category: Signal transduction]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Transducer~~]]	+

OCA at 19:15, 20 October 2021

OCA — Wed, 20 Oct 2021 19:15:50 GMT

←Older revision		Revision as of 19:15, 20 October 2021
Line 1:		Line 1:

	==Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP==		==Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP==
-	<StructureSection load='3cx6' size='340' side='right' caption='[[3cx6]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3cx6' size='340' side='right'caption='[[3cx6]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cx6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CX6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shz\|1shz]], [[3cx7\|3cx7]], [[3cx8\|3cx8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1shz\|1shz]], [[3cx7\|3cx7]], [[3cx8\|3cx8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gna13, Gna-13 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Arhgef11 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gna13, Gna-13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Arhgef11 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [~~http~~://pdbe.org/3cx6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cx6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cx6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [https://pdbe.org/3cx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [https://www.ebi.ac.uk/pdbsum/3cx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GNA13_MOUSE GNA13_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.	+	[[https://www.uniprot.org/uniprot/GNA13_MOUSE GNA13_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Rho guanine nucleotide exchange factor\|Rho guanine nucleotide exchange factor]]	+	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]

OCA at 13:15, 7 November 2018

OCA — Wed, 07 Nov 2018 13:15:09 GMT

←Older revision		Revision as of 13:15, 7 November 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cx6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cx6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 41:		Line 41:
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Sprang, S R]]		[[Category: Sprang, S R]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]

OCA at 08:00, 5 August 2016

OCA — Fri, 05 Aug 2016 08:00:51 GMT

←Older revision		Revision as of 08:00, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP==		==Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP==
	<StructureSection load='3cx6' size='340' side='right' caption='[[3cx6]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3cx6' size='340' side='right' caption='[[3cx6]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cx6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~] and [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cx6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CX6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shz\|1shz]], [[3cx7\|3cx7]], [[3cx8\|3cx8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shz\|1shz]], [[3cx7\|3cx7]], [[3cx8\|3cx8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gna13, Gna-13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), Arhgef11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gna13, Gna-13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Arhgef11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [http://www.ebi.ac.uk/pdbsum/3cx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [http://pdbe.org/3cx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [http://www.ebi.ac.uk/pdbsum/3cx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cx6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cx6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho guanine nucleotide exchange factor\|Rho guanine nucleotide exchange factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Buffalo rat]]
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Sprang, S R]]		[[Category: Sprang, S R]]

OCA at 17:06, 25 December 2014

OCA — Thu, 25 Dec 2014 17:06:23 GMT

←Older revision		Revision as of 17:06, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [http://www.ebi.ac.uk/pdbsum/3cx6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [http://www.ebi.ac.uk/pdbsum/3cx6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GNA13_MOUSE GNA13_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Chen, Z.]]	+	[[Category: Chen, Z]]
-	[[Category: Sprang, S R.]]	+	[[Category: Sprang, S R]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]

OCA at 09:21, 5 November 2014

OCA — Wed, 05 Nov 2014 09:21:08 GMT

←Older revision		Revision as of 09:21, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3cx6.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP==
		+	<StructureSection load='3cx6' size='340' side='right' caption='[[3cx6]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cx6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CX6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shz\|1shz]], [[3cx7\|3cx7]], [[3cx8\|3cx8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gna13, Gna-13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Arhgef11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cx6 RCSB], [http://www.ebi.ac.uk/pdbsum/3cx6 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cx6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G12 class heterotrimeric G proteins stimulate RhoA activation by RGS-RhoGEFs. However, p115RhoGEF is a GTPase Activating Protein (GAP) toward Galpha13, whereas PDZRhoGEF is not. We have characterized the interaction between the PDZRhoGEF rgRGS domain (PRG-rgRGS) and the alpha subunit of G13 and have determined crystal structures of their complexes in both the inactive state bound to GDP and the active states bound to GDPAlF (transition state) and GTPgammaS (Michaelis complex). PRG-rgRGS interacts extensively with the helical domain and the effector-binding sites on Galpha13 through contacts that are largely conserved in all three nucleotide-bound states, although PRG-rgRGS has highest affinity to the Michaelis complex. An acidic motif in the N terminus of PRG-rgRGS occupies the GAP binding site of Galpha13 and is flexible in the GDPAlF complex but well ordered in the GTPgammaS complex. Replacement of key residues in this motif with their counterparts in p115RhoGEF confers GAP activity.

-	~~{{STRUCTURE_3cx6\| PDB=3cx6 \| SCENE= }}~~	+	Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.,Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR Structure. 2008 Oct 8;16(10):1532-43. PMID:18940608<ref>PMID:18940608</ref>

-	~~===Crystal Structure~~ of ~~PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18940608}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cx6]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus] and [http://en~~.~~wikipedia.org~~/~~wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018940608<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA: Protected "3cx6" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:37:31 GMT

Protected "3cx6" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:37, 7 January 2013

OCA at 20:37, 7 January 2013

OCA — Mon, 07 Jan 2013 20:37:26 GMT

←Older revision		Revision as of 20:37, 7 January 2013
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-	{{Seed}}
	[[Image:3cx6.png\|left\|200px]]		[[Image:3cx6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cx6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cx6\| PDB=3cx6 \| SCENE= }}		{{STRUCTURE_3cx6\| PDB=3cx6 \| SCENE= }}

	===Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP===		===Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18940608}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18940608 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18940608}}		{{ABSTRACT_PUBMED_18940608}}

	==About this Structure==		==About this Structure==
-	~~3CX6~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA].	+	[[3cx6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18940608~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018940608</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
	[[Category: Sprang, S R.]]		[[Category: Sprang, S R.]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]
Line 42:		Line 28:
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Transducer]]		[[Category: Transducer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:17:43 2009''

OCA at 21:17, 17 February 2009

OCA — Tue, 17 Feb 2009 21:17:48 GMT

←Older revision		Revision as of 21:17, 17 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3cx6.~~jpg~~\|left\|200px]]	+	[[Image:3cx6.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CX6 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA].	+	3CX6 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA].

	==Reference==		==Reference==
-	~~Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF., Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR, Structure. 2008 Oct;16(10):1532-43.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18940608 18940608]~~	+	<ref group="xtra">PMID:18940608</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Protein complex]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
Line 44:		Line 43:
	[[Category: Transducer]]		[[Category: Transducer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 29 10~~:56:~~41 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:17:43 2009''

OCA at 08:56, 29 October 2008

OCA — Wed, 29 Oct 2008 08:56:43 GMT

←Older revision		Revision as of 08:56, 29 October 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3cx6.jpg\|left\|200px]]

-	The ~~entry 3cx6~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3cx6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3cx6\| PDB=3cx6 \| SCENE= }}

-	~~Authors: Sprang, S.R., Chen, Z.~~	+	===Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP===

-	Description: Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP

		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18940608}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18940608 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18940608}}

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 09~~:35:03 2008''	+	==About this Structure==
		+	3CX6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CX6 OCA].
		+
		+	==Reference==
		+	Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF., Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR, Structure. 2008 Oct;16(10):1532-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18940608 18940608]
		+	[[Category: Mus musculus]]
		+	[[Category: Protein complex]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Chen, Z.]]
		+	[[Category: Sprang, S R.]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Gtp-binding]]
		+	[[Category: Gtpase activation]]
		+	[[Category: Guanine-nucleotide releasing factor]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Membrane]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Palmitate]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein complex]]
		+	[[Category: Signal transduction]]
		+	[[Category: Signaling protein]]
		+	[[Category: Transducer]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 29 10:56:41 2008''