3cxb - Revision history

OCA at 08:23, 20 March 2024

OCA — Wed, 20 Mar 2024 08:23:33 GMT

←Older revision		Revision as of 08:23, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3cxb' size='340' side='right'caption='[[3cxb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3cxb' size='340' side='right'caption='[[3cxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXB FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PLEKHM2~~, ~~KIAA0842, SKIP (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [https://pdbe.org/3cxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [https://www.ebi.ac.uk/pdbsum/3cxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [https://pdbe.org/3cxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [https://www.ebi.ac.uk/pdbsum/3cxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref> [[https://www.uniprot.org/uniprot/PKHM2_HUMAN PKHM2_HUMAN]] May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.<ref>PMID:15905402</ref>	+	[https://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Salmonella typhimurium type III secretion effector protein SifA is essential for inducing tubulation of the Salmonella phagosome and binds the mammalian kinesin-binding protein SKIP. Coexpression of SifA with the effector SseJ induced tubulation of mammalian cell endosomes, similar to that induced by Salmonella infection. Interestingly, GTP-bound RhoA, RhoB, and RhoC also induced endosomal tubulation when coexpressed with SseJ, indicating that SifA likely mimics or activates a RhoA family GTPase. The structure of SifA in complex with the PH domain of SKIP revealed that SifA has two distinct domains; the amino terminus binds SKIP, and the carboxyl terminus has a fold similar to SopE, a Salmonella effector with Rho GTPase guanine nucleotide exchange factor activity (GEF). Similar to GEFs, SifA interacted with GDP-bound RhoA, and purified SseJ and RhoA formed a protein complex, suggesting that SifA, SKIP, SseJ, and RhoA family GTPases cooperatively promote host membrane tubulation.
-
-	Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.,Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI Cell Host Microbe. 2008 Nov 13;4(5):434-46. PMID:18996344<ref>PMID:18996344</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3cxb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chai, J~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-	[[Category: ~~Huang, Z~~]]	+	[[Category: Chai J]]
-	[[Category: ~~Complex]]~~	+	[[Category: Huang Z]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Sifa]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Skip]]~~	+
-	~~[[Category: Virulence~~]]	+

OCA at 07:47, 2 February 2022

OCA — Wed, 02 Feb 2022 07:47:38 GMT

←Older revision		Revision as of 07:47, 2 February 2022
Line 1:		Line 1:

	==Crystal Structure of sifa and skip==		==Crystal Structure of sifa and skip==
-	<StructureSection load='3cxb' size='340' side='right' caption='[[3cxb]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3cxb' size='340' side='right'caption='[[3cxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/ ] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXB FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHM2, KIAA0842, SKIP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHM2, KIAA0842, SKIP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [~~http~~://pdbe.org/3cxb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cxb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [https://pdbe.org/3cxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [https://www.ebi.ac.uk/pdbsum/3cxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref> [[~~http~~://www.uniprot.org/uniprot/PKHM2_HUMAN PKHM2_HUMAN]] May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.<ref>PMID:15905402</ref>	+	[[https://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref> [[https://www.uniprot.org/uniprot/PKHM2_HUMAN PKHM2_HUMAN]] May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.<ref>PMID:15905402</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Huang, Z]]		[[Category: Huang, Z]]

OCA at 13:53, 7 November 2018

OCA — Wed, 07 Nov 2018 13:53:58 GMT

←Older revision		Revision as of 13:53, 7 November 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	[[Category: Huang, Z]]		[[Category: Huang, Z]]
	[[Category: Complex]]		[[Category: Complex]]
		+	[[Category: Cytoplasm]]
	[[Category: Membrane]]		[[Category: Membrane]]
		+	[[Category: Polymorphism]]
	[[Category: Sifa]]		[[Category: Sifa]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Skip]]		[[Category: Skip]]
	[[Category: Virulence]]		[[Category: Virulence]]

OCA at 23:12, 5 August 2016

OCA — Fri, 05 Aug 2016 23:12:24 GMT

←Older revision		Revision as of 23:12, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of sifa and skip==		==Crystal Structure of sifa and skip==
	<StructureSection load='3cxb' size='340' side='right' caption='[[3cxb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3cxb' size='340' side='right' caption='[[3cxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CXB FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">~~sifA, STM1224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium]),~~ PLEKHM2, KIAA0842, SKIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHM2, KIAA0842, SKIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [http://www.ebi.ac.uk/pdbsum/3cxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [http://pdbe.org/3cxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [http://www.ebi.ac.uk/pdbsum/3cxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cxb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: Human]]
-	~~[[Category: Salmonella enterica subsp. enterica serovar typhimurium~~]]	+
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Huang, Z]]		[[Category: Huang, Z]]

OCA at 22:45, 25 December 2014

OCA — Thu, 25 Dec 2014 22:45:56 GMT

←Older revision		Revision as of 22:45, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [http://www.ebi.ac.uk/pdbsum/3cxb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [http://www.ebi.ac.uk/pdbsum/3cxb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref> [[http://www.uniprot.org/uniprot/PKHM2_HUMAN PKHM2_HUMAN]] May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.<ref>PMID:15905402</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Chai, J.]]	+	[[Category: Chai, J]]
-	[[Category: Huang, Z.]]	+	[[Category: Huang, Z]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 09:26, 5 November 2014

OCA — Wed, 05 Nov 2014 09:26:43 GMT

←Older revision		Revision as of 09:26, 5 November 2014
Line 1:		Line 1:
-	[[~~Image~~:3cxb.~~png\|left~~\|200px]]	+	==Crystal Structure of sifa and skip==
		+	<StructureSection load='3cxb' size='340' side='right' caption='[[3cxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CXB FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sifA, STM1224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium]), PLEKHM2, KIAA0842, SKIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [http://www.ebi.ac.uk/pdbsum/3cxb PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Salmonella typhimurium type III secretion effector protein SifA is essential for inducing tubulation of the Salmonella phagosome and binds the mammalian kinesin-binding protein SKIP. Coexpression of SifA with the effector SseJ induced tubulation of mammalian cell endosomes, similar to that induced by Salmonella infection. Interestingly, GTP-bound RhoA, RhoB, and RhoC also induced endosomal tubulation when coexpressed with SseJ, indicating that SifA likely mimics or activates a RhoA family GTPase. The structure of SifA in complex with the PH domain of SKIP revealed that SifA has two distinct domains; the amino terminus binds SKIP, and the carboxyl terminus has a fold similar to SopE, a Salmonella effector with Rho GTPase guanine nucleotide exchange factor activity (GEF). Similar to GEFs, SifA interacted with GDP-bound RhoA, and purified SseJ and RhoA formed a protein complex, suggesting that SifA, SKIP, SseJ, and RhoA family GTPases cooperatively promote host membrane tubulation.

-	~~{{STRUCTURE_3cxb\| PDB=3cxb \| SCENE= }}~~	+	Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.,Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI Cell Host Microbe. 2008 Nov 13;4(5):434-46. PMID:18996344<ref>PMID:18996344</ref>

-	~~===Crystal Structure~~ of ~~sifa and skip===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18996344}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cxb]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018996344<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]

OCA: Protected "3cxb" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 23:10:25 GMT

Protected "3cxb" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:10, 7 January 2013

OCA at 23:10, 7 January 2013

OCA — Mon, 07 Jan 2013 23:10:22 GMT

←Older revision		Revision as of 23:10, 7 January 2013
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-	{{Seed}}
	[[Image:3cxb.png\|left\|200px]]		[[Image:3cxb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cxb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cxb\| PDB=3cxb \| SCENE= }}		{{STRUCTURE_3cxb\| PDB=3cxb \| SCENE= }}

	===Crystal Structure of sifa and skip===		===Crystal Structure of sifa and skip===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18996344}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18996344 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18996344}}		{{ABSTRACT_PUBMED_18996344}}

	==About this Structure==		==About this Structure==
-	~~3CXB~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].	+	[[3cxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18996344~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018996344</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
Line 29:		Line 17:
	[[Category: Huang, Z.]]		[[Category: Huang, Z.]]
	[[Category: Complex]]		[[Category: Complex]]
-	[[Category: Cytoplasm]]
	[[Category: Membrane]]		[[Category: Membrane]]
-	[[Category: Polymorphism]]
	[[Category: Sifa]]		[[Category: Sifa]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Skip]]		[[Category: Skip]]
	[[Category: Virulence]]		[[Category: Virulence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:57:33 2010''

OCA at 08:48, 22 September 2010

OCA — Wed, 22 Sep 2010 08:48:35 GMT

←Older revision		Revision as of 08:48, 22 September 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CXB is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium~~ Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].	+	3CXB is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].

	==Reference==		==Reference==
-	Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation., Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI, Cell Host Microbe. 2008 Nov 13;4(5):434-46. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18996344 18996344]~~	+	<ref group="xtra">PMID:18996344</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Protein complex~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: ~~Salmonella typhimurium~~]]	+	[[Category: Chai, J.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx:audit_author~~.]]	+	[[Category: Huang, Z.]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Cytoplasm]]		[[Category: Cytoplasm]]
Line 37:		Line 37:
	[[Category: Virulence]]		[[Category: Virulence]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 4 20~~:04:~~38 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:57:33 2010''

OCA at 18:04, 4 March 2009

OCA — Wed, 04 Mar 2009 18:04:39 GMT

←Older revision		Revision as of 18:04, 4 March 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CXB is a ~~2 chains~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].	+	3CXB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].

	==Reference==		==Reference==
-	~~<ref group="xtra">~~PMID:~~18996344<~~/~~ref><references group="xtra"~~/>	+	Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation., Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI, Cell Host Microbe. 2008 Nov 13;4(5):434-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18996344 18996344]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Protein complex]]
	[[Category: Salmonella typhimurium]]		[[Category: Salmonella typhimurium]]
-	[[Category: ~~Chai~~, ~~J.]]~~	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
-	~~[[Category~~: ~~Huang, Z~~.]]	+
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Cytoplasm]]		[[Category: Cytoplasm]]
Line 37:		Line 37:
	[[Category: Virulence]]		[[Category: Virulence]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 13:59:29 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 20:04:38 2009''