3d2m - Revision history

OCA at 12:38, 30 August 2023

OCA — Wed, 30 Aug 2023 12:38:44 GMT

←Older revision		Revision as of 12:38, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3d2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D2M FirstGlance]. <br>		<table><tr><td colspan='2'>[[3d2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D2M FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~, ~~<scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.21Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3b8g\|3b8g]], [[2r8v\|2r8v]], [[3d2p\|3d2p]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>argA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~485 Neisseria gonorrhoeae])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [https://pdbe.org/3d2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [https://www.ebi.ac.uk/pdbsum/3d2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d2m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [https://pdbe.org/3d2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [https://www.ebi.ac.uk/pdbsum/3d2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d2m ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5FAK7_NEIG1 Q5FAK7_NEIG1]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Amino-acid N-acetyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: Allewell~~, N M~~]]	+	[[Category: Allewell NM]]
-	[[Category: Jin, Z]]	+	[[Category: Jin Z]]
-	[[Category: Min, L]]	+	[[Category: Min L]]
-	[[Category: Shi, D]]	+	[[Category: Shi D]]
-	[[Category: Tuchman, M]]	+	[[Category: Tuchman M]]
-	~~[[Category: Protein-coa-glu ternary complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 19:18, 20 October 2021

OCA — Wed, 20 Oct 2021 19:18:22 GMT

←Older revision		Revision as of 19:18, 20 October 2021
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	==Crystal structure of N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate==		==Crystal structure of N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate==
-	<StructureSection load='3d2m' size='340' side='right' caption='[[3d2m]], [[Resolution\|resolution]] 2.21Å' scene=''>	+	<StructureSection load='3d2m' size='340' side='right'caption='[[3d2m]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3d2m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3D2M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3d2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D2M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b8g\|3b8g]], [[2r8v\|2r8v]], [[3d2p\|3d2p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b8g\|3b8g]], [[2r8v\|2r8v]], [[3d2p\|3d2p]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 Neisseria gonorrhoeae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 Neisseria gonorrhoeae])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [~~http~~://pdbe.org/3d2m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3d2m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3d2m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [https://pdbe.org/3d2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [https://www.ebi.ac.uk/pdbsum/3d2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d2m ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Amino-acid N-acetyltransferase]]		[[Category: Amino-acid N-acetyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
	[[Category: Allewell, N M]]		[[Category: Allewell, N M]]

OCA at 09:29, 14 November 2018

OCA — Wed, 14 Nov 2018 09:29:44 GMT

←Older revision		Revision as of 09:29, 14 November 2018
Line 1:		Line 1:
		+
	==Crystal structure of N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate==		==Crystal structure of N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate==
	<StructureSection load='3d2m' size='340' side='right' caption='[[3d2m]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='3d2m' size='340' side='right' caption='[[3d2m]], [[Resolution\|resolution]] 2.21Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 Neisseria gonorrhoeae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 Neisseria gonorrhoeae])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [http://pdbe.org/3d2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [http://www.ebi.ac.uk/pdbsum/3d2m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [http://pdbe.org/3d2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [http://www.ebi.ac.uk/pdbsum/3d2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d2m ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/3d2m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/3d2m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:45, 7 February 2016

OCA — Sun, 07 Feb 2016 08:45:12 GMT

←Older revision		Revision as of 08:45, 7 February 2016
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 Neisseria gonorrhoeae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 Neisseria gonorrhoeae])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [http://www.ebi.ac.uk/pdbsum/3d2m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [http://pdbe.org/3d2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [http://www.ebi.ac.uk/pdbsum/3d2m PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d2m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3d2m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:59, 25 January 2015

OCA — Sun, 25 Jan 2015 10:59:59 GMT

←Older revision		Revision as of 10:59, 25 January 2015
Line 33:		Line 33:
	[[Category: Amino-acid N-acetyltransferase]]		[[Category: Amino-acid N-acetyltransferase]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: Allewell, N M.]]	+	[[Category: Allewell, N M]]
-	[[Category: Jin, Z.]]	+	[[Category: Jin, Z]]
-	[[Category: Min, L.]]	+	[[Category: Min, L]]
-	[[Category: Shi, D.]]	+	[[Category: Shi, D]]
-	[[Category: Tuchman, M.]]	+	[[Category: Tuchman, M]]
	[[Category: Protein-coa-glu ternary complex]]		[[Category: Protein-coa-glu ternary complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:28, 5 November 2014

OCA — Wed, 05 Nov 2014 09:28:51 GMT

←Older revision		Revision as of 09:28, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3d2m.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate==
		+	<StructureSection load='3d2m' size='340' side='right' caption='[[3d2m]], [[Resolution\|resolution]] 2.21Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3d2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D2M FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b8g\|3b8g]], [[2r8v\|2r8v]], [[3d2p\|3d2p]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">argA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 Neisseria gonorrhoeae])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amino-acid_N-acetyltransferase Amino-acid N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.1 2.3.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d2m RCSB], [http://www.ebi.ac.uk/pdbsum/3d2m PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/3d2m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-acetylglutamate synthase (NAGS)1 catalyzes the first committed step in L-arginine biosynthesis in plants and micro-organisms and is subject to feedback inhibition by L-arginine. This study compares the crystal structures of NAGS from Neisseria gonorrhoeae (ngNAGS) in the inactive T-state with L-arginine bound and in the active R-state complexed with Co-enzyme A (CoA) and L-glutamate. Under all conditions examined, the enzyme consists of two stacked trimers. Each monomer has two domains-an amino acid kinase (AAK) domain with an AAK-like fold, but lacking kinase activity, and an N-acetyltransferase (NAT) domain homologous to other GCN5-related transferases. Binding of L-arginine to the AAK domain induces a global conformational change that increases the diameter of the hexamer by ~10 A and decreases its height by ~20 A. AAK dimers move 5 A outward along their two-fold axes and their tilt relative to the plane of the hexamer decreases by ~4 masculine. The NAT domains rotate ~109 masculine relative to AAK domains enabling new interdomain interactions. Interactions between AAK and NAT domains on different subunits also change. Local motions of several loops at the L-arginine binding site enable the protein to close around the bound ligand, while several loops at the NAT active site become disordered, markedly reducing enzymatic specific activity.

-	~~{{STRUCTURE_3d2m\| PDB=3d2m \| SCENE= }}~~	+	Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine.,Min L, Jin Z, Caldovic L, Morizono H, Allewell NM, Tuchman M, Shi D J Biol Chem. 2008 Dec 18. PMID:19095660<ref>PMID:19095660</ref>

-	~~===Crystal structure~~ of ~~N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19095660}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3d2m]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019095660<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Amino-acid N-acetyltransferase]]		[[Category: Amino-acid N-acetyltransferase]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]

OCA: Protected "3d2m" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:05:12 GMT

Protected "3d2m" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:05, 7 January 2013

OCA at 20:05, 7 January 2013

OCA — Mon, 07 Jan 2013 20:05:08 GMT

←Older revision		Revision as of 20:05, 7 January 2013
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-	{{Seed}}
	[[Image:3d2m.png\|left\|200px]]		[[Image:3d2m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3d2m", creates the "Structure Box" on the page.
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	{{STRUCTURE_3d2m\| PDB=3d2m \| SCENE= }}		{{STRUCTURE_3d2m\| PDB=3d2m \| SCENE= }}

	===Crystal structure of N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate===		===Crystal structure of N-acetylglutamate synthase from Neisseria gonorrhoeae complexed with coenzyme A and L-glutamate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19095660}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_19095660}}		{{ABSTRACT_PUBMED_19095660}}

	==About this Structure==		==About this Structure==
-	~~3D2M~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA].	+	[[3d2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19095660~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019095660</ref><references group="xtra"/>
	[[Category: Amino-acid N-acetyltransferase]]		[[Category: Amino-acid N-acetyltransferase]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
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	[[Category: Protein-coa-glu ternary complex]]		[[Category: Protein-coa-glu ternary complex]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:36:45 2010''

OCA at 08:27, 22 September 2010

OCA — Wed, 22 Sep 2010 08:27:47 GMT

←Older revision		Revision as of 08:27, 22 September 2010
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	==About this Structure==		==About this Structure==
-	3D2M is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA].	+	3D2M is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA].

	==Reference==		==Reference==
-	~~Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine., Min L, Jin Z, Caldovic L, Morizono H, Allewell NM, Tuchman M, Shi D, J Biol Chem. 2008 Dec 18.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19095660 19095660]~~	+	<ref group="xtra">PMID:19095660</ref><references group="xtra"/>
	[[Category: Amino-acid N-acetyltransferase]]		[[Category: Amino-acid N-acetyltransferase]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Allewell, N M.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Jin, Z.]]
		+	[[Category: Min, L.]]
		+	[[Category: Shi, D.]]
		+	[[Category: Tuchman, M.]]
	[[Category: Protein-coa-glu ternary complex]]		[[Category: Protein-coa-glu ternary complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 4 20~~:15:~~50 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:36:45 2010''

OCA at 18:15, 4 March 2009

OCA — Wed, 04 Mar 2009 18:15:51 GMT

←Older revision		Revision as of 18:15, 4 March 2009
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	==About this Structure==		==About this Structure==
-	3D2M is a ~~1 chain~~ structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA].	+	3D2M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D2M OCA].

	==Reference==		==Reference==
-	~~<ref group="xtra">~~PMID:~~19095660<~~/~~ref><references group="xtra"~~/>	+	Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine., Min L, Jin Z, Caldovic L, Morizono H, Allewell NM, Tuchman M, Shi D, J Biol Chem. 2008 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19095660 19095660]
	[[Category: Amino-acid N-acetyltransferase]]		[[Category: Amino-acid N-acetyltransferase]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: ~~Allewell, N M.~~]]	+	[[Category: Single protein]]
-	[[Category: ~~Jin~~, ~~Z.]]~~	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
-	~~[[Category~~: ~~Min, L.]]~~	+
-	~~[[Category: Shi, D.]]~~	+
-	~~[[Category: Tuchman, M~~.]]	+
	[[Category: Protein-coa-glu ternary complex]]		[[Category: Protein-coa-glu ternary complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:10:40 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 20:15:50 2009''