3d95 - Revision history

OCA at 09:40, 21 February 2024

OCA — Wed, 21 Feb 2024 09:40:23 GMT

←Older revision		Revision as of 09:40, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3d95' size='340' side='right'caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3d95' size='340' side='right'caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D95 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D95 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CRABP2 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [https://pdbe.org/3d95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [https://www.ebi.ac.uk/pdbsum/3d95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d95 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [https://pdbe.org/3d95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [https://www.ebi.ac.uk/pdbsum/3d95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d95 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	+	[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d95 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d95 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structural integrity of cellular retinoic acid-binding protein II (CRABPII) has been investigated using the crystal structures of CRABPII mutants. The overall fold was well maintained by these CRABPII mutants, each of which carried multiple different mutations. A water-mediated network is found to be present across the large binding cavity, extending from Arg111 deep inside the cavity to the alpha2 helix at its entrance. This chain of interactions acts as a ;pillar' that maintains the integrity of the protein. The disruption of the water network upon loss of Arg111 leads to decreased structural integrity of the protein. A water-mediated network can be re-established by introducing the hydrophilic Glu121 inside the cavity, which results in a rigid protein with the alpha2 helix adopting an altered conformation compared with wild-type CRABPII.
-
-	Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding.,Vaezeslami S, Jia X, Vasileiou C, Borhan B, Geiger JH Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1228-39. Epub 2008, Nov 18. PMID:19018099<ref>PMID:19018099</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3d95" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 25:
	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]		*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]		*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Geiger~~, J H~~]]	+	[[Category: Geiger JH]]
-	[[Category: Vaezeslami, S]]	+	[[Category: Vaezeslami S]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Crabpii]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: High resolution]]~~	+
-	~~[[Category: Mutant]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Retinoic acid]]~~	+
-	~~[[Category: Retinoid]]~~	+
-	~~[[Category: Retinol-binding]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Vitamin some~~]]	+

OCA at 19:20, 20 October 2021

OCA — Wed, 20 Oct 2021 19:20:54 GMT

←Older revision		Revision as of 19:20, 20 October 2021
Line 1:		Line 1:

	==Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution==		==Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution==
-	<StructureSection load='3d95' size='340' side='right' caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='3d95' size='340' side='right'caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3D95 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D95 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [~~http~~://pdbe.org/3d95 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3d95 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3d95 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [https://pdbe.org/3d95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [https://www.ebi.ac.uk/pdbsum/3d95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d95 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	+	[[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d95_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d95_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3d95" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3d95" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein 3D structures\|Cellular retinoic acid-binding protein 3D structures]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Geiger, J H]]		[[Category: Geiger, J H]]
	[[Category: Vaezeslami, S]]		[[Category: Vaezeslami, S]]

OCA at 08:44, 25 October 2017

OCA — Wed, 25 Oct 2017 08:44:17 GMT

←Older revision		Revision as of 08:44, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution==		==Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution==
	<StructureSection load='3d95' size='340' side='right' caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3d95' size='340' side='right' caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [http://pdbe.org/3d95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [http://www.ebi.ac.uk/pdbsum/3d95 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [http://pdbe.org/3d95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [http://www.ebi.ac.uk/pdbsum/3d95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d95 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3d95" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3d95" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
-	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
-	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
-	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>
Line 43:		Line 38:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
		+	[[Category: Cytoplasm]]
	[[Category: High resolution]]		[[Category: High resolution]]
	[[Category: Mutant]]		[[Category: Mutant]]

OCA at 21:27, 7 February 2016

OCA — Sun, 07 Feb 2016 21:27:46 GMT

←Older revision		Revision as of 21:27, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3d95' size='340' side='right' caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3d95' size='340' side='right' caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D95 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D95 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [http://www.ebi.ac.uk/pdbsum/3d95 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [http://pdbe.org/3d95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [http://www.ebi.ac.uk/pdbsum/3d95 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d95 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3d95" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Geiger, J H]]		[[Category: Geiger, J H]]
	[[Category: Vaezeslami, S]]		[[Category: Vaezeslami, S]]

OCA at 18:21, 24 December 2014

OCA — Wed, 24 Dec 2014 18:21:43 GMT

←Older revision		Revision as of 18:21, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D95 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D95 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [http://www.ebi.ac.uk/pdbsum/3d95 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [http://www.ebi.ac.uk/pdbsum/3d95 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Geiger, J H.]]	+	[[Category: Geiger, J H]]
-	[[Category: Vaezeslami, S.]]	+	[[Category: Vaezeslami, S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]

OCA at 07:59, 29 September 2014

OCA — Mon, 29 Sep 2014 07:59:37 GMT

←Older revision		Revision as of 07:59, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3d95.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution==
		+	<StructureSection load='3d95' size='340' side='right' caption='[[3d95]], [[Resolution\|resolution]] 1.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3d95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D95 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d96\|3d96]], [[3d97\|3d97]], [[3cwk\|3cwk]], [[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2fs7\|2fs7]], [[2g78\|2g78]], [[2g79\|2g79]], [[2g7b\|2g7b]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d95 RCSB], [http://www.ebi.ac.uk/pdbsum/3d95 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d95_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structural integrity of cellular retinoic acid-binding protein II (CRABPII) has been investigated using the crystal structures of CRABPII mutants. The overall fold was well maintained by these CRABPII mutants, each of which carried multiple different mutations. A water-mediated network is found to be present across the large binding cavity, extending from Arg111 deep inside the cavity to the alpha2 helix at its entrance. This chain of interactions acts as a ;pillar' that maintains the integrity of the protein. The disruption of the water network upon loss of Arg111 leads to decreased structural integrity of the protein. A water-mediated network can be re-established by introducing the hydrophilic Glu121 inside the cavity, which results in a rigid protein with the alpha2 helix adopting an altered conformation compared with wild-type CRABPII.

-	~~{{STRUCTURE_3d95\| PDB=3d95 \| SCENE= }}~~	+	Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding.,Vaezeslami S, Jia X, Vasileiou C, Borhan B, Geiger JH Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1228-39. Epub 2008, Nov 18. PMID:19018099<ref>PMID:19018099</ref>

-	~~===Crystal Structure~~ of the ~~R132K:Y134F:R111L:L121E:T54V Mutant~~ of ~~Apo-Cellular Retinoic Acid Binding Protein Type II at 1~~.~~20 Angstroms Resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19018099}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3d95]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA].~~	+

	==See Also==		==See Also==
Line 15:		Line 31:
	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]		*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]		*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019018099<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]

OCA at 07:54, 20 October 2012

OCA — Sat, 20 Oct 2012 07:54:14 GMT

←Older revision		Revision as of 07:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3d95]] is a 2 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA].	+	[[3d95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA].

	==See Also==		==See Also==

OCA: Protected "3d95" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 17:50:58 GMT

Protected "3d95" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:50, 25 July 2012

OCA at 17:50, 25 July 2012

OCA — Wed, 25 Jul 2012 17:50:57 GMT

←Older revision		Revision as of 17:50, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3d95.png\|left\|200px]]		[[Image:3d95.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3d95", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3d95\| PDB=3d95 \| SCENE= }}		{{STRUCTURE_3d95\| PDB=3d95 \| SCENE= }}

	===Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution===		===Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19018099}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19018099 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19018099}}		{{ABSTRACT_PUBMED_19018099}}

	==About this Structure==		==About this Structure==
-	~~3D95~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA].	+	[[3d95]] is a 2 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA].
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19018099~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019018099</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]
Line 29:		Line 23:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
-	[[Category: Crystallography]]
-	[[Category: Cytoplasm]]
	[[Category: High resolution]]		[[Category: High resolution]]
	[[Category: Mutant]]		[[Category: Mutant]]
Line 40:		Line 32:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Vitamin some]]		[[Category: Vitamin some]]
-	[[Category: X-ray]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 09:31:12 2009''

OCA at 06:31, 3 June 2009

OCA — Wed, 03 Jun 2009 06:31:12 GMT

←Older revision		Revision as of 06:31, 3 June 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3D95 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA].	+	3D95 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D95 OCA].

	==Reference==		==Reference==
-	Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding., Vaezeslami S, Jia X, Vasileiou C, Borhan B, Geiger JH, Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1228-39. Epub 2008, Nov 18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19018099 19018099]~~	+	<ref group="xtra">PMID:19018099</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Geiger, J H.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx:audit_author~~.]]	+	[[Category: Vaezeslami, S.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
Line 42:		Line 42:
	[[Category: X-ray]]		[[Category: X-ray]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 11 20~~:04:37 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 09:31:12 2009''