3d9a - Revision history

OCA at 12:43, 30 August 2023

OCA — Wed, 30 Aug 2023 12:43:03 GMT

←Older revision		Revision as of 12:43, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D9A FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1ndm\|1ndm]]~~, [[~~3hfm~~\|~~3hfm~~]]~~</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1~~.17 3~~.2~~.1.17] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [https://pdbe.org/3d9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [https://www.ebi.ac.uk/pdbsum/3d9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d9a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [https://pdbe.org/3d9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [https://www.ebi.ac.uk/pdbsum/3d9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>	+	[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lysozyme]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Acchione, M]]	+	[[Category: Acchione M]]
-	[[Category: DeSantis~~, M E~~]]	+	[[Category: DeSantis ME]]
-	[[Category: Li, M]]	+	[[Category: Li M]]
-	[[Category: Shanmuganathan, A]]	+	[[Category: Shanmuganathan A]]
-	[[Category: Smith-Gill, S]]	+	[[Category: Smith-Gill S]]
-	[[Category: Walter, R]]	+	[[Category: Walter R]]
-	[[Category: Wlodawer, A]]	+	[[Category: Wlodawer A]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Antigen]]~~	+
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Bacteriolytic enzyme]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-immune system complex]]~~	+
-	~~[[Category: Hyhel10~~]]	+

OCA at 07:57, 2 February 2022

OCA — Wed, 02 Feb 2022 07:57:24 GMT

←Older revision		Revision as of 07:57, 2 February 2022
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	<StructureSection load='3d9a' size='340' side='right'caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3d9a' size='340' side='right'caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3D9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D9A FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndm\|1ndm]], [[3hfm\|3hfm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ndm\|1ndm]], [[3hfm\|3hfm]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [~~http~~://pdbe.org/3d9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3d9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3d9a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [https://pdbe.org/3d9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [https://www.ebi.ac.uk/pdbsum/3d9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>	+	[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:28, 31 July 2019

OCA — Wed, 31 Jul 2019 07:28:08 GMT

←Older revision		Revision as of 07:28, 31 July 2019
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	==High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme==		==High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme==
-	<StructureSection load='3d9a' size='340' side='right' caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='3d9a' size='340' side='right'caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9A FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d9a_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d9a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 08:44, 25 October 2017

OCA — Wed, 25 Oct 2017 08:44:28 GMT

←Older revision		Revision as of 08:44, 25 October 2017
Line 1:		Line 1:
		+
	==High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme==		==High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme==
	<StructureSection load='3d9a' size='340' side='right' caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3d9a' size='340' side='right' caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Chick Chick~~] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9A FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndm\|1ndm]], [[3hfm\|3hfm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndm\|1ndm]], [[3hfm\|3hfm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [http://pdbe.org/3d9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [http://www.ebi.ac.uk/pdbsum/3d9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [http://pdbe.org/3d9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [http://www.ebi.ac.uk/pdbsum/3d9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 04:14, 9 February 2016

OCA — Tue, 09 Feb 2016 04:14:20 GMT

←Older revision		Revision as of 04:14, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3d9a' size='340' side='right' caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3d9a' size='340' side='right' caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9A FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndm\|1ndm]], [[3hfm\|3hfm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndm\|1ndm]], [[3hfm\|3hfm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [http://www.ebi.ac.uk/pdbsum/3d9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [http://pdbe.org/3d9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [http://www.ebi.ac.uk/pdbsum/3d9a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d9a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3d9a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 04:21, 25 December 2014

OCA — Thu, 25 Dec 2014 04:21:25 GMT

←Older revision		Revision as of 04:21, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [http://www.ebi.ac.uk/pdbsum/3d9a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [http://www.ebi.ac.uk/pdbsum/3d9a PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:35, 18 December 2014

OCA — Thu, 18 Dec 2014 13:35:54 GMT

←Older revision		Revision as of 13:35, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3d9a\| PDB=3d9a \| SCENE= }}~~	+	==High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme==
-	===High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme===	+	<StructureSection load='3d9a' size='340' side='right' caption='[[3d9a]], [[Resolution\|resolution]] 1.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19781789}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9A FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndm\|1ndm]], [[3hfm\|3hfm]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d9a RCSB], [http://www.ebi.ac.uk/pdbsum/3d9a PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d9a_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thermodynamic and structural studies addressed the increased affinity due to L-chain somatic mutations in the HyHEL-10 family of affinity matured IgG antibodies, using ITC, SPR with van't Hoff analysis, and X-ray crystallography. When compared to the parental antibody H26L26, the H26L10 and H26L8 chimeras binding to lysozyme showed an increase in favorable DeltaG(o) of -1.2+/-0.1 kcal mol(-1) and -1.3+/-0.1 kcal mol(-1), respectively. Increase in affinity of the H26L10 chimera was due to a net increase in favorable enthalpy change with little difference in change in entropy compared to H26L26. The H26L8 chimera exhibited the greatest increase in favorable enthalpy but also showed an increase in unfavorable entropy change, with the result being that the affinities of both chimeras were essentially equivalent. Site-directed L-chain mutants identified the shared somatic mutation S30G as the dominant contributor to increasing affinity to lysozyme. This mutation was not influenced by H-chain somatic mutations. Residue 30L is at the periphery of the binding interface and S30G effects an increase in hydrophobicity and decrease in H-bonding ability and size, but does not make any new energetically important antigen contacts. A new 1.2-A structure of the H10L10-HEL complex showed changes in the pattern of both inter- and intra-molecular water bridging with no other significant structural alterations near the binding interface compared to the H26L26-HEL complex. These results highlight the necessity for investigating both the structure and the thermodynamics associated with introduced mutations, in order to better assess and understand their impact on binding. Furthermore, it provides an important example of how backbone flexibility and water-bridging may favorably influence the thermodynamics of an antibody-antigen interaction.

-	~~==Function==~~	+	Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies.,Acchione M, Lipschultz CA, DeSantis ME, Shanmuganathan A, Li M, Wlodawer A, Tarasov S, Smith-Gill SJ Mol Immunol. 2009 Dec;47(2-3):457-64. Epub 2009 Sep 24. PMID:19781789<ref>PMID:19781789</ref>
-	~~[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues~~ and ~~body fluids are associated with~~ the ~~monocyte~~-~~macrophage system and enhance the activity~~ of ~~immunoagents~~. ~~Has bacteriolytic activity against~~ M.~~luteus~~.<ref>PMID:~~22044478~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3d9a]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA].~~	+	</div>

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	*[[~~Hen Egg-White (HEW) Lysozyme~~\|~~Hen Egg-White (HEW) Lysozyme~~]]	+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019781789</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Acchione, M.]]	+	[[Category: Acchione, M]]
-	[[Category: DeSantis, M E.]]	+	[[Category: DeSantis, M E]]
-	[[Category: Li, M.]]	+	[[Category: Li, M]]
-	[[Category: Shanmuganathan, A.]]	+	[[Category: Shanmuganathan, A]]
-	[[Category: Smith-Gill, S.]]	+	[[Category: Smith-Gill, S]]
-	[[Category: Walter, R.]]	+	[[Category: Walter, R]]
-	[[Category: Wlodawer, A.]]	+	[[Category: Wlodawer, A]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Antibody]]		[[Category: Antibody]]
Line 35:		Line 53:
	[[Category: Hydrolase-immune system complex]]		[[Category: Hydrolase-immune system complex]]
	[[Category: Hyhel10]]		[[Category: Hyhel10]]
-	[[Category: Lysozyme]]

OCA at 06:33, 29 September 2013

OCA — Sun, 29 Sep 2013 06:33:21 GMT

←Older revision		Revision as of 06:33, 29 September 2013
Line 1:		Line 1:
-	[[Image:3d9a.png\|left\|200px]]
-
	{{STRUCTURE_3d9a\| PDB=3d9a \| SCENE= }}		{{STRUCTURE_3d9a\| PDB=3d9a \| SCENE= }}
-
	===High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme===		===High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme===
		+	{{ABSTRACT_PUBMED_19781789}}

-	~~{{ABSTRACT_PUBMED_19781789}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>

	==About this Structure==		==About this Structure==
Line 15:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019781789</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019781789</ref><references group="xtra"/><references/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 12:36, 20 October 2012

OCA — Sat, 20 Oct 2012 12:36:30 GMT

←Older revision		Revision as of 12:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3d9a]] is a 3 chain structure ~~of [[Antibody]] and [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA].	+	[[3d9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9A OCA].

	==See Also==		==See Also==

OCA: Protected "3d9a" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 09:17:14 GMT

Protected "3d9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:17, 26 July 2012