3dai - Revision history

OCA at 12:43, 30 August 2023

OCA — Wed, 30 Aug 2023 12:43:51 GMT

←Older revision		Revision as of 12:43, 30 August 2023
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	<StructureSection load='3dai' size='340' side='right'caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3dai' size='340' side='right'caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ATAD2 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [https://pdbe.org/3dai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [https://www.ebi.ac.uk/pdbsum/3dai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dai ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [https://pdbe.org/3dai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [https://www.ebi.ac.uk/pdbsum/3dai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dai ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>	+	[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Fedorov O]]
-	[[Category: Fedorov, O]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Keates T]]
-	[[Category: Keates, T]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Picaud S]]
-	[[Category: Picaud, S]]	+	[[Category: Roos AK]]
-	[[Category: Roos~~, A K~~]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Structural genomic]]~~	+
-	~~[[Category: Aaa domain containing 2]]~~	+
-	~~[[Category: Aaa+ nuclear coregulator cancer-associated pro2000 protein]]~~	+
-	~~[[Category: Ancca]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Atpase family]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Two aaa domain containing protein~~]]	+

OCA at 07:58, 2 February 2022

OCA — Wed, 02 Feb 2022 07:58:36 GMT

←Older revision		Revision as of 07:58, 2 February 2022
Line 1:		Line 1:

	==Crystal structure of the bromodomain of the human ATAD2==		==Crystal structure of the bromodomain of the human ATAD2==
-	<StructureSection load='3dai' size='340' side='right' caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3dai' size='340' side='right'caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DAI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [~~http~~://pdbe.org/3dai PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dai PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dai ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [https://pdbe.org/3dai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [https://www.ebi.ac.uk/pdbsum/3dai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dai ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>	+	[[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 3dai" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3dai" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase family AAA domain-containing protein\|ATPase family AAA domain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 06:41, 31 January 2018

OCA — Wed, 31 Jan 2018 06:41:37 GMT

←Older revision		Revision as of 06:41, 31 January 2018
Line 1:		Line 1:
		+
	==Crystal structure of the bromodomain of the human ATAD2==		==Crystal structure of the bromodomain of the human ATAD2==
	<StructureSection load='3dai' size='340' side='right' caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3dai' size='340' side='right' caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [http://pdbe.org/3dai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [http://www.ebi.ac.uk/pdbsum/3dai PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [http://pdbe.org/3dai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [http://www.ebi.ac.uk/pdbsum/3dai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dai ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dai_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dai_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
	[[Category: Fedorov, O]]		[[Category: Fedorov, O]]

OCA at 21:12, 9 February 2016

OCA — Tue, 09 Feb 2016 21:12:58 GMT

←Older revision		Revision as of 21:12, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3dai' size='340' side='right' caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3dai' size='340' side='right' caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [http://www.ebi.ac.uk/pdbsum/3dai PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [http://pdbe.org/3dai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [http://www.ebi.ac.uk/pdbsum/3dai PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dai ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3dai" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 09:34, 25 December 2014

OCA — Thu, 25 Dec 2014 09:34:23 GMT

←Older revision		Revision as of 09:34, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAI FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [http://www.ebi.ac.uk/pdbsum/3dai PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [http://www.ebi.ac.uk/pdbsum/3dai PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 25:
	Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>		Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Delft, F Von.]]	+	[[Category: Delft, F Von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Fedorov, O.]]	+	[[Category: Fedorov, O]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Keates, T.]]	+	[[Category: Keates, T]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Picaud, S.]]	+	[[Category: Picaud, S]]
-	[[Category: Roos, A K.]]	+	[[Category: Roos, A K]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Aaa domain containing 2]]		[[Category: Aaa domain containing 2]]
	[[Category: Aaa+ nuclear coregulator cancer-associated pro2000 protein]]		[[Category: Aaa+ nuclear coregulator cancer-associated pro2000 protein]]
Line 51:		Line 53:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-	[[Category: Structural genomics consortium]]
	[[Category: Two aaa domain containing protein]]		[[Category: Two aaa domain containing protein]]

OCA at 09:48, 21 May 2014

OCA — Wed, 21 May 2014 09:48:20 GMT

←Older revision		Revision as of 09:48, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3dai.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the bromodomain of the human ATAD2==
		+	<StructureSection load='3dai' size='340' side='right' caption='[[3dai]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3dai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dai RCSB], [http://www.ebi.ac.uk/pdbsum/3dai PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dai_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bromodomains (BRDs) are protein interaction modules that specifically recognize epsilon-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylation-dependent substrate recognition. Screening of more than 30 representative BRDs against systematic histone-peptide arrays identifies new BRD substrates and reveals a strong influence of flanking posttranslational modifications, such as acetylation and phosphorylation, suggesting that BRDs recognize combinations of marks rather than singly acetylated sequences. We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4. These data provide a foundation for structure-based drug design of specific inhibitors for this emerging target family.

-	<!--	+	Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3dai"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3dai\| PDB=3dai \| SCENE= }}~~	+

-	~~===Crystal structure~~ of the ~~bromodomain of the human ATAD2===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22464331 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22464331}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3dai]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022464331<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA: Protected "3dai" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2012 06:06:37 GMT

Protected "3dai" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:06, 11 April 2012

OCA at 06:06, 11 April 2012

OCA — Wed, 11 Apr 2012 06:06:35 GMT

←Older revision		Revision as of 06:06, 11 April 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3dai.png\|left\|200px]]		[[Image:3dai.png\|left\|200px]]

Line 10:		Line 9:
	{{STRUCTURE_3dai\| PDB=3dai \| SCENE= }}		{{STRUCTURE_3dai\| PDB=3dai \| SCENE= }}

-	===Crystal structure of the bromodomain of the human ATAD2 ~~(CASP Target)~~===	+	===Crystal structure of the bromodomain of the human ATAD2===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22464331 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22464331}}

	==About this Structure==		==About this Structure==
-	~~3DAI~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA].	+	[[3dai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022464331</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 29:		Line 37:
	[[Category: Aaa domain containing 2]]		[[Category: Aaa domain containing 2]]
	[[Category: Aaa+ nuclear coregulator cancer-associated pro2000 protein]]		[[Category: Aaa+ nuclear coregulator cancer-associated pro2000 protein]]
-	[[Category: Alternative splicing]]
	[[Category: Ancca]]		[[Category: Ancca]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Atpase family]]		[[Category: Atpase family]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
-	[[Category: Coiled coil]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
Line 41:		Line 47:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	[[Category: Two aaa domain containing protein]]		[[Category: Two aaa domain containing protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:47:24 2009''

OCA at 10:47, 17 February 2009

OCA — Tue, 17 Feb 2009 10:47:25 GMT

←Older revision		Revision as of 10:47, 17 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3dai.~~jpg~~\|left\|200px]]	+	[[Image:3dai.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	3DAI is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA].	+	3DAI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C.]]
Line 43:		Line 42:
	[[Category: Two aaa domain containing protein]]		[[Category: Two aaa domain containing protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 10 13~~:06:~~18 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:47:24 2009''

OCA at 10:06, 10 September 2008

OCA — Wed, 10 Sep 2008 10:06:18 GMT

←Older revision		Revision as of 10:06, 10 September 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3dai.jpg\|left\|200px]]

-	The ~~entry 3dai~~ is ~~ON HOLD~~ ~~until May 29 2010~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3dai", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3dai\| PDB=3dai \| SCENE= }}

-	~~Authors: Filippakopoulos, P., Keates, T., Picaud, S., Fedorov, O., Roos, A.K., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium~~ (~~SGC~~)	+	===Crystal structure of the bromodomain of the human ATAD2 (CASP Target)===

-	Description: Crystal structure of the bromodomain of the human ATAD2 (CASP Target)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri Jul 11~~ 13:05:52 2008''	+	==About this Structure==
		+	3DAI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAI OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Single protein]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Delft, F Von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Fedorov, O.]]
		+	[[Category: Filippakopoulos, P.]]
		+	[[Category: Keates, T.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Picaud, S.]]
		+	[[Category: Roos, A K.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Aaa domain containing 2]]
		+	[[Category: Aaa+ nuclear coregulator cancer-associated pro2000 protein]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Ancca]]
		+	[[Category: Atp-binding]]
		+	[[Category: Atpase family]]
		+	[[Category: Bromodomain]]
		+	[[Category: Coiled coil]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Sgc]]
		+	[[Category: Signaling protein]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Two aaa domain containing protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 13:06:18 2008''