3ddt - Revision history

OCA at 08:23, 20 March 2024

OCA — Wed, 20 Mar 2024 08:23:50 GMT

←Older revision		Revision as of 08:23, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3ddt' size='340' side='right'caption='[[3ddt]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3ddt' size='340' side='right'caption='[[3ddt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DDT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [~~http~~://pdbe.org/3ddt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ddt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ddt ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [https://pdbe.org/3ddt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [https://www.ebi.ac.uk/pdbsum/3ddt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ddt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>	+	[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ddt ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ddt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The B-box motif is the defining feature of the TRIM family of proteins, characterized by a RING finger-B-box-coiled coil tripartite fold. We have elucidated the crystal structure of B-box 2 (B2) from MuRF1, a TRIM protein that supports a wide variety of protein interactions in the sarcomere and regulates the trophic state of striated muscle tissue. MuRF1 B2 coordinates two zinc ions through a cross-brace alpha/beta-topology typical of members of the RING finger superfamily. However, it self-associates into dimers with high affinity. The dimerization pattern is mediated by the helical component of this fold and is unique among RING-like folds. This B2 reveals a long shallow groove that encircles the C-terminal metal binding site ZnII and appears as the defining protein-protein interaction feature of this domain. A cluster of conserved hydrophobic residues in this groove and, in particular, a highly conserved aromatic residue (Y133 in MuRF1 B2) is likely to be central to this role. We expect these findings to aid the future exploration of the cellular function and therapeutic potential of MuRF1.
-
-	Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold.,Mrosek M, Meier S, Ucurum-Fotiadis Z, von Castelmur E, Hedbom E, Lustig A, Grzesiek S, Labeit D, Labeit S, Mayans O Biochemistry. 2008 Oct 7;47(40):10722-30. Epub 2008 Sep 17. PMID:18795805<ref>PMID:18795805</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3ddt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mayans, O]]	+	[[Category: Mayans O]]
-	[[Category: Mrosek, M]]	+	[[Category: Mrosek M]]
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Muscle protein]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Ring-like fold]]~~	+
-	~~[[Category: Ubl conjugation pathway]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-binding motif]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 06:57, 19 August 2020

OCA — Wed, 19 Aug 2020 06:57:50 GMT

←Older revision		Revision as of 06:57, 19 August 2020
Line 1:		Line 1:

	==Crystal structure of the B2 box from MuRF1 in dimeric state==		==Crystal structure of the B2 box from MuRF1 in dimeric state==
-	<StructureSection load='3ddt' size='340' side='right' caption='[[3ddt]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3ddt' size='340' side='right'caption='[[3ddt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3DDT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://pdbe.org/3ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ddt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://pdbe.org/3ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ddt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:
	==See Also==		==See Also==
	*[[Mur ligase\|Mur ligase]]		*[[Mur ligase\|Mur ligase]]
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mayans, O]]		[[Category: Mayans, O]]
	[[Category: Mrosek, M]]		[[Category: Mrosek, M]]

OCA at 09:49, 14 November 2018

OCA — Wed, 14 Nov 2018 09:49:08 GMT

←Older revision		Revision as of 09:49, 14 November 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/3ddt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/3ddt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:

	==See Also==		==See Also==
		+	*[[Mur ligase\|Mur ligase]]
	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]		*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
Line 38:		Line 39:
	[[Category: Mayans, O]]		[[Category: Mayans, O]]
	[[Category: Mrosek, M]]		[[Category: Mrosek, M]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Muscle protein]]		[[Category: Muscle protein]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
		+	[[Category: Polymorphism]]
	[[Category: Ring-like fold]]		[[Category: Ring-like fold]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
		+	[[Category: Zinc]]
	[[Category: Zinc-binding motif]]		[[Category: Zinc-binding motif]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 15:10, 5 August 2016

OCA — Fri, 05 Aug 2016 15:10:48 GMT

←Older revision		Revision as of 15:10, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the B2 box from MuRF1 in dimeric state==		==Crystal structure of the B2 box from MuRF1 in dimeric state==
	<StructureSection load='3ddt' size='340' side='right' caption='[[3ddt]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3ddt' size='340' side='right' caption='[[3ddt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DDT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://pdbe.org/3ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ddt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ddt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ddt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mayans, O]]		[[Category: Mayans, O]]
	[[Category: Mrosek, M]]		[[Category: Mrosek, M]]

OCA at 19:50, 25 December 2014

OCA — Thu, 25 Dec 2014 19:50:18 GMT

←Older revision		Revision as of 19:50, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:06, 12 November 2014

OCA — Wed, 12 Nov 2014 08:06:13 GMT

←Older revision		Revision as of 08:06, 12 November 2014
Line 1:		Line 1:
-	[[~~Image~~:3ddt.~~png\|left~~\|200px]]	+	==Crystal structure of the B2 box from MuRF1 in dimeric state==
		+	<StructureSection load='3ddt' size='340' side='right' caption='[[3ddt]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DDT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/3ddt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The B-box motif is the defining feature of the TRIM family of proteins, characterized by a RING finger-B-box-coiled coil tripartite fold. We have elucidated the crystal structure of B-box 2 (B2) from MuRF1, a TRIM protein that supports a wide variety of protein interactions in the sarcomere and regulates the trophic state of striated muscle tissue. MuRF1 B2 coordinates two zinc ions through a cross-brace alpha/beta-topology typical of members of the RING finger superfamily. However, it self-associates into dimers with high affinity. The dimerization pattern is mediated by the helical component of this fold and is unique among RING-like folds. This B2 reveals a long shallow groove that encircles the C-terminal metal binding site ZnII and appears as the defining protein-protein interaction feature of this domain. A cluster of conserved hydrophobic residues in this groove and, in particular, a highly conserved aromatic residue (Y133 in MuRF1 B2) is likely to be central to this role. We expect these findings to aid the future exploration of the cellular function and therapeutic potential of MuRF1.

-	~~{{STRUCTURE_3ddt\| PDB=3ddt \| SCENE= }}~~	+	Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold.,Mrosek M, Meier S, Ucurum-Fotiadis Z, von Castelmur E, Hedbom E, Lustig A, Grzesiek S, Labeit D, Labeit S, Mayans O Biochemistry. 2008 Oct 7;47(40):10722-30. Epub 2008 Sep 17. PMID:18795805<ref>PMID:18795805</ref>

-	~~===Crystal structure~~ of the ~~B2 box from MuRF1 in dimeric state===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18795805}}~~	+	==See Also==
-		+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3ddt~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018795805<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Mayans, O.]]	+	[[Category: Mayans, O]]
-	[[Category: Mrosek, M.]]	+	[[Category: Mrosek, M]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]

OCA: Protected "3ddt" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:56:42 GMT

Protected "3ddt" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:56, 7 January 2013

OCA at 18:56, 7 January 2013

OCA — Mon, 07 Jan 2013 18:56:41 GMT

←Older revision		Revision as of 18:56, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ddt.png\|left\|200px]]		[[Image:3ddt.png\|left\|200px]]

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	===Crystal structure of the B2 box from MuRF1 in dimeric state===		===Crystal structure of the B2 box from MuRF1 in dimeric state===

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	==About this Structure==		==About this Structure==
-	~~3DDT~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA].	+	[[3ddt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18795805~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018795805</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mayans, O.]]		[[Category: Mayans, O.]]
	[[Category: Mrosek, M.]]		[[Category: Mrosek, M.]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Muscle protein]]		[[Category: Muscle protein]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
-	[[Category: Polymorphism]]
	[[Category: Ring-like fold]]		[[Category: Ring-like fold]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
-	[[Category: Zinc]]
	[[Category: Zinc-binding motif]]		[[Category: Zinc-binding motif]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
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OCA at 03:13, 18 February 2009

OCA — Wed, 18 Feb 2009 03:13:21 GMT

←Older revision		Revision as of 03:13, 18 February 2009
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	==About this Structure==		==About this Structure==
-	3DDT is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA].	+	3DDT is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA].

	==Reference==		==Reference==
-	Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold., Mrosek M, Meier S, Ucurum-Fotiadis Z, von Castelmur E, Hedbom E, Lustig A, Grzesiek S, Labeit D, Labeit S, Mayans O, Biochemistry. 2008 Oct 7;47(40):10722-30. Epub 2008 Sep 17. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18795805 18795805]~~	+	<ref group="xtra">PMID:18795805</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Mayans, O.]]		[[Category: Mayans, O.]]
	[[Category: Mrosek, M.]]		[[Category: Mrosek, M.]]
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	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

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OCA — Wed, 15 Oct 2008 10:38:37 GMT

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