3dhv - Revision history

OCA at 12:47, 30 August 2023

OCA — Wed, 30 Aug 2023 12:47:23 GMT

←Older revision		Revision as of 12:47, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3dhv' size='340' side='right'caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3dhv' size='340' side='right'caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dhv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baccr Baccr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DHV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dhv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_ATCC_14579 Bacillus cereus ATCC 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DHV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>~~, ~~<scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>dltA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~226900 BACCR])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/~~D-~~alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [https://pdbe.org/3dhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [https://www.ebi.ac.uk/pdbsum/3dhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dhv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [https://pdbe.org/3dhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [https://www.ebi.ac.uk/pdbsum/3dhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dhv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DLTA_BACCR DLTA_BACCR]] Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity).	+	[https://www.uniprot.org/uniprot/DLTA_BACCR DLTA_BACCR] Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Baccr~~]]	+	[[Category: Bacillus cereus ATCC 14579]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Du, L]]	+	[[Category: Du L]]
-	[[Category: He, Y]]	+	[[Category: He Y]]
-	[[Category: Luo, Y]]	+	[[Category: Luo Y]]
-	~~[[Category: Adenylation]]~~	+
-	~~[[Category: Amp-forming domain]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: D-alanine]]~~	+
-	~~[[Category: D-alanine carrier protein ligase]]~~	+
-	~~[[Category: Dlta]]~~	+
-	~~[[Category: Ligase~~]]	+

OCA at 19:23, 20 October 2021

OCA — Wed, 20 Oct 2021 19:23:49 GMT

←Older revision		Revision as of 19:23, 20 October 2021
Line 1:		Line 1:

	==Crystal structure of DltA protein in complex with D-alanine adenylate==		==Crystal structure of DltA protein in complex with D-alanine adenylate==
-	<StructureSection load='3dhv' size='340' side='right' caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3dhv' size='340' side='right'caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dhv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baccr Baccr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DHV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dhv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baccr Baccr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DHV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dltA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 BACCR])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dltA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 BACCR])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/D-alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [~~http~~://pdbe.org/3dhv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dhv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dhv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [https://pdbe.org/3dhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [https://www.ebi.ac.uk/pdbsum/3dhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dhv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DLTA_BACCR DLTA_BACCR]] Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity).	+	[[https://www.uniprot.org/uniprot/DLTA_BACCR DLTA_BACCR]] Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Baccr]]		[[Category: Baccr]]
		+	[[Category: Large Structures]]
	[[Category: Du, L]]		[[Category: Du, L]]
	[[Category: He, Y]]		[[Category: He, Y]]

OCA at 09:46, 14 November 2018

OCA — Wed, 14 Nov 2018 09:46:43 GMT

←Older revision		Revision as of 09:46, 14 November 2018
Line 1:		Line 1:
		+
	==Crystal structure of DltA protein in complex with D-alanine adenylate==		==Crystal structure of DltA protein in complex with D-alanine adenylate==
	<StructureSection load='3dhv' size='340' side='right' caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3dhv' size='340' side='right' caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dltA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 BACCR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dltA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 BACCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [http://pdbe.org/3dhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [http://www.ebi.ac.uk/pdbsum/3dhv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [http://pdbe.org/3dhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [http://www.ebi.ac.uk/pdbsum/3dhv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dhv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/3dhv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/3dhv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 40:
	[[Category: Adenylation]]		[[Category: Adenylation]]
	[[Category: Amp-forming domain]]		[[Category: Amp-forming domain]]
		+	[[Category: Cytoplasm]]
	[[Category: D-alanine]]		[[Category: D-alanine]]
	[[Category: D-alanine carrier protein ligase]]		[[Category: D-alanine carrier protein ligase]]
	[[Category: Dlta]]		[[Category: Dlta]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 09:21, 7 February 2016

OCA — Sun, 07 Feb 2016 09:21:30 GMT

←Older revision		Revision as of 09:21, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3dhv' size='340' side='right' caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3dhv' size='340' side='right' caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dhv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_cereus_atcc_14579 Bacillus cereus atcc 14579~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DHV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dhv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baccr Baccr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DHV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dltA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 ~~Bacillus cereus ATCC 14579~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dltA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 BACCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [http://www.ebi.ac.uk/pdbsum/3dhv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [http://pdbe.org/3dhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [http://www.ebi.ac.uk/pdbsum/3dhv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dhv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3dhv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus cereus atcc 14579~~]]	+	[[Category: Baccr]]
	[[Category: Du, L]]		[[Category: Du, L]]
	[[Category: He, Y]]		[[Category: He, Y]]

OCA at 14:00, 24 December 2014

OCA — Wed, 24 Dec 2014 14:00:38 GMT

←Older revision		Revision as of 14:00, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [http://www.ebi.ac.uk/pdbsum/3dhv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [http://www.ebi.ac.uk/pdbsum/3dhv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DLTA_BACCR DLTA_BACCR]] Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:03, 18 December 2014

OCA — Thu, 18 Dec 2014 14:03:26 GMT

←Older revision		Revision as of 14:03, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3dhv~~\| ~~PDB~~=3dhv \| ~~SCENE~~= }}	+	==Crystal structure of DltA protein in complex with D-alanine adenylate==
-	===~~Crystal~~ structure of DltA protein in complex with D-alanine adenylate~~===~~	+	<StructureSection load='3dhv' size='340' side='right' caption='[[3dhv]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18847223}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3dhv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus_atcc_14579 Bacillus cereus atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DHV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dltA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 Bacillus cereus ATCC 14579])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-alanine--poly(phosphoribitol)_ligase D-alanine--poly(phosphoribitol) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.13 6.1.1.13] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dhv RCSB], [http://www.ebi.ac.uk/pdbsum/3dhv PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/3dhv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ubiquitous D-alanylation of lipoteichoic acids modulates the surface charge and ligand binding of the gram-positive cell wall. Disruption of the bacterial DltABCD gene involved in teichoic acid alanylation, as well as inhibition of the DltA protein, has been shown to increase a gram-positive bacterium's susceptibility to antibiotics. The DltA D-alanyl carrier protein ligase promotes a two-step process starting with adenylation of D-alanine. We have determined the 2.0 A resolution crystal structure of a DltA protein from Bacillus cereus in complex with the D-alanine adenylate intermediate of the first reaction. Despite the low level of sequence similarity, the DltA structure resembles known structures of adenylation domains such as the acetyl-CoA synthetase. The enantiomer selection appears to be enhanced by the medium-sized side chain of Cys-269. The Ala-269 mutant protein shows marked loss of such selection. The network of noncovalent interactions between the D-alanine adenylate and DltA provides structure-based rationale for aiding the design of tight-binding DltA inhibitors for combating infectious gram-positive bacteria such as the notorious methicillin-resistant Staphylococcus aureus.

-	~~==Function==~~	+	Crystal structure and enantiomer selection by D-alanyl carrier protein ligase DltA from Bacillus cereus.,Du L, He Y, Luo Y Biochemistry. 2008 Nov 4;47(44):11473-80. Epub 2008 Oct 11. PMID:18847223<ref>PMID:18847223</ref>
-	~~[[http://www.uniprot.org/uniprot/DLTA_BACCR DLTA_BACCR]] Involved in the biosynthesis of~~ D-alanyl~~-lipoteichoic acid~~ (~~LTA~~)~~. Catalyzes an ATP~~-~~dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3dhv]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_cereus_atcc_14579 Bacillus cereus atcc 14579]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018847223</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus cereus atcc 14579]]		[[Category: Bacillus cereus atcc 14579]]
-	[[Category: Du, L.]]	+	[[Category: Du, L]]
-	[[Category: He, Y.]]	+	[[Category: He, Y]]
-	[[Category: Luo, Y.]]	+	[[Category: Luo, Y]]
	[[Category: Adenylation]]		[[Category: Adenylation]]
	[[Category: Amp-forming domain]]		[[Category: Amp-forming domain]]

OCA at 11:07, 3 July 2013

OCA — Wed, 03 Jul 2013 11:07:12 GMT

←Older revision		Revision as of 11:07, 3 July 2013
Line 1:		Line 1:
-	[[Image:3dhv.png\|left\|200px]]
-
	{{STRUCTURE_3dhv\| PDB=3dhv \| SCENE= }}		{{STRUCTURE_3dhv\| PDB=3dhv \| SCENE= }}
-
	===Crystal structure of DltA protein in complex with D-alanine adenylate===		===Crystal structure of DltA protein in complex with D-alanine adenylate===
		+	{{ABSTRACT_PUBMED_18847223}}

-	~~{{ABSTRACT_PUBMED_18847223}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DLTA_BACCR DLTA_BACCR]] Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity).

	==About this Structure==		==About this Structure==
-	[[3dhv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_cereus~~ Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA].	+	[[3dhv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus_atcc_14579 Bacillus cereus atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018847223</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018847223</ref><references group="xtra"/><references/>
-	[[Category: Bacillus cereus]]	+	[[Category: Bacillus cereus atcc 14579]]
	[[Category: Du, L.]]		[[Category: Du, L.]]
	[[Category: He, Y.]]		[[Category: He, Y.]]

OCA: Protected "3dhv" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:20:08 GMT

Protected "3dhv" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:20, 7 January 2013

OCA at 20:20, 7 January 2013

OCA — Mon, 07 Jan 2013 20:20:06 GMT

←Older revision		Revision as of 20:20, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3dhv.png\|left\|200px]]		[[Image:3dhv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3dhv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3dhv\| PDB=3dhv \| SCENE= }}		{{STRUCTURE_3dhv\| PDB=3dhv \| SCENE= }}

	===Crystal structure of DltA protein in complex with D-alanine adenylate===		===Crystal structure of DltA protein in complex with D-alanine adenylate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18847223}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18847223 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18847223}}		{{ABSTRACT_PUBMED_18847223}}

	==About this Structure==		==About this Structure==
-	~~3DHV~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA].	+	[[3dhv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18847223~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018847223</ref><references group="xtra"/>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
	[[Category: Du, L.]]		[[Category: Du, L.]]
Line 30:		Line 18:
	[[Category: Adenylation]]		[[Category: Adenylation]]
	[[Category: Amp-forming domain]]		[[Category: Amp-forming domain]]
-	[[Category: Cytoplasm]]
	[[Category: D-alanine]]		[[Category: D-alanine]]
	[[Category: D-alanine carrier protein ligase]]		[[Category: D-alanine carrier protein ligase]]
	[[Category: Dlta]]		[[Category: Dlta]]
-		+	[[Category: Ligase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 12:51:37 2009''~~	+

OCA at 10:51, 16 February 2009

OCA — Mon, 16 Feb 2009 10:51:38 GMT

←Older revision		Revision as of 10:51, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3DHV is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA].	+	3DHV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHV OCA].

	==Reference==		==Reference==
-	~~Crystal structure and enantiomer selection by D-alanyl carrier protein ligase DltA from Bacillus cereus., Du L, He Y, Luo Y, Biochemistry. 2008 Nov 4;47(44):11473-80. Epub 2008 Oct 11.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18847223 18847223]~~	+	<ref group="xtra">PMID:18847223</ref><references group="xtra"/>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
-	[[Category: Single protein]]
	[[Category: Du, L.]]		[[Category: Du, L.]]
	[[Category: He, Y.]]		[[Category: He, Y.]]
Line 36:		Line 35:
	[[Category: Dlta]]		[[Category: Dlta]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 12 20:30:~~40 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:51:37 2009''