3dj9 - Revision history

OCA at 12:47, 30 August 2023

OCA — Wed, 30 Aug 2023 12:47:52 GMT

←Older revision		Revision as of 12:47, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3dj9' size='340' side='right'caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3dj9' size='340' side='right'caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">IGHG1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [https://pdbe.org/3dj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [https://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [https://pdbe.org/3dj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [https://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.	+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dimitrov~~, D S~~]]	+	[[Category: Dimitrov DS]]
-	[[Category: Gan, J]]	+	[[Category: Gan J]]
-	[[Category: Ji, X]]	+	[[Category: Ji X]]
-	[[Category: Prabakaran, P]]	+	[[Category: Prabakaran P]]
-	[[Category: Vu~~, B K]]~~	+	[[Category: Vu BK]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Ch2 domain]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Immunoglobulin c region]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 07:59, 9 February 2022

OCA — Wed, 09 Feb 2022 07:59:49 GMT

←Older revision		Revision as of 07:59, 9 February 2022
Line 1:		Line 1:

	==Crystal Structure of an isolated, unglycosylated antibody CH2 domain==		==Crystal Structure of an isolated, unglycosylated antibody CH2 domain==
-	<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='3dj9' size='340' side='right'caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [~~http~~://pdbe.org/3dj9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [https://pdbe.org/3dj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [https://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[~~http~~://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.	+	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dimitrov, D S]]		[[Category: Dimitrov, D S]]
	[[Category: Gan, J]]		[[Category: Gan, J]]

OCA at 09:30, 14 November 2018

OCA — Wed, 14 Nov 2018 09:30:38 GMT

←Older revision		Revision as of 09:30, 14 November 2018
Line 3:		Line 3:
	<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [http://pdbe.org/3dj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [http://pdbe.org/3dj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/3dj9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/3dj9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Dimitrov, D S]]		[[Category: Dimitrov, D S]]
	[[Category: Gan, J]]		[[Category: Gan, J]]

OCA at 14:47, 22 December 2016

OCA — Thu, 22 Dec 2016 14:47:09 GMT

←Older revision		Revision as of 14:47, 22 December 2016
Line 1:		Line 1:

-	==~~Crytal~~ Structure of an isolated, unglycosylated antibody CH2 domain==	+	==Crystal Structure of an isolated, unglycosylated antibody CH2 domain==
	<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [http://pdbe.org/3dj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [http://pdbe.org/3dj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>
	</table>		</table>
Line 33:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Dimitrov, D S]]		[[Category: Dimitrov, D S]]
	[[Category: Gan, J]]		[[Category: Gan, J]]

OCA at 12:09, 5 August 2016

OCA — Fri, 05 Aug 2016 12:09:18 GMT

←Older revision		Revision as of 12:09, 5 August 2016
Line 1:		Line 1:
		+
	==Crytal Structure of an isolated, unglycosylated antibody CH2 domain==		==Crytal Structure of an isolated, unglycosylated antibody CH2 domain==
	<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [http://pdbe.org/3dj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dj9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3dj9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dimitrov, D S]]		[[Category: Dimitrov, D S]]
	[[Category: Gan, J]]		[[Category: Gan, J]]

OCA at 18:42, 25 December 2014

OCA — Thu, 25 Dec 2014 18:42:49 GMT

←Older revision		Revision as of 18:42, 25 December 2014
Line 9:		Line 9:
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.		[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
-	== Function ==
-
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:38, 18 December 2014

OCA — Thu, 18 Dec 2014 13:38:55 GMT

←Older revision		Revision as of 13:38, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3dj9\| PDB=3dj9 \| SCENE= }}~~	+	==Crytal Structure of an isolated, unglycosylated antibody CH2 domain==
-	===Crytal Structure of an isolated, unglycosylated antibody CH2 domain===	+	<StructureSection load='3dj9' size='340' side='right' caption='[[3dj9]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18931413}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3dj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ9 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hzh\|1hzh]], [[1oqo\|1oqo]], [[2dtq\|2dtq]], [[2dts\|2dts]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dj9 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj9 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.		[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	== Function ==
		+
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/3dj9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The C(H)2 (C(H)3 for IgM and IgE) domain of an antibody plays an important role in mediating effector functions and preserving antibody stability. It is the only domain in human immunoglobulins (Igs) which is involved in weak interchain protein-protein interactions with another C(H)2 domain solely through sugar moieties. The N-linked glycosylation at Asn297 is conserved in mammalian IgGs as well as in homologous regions of other antibody isotypes. To examine the structural details of the C(H)2 domain in the absence of glycosylation and other antibody domains, the crystal structure of an isolated unglycosylated antibody gamma1 C(H)2 domain was determined at 1.7 A resolution and compared with corresponding C(H)2 structures from intact Fc, IgG and Fc receptor complexes. Furthermore, the oligomeric state of the protein in solution was studied using size-exclusion chromatography. The results suggested that the unglycosylated human antibody C(H)2 domain is a monomer and that its structure is similar to that found in the intact Fc, IgG and Fc receptor complex structures. However, certain structural variations were observed in the Fc receptor-binding sites. Owing to its small size, stability and non-immunogenic Ig template, the C(H)2-domain structure could be useful for the development by protein design of antibody domains exerting effector functions and/or antigen specificity and as a robust scaffold in protein-engineering applications.
		+
		+	Structure of an isolated unglycosylated antibody C(H)2 domain.,Prabakaran P, Vu BK, Gan J, Feng Y, Dimitrov DS, Ji X Acta Crystallogr D Biol Crystallogr. 2008 Oct;64(Pt 10):1062-7. Epub 2008, Sep 19. PMID:18931413<ref>PMID:18931413</ref>

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3dj9]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA].~~	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dimitrov, D S.]]	+	[[Category: Dimitrov, D S]]
-	[[Category: Gan, J.]]	+	[[Category: Gan, J]]
-	[[Category: Ji, X.]]	+	[[Category: Ji, X]]
-	[[Category: Prabakaran, P.]]	+	[[Category: Prabakaran, P]]
-	[[Category: Vu, B K.]]	+	[[Category: Vu, B K]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Ch2 domain]]		[[Category: Ch2 domain]]

OCA at 21:55, 24 March 2013

OCA — Sun, 24 Mar 2013 21:55:15 GMT

←Older revision		Revision as of 21:55, 24 March 2013
Line 1:		Line 1:
-	[[Image:3dj9.png\|left\|200px]]
-
	{{STRUCTURE_3dj9\| PDB=3dj9 \| SCENE= }}		{{STRUCTURE_3dj9\| PDB=3dj9 \| SCENE= }}
-
	===Crytal Structure of an isolated, unglycosylated antibody CH2 domain===		===Crytal Structure of an isolated, unglycosylated antibody CH2 domain===
		+	{{ABSTRACT_PUBMED_18931413}}

-	~~{{ABSTRACT_PUBMED_18931413}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

	==About this Structure==		==About this Structure==

OCA: Protected "3dj9" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 05:18:34 GMT

Protected "3dj9" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 5 September 2012

OCA at 05:18, 5 September 2012

OCA — Wed, 05 Sep 2012 05:18:31 GMT

←Older revision		Revision as of 05:18, 5 September 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3dj9.png\|left\|200px]]		[[Image:3dj9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3dj9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3dj9\| PDB=3dj9 \| SCENE= }}		{{STRUCTURE_3dj9\| PDB=3dj9 \| SCENE= }}

	===Crytal Structure of an isolated, unglycosylated antibody CH2 domain===		===Crytal Structure of an isolated, unglycosylated antibody CH2 domain===

		+	{{ABSTRACT_PUBMED_18931413}}

	==About this Structure==		==About this Structure==
-	~~3DJ9~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA].	+	[[3dj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ9 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dimitrov, D S.]]		[[Category: Dimitrov, D S.]]
Line 23:		Line 17:
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Ch2 domain]]		[[Category: Ch2 domain]]
-	[[Category: Chromosomal rearrangement]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Immune system]]		[[Category: Immune system]]
Line 30:		Line 23:
	[[Category: Immunoglobulin domain]]		[[Category: Immunoglobulin domain]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:51:04 2009''