3dms - Revision history

OCA at 09:42, 21 February 2024

OCA — Wed, 21 Feb 2024 09:42:16 GMT

←Older revision		Revision as of 09:42, 21 February 2024
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	<StructureSection load='3dms' size='340' side='right'caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3dms' size='340' side='right'caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dms]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pseudomallei"_whitmore_1913 "bacillus~~ pseudomallei~~" whitmore 1913~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DMS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dms]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DMS FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>icd, BPSL0896 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~28450~~ "~~Bacillus pseudomallei~~" ~~Whitmore 1913])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'~~>[~~https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~1.~~1.1.42 1.1.1.42] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [https://pdbe.org/3dms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [https://www.ebi.ac.uk/pdbsum/3dms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dms ProSAT], [https://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [https://pdbe.org/3dms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [https://www.ebi.ac.uk/pdbsum/3dms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dms ProSAT], [https://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3JV82_BURP1 Q3JV82_BURP1]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dms ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dms ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Isocitrate dehydrogenase kinase/phosphatase (AceK) regulates entry into the glyoxylate bypass by reversibly phosphorylating isocitrate dehydrogenase (ICDH). On the basis of the recently determined structure of the AceK-ICDH complex from Escherichia coli, we have classified the structures of homodimeric NADP(+)-ICDHs to rationalize and predict which organisms likely contain substrates for AceK. One example is Burkholderia pseudomallei (Bp). Here we report a crystal structure of Bp-ICDH that exhibits the necessary structural elements required for AceK recognition. Kinetic analyses provided further confirmation that Bp-ICDH is a substrate for AceK. We conclude that the highly stringent AceK binding sites on ICDH are maintained only in Gram-negative bacteria.
-
-	Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.,Yates SP, Edwards TE, Bryan CM, Stein AJ, Van Voorhis WC, Myler PJ, Stewart LJ, Zheng J, Jia Z Biochemistry. 2011 Sep 27;50(38):8103-6. Epub 2011 Sep 2. PMID:21870819<ref>PMID:21870819</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3dms" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Isocitrate dehydrogenase 3D structures\|Isocitrate dehydrogenase 3D structures]]		*[[Isocitrate dehydrogenase 3D structures\|Isocitrate dehydrogenase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ pseudomallei ~~whitmore 1913~~]]	+	[[Category: Burkholderia pseudomallei]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Structural genomic]]
-	[[Category: Burkholderia]]
-	[[Category: Dehydrogenase]]
-	[[Category: Glyoxylate bypass]]
-	[[Category: Isocitrate]]
-	[[Category: Manganese]]
-	[[Category: Metal-binding]]
-	[[Category: Nadp]]
-	[[Category: Oxidoreductase]]
-	[[Category: Pseudomallei]]
-	[[Category: Ssgcid]]
-	[[Category: Tricarboxylic acid cycle]]

OCA at 08:02, 9 February 2022

OCA — Wed, 09 Feb 2022 08:02:59 GMT

←Older revision		Revision as of 08:02, 9 February 2022
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	==1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei==		==1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei==
-	<StructureSection load='3dms' size='340' side='right' caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='3dms' size='340' side='right'caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dms]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DMS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dms]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DMS FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icd, BPSL0896 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icd, BPSL0896 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [~~http~~://pdbe.org/3dms PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dms PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dms ProSAT], [~~http~~://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [https://pdbe.org/3dms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [https://www.ebi.ac.uk/pdbsum/3dms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dms ProSAT], [https://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/3dms_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/3dms_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 3dms" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3dms" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Isocitrate dehydrogenase 3D structures\|Isocitrate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus pseudomallei whitmore 1913]]		[[Category: Bacillus pseudomallei whitmore 1913]]
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Burkholderia]]		[[Category: Burkholderia]]

OCA at 06:54, 25 October 2017

OCA — Wed, 25 Oct 2017 06:54:03 GMT

←Older revision		Revision as of 06:54, 25 October 2017
Line 1:		Line 1:
		+
	==1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei==		==1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei==
	<StructureSection load='3dms' size='340' side='right' caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3dms' size='340' side='right' caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>
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	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icd, BPSL0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icd, BPSL0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [http://pdbe.org/3dms PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [http://www.ebi.ac.uk/pdbsum/3dms PDBsum], [http://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [http://pdbe.org/3dms PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [http://www.ebi.ac.uk/pdbsum/3dms PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dms ProSAT], [http://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 3dms" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3dms" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:37, 8 February 2016

OCA — Mon, 08 Feb 2016 03:37:12 GMT

←Older revision		Revision as of 03:37, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3dms' size='340' side='right' caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3dms' size='340' side='right' caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dms]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_pseudomallei Burkholderia~~ pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DMS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dms]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DMS FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icd, BPSL0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 ~~Burkholderia~~ pseudomallei])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icd, BPSL0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [http://www.ebi.ac.uk/pdbsum/3dms PDBsum], [http://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [http://pdbe.org/3dms PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [http://www.ebi.ac.uk/pdbsum/3dms PDBsum], [http://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dms ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3dms" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burkholderia~~ pseudomallei]]	+	[[Category: Bacillus pseudomallei whitmore 1913]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Burkholderia]]		[[Category: Burkholderia]]

OCA at 17:43, 21 December 2014

OCA — Sun, 21 Dec 2014 17:43:34 GMT

←Older revision		Revision as of 17:43, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3dms~~\| ~~PDB~~=3dms \| ~~SCENE~~= }}	+	==1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei==
-	===1.~~65A crystal~~ structure of ~~isocitrate dehydrogenase~~ from ~~Burkholderia pseudomallei~~===	+	<StructureSection load='3dms' size='340' side='right' caption='[[3dms]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21870819}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3dms]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DMS FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icd, BPSL0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dms OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dms RCSB], [http://www.ebi.ac.uk/pdbsum/3dms PDBsum], [http://www.topsan.org/Proteins/SSGCID/3dms TOPSAN]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/3dms_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Isocitrate dehydrogenase kinase/phosphatase (AceK) regulates entry into the glyoxylate bypass by reversibly phosphorylating isocitrate dehydrogenase (ICDH). On the basis of the recently determined structure of the AceK-ICDH complex from Escherichia coli, we have classified the structures of homodimeric NADP(+)-ICDHs to rationalize and predict which organisms likely contain substrates for AceK. One example is Burkholderia pseudomallei (Bp). Here we report a crystal structure of Bp-ICDH that exhibits the necessary structural elements required for AceK recognition. Kinetic analyses provided further confirmation that Bp-ICDH is a substrate for AceK. We conclude that the highly stringent AceK binding sites on ICDH are maintained only in Gram-negative bacteria.

-	~~==About this Structure==~~	+	Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.,Yates SP, Edwards TE, Bryan CM, Stein AJ, Van Voorhis WC, Myler PJ, Stewart LJ, Zheng J, Jia Z Biochemistry. 2011 Sep 27;50(38):8103-6. Epub 2011 Sep 2. PMID:21870819<ref>PMID:21870819</ref>
-	~~[[3dms]] is a 1 chain structure with sequence from [http:/~~/en.~~wikipedia~~.~~org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3DMS OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
-	*[[Ferguson sandbox 1\|Ferguson sandbox 1]]
	*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]		*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021870819</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Burkholderia]]		[[Category: Burkholderia]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
Line 23:		Line 43:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Pseudomallei]]		[[Category: Pseudomallei]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Tricarboxylic acid cycle]]		[[Category: Tricarboxylic acid cycle]]

OCA at 08:10, 30 October 2013

OCA — Wed, 30 Oct 2013 08:10:36 GMT

←Older revision		Revision as of 08:10, 30 October 2013
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-	[[Image:3dms.png\|left\|200px]]
-
	{{STRUCTURE_3dms\| PDB=3dms \| SCENE= }}		{{STRUCTURE_3dms\| PDB=3dms \| SCENE= }}
-
	===1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei===		===1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei===
-
	{{ABSTRACT_PUBMED_21870819}}		{{ABSTRACT_PUBMED_21870819}}

Line 15:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021870819</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021870819</ref><references group="xtra"/><references/>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 08:46, 20 October 2012

OCA — Sat, 20 Oct 2012 08:46:30 GMT

←Older revision		Revision as of 08:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3dms]] is a 1 chain structure ~~of [[Ferguson sandbox 1]] and [[Isocitrate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA].	+	[[3dms]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA].

	==See Also==		==See Also==

OCA at 20:42, 25 July 2012

OCA — Wed, 25 Jul 2012 20:42:55 GMT

←Older revision		Revision as of 20:42, 25 July 2012
Line 1:		Line 1:
	[[Image:3dms.png\|left\|200px]]		[[Image:3dms.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3dms", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3dms\| PDB=3dms \| SCENE= }}		{{STRUCTURE_3dms\| PDB=3dms \| SCENE= }}

	===1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei===		===1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21870819}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21870819 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21870819}}		{{ABSTRACT_PUBMED_21870819}}

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	==See Also==		==See Also==
-	*[[Ferguson sandbox 1]]	+	*[[Ferguson sandbox 1\|Ferguson sandbox 1]]
-	*[[Isocitrate dehydrogenase]]	+	*[[Isocitrate dehydrogenase\|Isocitrate dehydrogenase]]

	==Reference==		==Reference==

OCA at 05:36, 5 October 2011

OCA — Wed, 05 Oct 2011 05:36:20 GMT

←Older revision		Revision as of 05:36, 5 October 2011
Line 11:		Line 11:
	===1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei===		===1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21870819}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21870819 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21870819}}

	==About this Structure==		==About this Structure==
-	[[3dms]] is a 1 chain structure of [[Isocitrate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA].	+	[[3dms]] is a 1 chain structure of [[Ferguson sandbox 1]] and [[Isocitrate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMS OCA].

	==See Also==		==See Also==
		+	*[[Ferguson sandbox 1]]
	*[[Isocitrate dehydrogenase]]		*[[Isocitrate dehydrogenase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021870819</ref><references group="xtra"/>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA: Protected "3dms" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 00:53:13 GMT

Protected "3dms" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:53, 27 December 2010