3dre - Revision history

OCA at 08:24, 20 March 2024

OCA — Wed, 20 Mar 2024 08:24:21 GMT

←Older revision		Revision as of 08:24, 20 March 2024
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	<StructureSection load='3dre' size='340' side='right'caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dre' size='340' side='right'caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DRE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[3b6r\|3b6r]]~~, [[~~3drb~~\|~~3drb~~]]~~</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2~~.7.3~~.2 ~~2.7.3.2] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [https://pdbe.org/3dre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [https://www.ebi.ac.uk/pdbsum/3dre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dre ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [https://pdbe.org/3dre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [https://www.ebi.ac.uk/pdbsum/3dre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dre ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KCRB_HUMAN KCRB_HUMAN]] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	+	[https://www.uniprot.org/uniprot/KCRB_HUMAN KCRB_HUMAN] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dre ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dre ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Creatine kinase is a member of the phosphagen kinase family, which catalyzes the reversible phosphoryl transfer reaction that occurs between ATP and creatine to produce ADP and phosphocreatine. Here, three structural aspects of human-brain-type-creatine-kinase (hBB-CK) were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A. The structures of ligand-bound hBB-CK revealed two different monomeric states in a single homodimer. One monomer is a closed form, either bound to TSAC or the ADP-Mg2+-complex, and the second monomer is an unliganded open form. These structural studies provide a detailed mechanism indicating that the binding of ADP-Mg2+ alone may trigger conformational changes in hBB-CK that were not observed with muscle-type-CK.
-
-	Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex.,Bong SM, Moon JH, Nam KH, Lee KS, Chi YM, Hwang KY FEBS Lett. 2008 Nov 26;582(28):3959-65. Epub 2008 Oct 31. PMID:18977227<ref>PMID:18977227</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3dre" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Creatine kinase 3D structures\|Creatine kinase 3D structures]]		*[[Creatine kinase 3D structures\|Creatine kinase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Creatine kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bong~~, S M~~]]	+	[[Category: Bong SM]]
-	[[Category: Chi~~, Y M~~]]	+	[[Category: Chi YM]]
-	[[Category: Hwang~~, K Y~~]]	+	[[Category: Hwang KY]]
-	[[Category: Moon~~, J H]]~~	+	[[Category: Moon JH]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:06, 9 February 2022

OCA — Wed, 09 Feb 2022 08:06:08 GMT

←Older revision		Revision as of 08:06, 9 February 2022
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	<StructureSection load='3dre' size='340' side='right'caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dre' size='340' side='right'caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DRE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b6r\|3b6r]], [[3drb\|3drb]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [~~http~~://pdbe.org/3dre PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dre PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dre ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [https://pdbe.org/3dre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [https://www.ebi.ac.uk/pdbsum/3dre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dre ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KCRB_HUMAN KCRB_HUMAN]] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	+	[[https://www.uniprot.org/uniprot/KCRB_HUMAN KCRB_HUMAN]] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:57, 31 July 2019

OCA — Wed, 31 Jul 2019 07:57:02 GMT

←Older revision		Revision as of 07:57, 31 July 2019
Line 1:		Line 1:

	==Crystal structure of Human Brain-type Creatine Kinase==		==Crystal structure of Human Brain-type Creatine Kinase==
-	<StructureSection load='3dre' size='340' side='right' caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3dre' size='340' side='right'caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRE FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dre_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dre_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3dre" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3dre" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Creatine kinase 3D structures\|Creatine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Creatine kinase]]		[[Category: Creatine kinase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bong, S M]]		[[Category: Bong, S M]]
	[[Category: Chi, Y M]]		[[Category: Chi, Y M]]

OCA at 08:55, 25 October 2017

OCA — Wed, 25 Oct 2017 08:55:16 GMT

←Older revision		Revision as of 08:55, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of Human Brain-type Creatine Kinase==		==Crystal structure of Human Brain-type Creatine Kinase==
	<StructureSection load='3dre' size='340' side='right' caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dre' size='340' side='right' caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [http://pdbe.org/3dre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [http://www.ebi.ac.uk/pdbsum/3dre PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [http://pdbe.org/3dre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [http://www.ebi.ac.uk/pdbsum/3dre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dre ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3dre" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3dre" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Creatine Kinase\|Creatine Kinase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Moon, J H]]		[[Category: Moon, J H]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
		+	[[Category: Cytoplasm]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 12:14, 9 February 2016

OCA — Tue, 09 Feb 2016 12:14:03 GMT

←Older revision		Revision as of 12:14, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3dre' size='340' side='right' caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dre' size='340' side='right' caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [http://www.ebi.ac.uk/pdbsum/3dre PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [http://pdbe.org/3dre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [http://www.ebi.ac.uk/pdbsum/3dre PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dre ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3dre" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Creatine kinase]]		[[Category: Creatine kinase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bong, S M]]		[[Category: Bong, S M]]
	[[Category: Chi, Y M]]		[[Category: Chi, Y M]]
Line 41:		Line 42:
	[[Category: Moon, J H]]		[[Category: Moon, J H]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
-	[[Category: Human]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:44, 25 December 2014

OCA — Thu, 25 Dec 2014 06:44:47 GMT

←Older revision		Revision as of 06:44, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [http://www.ebi.ac.uk/pdbsum/3dre PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [http://www.ebi.ac.uk/pdbsum/3dre PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCRB_HUMAN KCRB_HUMAN]] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Creatine kinase]]		[[Category: Creatine kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bong, S M.]]	+	[[Category: Bong, S M]]
-	[[Category: Chi, Y M.]]	+	[[Category: Chi, Y M]]
-	[[Category: Hwang, K Y.]]	+	[[Category: Hwang, K Y]]
-	[[Category: Moon, J H.]]	+	[[Category: Moon, J H]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
-	[[Category: Creatine kinase]]
	[[Category: Human]]		[[Category: Human]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 13:32, 29 September 2014

OCA — Mon, 29 Sep 2014 13:32:35 GMT

←Older revision		Revision as of 13:32, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3dre.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Human Brain-type Creatine Kinase==
		+	<StructureSection load='3dre' size='340' side='right' caption='[[3dre]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b6r\|3b6r]], [[3drb\|3drb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dre RCSB], [http://www.ebi.ac.uk/pdbsum/3dre PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dre_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Creatine kinase is a member of the phosphagen kinase family, which catalyzes the reversible phosphoryl transfer reaction that occurs between ATP and creatine to produce ADP and phosphocreatine. Here, three structural aspects of human-brain-type-creatine-kinase (hBB-CK) were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A. The structures of ligand-bound hBB-CK revealed two different monomeric states in a single homodimer. One monomer is a closed form, either bound to TSAC or the ADP-Mg2+-complex, and the second monomer is an unliganded open form. These structural studies provide a detailed mechanism indicating that the binding of ADP-Mg2+ alone may trigger conformational changes in hBB-CK that were not observed with muscle-type-CK.

-	~~{{STRUCTURE_3dre\| PDB=3dre \| SCENE= }}~~	+	Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex.,Bong SM, Moon JH, Nam KH, Lee KS, Chi YM, Hwang KY FEBS Lett. 2008 Nov 26;582(28):3959-65. Epub 2008 Oct 31. PMID:18977227<ref>PMID:18977227</ref>

-	~~===Crystal structure~~ of ~~Human Brain-type Creatine Kinase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18977227}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3dre]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA].~~	+

	==See Also==		==See Also==
	*[[Creatine Kinase\|Creatine Kinase]]		*[[Creatine Kinase\|Creatine Kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018977227<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Creatine kinase]]		[[Category: Creatine kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 13:48, 20 October 2012

OCA — Sat, 20 Oct 2012 13:48:05 GMT

←Older revision		Revision as of 13:48, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3dre]] is a 2 chain structure ~~of [[Creatine Kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA].	+	[[3dre]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA].

	==See Also==		==See Also==

OCA: Protected "3dre" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 13:09:07 GMT

Protected "3dre" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 26 July 2012

OCA at 13:09, 26 July 2012

OCA — Thu, 26 Jul 2012 13:09:06 GMT

←Older revision		Revision as of 13:09, 26 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3dre.png\|left\|200px]]

-	~~The entry~~ 3dre ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3dre\| PDB=3dre \| SCENE= }}

-	~~Authors: Moon, J.H., Bong, S.M., Hwang, K.Y., Chi, Y.M.~~	+	===Crystal structure of Human Brain-type Creatine Kinase===

-	~~Description: Crystal structure of Human Brain-type Creatine Kinase~~	+	{{ABSTRACT_PUBMED_18977227}}

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Aug 27 10~~:58:~~35 2008''~~	+	==About this Structure==
		+	[[3dre]] is a 2 chain structure of [[Creatine Kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRE OCA].
		+
		+	==See Also==
		+	*[[Creatine Kinase\|Creatine Kinase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:018977227</ref><references group="xtra"/>
		+	[[Category: Creatine kinase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Bong, S M.]]
		+	[[Category: Chi, Y M.]]
		+	[[Category: Hwang, K Y.]]
		+	[[Category: Moon, J H.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Creatine kinase]]
		+	[[Category: Human]]
		+	[[Category: Kinase]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Transferase]]