3dyd - Revision history

OCA at 12:55, 30 August 2023

OCA — Wed, 30 Aug 2023 12:55:01 GMT

←Older revision		Revision as of 12:55, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3dyd' size='340' side='right'caption='[[3dyd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3dyd' size='340' side='right'caption='[[3dyd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DYD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PLP:PYRIDOXAL~~-~~5-PHOSPHATE'>PLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TAT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.6.1.~~5 ~~2.6.1.5]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [https://pdbe.org/3dyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [https://www.ebi.ac.uk/pdbsum/3dyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [https://pdbe.org/3dyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [https://www.ebi.ac.uk/pdbsum/3dyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[https://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>	+	[https://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[https://omim.org/entry/276600 276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref> <ref>PMID:16640556</ref>	+	[https://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref> <ref>PMID:16640556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Tyrosine transaminase]]~~	+	[[Category: Andersson J]]
-	[[Category: Andersson, J]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Berglund H]]
-	~~[[Category: Berg, S Van Den~~]]	+	[[Category: Collins R]]
-	[[Category: Berglund, H]]	+	[[Category: Dahlgren LG]]
-	[[Category: Collins, R]]	+	[[Category: Edwards AM]]
-	[[Category: Dahlgren~~, L G~~]]	+	[[Category: Flodin S]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Flores A]]
-	[[Category: Flodin, S]]	+	[[Category: Graslund S]]
-	[[Category: Flores, A]]	+	[[Category: Hammarstrom M]]
-	[[Category: Graslund, S]]	+	[[Category: Johansson A]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Johansson I]]
-	[[Category: Johansson, A]]	+	[[Category: Karlberg T]]
-	[[Category: Johansson, I]]	+	[[Category: Kotenyova T]]
-	[[Category: Karlberg, T]]	+	[[Category: Lehtio L]]
-	[[Category: Kotenyova, T]]	+	[[Category: Moche M]]
-	[[Category: Lehtio, L]]	+	[[Category: Nilsson ME]]
-	[[Category: Moche, M]]	+	[[Category: Nordlund P]]
-	[[Category: Nilsson~~, M E~~]]	+	[[Category: Nyman T]]
-	[[Category: Nordlund, P]]	+	[[Category: Olesen K]]
-	[[Category: Nyman, T]]	+	[[Category: Persson C]]
-	[[Category: Olesen, K]]	+	[[Category: Sagemark J]]
-	[[Category: Persson, C]]	+	[[Category: Schuler H]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Thorsell AG]]
-	[[Category: Sagemark, J]]	+	[[Category: Tresaugues L]]
-	[[Category: Schuler, H]]	+	[[Category: Van Den Berg S]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Weigelt J]]
-	[[Category: Tresaugues, L]]	+	[[Category: Welin M]]
-	[[Category: ~~Weigelt, J~~]]	+	[[Category: Wikstrom M]]
-	[[Category: ~~Welin, M~~]]	+	[[Category: Wisniewska M]]
-	[[Category: ~~Wikstrom,~~ M]]	+
-	[[Category: ~~Wisniewska,~~ M]]	+
-	[[Category: ~~Aminotransferase]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Phenylalanine catabolism]]~~	+
-	~~[[Category: Plp]]~~	+
-	~~[[Category: Pyridoxal phosphate]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tyrosine]]~~	+
-	~~[[Category: Tyrosine catabolism~~]]	+

OCA at 08:10, 9 February 2022

OCA — Wed, 09 Feb 2022 08:10:54 GMT

←Older revision		Revision as of 08:10, 9 February 2022
Line 1:		Line 1:

	==Human Tyrosine Aminotransferase==		==Human Tyrosine Aminotransferase==
-	<StructureSection load='3dyd' size='340' side='right' caption='[[3dyd]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3dyd' size='340' side='right'caption='[[3dyd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DYD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TAT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TAT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5 2.6.1.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5 2.6.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [~~http~~://pdbe.org/3dyd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dyd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [https://pdbe.org/3dyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [https://www.ebi.ac.uk/pdbsum/3dyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[~~http~~://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>	+	[[https://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[https://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref> <ref>PMID:16640556</ref>	+	[[https://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref> <ref>PMID:16640556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dyd ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dyd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Tyrosine transaminase]]		[[Category: Tyrosine transaminase]]
	[[Category: Andersson, J]]		[[Category: Andersson, J]]

OCA at 19:14, 24 January 2018

OCA — Wed, 24 Jan 2018 19:14:39 GMT

←Older revision		Revision as of 19:14, 24 January 2018
Line 17:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dyd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dyd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 23:		Line 23:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dyd ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dyd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:47, 5 August 2016

OCA — Fri, 05 Aug 2016 16:47:29 GMT

←Older revision		Revision as of 16:47, 5 August 2016
Line 1:		Line 1:
		+
	==Human Tyrosine Aminotransferase==		==Human Tyrosine Aminotransferase==
	<StructureSection load='3dyd' size='340' side='right' caption='[[3dyd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3dyd' size='340' side='right' caption='[[3dyd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DYD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5 2.6.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5 2.6.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [http://www.ebi.ac.uk/pdbsum/3dyd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [http://pdbe.org/3dyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [http://www.ebi.ac.uk/pdbsum/3dyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dyd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Tyrosine transaminase]]		[[Category: Tyrosine transaminase]]
	[[Category: Andersson, J]]		[[Category: Andersson, J]]

OCA at 14:24, 18 December 2014

OCA — Thu, 18 Dec 2014 14:24:00 GMT

←Older revision		Revision as of 14:24, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3dyd~~\| ~~PDB~~=3dyd \| ~~SCENE~~= }}	+	==Human Tyrosine Aminotransferase==
-	===~~Human~~ Tyrosine ~~Aminotransferase~~===	+	<StructureSection load='3dyd' size='340' side='right' caption='[[3dyd]], [[Resolution\|resolution]] 2.30Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DYD FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[http://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==Function==	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5 2.6.1.5] </span></td></tr>
-	[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref><ref>PMID:16640556</ref>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [http://www.ebi.ac.uk/pdbsum/3dyd PDBsum]</span></td></tr>
-		+	</table>
-	==~~About this Structure~~==	+	== Disease ==
-	[[~~3dyd~~]] ~~is a 2 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~3DYD OCA~~].	+	[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[http://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>
-		+	== Function ==
-	==~~Reference~~==	+	[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref> <ref>PMID:16640556</ref>
-	<references ~~group="xtra"~~/><~~references~~/>	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dyd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tyrosine transaminase]]		[[Category: Tyrosine transaminase]]
-	[[Category: Andersson, J.]]	+	[[Category: Andersson, J]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S Van Den.]]	+	[[Category: Berg, S Van Den]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: Dahlgren, L G.]]	+	[[Category: Dahlgren, L G]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Johansson, A.]]	+	[[Category: Johansson, A]]
-	[[Category: Johansson, I.]]	+	[[Category: Johansson, I]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
-	[[Category: Nilsson, M E.]]	+	[[Category: Nilsson, M E]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Olesen, K.]]	+	[[Category: Olesen, K]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sagemark, J.]]	+	[[Category: Sagemark, J]]
-	[[Category: Schuler, H.]]	+	[[Category: Schuler, H]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Tresaugues, L.]]	+	[[Category: Tresaugues, L]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
-	[[Category: Wikstrom, M.]]	+	[[Category: Wikstrom, M]]
-	[[Category: Wisniewska, M.]]	+	[[Category: Wisniewska, M]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 52:		Line 65:
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tyrosine]]		[[Category: Tyrosine]]
	[[Category: Tyrosine catabolism]]		[[Category: Tyrosine catabolism]]

OCA at 01:55, 25 March 2013

OCA — Mon, 25 Mar 2013 01:55:37 GMT

←Older revision		Revision as of 01:55, 25 March 2013
Line 1:		Line 1:
-	[[Image:3dyd.png\|left\|200px]]
-
	{{STRUCTURE_3dyd\| PDB=3dyd \| SCENE= }}		{{STRUCTURE_3dyd\| PDB=3dyd \| SCENE= }}
-
	===Human Tyrosine Aminotransferase===		===Human Tyrosine Aminotransferase===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[http://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref><ref>PMID:16640556</ref>

	==About this Structure==		==About this Structure==
	[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA].		[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tyrosine transaminase]]		[[Category: Tyrosine transaminase]]

OCA: Protected "3dyd" [edit=sysop:move=sysop]

OCA — Wed, 09 Jan 2013 09:05:49 GMT

Protected "3dyd" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:05, 9 January 2013

OCA at 09:05, 9 January 2013

OCA — Wed, 09 Jan 2013 09:05:45 GMT

←Older revision		Revision as of 09:05, 9 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3dyd.png\|left\|200px]]		[[Image:3dyd.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3dyd", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3dyd\| PDB=3dyd \| SCENE= }}		{{STRUCTURE_3dyd\| PDB=3dyd \| SCENE= }}

	===Human Tyrosine Aminotransferase===		===Human Tyrosine Aminotransferase===

-
-	==Disease==
-	Known disease associated with this structure: Tyrosinemia, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=276600 276600]]

	==About this Structure==		==About this Structure==
-	~~3DYD~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA].	+	[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tyrosine transaminase]]		[[Category: Tyrosine transaminase]]
Line 62:		Line 52:
	[[Category: Tyrosine]]		[[Category: Tyrosine]]
	[[Category: Tyrosine catabolism]]		[[Category: Tyrosine catabolism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:08:41 2009''

OCA at 04:08, 18 February 2009

OCA — Wed, 18 Feb 2009 04:08:42 GMT

←Older revision		Revision as of 04:08, 18 February 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3dyd.png\|left\|200px]]

-	The ~~entry 3dyd~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3dyd", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3dyd\| PDB=3dyd \| SCENE= }}

-	Authors: Karlberg, T., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nordlund, P.	+	===Human Tyrosine Aminotransferase===

-	Description: Human Tyrosine Aminotransferase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 6 12~~:31:~~57 2008~~''	+	==Disease==
		+	Known disease associated with this structure: Tyrosinemia, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=276600 276600]]
		+
		+	==About this Structure==
		+	3DYD is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Tyrosine transaminase]]
		+	[[Category: Andersson, J.]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Berg, S Van Den.]]
		+	[[Category: Berglund, H.]]
		+	[[Category: Collins, R.]]
		+	[[Category: Dahlgren, L G.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Flodin, S.]]
		+	[[Category: Flores, A.]]
		+	[[Category: Graslund, S.]]
		+	[[Category: Hammarstrom, M.]]
		+	[[Category: Johansson, A.]]
		+	[[Category: Johansson, I.]]
		+	[[Category: Karlberg, T.]]
		+	[[Category: Kotenyova, T.]]
		+	[[Category: Lehtio, L.]]
		+	[[Category: Moche, M.]]
		+	[[Category: Nilsson, M E.]]
		+	[[Category: Nordlund, P.]]
		+	[[Category: Nyman, T.]]
		+	[[Category: Olesen, K.]]
		+	[[Category: Persson, C.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Sagemark, J.]]
		+	[[Category: Schuler, H.]]
		+	[[Category: Thorsell, A G.]]
		+	[[Category: Tresaugues, L.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Welin, M.]]
		+	[[Category: Wikstrom, M.]]
		+	[[Category: Wisniewska, M.]]
		+	[[Category: Aminotransferase]]
		+	[[Category: Disease mutation]]
		+	[[Category: Phenylalanine catabolism]]
		+	[[Category: Plp]]
		+	[[Category: Pyridoxal phosphate]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transferase]]
		+	[[Category: Tyrosine]]
		+	[[Category: Tyrosine catabolism]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:08:41 2009''

OCA: New page: '''Unreleased structure''' The entry 3dyd is ON HOLD Authors: Karlberg, T., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin,...

OCA — Wed, 06 Aug 2008 09:31:57 GMT

New page: '''Unreleased structure''' The entry 3dyd is ON HOLD Authors: Karlberg, T., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin,...

New page

'''Unreleased structure'''

The entry 3dyd is ON HOLD

Authors: Karlberg, T., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nordlund, P.

Description: Human Tyrosine Aminotransferase

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 6 12:31:57 2008''