3e08 - Revision history

OCA at 15:16, 1 November 2023

OCA — Wed, 01 Nov 2023 15:16:35 GMT

←Older revision		Revision as of 15:16, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3e08' size='340' side='right'caption='[[3e08]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3e08' size='340' side='right'caption='[[3e08]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e08]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Xance Xance~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e08]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E08 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~, ~~<scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3bk9\|3bk9]], [[2nw7\|2nw7]], [[2nw8\|2nw8]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>xccb100_0466 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~340 XANCE])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e08 OCA], [https://pdbe.org/3e08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e08 RCSB], [https://www.ebi.ac.uk/pdbsum/3e08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e08 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e08 OCA], [https://pdbe.org/3e08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e08 RCSB], [https://www.ebi.ac.uk/pdbsum/3e08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e08 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/T23O_XANCP T23O_XANCP]] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.[HAMAP-Rule:MF_01972]<ref>PMID:17197414</ref> <ref>PMID:18783250</ref>	+	[https://www.uniprot.org/uniprot/T23O_XANCP T23O_XANCP] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.[HAMAP-Rule:MF_01972]<ref>PMID:17197414</ref> <ref>PMID:18783250</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Tryptophan 2,3-dioxygenase]]~~	+	[[Category: Xanthomonas campestris pv. campestris]]
-	~~[[Category: Xance~~]]	+	[[Category: Campbell LP]]
-	[[Category: Campbell~~, L P~~]]	+	[[Category: Mowat CG]]
-	[[Category: Mowat~~, C G]]~~	+
-	~~[[Category: 3-dioxygenase]]~~	+
-	~~[[Category: Dioxygenase]]~~	+
-	~~[[Category: H55]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Tdo]]~~	+
-	~~[[Category: Tryptophan 2~~]]	+

OCA at 07:34, 10 November 2021

OCA — Wed, 10 Nov 2021 07:34:08 GMT

←Older revision		Revision as of 07:34, 10 November 2021
Line 1:		Line 1:

	==H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase==		==H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase==
-	<StructureSection load='3e08' size='340' side='right' caption='[[3e08]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3e08' size='340' side='right'caption='[[3e08]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e08]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3E08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e08]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E08 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bk9\|3bk9]], [[2nw7\|2nw7]], [[2nw8\|2nw8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bk9\|3bk9]], [[2nw7\|2nw7]], [[2nw8\|2nw8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">xccb100_0466 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=340 XANCE])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">xccb100_0466 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=340 XANCE])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e08 OCA], [~~http~~://pdbe.org/3e08 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3e08 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3e08 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3e08 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e08 OCA], [https://pdbe.org/3e08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e08 RCSB], [https://www.ebi.ac.uk/pdbsum/3e08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e08 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/T23O_XANCP T23O_XANCP]] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.[HAMAP-Rule:MF_01972]<ref>PMID:17197414</ref> <ref>PMID:18783250</ref>	+	[[https://www.uniprot.org/uniprot/T23O_XANCP T23O_XANCP]] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.[HAMAP-Rule:MF_01972]<ref>PMID:17197414</ref> <ref>PMID:18783250</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Dioxygenase\|Dioxygenase]]	+	*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Tryptophan 2,3-dioxygenase]]		[[Category: Tryptophan 2,3-dioxygenase]]
	[[Category: Xance]]		[[Category: Xance]]

OCA at 10:04, 14 November 2018

OCA — Wed, 14 Nov 2018 10:04:49 GMT

←Older revision		Revision as of 10:04, 14 November 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e08_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e08_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:26, 11 August 2016

OCA — Thu, 11 Aug 2016 21:26:40 GMT

←Older revision		Revision as of 21:26, 11 August 2016
Line 1:		Line 1:
		+
	==H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase==		==H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase==
	<StructureSection load='3e08' size='340' side='right' caption='[[3e08]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3e08' size='340' side='right' caption='[[3e08]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e08]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e08]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E08 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bk9\|3bk9]], [[2nw7\|2nw7]], [[2nw8\|2nw8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bk9\|3bk9]], [[2nw7\|2nw7]], [[2nw8\|2nw8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">xccb100_0466 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=340 ~~Xanthomonas campestris pv. campestris~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">xccb100_0466 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=340 XANCE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e08 RCSB], [http://www.ebi.ac.uk/pdbsum/3e08 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e08 OCA], [http://pdbe.org/3e08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e08 RCSB], [http://www.ebi.ac.uk/pdbsum/3e08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e08 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/T23O_XANCP T23O_XANCP]] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.[HAMAP-Rule:MF_01972]<ref>PMID:17197414</ref> <ref>PMID:18783250</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e08 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3e08" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Tryptophan 2,3-dioxygenase]]		[[Category: Tryptophan 2,3-dioxygenase]]
-	[[Category: ~~Xanthomonas campestris pv. campestris~~]]	+	[[Category: Xance]]
	[[Category: Campbell, L P]]		[[Category: Campbell, L P]]
	[[Category: Mowat, C G]]		[[Category: Mowat, C G]]

OCA at 13:38, 19 November 2014

OCA — Wed, 19 Nov 2014 13:38:59 GMT

←Older revision		Revision as of 13:38, 19 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3e08.~~png~~\|~~left~~\|200px]]	+	==H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase==
		+	<StructureSection load='3e08' size='340' side='right' caption='[[3e08]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3e08]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E08 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bk9\|3bk9]], [[2nw7\|2nw7]], [[2nw8\|2nw8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">xccb100_0466 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=340 Xanthomonas campestris pv. campestris])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e08 RCSB], [http://www.ebi.ac.uk/pdbsum/3e08 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e08_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tryptophan 2,3-dioxygenase (TDO) from Xanthomonas campestris is a highly specific heme-containing enzyme from a small family of homologous enzymes, which includes indoleamine 2,3-dioxygenase (IDO). The structure of wild type (WT TDO) in the catalytically active, ferrous (Fe (2+)) form and in complex with its substrate l-tryptophan ( l-Trp) was recently reported [Forouhar et al. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 473-478] and revealed that histidine 55 hydrogen bonds to l-Trp, precisely positioning it in the active site and implicating it as a possible active site base. In this study the substitution of the active site residue histidine 55 by alanine and serine (H55A and H55S) provides insight into the molecular mechanism used by the enzyme to control substrate binding. We report the crystal structure of the H55A and H55S mutant forms at 2.15 and 1.90 A resolution, respectively, in binary complexes with l-Trp. These structural data, in conjunction with potentiometric and kinetic studies on both mutants, reveal that histidine 55 is not essential for turnover but greatly disfavors the mechanistically unproductive binding of l-Trp to the oxidized enzyme allowing control of catalysis. This is demonstrated by the difference in the K d values for l-Trp binding to the two oxidation states of wild-type TDO (3.8 mM oxidized, 4.1 microM reduced), H55A TDO (11.8 microM oxidized, 3.7 microM reduced), and H55S TDO (18.4 microM oxidized, 5.3 microM reduced).

-	~~{{STRUCTURE_3e08\| PDB=3e08 \| SCENE= }}~~	+	Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding.,Thackray SJ, Bruckmann C, Anderson JL, Campbell LP, Xiao R, Zhao L, Mowat CG, Forouhar F, Tong L, Chapman SK Biochemistry. 2008 Oct 7;47(40):10677-84. Epub 2008 Sep 11. PMID:18783250<ref>PMID:18783250</ref>

-	~~===H55S mutant Xanthomonas campestris tryptophan 2~~,~~3-dioxygenase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18783250}}~~	+	==See Also==
-		+	*[[Dioxygenase\|Dioxygenase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3e08~~]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018783250<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Tryptophan 2,3-dioxygenase]]		[[Category: Tryptophan 2,3-dioxygenase]]
	[[Category: Xanthomonas campestris pv. campestris]]		[[Category: Xanthomonas campestris pv. campestris]]
-	[[Category: Campbell, L P.]]	+	[[Category: Campbell, L P]]
-	[[Category: Mowat, C G.]]	+	[[Category: Mowat, C G]]
	[[Category: 3-dioxygenase]]		[[Category: 3-dioxygenase]]
	[[Category: Dioxygenase]]		[[Category: Dioxygenase]]

OCA: Protected "3e08" [edit=sysop:move=sysop]

OCA — Wed, 09 Jan 2013 09:09:22 GMT

Protected "3e08" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:09, 9 January 2013

OCA at 09:09, 9 January 2013

OCA — Wed, 09 Jan 2013 09:09:16 GMT

←Older revision		Revision as of 09:09, 9 January 2013
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-	{{Seed}}
	[[Image:3e08.png\|left\|200px]]		[[Image:3e08.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3e08", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3e08\| PDB=3e08 \| SCENE= }}		{{STRUCTURE_3e08\| PDB=3e08 \| SCENE= }}

	===H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase===		===H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18783250}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18783250 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18783250}}		{{ABSTRACT_PUBMED_18783250}}

	==About this Structure==		==About this Structure==
-	~~3E08~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA].	+	[[3e08]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18783250~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018783250</ref><references group="xtra"/>
	[[Category: Tryptophan 2,3-dioxygenase]]		[[Category: Tryptophan 2,3-dioxygenase]]
	[[Category: Xanthomonas campestris pv. campestris]]		[[Category: Xanthomonas campestris pv. campestris]]
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	[[Category: Tdo]]		[[Category: Tdo]]
	[[Category: Tryptophan 2]]		[[Category: Tryptophan 2]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:14:07 2009''

OCA at 08:14, 18 February 2009

OCA — Wed, 18 Feb 2009 08:14:09 GMT

←Older revision		Revision as of 08:14, 18 February 2009
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	==About this Structure==		==About this Structure==
-	3E08 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA].	+	3E08 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA].

	==Reference==		==Reference==
-	Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding., Thackray SJ, Bruckmann C, Anderson JL, Campbell LP, Xiao R, Zhao L, Mowat CG, Forouhar F, Tong L, Chapman SK, Biochemistry. 2008 Oct 7;47(40):10677-84. Epub 2008 Sep 11. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18783250 18783250]~~	+	<ref group="xtra">PMID:18783250</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Tryptophan 2,3-dioxygenase]]		[[Category: Tryptophan 2,3-dioxygenase]]
	[[Category: Xanthomonas campestris pv. campestris]]		[[Category: Xanthomonas campestris pv. campestris]]
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	[[Category: Tryptophan 2]]		[[Category: Tryptophan 2]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 15 12~~:52:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:14:07 2009''

OCA at 10:52, 15 October 2008

OCA — Wed, 15 Oct 2008 10:52:55 GMT

←Older revision		Revision as of 10:52, 15 October 2008
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	{{Seed}}		{{Seed}}
-	[[Image:3e08.~~jpg~~\|left\|200px]]	+	[[Image:3e08.png\|left\|200px]]

	<!--		<!--
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	[[Category: Tryptophan 2]]		[[Category: Tryptophan 2]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct ~~1 21~~:50:21 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 15 12:52:55 2008''

OCA at 18:50, 1 October 2008

OCA — Wed, 01 Oct 2008 18:50:56 GMT

←Older revision		Revision as of 18:50, 1 October 2008
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3e08.jpg\|left\|200px]]

-	The ~~entry 3e08~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3e08", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3e08\| PDB=3e08 \| SCENE= }}

-	~~Authors: Thackray~~, ~~S.J., Bruckmann, C., Anderson, J.L.R., Campbell, L.P., Xiao, R., Zhao, L., Mowat, C.G., Forouhar, F., Tong, L., Chapman, S.K.~~	+	===H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase===

-	Description: H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 13 13~~:43:16 2008''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18783250}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18783250 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18783250}}
		+
		+	==About this Structure==
		+	3E08 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E08 OCA].
		+
		+	==Reference==
		+	Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding., Thackray SJ, Bruckmann C, Anderson JL, Campbell LP, Xiao R, Zhao L, Mowat CG, Forouhar F, Tong L, Chapman SK, Biochemistry. 2008 Oct 7;47(40):10677-84. Epub 2008 Sep 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18783250 18783250]
		+	[[Category: Single protein]]
		+	[[Category: Tryptophan 2,3-dioxygenase]]
		+	[[Category: Xanthomonas campestris pv. campestris]]
		+	[[Category: Campbell, L P.]]
		+	[[Category: Mowat, C G.]]
		+	[[Category: 3-dioxygenase]]
		+	[[Category: Dioxygenase]]
		+	[[Category: H55]]
		+	[[Category: Heme]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tdo]]
		+	[[Category: Tryptophan 2]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 1 21:50:21 2008''