3ega - Revision history

OCA at 13:13, 26 July 2023

OCA — Wed, 26 Jul 2023 13:13:04 GMT

←Older revision		Revision as of 13:13, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='3ega' size='340' side='right'caption='[[3ega]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ega' size='340' side='right'caption='[[3ega]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[3egb\|3egb]]~~</~~div~~>~~</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [https://pdbe.org/3ega PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [https://www.ebi.ac.uk/pdbsum/3ega PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ega ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [https://pdbe.org/3ega PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [https://www.ebi.ac.uk/pdbsum/3ega PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ega ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN]] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>	+	[https://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ferguson~~, K M~~]]	+	[[Category: Ferguson KM]]
-	[[Category: Lin, C]]	+	[[Category: Lin C]]
-	[[Category: Schmitz~~, K R]]~~	+	[[Category: Schmitz KR]]
-	~~[[Category: E3 ubiquitin ligase]]~~	+
-	~~[[Category: Fha domain]]~~	+
-	~~[[Category: Pellino]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Substrate binding domain~~]]	+

OCA at 19:39, 20 October 2021

OCA — Wed, 20 Oct 2021 19:39:55 GMT

←Older revision		Revision as of 19:39, 20 October 2021
Line 1:		Line 1:

	==Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution==		==Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution==
-	<StructureSection load='3ega' size='340' side='right' caption='[[3ega]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3ega' size='340' side='right'caption='[[3ega]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EGA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3egb\|3egb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3egb\|3egb]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [~~http~~://pdbe.org/3ega PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ega PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ega ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [https://pdbe.org/3ega PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [https://www.ebi.ac.uk/pdbsum/3ega PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ega ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN]] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>	+	[[https://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN]] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ferguson, K M]]		[[Category: Ferguson, K M]]
	[[Category: Lin, C]]		[[Category: Lin, C]]

OCA at 17:28, 5 August 2016

OCA — Fri, 05 Aug 2016 17:28:25 GMT

←Older revision		Revision as of 17:28, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution==		==Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution==
	<StructureSection load='3ega' size='340' side='right' caption='[[3ega]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ega' size='340' side='right' caption='[[3ega]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EGA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EGA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3egb\|3egb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3egb\|3egb]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [http://www.ebi.ac.uk/pdbsum/3ega PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [http://pdbe.org/3ega PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [http://www.ebi.ac.uk/pdbsum/3ega PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ega ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ega" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ferguson, K M]]		[[Category: Ferguson, K M]]
	[[Category: Lin, C]]		[[Category: Lin, C]]

OCA at 20:38, 25 December 2014

OCA — Thu, 25 Dec 2014 20:38:18 GMT

←Older revision		Revision as of 20:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EGA FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EGA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3egb\|3egb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3egb\|3egb]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [http://www.ebi.ac.uk/pdbsum/3ega PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [http://www.ebi.ac.uk/pdbsum/3ega PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN]] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.,Lin CC, Huoh YS, Schmitz KR, Jensen LE, Ferguson KM Structure. 2008 Dec 10;16(12):1806-16. PMID:19081057<ref>PMID:19081057</ref>		Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.,Lin CC, Huoh YS, Schmitz KR, Jensen LE, Ferguson KM Structure. 2008 Dec 10;16(12):1806-16. PMID:19081057<ref>PMID:19081057</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ferguson, K M.]]	+	[[Category: Ferguson, K M]]
-	[[Category: Lin, C.]]	+	[[Category: Lin, C]]
-	[[Category: Schmitz, K R.]]	+	[[Category: Schmitz, K R]]
	[[Category: E3 ubiquitin ligase]]		[[Category: E3 ubiquitin ligase]]
	[[Category: Fha domain]]		[[Category: Fha domain]]

OCA at 09:52, 21 May 2014

OCA — Wed, 21 May 2014 09:52:13 GMT

←Older revision		Revision as of 09:52, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3ega.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution==
		+	<StructureSection load='3ega' size='340' side='right' caption='[[3ega]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ega]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EGA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3egb\|3egb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ega OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ega RCSB], [http://www.ebi.ac.uk/pdbsum/3ega PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pellino proteins are RING E3 ubiquitin ligases involved in signaling events downstream of the Toll and interleukin-1 (IL-1) receptors, key initiators of innate immune and inflammatory responses. Pellino proteins associate with and ubiquitinate proteins in these pathways, including the interleukin-1 receptor associated kinase-1 (IRAK1). We determined the X-ray crystal structure of a Pellino2 fragment lacking only the RING domain. This structure reveals that the IRAK1-binding region of Pellino proteins consists largely of a previously unidentified forkhead-associated (FHA) domain. FHA domains are well-characterized phosphothreonine-binding modules, and this cryptic example in Pellino2 can drive interaction of this protein with phosphorylated IRAK1. The Pellino FHA domain is decorated with an unusual appendage or "wing" composed of two long inserts that lie within the FHA homology region. Delineating how this E3 ligase associates with substrates, and how these interactions are regulated by phosphorylation, is crucial for a complete understanding of Toll/IL-1 receptor signaling.

-	~~<!--~~	+	Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.,Lin CC, Huoh YS, Schmitz KR, Jensen LE, Ferguson KM Structure. 2008 Dec 10;16(12):1806-16. PMID:19081057<ref>PMID:19081057</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3ega"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3ega\| PDB=3ega \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~Pellino2 FHA Domain at 1.8 Angstroms resolution===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19081057}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19081057 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19081057}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ega]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019081057<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ferguson, K M.]]		[[Category: Ferguson, K M.]]

OCA: Protected "3ega" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2012 06:52:06 GMT

Protected "3ega" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 21 March 2012

OCA at 06:52, 21 March 2012

OCA — Wed, 21 Mar 2012 06:52:03 GMT

←Older revision		Revision as of 06:52, 21 March 2012
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-	~~{{Seed}}~~	+	[[Image:3ega.png\|left\|200px]]
-	[[Image:3ega.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution===		===Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19081057}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19081057 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19081057}}

	==About this Structure==		==About this Structure==
-	~~3EGA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA].	+	[[3ega]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019081057</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ferguson, K M.]]		[[Category: Ferguson, K M.]]
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	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Substrate binding domain]]		[[Category: Substrate binding domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:31:44 2008''

OCA at 09:31, 24 December 2008

OCA — Wed, 24 Dec 2008 09:31:47 GMT

←Older revision		Revision as of 09:31, 24 December 2008
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ega.jpg\|left\|200px]]

-	The ~~entry 3ega~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ega", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ega\| PDB=3ega \| SCENE= }}

-	~~Authors: Ferguson, K.M., Lin, C., Schmitz, K.R~~.	+	===Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution===

-	Description: Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 8 09~~:19:33 2008''	+	==About this Structure==
		+	3EGA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGA OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Ferguson, K M.]]
		+	[[Category: Lin, C.]]
		+	[[Category: Schmitz, K R.]]
		+	[[Category: E3 ubiquitin ligase]]
		+	[[Category: Fha domain]]
		+	[[Category: Pellino]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein binding]]
		+	[[Category: Substrate binding domain]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:31:44 2008''

OCA at 07:19, 8 October 2008

OCA — Wed, 08 Oct 2008 07:19:34 GMT

←Older revision		Revision as of 07:19, 8 October 2008
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ega is ON HOLD	+	The entry 3ega is ON HOLD until Paper Publication

	Authors: Ferguson, K.M., Lin, C., Schmitz, K.R.		Authors: Ferguson, K.M., Lin, C., Schmitz, K.R.
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	Description: Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution		Description: Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 24 10~~:15:21 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 09:19:33 2008''

OCA at 07:15, 24 September 2008

OCA — Wed, 24 Sep 2008 07:15:21 GMT

←Older revision		Revision as of 07:15, 24 September 2008
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	The entry 3ega is ON HOLD		The entry 3ega is ON HOLD

-	Authors: Ferguson, K. M., Lin, C., Schmitz, K. R.	+	Authors: Ferguson, K.M., Lin, C., Schmitz, K.R.

	Description: Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution		Description: Crystal structure of Pellino2 FHA Domain at 1.8 Angstroms resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~17 13~~:42:07 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 10:15:21 2008''