3eij - Revision history

OCA at 08:24, 20 March 2024

OCA — Wed, 20 Mar 2024 08:24:59 GMT

←Older revision		Revision as of 08:24, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3eij' size='340' side='right'caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3eij' size='340' side='right'caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~3eiq~~\|~~3eiq~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [~~http~~://pdbe.org/3eij PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eij PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eij ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [https://pdbe.org/3eij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [https://www.ebi.ac.uk/pdbsum/3eij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eij ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>	+	[https://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eij ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eij ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Pdcd4 is a tumour suppressor protein. It inhibits translation through interaction with translation initiator eIF4A, resulting in the suppression of neoplastic transformation and tumour invasion. Here, we present the crystal structures of an N-terminal-truncated Pdcd4 in free form and in complex with eIF4A. Upon binding to eIF4A, Pdcd4 undergoes a marked conformational change to form a heterotrimeric complex with eIF4A, with one Pdcd4 binding to two eIF4A molecules in two different modes. The binding of Pdcd4 to eIF4A is required to inhibit the enzymatic activity of eIF4A, translation initiation, and AP-1-dependent transcription. Both MA3 domains are required to efficiently compete with the C-terminal domain of eIF4G (eIF4Gc) for binding to eIF4A whereas a single MA3 is sufficient to inhibit translation. Our structural and mutational analyses reveal that Pdcd4 inhibits translation initiation by trapping eIF4A in an inactive conformation, and blocking its incorporation into the eIF4F complex.
-
-	Structural basis for translational inhibition by the tumour suppressor Pdcd4.,Loh PG, Yang HS, Walsh MA, Wang Q, Wang X, Cheng Z, Liu D, Song H EMBO J. 2009 Feb 4;28(3):274-85. Epub 2009 Jan 15. PMID:19153607<ref>PMID:19153607</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3eij" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Loh~~, P G]]~~	+	[[Category: Loh PG]]
-	~~[[Category: Anti-oncogene]]~~	+
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Heat motif]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 10:22, 9 September 2020

OCA — Wed, 09 Sep 2020 10:22:57 GMT

←Older revision		Revision as of 10:22, 9 September 2020
Line 1:		Line 1:

	==Crystal structure of Pdcd4==		==Crystal structure of Pdcd4==
-	<StructureSection load='3eij' size='340' side='right' caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3eij' size='340' side='right'caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://pdbe.org/3eij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eij ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://pdbe.org/3eij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eij ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Cell death protein\|Cell death protein]]	+	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Loh, P G]]		[[Category: Loh, P G]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]

OCA at 22:13, 2 December 2018

OCA — Sun, 02 Dec 2018 22:13:08 GMT

←Older revision		Revision as of 22:13, 2 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of Pdcd4==		==Crystal structure of Pdcd4==
	<StructureSection load='3eij' size='340' side='right' caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3eij' size='340' side='right' caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://pdbe.org/3eij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://pdbe.org/3eij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eij ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/3eij_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/3eij_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:40, 10 February 2016

OCA — Wed, 10 Feb 2016 00:40:13 GMT

←Older revision		Revision as of 00:40, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3eij' size='340' side='right' caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3eij' size='340' side='right' caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://pdbe.org/3eij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eij ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3eij" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Loh, P G]]		[[Category: Loh, P G]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]

OCA at 10:35, 25 December 2014

OCA — Thu, 25 Dec 2014 10:35:12 GMT

←Older revision		Revision as of 10:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Loh, P G.]]	+	[[Category: Loh, P G]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]

OCA at 12:40, 29 September 2014

OCA — Mon, 29 Sep 2014 12:40:59 GMT

←Older revision		Revision as of 12:40, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3eij.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Pdcd4==
		+	<StructureSection load='3eij' size='340' side='right' caption='[[3eij]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eiq\|3eiq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [http://www.ebi.ac.uk/pdbsum/3eij PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/3eij_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pdcd4 is a tumour suppressor protein. It inhibits translation through interaction with translation initiator eIF4A, resulting in the suppression of neoplastic transformation and tumour invasion. Here, we present the crystal structures of an N-terminal-truncated Pdcd4 in free form and in complex with eIF4A. Upon binding to eIF4A, Pdcd4 undergoes a marked conformational change to form a heterotrimeric complex with eIF4A, with one Pdcd4 binding to two eIF4A molecules in two different modes. The binding of Pdcd4 to eIF4A is required to inhibit the enzymatic activity of eIF4A, translation initiation, and AP-1-dependent transcription. Both MA3 domains are required to efficiently compete with the C-terminal domain of eIF4G (eIF4Gc) for binding to eIF4A whereas a single MA3 is sufficient to inhibit translation. Our structural and mutational analyses reveal that Pdcd4 inhibits translation initiation by trapping eIF4A in an inactive conformation, and blocking its incorporation into the eIF4F complex.

-	~~{{STRUCTURE_3eij\| PDB=3eij \| SCENE= }}~~	+	Structural basis for translational inhibition by the tumour suppressor Pdcd4.,Loh PG, Yang HS, Walsh MA, Wang Q, Wang X, Cheng Z, Liu D, Song H EMBO J. 2009 Feb 4;28(3):274-85. Epub 2009 Jan 15. PMID:19153607<ref>PMID:19153607</ref>

-	~~===Crystal structure~~ of ~~Pdcd4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19153607}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3eij]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA].~~	+

	==See Also==		==See Also==
	*[[Cell death protein\|Cell death protein]]		*[[Cell death protein\|Cell death protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019153607<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Loh, P G.]]		[[Category: Loh, P G.]]

OCA: Protected "3eij" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 15:42:20 GMT

Protected "3eij" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:42, 20 October 2012

OCA at 15:42, 20 October 2012

OCA — Sat, 20 Oct 2012 15:42:16 GMT

←Older revision		Revision as of 15:42, 20 October 2012
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-	~~{{Seed}}~~	+	[[Image:3eij.png\|left\|200px]]
-	[[Image:3eij.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3eij", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3eij\| PDB=3eij \| SCENE= }}		{{STRUCTURE_3eij\| PDB=3eij \| SCENE= }}

	===Crystal structure of Pdcd4===		===Crystal structure of Pdcd4===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19153607}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19153607 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19153607}}		{{ABSTRACT_PUBMED_19153607}}

	==About this Structure==		==About this Structure==
-	~~3EIJ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA].	+	[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA].
		+
		+	==See Also==
		+	*[[Cell death protein\|Cell death protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19153607~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019153607</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Loh, P G.]]		[[Category: Loh, P G.]]
Line 30:		Line 21:
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
-	[[Category: Cytoplasm]]
	[[Category: Heat motif]]		[[Category: Heat motif]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Protein]]		[[Category: Protein]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Translation]]		[[Category: Translation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:06:01 2009''

OCA at 07:06, 18 February 2009

OCA — Wed, 18 Feb 2009 07:06:01 GMT

←Older revision		Revision as of 07:06, 18 February 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3eij.jpg\|left\|200px]]

-	The ~~entry 3eij~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3eij", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3eij\| PDB=3eij \| SCENE= }}

-	~~Authors: Loh, P.G.~~	+	===Crystal structure of Pdcd4===

-	Description: Crystal structure of Pdcd4

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb ~~4 11~~:17:21 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19153607}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19153607 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19153607}}
		+
		+	==About this Structure==
		+	3EIJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19153607</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Loh, P G.]]
		+	[[Category: Anti-oncogene]]
		+	[[Category: Antitumor protein]]
		+	[[Category: Apoptosis]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Heat motif]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Protein]]
		+	[[Category: Rna-binding]]
		+	[[Category: Translation]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:06:01 2009''

OCA at 09:17, 4 February 2009

OCA — Wed, 04 Feb 2009 09:17:22 GMT

←Older revision		Revision as of 09:17, 4 February 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3eij is ON HOLD until ~~sometime in the future~~	+	The entry 3eij is ON HOLD until Paper Publication

	Authors: Loh, P.G.		Authors: Loh, P.G.
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	Description: Crystal structure of Pdcd4		Description: Crystal structure of Pdcd4

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 15 14~~:05:~~32 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 4 11:17:21 2009''