3ek9 - Revision history

OCA at 13:06, 30 August 2023

OCA — Wed, 30 Aug 2023 13:06:48 GMT

←Older revision		Revision as of 13:06, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3ek9' size='340' side='right'caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3ek9' size='340' side='right'caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Spsb2, Grcc9, Ssb2 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [https://pdbe.org/3ek9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ek9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ek9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [https://pdbe.org/3ek9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ek9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ek9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPSB2_MOUSE SPSB2_MOUSE]] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).	+	[https://www.uniprot.org/uniprot/SPSB2_MOUSE SPSB2_MOUSE] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Garrett~~, T J.P~~]]	+	[[Category: Garrett TJP]]
-	[[Category: Kuang, Z]]	+	[[Category: Kuang Z]]
-	[[Category: Norton~~, R S~~]]	+	[[Category: Norton RS]]
-	[[Category: Xu, Y]]	+	[[Category: Xu Y]]
-	[[Category: Yao, S]]	+	[[Category: Yao S]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Spry domain]]~~	+
-	~~[[Category: Ubl conjugation pathway~~]]	+

OCA at 11:51, 16 February 2022

OCA — Wed, 16 Feb 2022 11:51:52 GMT

←Older revision		Revision as of 11:51, 16 February 2022
Line 1:		Line 1:

	==SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding==		==SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding==
-	<StructureSection load='3ek9' size='340' side='right' caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3ek9' size='340' side='right'caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [~~http~~://pdbe.org/3ek9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ek9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ek9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [https://pdbe.org/3ek9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ek9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ek9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPSB2_MOUSE SPSB2_MOUSE]] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).	+	[[https://www.uniprot.org/uniprot/SPSB2_MOUSE SPSB2_MOUSE]] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Garrett, T J.P]]		[[Category: Garrett, T J.P]]

OCA at 21:21, 2 December 2018

OCA — Sun, 02 Dec 2018 21:21:36 GMT

←Older revision		Revision as of 21:21, 2 December 2018
Line 1:		Line 1:
		+
	==SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding==		==SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding==
	<StructureSection load='3ek9' size='340' side='right' caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3ek9' size='340' side='right' caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://pdbe.org/3ek9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://pdbe.org/3ek9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ek9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ek/3ek9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ek/3ek9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:51, 10 February 2016

OCA — Wed, 10 Feb 2016 00:51:15 GMT

←Older revision		Revision as of 00:51, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3ek9' size='340' side='right' caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3ek9' size='340' side='right' caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://pdbe.org/3ek9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ek9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ek9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Garrett, T J.P]]		[[Category: Garrett, T J.P]]
	[[Category: Kuang, Z]]		[[Category: Kuang, Z]]

OCA at 10:38, 25 December 2014

OCA — Thu, 25 Dec 2014 10:38:41 GMT

←Older revision		Revision as of 10:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPSB2_MOUSE SPSB2_MOUSE]] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 25:
	SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.,Kuang Z, Yao S, Xu Y, Lewis RS, Low A, Masters SL, Willson TA, Kolesnik TB, Nicholson SE, Garrett TJ, Norton RS J Mol Biol. 2009 Feb 27;386(3):662-74. Epub 2009 Jan 6. PMID:19154741<ref>PMID:19154741</ref>		SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.,Kuang Z, Yao S, Xu Y, Lewis RS, Low A, Masters SL, Willson TA, Kolesnik TB, Nicholson SE, Garrett TJ, Norton RS J Mol Biol. 2009 Feb 27;386(3):662-74. Epub 2009 Jan 6. PMID:19154741<ref>PMID:19154741</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Garrett, T J.P.]]	+	[[Category: Garrett, T J.P]]
-	[[Category: Kuang, Z.]]	+	[[Category: Kuang, Z]]
-	[[Category: Norton, R S.]]	+	[[Category: Norton, R S]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
-	[[Category: Yao, S.]]	+	[[Category: Yao, S]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Spry domain]]		[[Category: Spry domain]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]

OCA at 09:39, 21 May 2014

OCA — Wed, 21 May 2014 09:39:00 GMT

←Older revision		Revision as of 09:39, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3ek9.~~png~~\|~~left~~\|200px]]	+	==SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding==
		+	<StructureSection load='3ek9' size='340' side='right' caption='[[3ek9]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EK9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Spsb2, Grcc9, Ssb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ek9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ek9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ek/3ek9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The four mammalian SPRY (a sequence repeat in dual-specificity kinase splA and ryanodine receptors) domain-containing suppressor of cytokine signalling (SOCS) box proteins (SSB-1 to -4) are characterised by a C-terminal SOCS box and a central SPRY domain. The latter is a protein interaction module found in over 1600 proteins, with more than 70 encoded in the human genome. Here we report the crystal structure of the SPRY domain of murine SSB-2 and compare it with the SSB-2 solution structure and crystal structures of other B30.2/SPRY domain-containing family proteins. The structure is a bent beta-sandwich, consisting of two seven-stranded beta-sheets wrapped around a long loop that extends from the centre strands of the inner or concave beta-sheet; it closely matches those of GUSTAVUS and SSB-4. The structure is also similar to those of two recently determined Neuralized homology repeat (NHR) domains (also known as NEUZ domains), with detailed comparisons, suggesting that the NEUZ/NHR domains form a subclass of SPRY domains. The binding site on SSB-2 for the prostate apoptosis response-4 (Par-4) protein has been mapped in finer detail using mutational analyses. Moreover, SSB-1 was shown to have a Par-4 binding surface similar to that identified for SSB-2. Structural perturbations of SSB-2 induced by mutations affecting its interaction with Par-4 and/or c-Met have been characterised by NMR. These comparisons, in conjunction with previously published dynamics data from NMR relaxation studies and coarse-grained dynamics simulation using normal mode analysis, further refine our understanding of the structural basis for protein recognition of SPRY domain-containing proteins.

-	<!--	+	SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.,Kuang Z, Yao S, Xu Y, Lewis RS, Low A, Masters SL, Willson TA, Kolesnik TB, Nicholson SE, Garrett TJ, Norton RS J Mol Biol. 2009 Feb 27;386(3):662-74. Epub 2009 Jan 6. PMID:19154741<ref>PMID:19154741</ref>
-	~~The line below this paragraph,~~ containing ~~"STRUCTURE_3ek9"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3ek9\| PDB=3ek9 \| SCENE= }}~~	+

-	~~===SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19154741}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19154741 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19154741}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ek9]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019154741<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Garrett, T J.P.]]		[[Category: Garrett, T J.P.]]

OCA: Protected "3ek9" [edit=sysop:move=sysop]

OCA — Wed, 08 Feb 2012 05:42:00 GMT

Protected "3ek9" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 8 February 2012

OCA at 05:41, 8 February 2012

OCA — Wed, 08 Feb 2012 05:41:58 GMT

←Older revision		Revision as of 05:41, 8 February 2012
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-	~~{{Seed}}~~	+	[[Image:3ek9.png\|left\|200px]]
-	[[Image:3ek9.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3EK9~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA].	+	[[3ek9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19154741~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019154741</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Garrett, T J.P.]]		[[Category: Garrett, T J.P.]]
-	[[Category: Kuang, Z K.]]	+	[[Category: Kuang, Z.]]
	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Xu, Y.]]		[[Category: Xu, Y.]]
	[[Category: Yao, S.]]		[[Category: Yao, S.]]
-	[[Category: Alternative splicing]]
-	[[Category: Cytoplasm]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Spry domain]]		[[Category: Spry domain]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:32:46 2009''

OCA at 07:32, 25 February 2009

OCA — Wed, 25 Feb 2009 07:32:48 GMT

←Older revision		Revision as of 07:32, 25 February 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ek9.jpg\|left\|200px]]

-	The ~~entry 3ek9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ek9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ek9\| PDB=3ek9 \| SCENE= }}

-	~~Authors~~: ~~Kuang, Z.K., Yao, S., Xu, Y., Garrett, T.J.P., Norton, R.S.~~	+	===SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding===

-	Description: SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Nov 20 07~~:39:~~17 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19154741}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19154741 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19154741}}
		+
		+	==About this Structure==
		+	3EK9 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EK9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19154741</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Garrett, T J.P.]]
		+	[[Category: Kuang, Z K.]]
		+	[[Category: Norton, R S.]]
		+	[[Category: Xu, Y.]]
		+	[[Category: Yao, S.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Protein binding]]
		+	[[Category: Signaling protein]]
		+	[[Category: Spry domain]]
		+	[[Category: Ubl conjugation pathway]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:32:46 2009''

OCA at 05:39, 20 November 2008

OCA — Thu, 20 Nov 2008 05:39:18 GMT

←Older revision		Revision as of 05:39, 20 November 2008
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ek9 is ON HOLD	+	The entry 3ek9 is ON HOLD until Paper Publication

	Authors: Kuang, Z.K., Yao, S., Xu, Y., Garrett, T.J.P., Norton, R.S.		Authors: Kuang, Z.K., Yao, S., Xu, Y., Garrett, T.J.P., Norton, R.S.
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	Description: SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding		Description: SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 1 21~~:13:32 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:39:17 2008''