3elz - Revision history

OCA at 06:29, 6 September 2023

OCA — Wed, 06 Sep 2023 06:29:16 GMT

←Older revision		Revision as of 06:29, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3elz' size='340' side='right'caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3elz' size='340' side='right'caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3elz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ELZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3elz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ELZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3elx\|3elx]], [[3em0\|3em0]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">fabp6, zgc:92421 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [https://pdbe.org/3elz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [https://www.ebi.ac.uk/pdbsum/3elz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3elz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [https://pdbe.org/3elz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [https://www.ebi.ac.uk/pdbsum/3elz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3elz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6IMW5_DANRE Q6IMW5_DANRE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Capaldi, S]]	+	[[Category: Capaldi S]]
-	[[Category: Fessas, D]]	+	[[Category: Fessas D]]
-	[[Category: Monaco~~, H L~~]]	+	[[Category: Monaco HL]]
-	[[Category: Perduca, M]]	+	[[Category: Perduca M]]
-	[[Category: Saccomani, G]]	+	[[Category: Saccomani G]]
-	[[Category: Signorelli, M]]	+	[[Category: Signorelli M]]
-	~~[[Category: Cholic acid]]~~	+
-	~~[[Category: Ileal bile acid-binding protein]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 11:53, 16 February 2022

OCA — Wed, 16 Feb 2022 11:53:02 GMT

←Older revision		Revision as of 11:53, 16 February 2022
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	==Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).==		==Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).==
-	<StructureSection load='3elz' size='340' side='right' caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3elz' size='340' side='right'caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3elz]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ELZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3elz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ELZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elx\|3elx]], [[3em0\|3em0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3elx\|3elx]], [[3em0\|3em0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabp6, zgc:92421 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabp6, zgc:92421 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [~~http~~://pdbe.org/3elz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3elz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3elz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [https://pdbe.org/3elz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [https://www.ebi.ac.uk/pdbsum/3elz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3elz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]	+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Capaldi, S]]		[[Category: Capaldi, S]]
	[[Category: Fessas, D]]		[[Category: Fessas, D]]

OCA at 21:48, 2 December 2018

OCA — Sun, 02 Dec 2018 21:48:28 GMT

←Older revision		Revision as of 21:48, 2 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).==		==Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).==
	<StructureSection load='3elz' size='340' side='right' caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3elz' size='340' side='right' caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elx\|3elx]], [[3em0\|3em0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elx\|3elx]], [[3em0\|3em0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabp6, zgc:92421 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabp6, zgc:92421 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [http://pdbe.org/3elz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [http://www.ebi.ac.uk/pdbsum/3elz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [http://pdbe.org/3elz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [http://www.ebi.ac.uk/pdbsum/3elz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3elz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/3elz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/3elz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:05, 7 February 2016

OCA — Sun, 07 Feb 2016 11:05:31 GMT

←Older revision		Revision as of 11:05, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3elz' size='340' side='right' caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3elz' size='340' side='right' caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3elz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Danio_rerio Danio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ELZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3elz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ELZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elx\|3elx]], [[3em0\|3em0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elx\|3elx]], [[3em0\|3em0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabp6, zgc:92421 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 ~~Danio~~ rerio])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabp6, zgc:92421 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [http://www.ebi.ac.uk/pdbsum/3elz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [http://pdbe.org/3elz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [http://www.ebi.ac.uk/pdbsum/3elz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3elz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3elz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Danio~~ rerio]]	+	[[Category: Brachidanio rerio]]
	[[Category: Capaldi, S]]		[[Category: Capaldi, S]]
	[[Category: Fessas, D]]		[[Category: Fessas, D]]

OCA at 13:38, 19 November 2014

OCA — Wed, 19 Nov 2014 13:38:47 GMT

←Older revision		Revision as of 13:38, 19 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3elz.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).==
		+	<StructureSection load='3elz' size='340' side='right' caption='[[3elz]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3elz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ELZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elx\|3elx]], [[3em0\|3em0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabp6, zgc:92421 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3elz RCSB], [http://www.ebi.ac.uk/pdbsum/3elz PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/3elz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ileal bile acid-binding proteins (I-BABPs), also called ileal lipid-binding proteins or gastrotropins, belong to the family of the fatty acid-binding proteins and play an important role in the solubilization and transport of bile acids in the enterocyte. This article describes the expression, purification, crystallization, and three-dimensional structure determination of zebrafish (Danio rerio) I-BABP both in its apo form and bound to cholic acid. This is the first X-ray structure of an I-BABP. The structure of the apoprotein was determined to a resolution of 1.6 A, and two different monoclinic crystal forms of the holoprotein were solved and refined to 2.2 A resolution. Three protein molecules are present in the asymmetric unit of one of the co-crystal forms and two in the other, and therefore, the results of this study refer to observations made on five different protein molecules in the crystalline state. In every case, two cholate ligands were found bound in approximately the same position in the internal cavity of the protein molecules, but an unexpected result is the presence of clear and unambiguous electron density for several cholate molecules bound on hydrophobic patches on the surface of all the five independent protein molecules examined. Isothermal titration calorimetry was used for the thermodynamic characterization of the binding mechanism and has yielded results that are consistent with the X-ray data. Ligand binding is described in detail, and the conformational changes undergone by the protein molecule in the apo-to-holo transition are examined by superposition of the apo- and holoprotein models. The structure of the holoprotein is also compared with that of the liver BABP from the same species and those of other I-BABPs determined by NMR.

-	~~{{STRUCTURE_3elz\| PDB=3elz \| SCENE= }}~~	+	The X-Ray structure of zebrafish (Danio rerio) ileal bile acid-binding protein reveals the presence of binding sites on the surface of the protein molecule.,Capaldi S, Saccomani G, Fessas D, Signorelli M, Perduca M, Monaco HL J Mol Biol. 2009 Jan 9;385(1):99-116. Epub 2008 Oct 14. PMID:18952094<ref>PMID:18952094</ref>

-	~~===Crystal structure~~ of ~~Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A)~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18952094}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3elz]] is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA].~~	+	</StructureSection>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
-	[[Category: Capaldi, S.]]	+	[[Category: Capaldi, S]]
-	[[Category: Fessas, D.]]	+	[[Category: Fessas, D]]
-	[[Category: Monaco, H L.]]	+	[[Category: Monaco, H L]]
-	[[Category: Perduca, M.]]	+	[[Category: Perduca, M]]
-	[[Category: Saccomani, G.]]	+	[[Category: Saccomani, G]]
-	[[Category: Signorelli, M.]]	+	[[Category: Signorelli, M]]
	[[Category: Cholic acid]]		[[Category: Cholic acid]]
	[[Category: Ileal bile acid-binding protein]]		[[Category: Ileal bile acid-binding protein]]

OCA: Protected "3elz" [edit=sysop:move=sysop]

OCA — Wed, 09 Jan 2013 09:09:01 GMT

Protected "3elz" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:09, 9 January 2013

OCA at 09:08, 9 January 2013

OCA — Wed, 09 Jan 2013 09:08:57 GMT

←Older revision		Revision as of 09:08, 9 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3elz.png\|left\|200px]]
-	[[Image:3elz.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3elz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3elz\| PDB=3elz \| SCENE= }}		{{STRUCTURE_3elz\| PDB=3elz \| SCENE= }}

	===Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).===		===Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18952094}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18952094 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18952094}}		{{ABSTRACT_PUBMED_18952094}}

	==About this Structure==		==About this Structure==
-	~~3ELZ~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA].	+	[[3elz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA].
-		+
-	~~==Reference==~~	+
-	The X-ray structure of zebrafish (Danio rerio) ileal bile acid-binding protein reveals the presence of binding sites on the surface of the protein molecule., Capaldi S, Saccomani G, Fessas D, Signorelli M, Perduca M, Monaco HL, J Mol Biol. 2009 Jan 9;385(1):99-116. Epub 2008 Oct 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18952094 18952094]	+
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
	[[Category: Capaldi, S.]]		[[Category: Capaldi, S.]]
Line 36:		Line 21:
	[[Category: Lipid-binding]]		[[Category: Lipid-binding]]
	[[Category: Transport]]		[[Category: Transport]]
-	[[Category: X-ray structure]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 13:33:35 2009''

OCA at 11:33, 14 January 2009

OCA — Wed, 14 Jan 2009 11:33:36 GMT

←Older revision		Revision as of 11:33, 14 January 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3elz.jpg\|left\|200px]]

-	The ~~entry 3elz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3elz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3elz\| PDB=3elz \| SCENE= }}

-	~~Authors: Capaldi, S., Saccomani, G., Fessas, D., Signorelli, M., Perduca, M., Monaco, H.L~~.	+	===Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).===

-	Description: Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 1 21:~~14:~~49 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18952094}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18952094 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18952094}}
		+
		+	==About this Structure==
		+	3ELZ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELZ OCA].
		+
		+	==Reference==
		+	The X-ray structure of zebrafish (Danio rerio) ileal bile acid-binding protein reveals the presence of binding sites on the surface of the protein molecule., Capaldi S, Saccomani G, Fessas D, Signorelli M, Perduca M, Monaco HL, J Mol Biol. 2009 Jan 9;385(1):99-116. Epub 2008 Oct 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18952094 18952094]
		+	[[Category: Danio rerio]]
		+	[[Category: Capaldi, S.]]
		+	[[Category: Fessas, D.]]
		+	[[Category: Monaco, H L.]]
		+	[[Category: Perduca, M.]]
		+	[[Category: Saccomani, G.]]
		+	[[Category: Signorelli, M.]]
		+	[[Category: Cholic acid]]
		+	[[Category: Ileal bile acid-binding protein]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Lipid-binding]]
		+	[[Category: Transport]]
		+	[[Category: X-ray structure]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 13:33:35 2009''

OCA: New page: '''Unreleased structure''' The entry 3elz is ON HOLD until Paper Publication Authors: Capaldi, S., Saccomani, G., Fessas, D., Signorelli, M., Perduca, M., Monaco, H.L. Description: Cry...

OCA — Wed, 01 Oct 2008 18:14:50 GMT

New page: '''Unreleased structure''' The entry 3elz is ON HOLD until Paper Publication Authors: Capaldi, S., Saccomani, G., Fessas, D., Signorelli, M., Perduca, M., Monaco, H.L. Description: Cry...

New page

'''Unreleased structure'''

The entry 3elz is ON HOLD until Paper Publication

Authors: Capaldi, S., Saccomani, G., Fessas, D., Signorelli, M., Perduca, M., Monaco, H.L.

Description: Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 1 21:14:49 2008''