3erw - Revision history

OCA at 00:23, 28 December 2023

OCA — Thu, 28 Dec 2023 00:23:56 GMT

←Older revision		Revision as of 00:23, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='3erw' size='340' side='right'caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3erw' size='340' side='right'caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERW FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>BSU13840, spoIVH, stoA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1423~~ "~~Vibrio subtilis~~" ~~Ehrenberg 1835])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [https://pdbe.org/3erw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [https://www.ebi.ac.uk/pdbsum/3erw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3erw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [https://pdbe.org/3erw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [https://www.ebi.ac.uk/pdbsum/3erw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3erw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/STOA_BACSU STOA_BACSU]] Thiol-disulfide oxidoreductase with a reductive function, involved in spore cortex synthesis. It could be involved either in breaking disulfide bonds in cortex components or in proteins that are important for cortex synthesis, or in thiol/disulfide bond interchange.<ref>PMID:15292147</ref> <ref>PMID:15342593</ref>	+	[https://www.uniprot.org/uniprot/STOA_BACSU STOA_BACSU] Thiol-disulfide oxidoreductase with a reductive function, involved in spore cortex synthesis. It could be involved either in breaking disulfide bonds in cortex components or in proteins that are important for cortex synthesis, or in thiol/disulfide bond interchange.<ref>PMID:15292147</ref> <ref>PMID:15342593</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]	+	*[[Protein disulfide oxidoreductase 3D structures\|Protein disulfide oxidoreductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Brun, N E.Le]]~~	+	[[Category: Crow A]]
-	[[Category: Crow, A]]	+	[[Category: Hederstedt L]]
-	[[Category: Hederstedt, L]]	+	[[Category: Le Brun NE]]
-	[[Category: ~~Liu, Y~~]]	+	[[Category: Liu Y]]
-	[[Category: ~~Moller, M C~~]]	+	[[Category: Moller MC]]
-	[[Category: ~~Disulfide]]~~	+
-	~~[[Category: Dithiol]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Redox-active center]]~~	+
-	~~[[Category: Resa-like fold]]~~	+
-	~~[[Category: Sporulation]]~~	+
-	~~[[Category: Stoa]]~~	+
-	~~[[Category: Thioredoxin-like fold~~]]	+

OCA at 09:14, 23 February 2022

OCA — Wed, 23 Feb 2022 09:14:37 GMT

←Older revision		Revision as of 09:14, 23 February 2022
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	==Crystal Structure of StoA from Bacillus subtilis==		==Crystal Structure of StoA from Bacillus subtilis==
-	<StructureSection load='3erw' size='340' side='right' caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3erw' size='340' side='right'caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ERW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [~~http~~://pdbe.org/3erw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3erw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3erw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [https://pdbe.org/3erw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [https://www.ebi.ac.uk/pdbsum/3erw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3erw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/STOA_BACSU STOA_BACSU]] Thiol-disulfide oxidoreductase with a reductive function, involved in spore cortex synthesis. It could be involved either in breaking disulfide bonds in cortex components or in proteins that are important for cortex synthesis, or in thiol/disulfide bond interchange.<ref>PMID:15292147</ref> <ref>PMID:15342593</ref>	+	[[https://www.uniprot.org/uniprot/STOA_BACSU STOA_BACSU]] Thiol-disulfide oxidoreductase with a reductive function, involved in spore cortex synthesis. It could be involved either in breaking disulfide bonds in cortex components or in proteins that are important for cortex synthesis, or in thiol/disulfide bond interchange.<ref>PMID:15292147</ref> <ref>PMID:15342593</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Brun, N E.Le]]		[[Category: Brun, N E.Le]]
	[[Category: Crow, A]]		[[Category: Crow, A]]

OCA at 21:19, 2 December 2018

OCA — Sun, 02 Dec 2018 21:19:51 GMT

←Older revision		Revision as of 21:19, 2 December 2018
Line 1:		Line 1:
		+
	==Crystal Structure of StoA from Bacillus subtilis==		==Crystal Structure of StoA from Bacillus subtilis==
	<StructureSection load='3erw' size='340' side='right' caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3erw' size='340' side='right' caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "~~Bacillus globigii~~" ~~Migula 1900~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [http://pdbe.org/3erw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [http://www.ebi.ac.uk/pdbsum/3erw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [http://pdbe.org/3erw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [http://www.ebi.ac.uk/pdbsum/3erw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3erw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3erw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3erw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Brun, N E.Le]]		[[Category: Brun, N E.Le]]
	[[Category: Crow, A]]		[[Category: Crow, A]]

OCA at 19:48, 9 February 2016

OCA — Tue, 09 Feb 2016 19:48:12 GMT

←Older revision		Revision as of 19:48, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3erw' size='340' side='right' caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3erw' size='340' side='right' caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [http://www.ebi.ac.uk/pdbsum/3erw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [http://pdbe.org/3erw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [http://www.ebi.ac.uk/pdbsum/3erw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3erw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3erw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Brun, N E.Le]]		[[Category: Brun, N E.Le]]
	[[Category: Crow, A]]		[[Category: Crow, A]]

OCA at 09:08, 25 December 2014

OCA — Thu, 25 Dec 2014 09:08:22 GMT

←Older revision		Revision as of 09:08, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERW FirstGlance]. <br>		<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [http://www.ebi.ac.uk/pdbsum/3erw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [http://www.ebi.ac.uk/pdbsum/3erw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STOA_BACSU STOA_BACSU]] Thiol-disulfide oxidoreductase with a reductive function, involved in spore cortex synthesis. It could be involved either in breaking disulfide bonds in cortex components or in proteins that are important for cortex synthesis, or in thiol/disulfide bond interchange.<ref>PMID:15292147</ref> <ref>PMID:15342593</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Brun, N E.Le.]]	+	[[Category: Brun, N E.Le]]
-	[[Category: Crow, A.]]	+	[[Category: Crow, A]]
-	[[Category: Hederstedt, L.]]	+	[[Category: Hederstedt, L]]
-	[[Category: Liu, Y.]]	+	[[Category: Liu, Y]]
-	[[Category: Moller, M C.]]	+	[[Category: Moller, M C]]
	[[Category: Disulfide]]		[[Category: Disulfide]]
	[[Category: Dithiol]]		[[Category: Dithiol]]

OCA at 10:48, 29 September 2014

OCA — Mon, 29 Sep 2014 10:48:30 GMT

←Older revision		Revision as of 10:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3erw.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of StoA from Bacillus subtilis==
		+	<StructureSection load='3erw' size='340' side='right' caption='[[3erw]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU13840, spoIVH, stoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3erw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3erw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3erw RCSB], [http://www.ebi.ac.uk/pdbsum/3erw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3erw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacillus subtilis StoA is an extracytoplasmic thiol-disulfide oxidoreductase (TDOR) important for the synthesis of the endospore peptidoglycan cortex protective layer. Here we demonstrate that StoA is membrane-associated in B. subtilis and report the crystal structure of the soluble protein lacking its membrane anchor. This showed that StoA adopts a thioredoxin-like fold with N-terminal and internal additions that are characteristic of extracytoplasmic TDORs. The CXXC active site of the crystallized protein was found to be in a mixture of oxidized and reduced states, illustrating that there is little conformational variation between redox states. The midpoint reduction potential was determined as -248 mV versus normal hydrogen electrode at pH 7 consistent with StoA fulfilling a reductive role in endospore biogenesis. pK(a) values of the active site cysteines, Cys-65 and Cys-68, were determined to be 5.5 and 7.8. Although Cys-68 is buried within the structure, both cysteines were found to be accessible to cysteine-specific alkylating reagents. In vivo studies of site-directed variants of StoA revealed that the active site cysteines are functionally important, as is Glu-71, which lies close to the active site and is conserved in many reducing extracytoplasmic TDORs. The structure and biophysical properties of StoA are very similar to those of ResA, a B. subtilis extracytoplasmic TDOR involved in cytochrome c maturation, raising important general questions about how these similar but non-redundant proteins achieve specificity. A detailed comparison of the two proteins demonstrates that relatively subtle differences, largely located around the active sites of the proteins, are sufficient to confer specificity.

-	~~{{STRUCTURE_3erw\| PDB=3erw \| SCENE= }}~~	+	Structure and functional properties of Bacillus subtilis endospore biogenesis factor StoA.,Crow A, Liu Y, Moller MC, Le Brun NE, Hederstedt L J Biol Chem. 2009 Apr 10;284(15):10056-66. Epub 2009 Jan 13. PMID:19144642<ref>PMID:19144642</ref>

-	~~===Crystal Structure~~ of ~~StoA from Bacillus subtilis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19144642}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3erw]] is a 7 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA].~~	+

	==See Also==		==See Also==
	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]		*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019144642<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brun, N E.Le.]]		[[Category: Brun, N E.Le.]]

OCA at 14:56, 20 October 2012

OCA — Sat, 20 Oct 2012 14:56:14 GMT

←Older revision		Revision as of 14:56, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3erw]] is a 7 chain structure ~~of [[Protein disulfide oxidoreductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA].	+	[[3erw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA].

	==See Also==		==See Also==

OCA: Protected "3erw" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 16:45:16 GMT

Protected "3erw" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:45, 26 July 2012

OCA at 16:45, 26 July 2012

OCA — Thu, 26 Jul 2012 16:45:15 GMT

←Older revision		Revision as of 16:45, 26 July 2012
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-	{{Seed}}
	[[Image:3erw.png\|left\|200px]]		[[Image:3erw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3erw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3erw\| PDB=3erw \| SCENE= }}		{{STRUCTURE_3erw\| PDB=3erw \| SCENE= }}

	===Crystal Structure of StoA from Bacillus subtilis===		===Crystal Structure of StoA from Bacillus subtilis===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19144642}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19144642 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19144642}}		{{ABSTRACT_PUBMED_19144642}}

	==About this Structure==		==About this Structure==
-	~~3ERW~~ is a 7 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA].	+	[[3erw]] is a 7 chain structure of [[Protein disulfide oxidoreductase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA].
		+
		+	==See Also==
		+	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19144642~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019144642</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brun, N E.Le.]]		[[Category: Brun, N E.Le.]]
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	[[Category: Stoa]]		[[Category: Stoa]]
	[[Category: Thioredoxin-like fold]]		[[Category: Thioredoxin-like fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 29 20:09:29 2009''

OCA at 17:09, 29 April 2009

OCA — Wed, 29 Apr 2009 17:09:30 GMT

←Older revision		Revision as of 17:09, 29 April 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3erw.~~jpg~~\|left\|200px]]	+	[[Image:3erw.png\|left\|200px]]

	<!--		<!--
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	===Crystal Structure of StoA from Bacillus subtilis===		===Crystal Structure of StoA from Bacillus subtilis===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19144642}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19144642 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19144642}}

	==About this Structure==		==About this Structure==
	3ERW is a 7 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA].		3ERW is a 7 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19144642</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brun, N E.Le.]]		[[Category: Brun, N E.Le.]]
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	[[Category: Thioredoxin-like fold]]		[[Category: Thioredoxin-like fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 21 10~~:46:47 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 29 20:09:29 2009''