3eut - Revision history

OCA at 00:24, 28 December 2023

OCA — Thu, 28 Dec 2023 00:24:42 GMT

←Older revision		Revision as of 00:24, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='3eut' size='340' side='right'caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3eut' size='340' side='right'caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eut]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chrysonilia_crassa Chrysonilia~~ crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eut]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EUT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DCR:ICOSANOIC+ACID'>DCR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=DCR:ICOSANOIC+ACID'>DCR</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[3euq\|3euq]]~~</~~div~~>~~</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [https://pdbe.org/3eut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [https://www.ebi.ac.uk/pdbsum/3eut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eut ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [https://pdbe.org/3eut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [https://www.ebi.ac.uk/pdbsum/3eut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eut ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7S6N4_NEUCR Q7S6N4_NEUCR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chrysonilia crassa]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brunzelle, J S~~]]	+	[[Category: Neurospora crassa]]
-	[[Category: ~~Nair, S K~~]]	+	[[Category: Brunzelle JS]]
-	[[Category: ~~Zhang, H~~]]	+	[[Category: Nair SK]]
-	[[Category: ~~Acyltransferase]]~~	+	[[Category: Zhang H]]
-	~~[[Category: Ora]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:16, 23 February 2022

OCA — Wed, 23 Feb 2022 09:16:54 GMT

←Older revision		Revision as of 09:16, 23 February 2022
Line 1:		Line 1:

	==X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa==		==X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa==
-	<StructureSection load='3eut' size='340' side='right' caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3eut' size='340' side='right'caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eut]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eut]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EUT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCR:ICOSANOIC+ACID'>DCR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCR:ICOSANOIC+ACID'>DCR</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3euq\|3euq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3euq\|3euq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [~~http~~://pdbe.org/3eut PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eut PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eut ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [https://pdbe.org/3eut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [https://www.ebi.ac.uk/pdbsum/3eut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eut ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Chrysonilia crassa]]		[[Category: Chrysonilia crassa]]
		+	[[Category: Large Structures]]
	[[Category: Brunzelle, J S]]		[[Category: Brunzelle, J S]]
	[[Category: Nair, S K]]		[[Category: Nair, S K]]

OCA at 21:25, 2 December 2018

OCA — Sun, 02 Dec 2018 21:25:55 GMT

←Older revision		Revision as of 21:25, 2 December 2018
Line 1:		Line 1:
		+
	==X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa==		==X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa==
	<StructureSection load='3eut' size='340' side='right' caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3eut' size='340' side='right' caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3euq\|3euq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3euq\|3euq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [http://pdbe.org/3eut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [http://www.ebi.ac.uk/pdbsum/3eut PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [http://pdbe.org/3eut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [http://www.ebi.ac.uk/pdbsum/3eut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eut ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/3eut_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/3eut_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:19, 9 February 2016

OCA — Tue, 09 Feb 2016 16:19:37 GMT

←Older revision		Revision as of 16:19, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3eut' size='340' side='right' caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3eut' size='340' side='right' caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eut]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Neurospora_crassa Neurospora~~ crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eut]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCR:ICOSANOIC+ACID'>DCR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCR:ICOSANOIC+ACID'>DCR</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3euq\|3euq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3euq\|3euq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 ~~Neurospora~~ crassa])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [http://www.ebi.ac.uk/pdbsum/3eut PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [http://pdbe.org/3eut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [http://www.ebi.ac.uk/pdbsum/3eut PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eut ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3eut" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Neurospora~~ crassa]]	+	[[Category: Chrysonilia crassa]]
	[[Category: Brunzelle, J S]]		[[Category: Brunzelle, J S]]
	[[Category: Nair, S K]]		[[Category: Nair, S K]]

OCA at 08:39, 26 November 2014

OCA — Wed, 26 Nov 2014 08:39:26 GMT

←Older revision		Revision as of 08:39, 26 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3eut.~~png~~\|~~left~~\|200px]]	+	==X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa==
		+	<StructureSection load='3eut' size='340' side='right' caption='[[3eut]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3eut]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EUT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCR:ICOSANOIC+ACID'>DCR</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3euq\|3euq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU04801, NCU04801.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Neurospora crassa])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eut RCSB], [http://www.ebi.ac.uk/pdbsum/3eut PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/3eut_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The fungal type III polyketide synthase 2'-oxoalkylresorcylic acid synthase (ORAS) primes with a range of acyl-Coenzyme A thioesters (C4-C20) and extends using malonyl-Coenzyme A to produce pyrones, resorcinols, and resorcylic acids. To gain insight into this unusual substrate specificity and product profile, we have determined the crystal structures of ORAS to 1.75 A resolution, the Phe-252-->Gly site-directed mutant to 2.1 A resolution, and a binary complex of ORAS with eicosanoic acid to 2.0 A resolution. The structures reveal a distinct rearrangement of structural elements near the active site that allows accommodation of long-chain fatty acid esters and a reorientation of the gating mechanism that controls cyclization and polyketide chain length. The roles of these structural elements are further elucidated by characterization of various structure-based site-directed variants. These studies establish an unexpected plasticity to the PKS fold, unanticipated from structural studies of other members of this enzyme family.

-	~~{{STRUCTURE_3eut\| PDB=3eut \| SCENE= }}~~	+	Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa.,Rubin-Pitel SB, Zhang H, Vu T, Brunzelle JS, Zhao H, Nair SK Chem Biol. 2008 Oct 20;15(10):1079-90. PMID:18940668<ref>PMID:18940668</ref>

-	~~===X-ray crystal structure~~ of ~~a type III pentaketide synthase from Neurospora crassa===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18940668}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3eut]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Neurospora_crassa Neurospora crassa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018940668<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Neurospora crassa]]		[[Category: Neurospora crassa]]
-	[[Category: Brunzelle, J S.]]	+	[[Category: Brunzelle, J S]]
-	[[Category: Nair, S K.]]	+	[[Category: Nair, S K]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Ora]]		[[Category: Ora]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA: Protected "3eut" [edit=sysop:move=sysop]

OCA — Wed, 06 Feb 2013 13:22:26 GMT

Protected "3eut" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:22, 6 February 2013

OCA at 13:22, 6 February 2013

OCA — Wed, 06 Feb 2013 13:22:24 GMT

←Older revision		Revision as of 13:22, 6 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3eut.png\|left\|200px]]		[[Image:3eut.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3eut", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3eut\| PDB=3eut \| SCENE= }}		{{STRUCTURE_3eut\| PDB=3eut \| SCENE= }}

	===X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa===		===X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18940668}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18940668 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18940668}}		{{ABSTRACT_PUBMED_18940668}}

	==About this Structure==		==About this Structure==
-	~~3EUT~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA].	+	[[3eut]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18940668~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018940668</ref><references group="xtra"/>
	[[Category: Neurospora crassa]]		[[Category: Neurospora crassa]]
	[[Category: Brunzelle, J S.]]		[[Category: Brunzelle, J S.]]
Line 31:		Line 19:
	[[Category: Ora]]		[[Category: Ora]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:08:02 2009''

OCA at 09:08, 17 February 2009

OCA — Tue, 17 Feb 2009 09:08:04 GMT

←Older revision		Revision as of 09:08, 17 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3eut.~~jpg~~\|left\|200px]]	+	[[Image:3eut.png\|left\|200px]]

	<!--		<!--
Line 23:		Line 23:

	==Reference==		==Reference==
-	Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa., Rubin-Pitel SB, Zhang H, Vu T, Brunzelle JS, Zhao H, Nair SK, Chem Biol. 2008 Oct 20;15(10):1079-90. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18940668 18940668]~~	+	<ref group="xtra">PMID:18940668</ref><references group="xtra"/>
	[[Category: Neurospora crassa]]		[[Category: Neurospora crassa]]
	[[Category: Brunzelle, J S.]]		[[Category: Brunzelle, J S.]]
Line 32:		Line 32:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 12 10~~:50:~~33 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:08:02 2009''

OCA at 08:50, 12 November 2008

OCA — Wed, 12 Nov 2008 08:50:35 GMT

←Older revision		Revision as of 08:50, 12 November 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3eut.jpg\|left\|200px]]

-	The ~~entry 3eut~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3eut", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3eut\| PDB=3eut \| SCENE= }}

-	~~Authors: Zhang, H., Brunzelle, J.S., Nair, S.K.~~	+	===X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa===

-	Description: X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 22~~ 10:18:55 2008''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18940668}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18940668 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18940668}}
		+
		+	==About this Structure==
		+	3EUT is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUT OCA].
		+
		+	==Reference==
		+	Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa., Rubin-Pitel SB, Zhang H, Vu T, Brunzelle JS, Zhao H, Nair SK, Chem Biol. 2008 Oct 20;15(10):1079-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18940668 18940668]
		+	[[Category: Neurospora crassa]]
		+	[[Category: Brunzelle, J S.]]
		+	[[Category: Nair, S K.]]
		+	[[Category: Zhang, H.]]
		+	[[Category: Acyltransferase]]
		+	[[Category: Ora]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 10:50:33 2008''

OCA: New page: '''Unreleased structure''' The entry 3eut is ON HOLD Authors: Zhang, H., Brunzelle, J.S., Nair, S.K. Description: X-ray crystal structure of a type III pentaketide synthase from Neuros...

OCA — Wed, 22 Oct 2008 08:18:55 GMT

New page: '''Unreleased structure''' The entry 3eut is ON HOLD Authors: Zhang, H., Brunzelle, J.S., Nair, S.K. Description: X-ray crystal structure of a type III pentaketide synthase from Neuros...

New page

'''Unreleased structure'''

The entry 3eut is ON HOLD

Authors: Zhang, H., Brunzelle, J.S., Nair, S.K.

Description: X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 22 10:18:55 2008''