3ev5 - Revision history

OCA at 00:24, 28 December 2023

OCA — Thu, 28 Dec 2023 00:24:53 GMT

←Older revision		Revision as of 00:24, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.68Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [https://pdbe.org/3ev5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ev5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ev5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [https://pdbe.org/3ev5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ev5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ev5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>	+	[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pancreatic ribonuclease]]~~	+	[[Category: Dechene M]]
-	[[Category: Dechene, M]]	+	[[Category: Mattos C]]
-	[[Category: Mattos, C]]	+	[[Category: Smith M]]
-	[[Category: Smith, M]]	+	[[Category: Swartz P]]
-	[[Category: Swartz, P]]	+	[[Category: Wink G]]
-	[[Category: Wink, G]]	+
-	~~[[Category: Endonuclease]]~~	+
-	~~[[Category: Glycation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Multiple solvent crystal structure]]~~	+
-	~~[[Category: Nuclease]]~~	+
-	~~[[Category: Organic solvent]]~~	+
-	~~[[Category: Rnase]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 09:17, 23 February 2022

OCA — Wed, 23 Feb 2022 09:17:15 GMT

←Older revision		Revision as of 09:17, 23 February 2022
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	<StructureSection load='3ev5' size='340' side='right'caption='[[3ev5]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='3ev5' size='340' side='right'caption='[[3ev5]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [~~http~~://pdbe.org/3ev5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ev5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ev5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [https://pdbe.org/3ev5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ev5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ev5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>	+	[[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	*[[Temp\|Temp]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:56, 7 August 2019

OCA — Wed, 07 Aug 2019 06:56:51 GMT

←Older revision		Revision as of 06:56, 7 August 2019
Line 1:		Line 1:

	==Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide==		==Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide==
-	<StructureSection load='3ev5' size='340' side='right' caption='[[3ev5]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='3ev5' size='340' side='right'caption='[[3ev5]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/3ev5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/3ev5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
	[[Category: Dechene, M]]		[[Category: Dechene, M]]

OCA at 09:20, 25 October 2017

OCA — Wed, 25 Oct 2017 09:20:39 GMT

←Older revision		Revision as of 09:20, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide==		==Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide==
	<StructureSection load='3ev5' size='340' side='right' caption='[[3ev5]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='3ev5' size='340' side='right' caption='[[3ev5]], [[Resolution\|resolution]] 1.68Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [http://pdbe.org/3ev5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ev5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [http://pdbe.org/3ev5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ev5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ev5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:39, 9 February 2016

OCA — Tue, 09 Feb 2016 09:39:18 GMT

←Older revision		Revision as of 09:39, 9 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ev5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [http://pdbe.org/3ev5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ev5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ev5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ev5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
-	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:01, 25 December 2014

OCA — Thu, 25 Dec 2014 06:01:30 GMT

←Older revision		Revision as of 06:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ev5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ev5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
		+	*[[Temp\|Temp]]
		+	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 39:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
-	[[Category: Dechene, M.]]	+	[[Category: Dechene, M]]
-	[[Category: Mattos, C.]]	+	[[Category: Mattos, C]]
-	[[Category: Smith, M.]]	+	[[Category: Smith, M]]
-	[[Category: Swartz, P.]]	+	[[Category: Swartz, P]]
-	[[Category: Wink, G.]]	+	[[Category: Wink, G]]
	[[Category: Endonuclease]]		[[Category: Endonuclease]]
	[[Category: Glycation]]		[[Category: Glycation]]

OCA at 12:24, 29 September 2014

OCA — Mon, 29 Sep 2014 12:24:39 GMT

←Older revision		Revision as of 12:24, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3ev5.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide==
		+	<StructureSection load='3ev5' size='340' side='right' caption='[[3ev5]], [[Resolution\|resolution]] 1.68Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EV5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3eux\|3eux]], [[3euy\|3euy]], [[3euz\|3euz]], [[3ev0\|3ev0]], [[3ev1\|3ev1]], [[3ev2\|3ev2]], [[3ev3\|3ev3]], [[3ev4\|3ev4]], [[3ev6\|3ev6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ev5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/3ev5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The multiple solvent crystal structures (MSCS) method uses organic solvents to map the surfaces of proteins. It identifies binding sites and allows for a more thorough examination of protein plasticity and hydration than could be achieved by a single structure. The crystal structures of bovine pancreatic ribonuclease A (RNAse A) soaked in the following organic solvents are presented: 50% dioxane, 50% dimethylformamide, 70% dimethylsulfoxide, 70% 1,6-hexanediol, 70% isopropanol, 50% R,S,R-bisfuran alcohol, 70% t-butanol, 50% trifluoroethanol, or 1.0M trimethylamine-N-oxide. This set of structures is compared with four sets of crystal structures of RNAse A from the protein data bank (PDB) and with the solution NMR structure to assess the validity of previously untested assumptions associated with MSCS analysis. Plasticity from MSCS is the same as from PDB structures obtained in the same crystal form and deviates only at crystal contacts when compared to structures from a diverse set of crystal environments. Furthermore, there is a good correlation between plasticity as observed by MSCS and the dynamic regions seen by NMR. Conserved water binding sites are identified by MSCS to be those that are conserved in the sets of structures taken from the PDB. Comparison of the MSCS structures with inhibitor-bound crystal structures of RNAse A reveals that the organic solvent molecules identify key interactions made by inhibitor molecules, highlighting ligand binding hot-spots in the active site. The present work firmly establishes the relevance of information obtained by MSCS. Proteins 2009. (c) 2009 Wiley-Liss, Inc.

-	~~{{STRUCTURE_3ev5\| PDB=3ev5 \| SCENE= }}~~	+	Multiple solvent crystal structures of ribonuclease A: An assessment of the method.,Dechene M, Wink G, Smith M, Swartz P, Mattos C Proteins. 2009 Feb 2. PMID:19291738<ref>PMID:19291738</ref>

-	~~===Crystal Structure~~ of ~~Ribonuclease A in 1M Trimethylamine N-Oxide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19291738}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ev5]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA].~~	+

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019291738<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]

OCA at 13:26, 20 October 2012

OCA — Sat, 20 Oct 2012 13:26:48 GMT

←Older revision		Revision as of 13:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ev5]] is a 2 chain structure ~~of [[Ribonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA].	+	[[3ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA].

	==See Also==		==See Also==

OCA: Protected "3ev5" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 11:59:07 GMT

Protected "3ev5" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:59, 26 July 2012

OCA at 11:59, 26 July 2012

OCA — Thu, 26 Jul 2012 11:59:05 GMT

←Older revision		Revision as of 11:59, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ev5.png\|left\|200px]]		[[Image:3ev5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ev5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3ev5\| PDB=3ev5 \| SCENE= }}		{{STRUCTURE_3ev5\| PDB=3ev5 \| SCENE= }}

	===Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide===		===Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19291738}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19291738 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19291738}}		{{ABSTRACT_PUBMED_19291738}}

	==About this Structure==		==About this Structure==
-	~~3EV5~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA].	+	[[3ev5]] is a 2 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EV5 OCA].
		+
		+	==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19291738~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019291738</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
Line 40:		Line 31:
	[[Category: Rnase]]		[[Category: Rnase]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:04:45 2010''