3ewq - Revision history

OCA at 00:25, 28 December 2023

OCA — Thu, 28 Dec 2023 00:25:29 GMT

←Older revision		Revision as of 00:25, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='3ewq' size='340' side='right'caption='[[3ewq]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ewq' size='340' side='right'caption='[[3ewq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ewq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cvh22 Cvh22~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ewq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3ewo\|3ewo]], [[3ewp\|3ewp]], [[3ewr\|3ewr]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">1a ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=11137 CVH22])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [https://pdbe.org/3ewq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [https://www.ebi.ac.uk/pdbsum/3ewq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [https://pdbe.org/3ewq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [https://www.ebi.ac.uk/pdbsum/3ewq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/R1A_CVH22 R1A_CVH22]] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).	+	[https://www.uniprot.org/uniprot/R1A_CVH22 R1A_CVH22] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cvh22~~]]	+	[[Category: Human coronavirus 229E]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bartlam, M]]	+	[[Category: Bartlam M]]
-	[[Category: Chen, C]]	+	[[Category: Chen C]]
-	[[Category: Cong, L]]	+	[[Category: Cong L]]
-	[[Category: Ma, Y]]	+	[[Category: Ma Y]]
-	[[Category: Rao, Z]]	+	[[Category: Rao Z]]
-	[[Category: Wei, L]]	+	[[Category: Wei L]]
-	[[Category: Xu, X]]	+	[[Category: Xu X]]
-	[[Category: Xu, Y]]	+	[[Category: Xu Y]]
-	[[Category: Zhao, Q]]	+	[[Category: Zhao Q]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Globular like]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Ribosomal frameshifting]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Thiol protease]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 09:18, 23 February 2022

OCA — Wed, 23 Feb 2022 09:18:18 GMT

←Older revision		Revision as of 09:18, 23 February 2022
Line 1:		Line 1:

	==HCov-229E Nsp3 ADRP domain==		==HCov-229E Nsp3 ADRP domain==
-	<StructureSection load='3ewq' size='340' side='right' caption='[[3ewq]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3ewq' size='340' side='right'caption='[[3ewq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ewq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cvh22 Cvh22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EWQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ewq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cvh22 Cvh22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWQ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ewo\|3ewo]], [[3ewp\|3ewp]], [[3ewr\|3ewr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ewo\|3ewo]], [[3ewp\|3ewp]], [[3ewr\|3ewr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11137 CVH22])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11137 CVH22])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [~~http~~://pdbe.org/3ewq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ewq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [https://pdbe.org/3ewq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [https://www.ebi.ac.uk/pdbsum/3ewq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/R1A_CVH22 R1A_CVH22]] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).	+	[[https://www.uniprot.org/uniprot/R1A_CVH22 R1A_CVH22]] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Cvh22]]		[[Category: Cvh22]]
		+	[[Category: Large Structures]]
	[[Category: Bartlam, M]]		[[Category: Bartlam, M]]
	[[Category: Chen, C]]		[[Category: Chen, C]]

OCA at 21:58, 2 December 2018

OCA — Sun, 02 Dec 2018 21:58:13 GMT

←Older revision		Revision as of 21:58, 2 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 43:		Line 43:
	[[Category: Xu, Y]]		[[Category: Xu, Y]]
	[[Category: Zhao, Q]]		[[Category: Zhao, Q]]
		+	[[Category: Cytoplasm]]
	[[Category: Globular like]]		[[Category: Globular like]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 48:		Line 49:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Protease]]		[[Category: Protease]]
		+	[[Category: Ribosomal frameshifting]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 06:05, 5 August 2016

OCA — Fri, 05 Aug 2016 06:05:27 GMT

←Older revision		Revision as of 06:05, 5 August 2016
Line 1:		Line 1:
		+
	==HCov-229E Nsp3 ADRP domain==		==HCov-229E Nsp3 ADRP domain==
	<StructureSection load='3ewq' size='340' side='right' caption='[[3ewq]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ewq' size='340' side='right' caption='[[3ewq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ewq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_coronavirus_229e Human coronavirus 229e~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EWQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ewq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvh22 Cvh22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EWQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ewo\|3ewo]], [[3ewp\|3ewp]], [[3ewr\|3ewr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ewo\|3ewo]], [[3ewp\|3ewp]], [[3ewr\|3ewr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11137 ~~Human coronavirus 229E~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11137 CVH22])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [http://www.ebi.ac.uk/pdbsum/3ewq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [http://pdbe.org/3ewq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [http://www.ebi.ac.uk/pdbsum/3ewq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ewq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ewq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human coronavirus 229e~~]]	+	[[Category: Cvh22]]
	[[Category: Bartlam, M]]		[[Category: Bartlam, M]]
	[[Category: Chen, C]]		[[Category: Chen, C]]

OCA at 16:23, 25 December 2014

OCA — Thu, 25 Dec 2014 16:23:18 GMT

←Older revision		Revision as of 16:23, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [http://www.ebi.ac.uk/pdbsum/3ewq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [http://www.ebi.ac.uk/pdbsum/3ewq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/R1A_CVH22 R1A_CVH22]] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:43, 26 November 2014

OCA — Wed, 26 Nov 2014 08:43:30 GMT

←Older revision		Revision as of 08:43, 26 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3ewq.~~png~~\|~~left~~\|200px]]	+	==HCov-229E Nsp3 ADRP domain==
		+	<StructureSection load='3ewq' size='340' side='right' caption='[[3ewq]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ewq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_coronavirus_229e Human coronavirus 229e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EWQ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ewo\|3ewo]], [[3ewp\|3ewp]], [[3ewr\|3ewr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11137 Human coronavirus 229E])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ewq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ewq RCSB], [http://www.ebi.ac.uk/pdbsum/3ewq PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coronaviruses are a large family of plus-strand RNA viruses that cause a wide variety of diseases both in humans and in other organisms. The coronaviruses are composed of three main lineages and have a complex organization of nonstructural proteins (nsp's). In the coronavirus, nsp3 resides a domain with the macroH2A-like fold and ADP-ribose-1"-monophosphatase (ADRP) activity, which is proposed to play a regulatory role in the replication process. However, the significance of this domain for the coronaviruses is still poorly understood due to the lack of structural information from different lineages. We have determined the crystal structures of two viral ADRP domains, from the group I human coronavirus 229E and the group III avian infectious bronchitis virus, as well as their respective complexes with ADP-ribose. The structures were individually solved to elucidate the structural similarities and differences of the ADRP domains among various coronavirus species. The active-site residues responsible for mediating ADRP activity were found to be highly conserved in terms of both sequence alignment and structural superposition, whereas the substrate binding pocket exhibited variations in structure but not in sequence. Together with data from a previous analysis of the ADRP domain from the group II severe acute respiratory syndrome coronavirus and from other related functional studies of ADRP domains, a systematic structural analysis of the coronavirus ADRP domains was realized for the first time to provide a structural basis for the function of this domain in the coronavirus replication process.

-	~~{{STRUCTURE_3ewq\| PDB=3ewq \| SCENE= }}~~	+	Crystal structures of two coronavirus ADP-ribose-1''-monophosphatases and their complexes with ADP-Ribose: a systematic structural analysis of the viral ADRP domain.,Xu Y, Cong L, Chen C, Wei L, Zhao Q, Xu X, Ma Y, Bartlam M, Rao Z J Virol. 2009 Jan;83(2):1083-92. Epub 2008 Nov 5. PMID:18987156<ref>PMID:18987156</ref>

-	~~===HCov-229E Nsp3 ADRP domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18987156}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3ewq]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Human_coronavirus_229e Human coronavirus 229e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA].~~	+	</StructureSection>
	[[Category: Human coronavirus 229e]]		[[Category: Human coronavirus 229e]]
-	[[Category: Bartlam, M.]]	+	[[Category: Bartlam, M]]
-	[[Category: Chen, C.]]	+	[[Category: Chen, C]]
-	[[Category: Cong, L.]]	+	[[Category: Cong, L]]
-	[[Category: Ma, Y.]]	+	[[Category: Ma, Y]]
-	[[Category: Rao, Z.]]	+	[[Category: Rao, Z]]
-	[[Category: Wei, L.]]	+	[[Category: Wei, L]]
-	[[Category: Xu, X.]]	+	[[Category: Xu, X]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
-	[[Category: Zhao, Q.]]	+	[[Category: Zhao, Q]]
	[[Category: Globular like]]		[[Category: Globular like]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA: Protected "3ewq" [edit=sysop:move=sysop]

OCA — Wed, 06 Feb 2013 13:26:57 GMT

Protected "3ewq" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:26, 6 February 2013

OCA at 13:26, 6 February 2013

OCA — Wed, 06 Feb 2013 13:26:53 GMT

←Older revision		Revision as of 13:26, 6 February 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3ewq.png\|left\|200px]]
-	[[Image:3ewq.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ewq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ewq\| PDB=3ewq \| SCENE= }}		{{STRUCTURE_3ewq\| PDB=3ewq \| SCENE= }}

	===HCov-229E Nsp3 ADRP domain===		===HCov-229E Nsp3 ADRP domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18987156}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18987156 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18987156}}		{{ABSTRACT_PUBMED_18987156}}

	==About this Structure==		==About this Structure==
-	~~3EWQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_coronavirus_229e Human coronavirus 229e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA].	+	[[3ewq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_coronavirus_229e Human coronavirus 229e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA].
-		+
-	~~==Reference==~~	+
-	Crystal structures of two coronavirus ADP-ribose-1''-monophosphatases and their complexes with ADP-Ribose: a systematic structural analysis of the viral ADRP domain., Xu Y, Cong L, Chen C, Wei L, Zhao Q, Xu X, Ma Y, Bartlam M, Rao Z, J Virol. 2009 Jan;83(2):1083-92. Epub 2008 Nov 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18987156 18987156]	+
	[[Category: Human coronavirus 229e]]		[[Category: Human coronavirus 229e]]
	[[Category: Bartlam, M.]]		[[Category: Bartlam, M.]]
Line 34:		Line 19:
	[[Category: Xu, Y.]]		[[Category: Xu, Y.]]
	[[Category: Zhao, Q.]]		[[Category: Zhao, Q.]]
-	[[Category: Cytoplasm]]
	[[Category: Globular like]]		[[Category: Globular like]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 40:		Line 24:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Protease]]		[[Category: Protease]]
-	[[Category: Ribosomal frameshifting]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 13:16:59 2009''

OCA at 11:17, 14 January 2009

OCA — Wed, 14 Jan 2009 11:17:00 GMT

←Older revision		Revision as of 11:17, 14 January 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ewq.jpg\|left\|200px]]

-	The ~~entry 3ewq~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ewq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ewq\| PDB=3ewq \| SCENE= }}

-	~~Authors: Xu, Y., Cong, L., Chen, C., Wei, L., Zhao, Q., Xu, X., Ma, Y., Bartlam, M., Rao, Z.~~	+	===HCov-229E Nsp3 ADRP domain===

-	Description: HCov-229E Nsp3 ADRP domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 5 11~~:43:~~07 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18987156}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18987156 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18987156}}
		+
		+	==About this Structure==
		+	3EWQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_coronavirus_229e Human coronavirus 229e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWQ OCA].
		+
		+	==Reference==
		+	Crystal structures of two coronavirus ADP-ribose-1''-monophosphatases and their complexes with ADP-Ribose: a systematic structural analysis of the viral ADRP domain., Xu Y, Cong L, Chen C, Wei L, Zhao Q, Xu X, Ma Y, Bartlam M, Rao Z, J Virol. 2009 Jan;83(2):1083-92. Epub 2008 Nov 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18987156 18987156]
		+	[[Category: Human coronavirus 229e]]
		+	[[Category: Bartlam, M.]]
		+	[[Category: Chen, C.]]
		+	[[Category: Cong, L.]]
		+	[[Category: Ma, Y.]]
		+	[[Category: Rao, Z.]]
		+	[[Category: Wei, L.]]
		+	[[Category: Xu, X.]]
		+	[[Category: Xu, Y.]]
		+	[[Category: Zhao, Q.]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Globular like]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane]]
		+	[[Category: Metal-binding]]
		+	[[Category: Protease]]
		+	[[Category: Ribosomal frameshifting]]
		+	[[Category: Rna-binding]]
		+	[[Category: Thiol protease]]
		+	[[Category: Transmembrane]]
		+	[[Category: Zinc]]
		+	[[Category: Zinc-finger]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 13:16:59 2009''

OCA at 09:43, 5 November 2008

OCA — Wed, 05 Nov 2008 09:43:07 GMT

←Older revision		Revision as of 09:43, 5 November 2008
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ewq is ON HOLD	+	The entry 3ewq is ON HOLD until Paper Publication

	Authors: Xu, Y., Cong, L., Chen, C., Wei, L., Zhao, Q., Xu, X., Ma, Y., Bartlam, M., Rao, Z.		Authors: Xu, Y., Cong, L., Chen, C., Wei, L., Zhao, Q., Xu, X., Ma, Y., Bartlam, M., Rao, Z.
Line 7:		Line 7:
	Description: HCov-229E Nsp3 ADRP domain		Description: HCov-229E Nsp3 ADRP domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 29 10~~:29:40 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 11:43:07 2008''