3eyi - Revision history

OCA at 00:26, 28 December 2023

OCA — Thu, 28 Dec 2023 00:26:38 GMT

←Older revision		Revision as of 00:26, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='3eyi' size='340' side='right'caption='[[3eyi]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3eyi' size='340' side='right'caption='[[3eyi]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EYI FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~C20orf183~~, ~~DLM1, ZBP1, ZBP1/DLM1 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [https://pdbe.org/3eyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [https://www.ebi.ac.uk/pdbsum/3eyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eyi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [https://pdbe.org/3eyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [https://www.ebi.ac.uk/pdbsum/3eyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eyi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).	+	[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ha~~, S C~~]]	+	[[Category: Ha SC]]
-	[[Category: Kim~~, K K]]~~	+	[[Category: Kim KK]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Dna binding protein-dna complex]]~~	+
-	~~[[Category: Dna binding protein-z-dna complex]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Polymorphism~~]]	+

OCA at 09:19, 23 February 2022

OCA — Wed, 23 Feb 2022 09:19:27 GMT

←Older revision		Revision as of 09:19, 23 February 2022
Line 1:		Line 1:

	==The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA==		==The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA==
-	<StructureSection load='3eyi' size='340' side='right' caption='[[3eyi]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='3eyi' size='340' side='right'caption='[[3eyi]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EYI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf183, DLM1, ZBP1, ZBP1/DLM1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf183, DLM1, ZBP1, ZBP1/DLM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [~~http~~://pdbe.org/3eyi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eyi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eyi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [https://pdbe.org/3eyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [https://www.ebi.ac.uk/pdbsum/3eyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eyi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).	+	[[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ha, S C]]		[[Category: Ha, S C]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]

OCA at 21:41, 2 December 2018

OCA — Sun, 02 Dec 2018 21:41:33 GMT

←Older revision		Revision as of 21:41, 2 December 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/3eyi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/3eyi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3eyi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3eyi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Z-DNA\|Z-DNA]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	[[Category: Ha, S C]]		[[Category: Ha, S C]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]
		+	[[Category: Alternative splicing]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]
	[[Category: Dna binding protein-z-dna complex]]		[[Category: Dna binding protein-z-dna complex]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
		+	[[Category: Polymorphism]]

OCA at 21:26, 5 August 2016

OCA — Fri, 05 Aug 2016 21:26:44 GMT

←Older revision		Revision as of 21:26, 5 August 2016
Line 1:		Line 1:
		+
	==The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA==		==The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA==
	<StructureSection load='3eyi' size='340' side='right' caption='[[3eyi]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3eyi' size='340' side='right' caption='[[3eyi]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EYI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf183, DLM1, ZBP1, ZBP1/DLM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf183, DLM1, ZBP1, ZBP1/DLM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [http://www.ebi.ac.uk/pdbsum/3eyi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [http://pdbe.org/3eyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [http://www.ebi.ac.uk/pdbsum/3eyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eyi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eyi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3eyi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ha, S C]]		[[Category: Ha, S C]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]

OCA at 22:01, 25 December 2014

OCA — Thu, 25 Dec 2014 22:01:53 GMT

←Older revision		Revision as of 22:01, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [http://www.ebi.ac.uk/pdbsum/3eyi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [http://www.ebi.ac.uk/pdbsum/3eyi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:52, 26 November 2014

OCA — Wed, 26 Nov 2014 08:52:32 GMT

←Older revision		Revision as of 08:52, 26 November 2014
Line 1:		Line 1:
-	[[~~Image~~:3eyi.~~png\|left~~\|200px]]	+	==The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA==
		+	<StructureSection load='3eyi' size='340' side='right' caption='[[3eyi]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EYI FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf183, DLM1, ZBP1, ZBP1/DLM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [http://www.ebi.ac.uk/pdbsum/3eyi PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/3eyi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian DAI (DNA-dependent activator of IFN-regulatory factors), an activator of the innate immune response, senses cytosolic DNA by using 2 N-terminal Z-DNA binding domains (ZBDs) and a third putative DNA binding domain located next to the second ZBD. Compared with other previously known ZBDs, the second ZBD of human DAI (hZbeta(DAI)) shows significant variation in the sequence of the residues that are essential for DNA binding. In this article, the crystal structure of the hZbeta(DAI)/Z-DNA complex reveals that hZbeta(DAI) has a similar fold to that of other ZBDs, but adopts an unusual binding mode for recognition of Z-DNA. A residue in the first beta-strand rather than residues in the beta-loop contributes to DNA binding, and part of the (alpha3) recognition helix adopts a 3(10) helix conformation. The role of each residue that makes contact with DNA was confirmed by mutational analysis. The 2 ZBDs of DAI can together bind to DNA and both are necessary for full B-to-Z conversion. It is possible that binding 2 DAIs to 1 dsDNA brings about dimerization of DAI that might facilitate DNA-mediated innate immune activation.

-	~~{{STRUCTURE_3eyi\| PDB=3eyi \| SCENE= }}~~	+	The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA.,Ha SC, Kim D, Hwang HY, Rich A, Kim YG, Kim KK Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20671-6. Epub 2008 Dec 18. PMID:19095800<ref>PMID:19095800</ref>

-	~~===The crystal structure~~ of the ~~second Z-DNA binding domain~~ of ~~human DAI (ZBP1) in complex with Z-DNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19095800}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3eyi]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ha, S C.]]	+	[[Category: Ha, S C]]
-	[[Category: Kim, K K.]]	+	[[Category: Kim, K K]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]
	[[Category: Dna binding protein-z-dna complex]]		[[Category: Dna binding protein-z-dna complex]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA: Protected "3eyi" [edit=sysop:move=sysop]

OCA — Wed, 06 Feb 2013 13:40:06 GMT

Protected "3eyi" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:40, 6 February 2013

OCA at 13:40, 6 February 2013

OCA — Wed, 06 Feb 2013 13:40:01 GMT

←Older revision		Revision as of 13:40, 6 February 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3eyi.png\|left\|200px]]
-	[[Image:3eyi.~~jpg~~\|left\|200px]]	+

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3eyi\| PDB=3eyi \| SCENE= }}		{{STRUCTURE_3eyi\| PDB=3eyi \| SCENE= }}

	===The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA===		===The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19095800}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19095800 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19095800}}		{{ABSTRACT_PUBMED_19095800}}

	==About this Structure==		==About this Structure==
-	~~3EYI~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA].	+	[[3eyi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA].
-		+
-	~~==Reference==~~	+
-	The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA., Ha SC, Kim D, Hwang HY, Rich A, Kim YG, Kim KK, Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20671-6. Epub 2008 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19095800 19095800]	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ha, S C.]]		[[Category: Ha, S C.]]
	[[Category: Kim, K K.]]		[[Category: Kim, K K.]]
-	~~[[Category: Alternative splicing]]~~	+	[[Category: Dna binding protein-dna complex]]
-	[[Category: Dna binding protein/dna complex]]	+	[[Category: Dna binding protein-z-dna complex]]
-	[[Category: Dna binding protein/z-dna complex]]	+
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
-	[[Category: Polymorphism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 13:12:18 2009''

OCA at 11:12, 14 January 2009

OCA — Wed, 14 Jan 2009 11:12:18 GMT

←Older revision		Revision as of 11:12, 14 January 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3eyi.jpg\|left\|200px]]

-	The ~~entry 3eyi~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3eyi", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3eyi\| PDB=3eyi \| SCENE= }}

-	~~Authors: Ha, S.C., Kim, K.K.~~	+	===The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA===

-	Description: The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 29 10~~:30:~~30 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19095800}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19095800 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19095800}}
		+
		+	==About this Structure==
		+	3EYI is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA].
		+
		+	==Reference==
		+	The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA., Ha SC, Kim D, Hwang HY, Rich A, Kim YG, Kim KK, Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20671-6. Epub 2008 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19095800 19095800]
		+	[[Category: Homo sapiens]]
		+	[[Category: Ha, S C.]]
		+	[[Category: Kim, K K.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Dna binding protein/dna complex]]
		+	[[Category: Dna binding protein/z-dna complex]]
		+	[[Category: Dna-binding]]
		+	[[Category: Polymorphism]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 13:12:18 2009''

OCA: New page: '''Unreleased structure''' The entry 3eyi is ON HOLD Authors: Ha, S.C., Kim, K.K. Description: The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex w...

OCA — Wed, 29 Oct 2008 08:30:30 GMT

New page: '''Unreleased structure''' The entry 3eyi is ON HOLD Authors: Ha, S.C., Kim, K.K. Description: The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex w...

New page

'''Unreleased structure'''

The entry 3eyi is ON HOLD

Authors: Ha, S.C., Kim, K.K.

Description: The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 29 10:30:30 2008''