3f0t - Revision history

OCA at 06:40, 6 September 2023

OCA — Wed, 06 Sep 2023 06:40:01 GMT

←Older revision		Revision as of 06:40, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3f0t' size='340' side='right'caption='[[3f0t]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3f0t' size='340' side='right'caption='[[3f0t]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hhv-1 Hhv-~~1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F0T FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NCV:N~~-~~METHYL-6-(1~~,~~3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1e2p\|1e2p]], [[1e2h\|1e2h]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TK, UL23 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10299 HHV~~-1])~~</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [https://pdbe.org/3f0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [https://www.ebi.ac.uk/pdbsum/3f0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [https://pdbe.org/3f0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [https://www.ebi.ac.uk/pdbsum/3f0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).	+	[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 31:

	==See Also==		==See Also==
-	*[[Thymidine kinase\|Thymidine kinase]]	+	*[[Thymidine kinase 3D structures\|Thymidine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hhv-~~1]]	+	[[Category: Human alphaherpesvirus 1 strain 17]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Thymidine kinase]]~~	+	[[Category: Ametamey S]]
-	[[Category: Ametamey, S]]	+	[[Category: Martic M]]
-	[[Category: Martic, M]]	+	[[Category: Pernot L]]
-	[[Category: Pernot, L]]	+	[[Category: Perozzo R]]
-	[[Category: Perozzo, R]]	+	[[Category: Scapozza L]]
-	[[Category: Scapozza, L]]	+	[[Category: Westermaier Y]]
-	[[Category: Westermaier, Y]]	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Dna synthesis]]~~	+
-	~~[[Category: Dna-synthesis]]~~	+
-	~~[[Category: Early protein]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Pet tracer]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:21, 23 February 2022

OCA — Wed, 23 Feb 2022 09:21:04 GMT

←Older revision		Revision as of 09:21, 23 February 2022
Line 1:		Line 1:

	==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT==		==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT==
-	<StructureSection load='3f0t' size='340' side='right' caption='[[3f0t]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3f0t' size='340' side='right'caption='[[3f0t]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F0T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e2p\|1e2p]], [[1e2h\|1e2h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e2p\|1e2p]], [[1e2h\|1e2h]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [~~http~~://pdbe.org/3f0t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f0t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [https://pdbe.org/3f0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [https://www.ebi.ac.uk/pdbsum/3f0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).	+	[[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Hhv-1]]		[[Category: Hhv-1]]
		+	[[Category: Large Structures]]
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Ametamey, S]]		[[Category: Ametamey, S]]

OCA at 21:19, 2 December 2018

OCA — Sun, 02 Dec 2018 21:19:35 GMT

←Older revision		Revision as of 21:19, 2 December 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/3f0t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/3f0t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:14, 5 August 2016

OCA — Fri, 05 Aug 2016 22:14:04 GMT

←Older revision		Revision as of 22:14, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT==		==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT==
	<StructureSection load='3f0t' size='340' side='right' caption='[[3f0t]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3f0t' size='340' side='right' caption='[[3f0t]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type~~ 1 ~~/ strain 17)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F0T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e2p\|1e2p]], [[1e2h\|1e2h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e2p\|1e2p]], [[1e2h\|1e2h]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 ~~Herpes simplex virus (type~~ 1 ~~/ strain 17)~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [http://www.ebi.ac.uk/pdbsum/3f0t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [http://pdbe.org/3f0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [http://www.ebi.ac.uk/pdbsum/3f0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f0t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f0t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hhv-1]]
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Ametamey, S]]		[[Category: Ametamey, S]]

OCA at 22:22, 25 December 2014

OCA — Thu, 25 Dec 2014 22:22:27 GMT

←Older revision		Revision as of 22:22, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3f0t\| PDB=3f0t \| SCENE= }}~~	+	==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT==
-	===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT===	+	<StructureSection load='3f0t' size='340' side='right' caption='[[3f0t]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21623543}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F0T FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCV:N-METHYL-6-(1,3-DIHYDROXY-ISOBUTYL)THYMINE'>NCV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e2p\|1e2p]], [[1e2h\|1e2h]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 Herpes simplex virus (type 1 / strain 17)])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f0t RCSB], [http://www.ebi.ac.uk/pdbsum/3f0t PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).		[[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/3f0t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed that our lead compound, N-methyl DHBT (N-methyl-6-(1,3-dihydroxyisobutyl) thymine; N-Me DHBT), is phosphorylated at a similar rate compared to "gold standard" 9-[4-fluoro-3-(hydroxymethyl)butyl]guanine, FHBG, (K(m) = 10 +/- 0.3 muM; k(cat) = 0.036 +/- 0.015 sec(-1)). Additionally, it does not show cytotoxic properties on B16F1 cells up to a concentration of 10 mM. The x-ray analysis of the crystal structures of HSV1-TK with N-Me DHBT and of HSV1-TK with the fluorinated derivative N-Me FHBT confirmed the binding mode predicted by docking studies and their substrate characteristics. Moreover, the crystal structure of HSV1-TK with N-Me DHBT revealed an additional water-mediated H-bond interesting for the design of further analogues.

-	~~==About this Structure==~~	+	Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.,Martic M, Pernot L, Westermaier Y, Perozzo R, Kraljevic TG, Kristafor S, Raic-Malic S, Scapozza L, Ametamey S Nucleosides Nucleotides Nucleic Acids. 2011 Apr;30(4):293-315. PMID:21623543<ref>PMID:21623543</ref>
-	~~[[3f0t]] is a 2 chain~~ structure ~~with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Herpes_simplex_virus_~~(~~type_1_/_strain_17~~) ~~Herpes simplex virus (type 1 / strain 17)]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3F0T OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Thymidine kinase\|Thymidine kinase]]		*[[Thymidine kinase\|Thymidine kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021623543</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
-	[[Category: Ametamey, S.]]	+	[[Category: Ametamey, S]]
-	[[Category: Martic, M.]]	+	[[Category: Martic, M]]
-	[[Category: Pernot, L.]]	+	[[Category: Pernot, L]]
-	[[Category: Perozzo, R.]]	+	[[Category: Perozzo, R]]
-	[[Category: Scapozza, L.]]	+	[[Category: Scapozza, L]]
-	[[Category: Westermaier, Y.]]	+	[[Category: Westermaier, Y]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Dna synthesis]]		[[Category: Dna synthesis]]
Line 27:		Line 49:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Pet tracer]]		[[Category: Pet tracer]]
-	[[Category: Thymidine kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:53, 2 October 2013

OCA — Wed, 02 Oct 2013 05:53:36 GMT

←Older revision		Revision as of 05:53, 2 October 2013
Line 1:		Line 1:
-	[[Image:3f0t.png\|left\|200px]]
-
	{{STRUCTURE_3f0t\| PDB=3f0t \| SCENE= }}		{{STRUCTURE_3f0t\| PDB=3f0t \| SCENE= }}
-
	===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT===		===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT===
		+	{{ABSTRACT_PUBMED_21623543}}

-	~~{{ABSTRACT_PUBMED_21623543}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).

	==About this Structure==		==About this Structure==
-	[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA].	+	[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021623543</ref><~~ref~~ group="xtra"~~>PMID:011056041<~~/~~ref~~><references ~~group="xtra"~~/>	+	<ref group="xtra">PMID:021623543</ref><references group="xtra"/><references/>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
-	[[Category: Viruses]]
	[[Category: Ametamey, S.]]		[[Category: Ametamey, S.]]
	[[Category: Martic, M.]]		[[Category: Martic, M.]]
Line 22:		Line 20:
	[[Category: Perozzo, R.]]		[[Category: Perozzo, R.]]
	[[Category: Scapozza, L.]]		[[Category: Scapozza, L.]]
		+	[[Category: Westermaier, Y.]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Dna synthesis]]		[[Category: Dna synthesis]]

OCA at 22:20, 20 October 2012

OCA — Sat, 20 Oct 2012 22:20:50 GMT

←Older revision		Revision as of 22:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3f0t]] is a 2 chain structure ~~of [[Thymidine kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA].	+	[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021623543</ref><ref group="xtra">PMID:011056041~~</ref><ref group="xtra">PMID:007628623</ref><ref group="xtra">PMID:007552712~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021623543</ref><ref group="xtra">PMID:011056041</ref><references group="xtra"/>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Viruses]]		[[Category: Viruses]]

OCA at 16:00, 27 July 2012

OCA — Fri, 27 Jul 2012 16:00:06 GMT

←Older revision		Revision as of 16:00, 27 July 2012
Line 1:		Line 1:
	[[Image:3f0t.png\|left\|200px]]		[[Image:3f0t.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3f0t", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3f0t\| PDB=3f0t \| SCENE= }}		{{STRUCTURE_3f0t\| PDB=3f0t \| SCENE= }}

	===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT===		===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21623543}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21623543 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21623543}}		{{ABSTRACT_PUBMED_21623543}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Thymidine kinase]]	+	*[[Thymidine kinase\|Thymidine kinase]]

	==Reference==		==Reference==

OCA at 07:48, 3 August 2011

OCA — Wed, 03 Aug 2011 07:48:22 GMT

←Older revision		Revision as of 07:48, 3 August 2011
Line 13:		Line 13:

	<!--		<!--
-	The line below this paragraph, {{~~ABSTRACT_PUBMED_11056041~~}}, adds the Publication Abstract to the page	+	The line below this paragraph, {{ABSTRACT_PUBMED_21623543}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where ~~11056041~~ is the PubMed ID number.	+	(as it appears on PubMed at http://www.pubmed.gov), where 21623543 is the PubMed ID number.
	-->		-->
-	{{~~ABSTRACT_PUBMED_11056041~~}}	+	{{ABSTRACT_PUBMED_21623543}}

	==About this Structure==		==About this Structure==
-	[[3f0t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA].	+	[[3f0t]] is a 2 chain structure of [[Thymidine kinase]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0T OCA].
		+
		+	==See Also==
		+	*[[Thymidine kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11056041~~</ref><ref group="xtra">PMID:~~7628623~~</ref><ref group="xtra">PMID:~~7552712~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021623543</ref><ref group="xtra">PMID:011056041</ref><ref group="xtra">PMID:007628623</ref><ref group="xtra">PMID:007552712</ref><references group="xtra"/>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Viruses]]		[[Category: Viruses]]

OCA: Protected "3f0t" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 23:04:50 GMT

Protected "3f0t" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:04, 14 March 2011