3f34 - Revision history

OCA at 06:41, 6 September 2023

OCA — Wed, 06 Sep 2023 06:41:12 GMT

←Older revision		Revision as of 06:41, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3f34' size='340' side='right'caption='[[3f34]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='3f34' size='340' side='right'caption='[[3f34]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f34]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3F34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F34 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.68Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [~~http~~://pdbe.org/3f34 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f34 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f34 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [https://pdbe.org/3f34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [https://www.ebi.ac.uk/pdbsum/3f34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	+	[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eckenhoff~~, R G~~]]	+	[[Category: Eckenhoff RG]]
-	[[Category: Economou~~, N J~~]]	+	[[Category: Economou NJ]]
-	[[Category: Loll~~, P J~~]]	+	[[Category: Loll PJ]]
-	[[Category: Rossi~~, M J~~]]	+	[[Category: Rossi MJ]]
-	[[Category: Vedula~~, L S]]~~	+	[[Category: Vedula LS]]
-	~~[[Category: 4-helix bundle]]~~	+
-	~~[[Category: 6-diethylphenol]]~~	+
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Anesthetic]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Iron storage]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Propofol analogue~~]]	+

OCA at 10:27, 9 September 2020

OCA — Wed, 09 Sep 2020 10:27:10 GMT

←Older revision		Revision as of 10:27, 9 September 2020
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	==Apoferritin: complex with 2,6-diethylphenol==		==Apoferritin: complex with 2,6-diethylphenol==
-	<StructureSection load='3f34' size='340' side='right' caption='[[3f34]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='3f34' size='340' side='right'caption='[[3f34]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3F34 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://pdbe.org/3f34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f34 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://pdbe.org/3f34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Ferritin\|Ferritin]]	+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
	[[Category: Eckenhoff, R G]]		[[Category: Eckenhoff, R G]]
	[[Category: Economou, N J]]		[[Category: Economou, N J]]

OCA at 21:24, 2 December 2018

OCA — Sun, 02 Dec 2018 21:24:01 GMT

←Older revision		Revision as of 21:24, 2 December 2018
Line 1:		Line 1:
		+
	==Apoferritin: complex with 2,6-diethylphenol==		==Apoferritin: complex with 2,6-diethylphenol==
	<StructureSection load='3f34' size='340' side='right' caption='[[3f34]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='3f34' size='340' side='right' caption='[[3f34]], [[Resolution\|resolution]] 1.68Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://pdbe.org/3f34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://pdbe.org/3f34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/3f34_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/3f34_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 43:		Line 44:
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: 6-diethylphenol]]		[[Category: 6-diethylphenol]]
		+	[[Category: Acetylation]]
	[[Category: Anesthetic]]		[[Category: Anesthetic]]
	[[Category: Iron]]		[[Category: Iron]]

OCA at 19:57, 9 February 2016

OCA — Tue, 09 Feb 2016 19:57:34 GMT

←Older revision		Revision as of 19:57, 9 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://pdbe.org/3f34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f34 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f34" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:10, 25 December 2014

OCA — Thu, 25 Dec 2014 09:10:37 GMT

←Older revision		Revision as of 09:10, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3f34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F34 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3f34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F34 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
-	[[Category: Eckenhoff, R G.]]	+	[[Category: Eckenhoff, R G]]
-	[[Category: Economou, N J.]]	+	[[Category: Economou, N J]]
-	[[Category: Loll, P J.]]	+	[[Category: Loll, P J]]
-	[[Category: Rossi, M J.]]	+	[[Category: Rossi, M J]]
-	[[Category: Vedula, L S.]]	+	[[Category: Vedula, L S]]
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: 6-diethylphenol]]		[[Category: 6-diethylphenol]]

OCA at 10:50, 29 September 2014

OCA — Mon, 29 Sep 2014 10:50:45 GMT

←Older revision		Revision as of 10:50, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3f34.~~png~~\|~~left~~\|200px]]	+	==Apoferritin: complex with 2,6-diethylphenol==
		+	<StructureSection load='3f34' size='340' side='right' caption='[[3f34]], [[Resolution\|resolution]] 1.68Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F34 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DIE:2,6-DIETHYLPHENOL'>DIE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xz1\|1xz1]], [[1xz3\|1xz3]], [[3f32\|3f32]], [[3f33\|3f33]], [[3f35\|3f35]], [[3f36\|3f36]], [[3f37\|3f37]], [[3f38\|3f38]], [[3f39\|3f39]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f34 RCSB], [http://www.ebi.ac.uk/pdbsum/3f34 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/3f34_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Propofol is the most widely used injectable general anesthetic. Its targets include ligand-gated ion channels such as the GABA(A) receptor, but such receptor-channel complexes remain challenging to study at atomic resolution. Until structural biology methods advance to the point of being able to deal with systems such as the GABA(A) receptor, it will be necessary to use more tractable surrogates to probe the molecular details of anesthetic recognition. We have previously shown that recognition of inhalational general anesthetics by the model protein apoferritin closely mirrors recognition by more complex and clinically relevant protein targets; here we show that apoferritin also binds propofol and related GABAergic anesthetics, and that the same binding site mediates recognition of both inhalational and injectable anesthetics. Apoferritin binding affinities for a series of propofol analogs were found to be strongly correlated with the ability to potentiate GABA responses at GABA(A) receptors, validating this model system for injectable anesthetics. High resolution x-ray crystal structures reveal that, despite the presence of hydrogen bond donors and acceptors, anesthetic recognition is mediated largely by van der Waals forces and the hydrophobic effect. Molecular dynamics simulations indicate that the ligands undergo considerable fluctuations about their equilibrium positions. Finally, apoferritin displays both structural and dynamic responses to anesthetic binding, which may mimic changes elicited by anesthetics in physiologic targets like ion channels.

-	~~{{STRUCTURE_3f34\| PDB=3f34 \| SCENE= }}~~	+	A unitary anesthetic binding site at high resolution.,Vedula LS, Brannigan G, Economou NJ, Xi J, Hall MA, Liu R, Rossi MJ, Dailey WP, Grasty KC, Klein ML, Eckenhoff RG, Loll PJ J Biol Chem. 2009 Sep 4;284(36):24176-84. Epub 2009 Jul 15. PMID:19605349<ref>PMID:19605349</ref>

-	~~===Apoferritin: complex with 2~~,~~6-diethylphenol===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19605349}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3f34]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Equus_caballus Equus caballus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA].~~	+

	==See Also==		==See Also==
	*[[Ferritin\|Ferritin]]		*[[Ferritin\|Ferritin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019605349<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Eckenhoff, R G.]]		[[Category: Eckenhoff, R G.]]

OCA at 14:57, 20 October 2012

OCA — Sat, 20 Oct 2012 14:57:27 GMT

←Older revision		Revision as of 14:57, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3f34]] is a 1 chain structure ~~of [[Ferritin]]~~ with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA].	+	[[3f34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA].

	==See Also==		==See Also==

OCA at 16:49, 26 July 2012

OCA — Thu, 26 Jul 2012 16:49:02 GMT

←Older revision		Revision as of 16:49, 26 July 2012
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	[[Image:3f34.png\|left\|200px]]		[[Image:3f34.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3f34", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3f34\| PDB=3f34 \| SCENE= }}		{{STRUCTURE_3f34\| PDB=3f34 \| SCENE= }}

	===Apoferritin: complex with 2,6-diethylphenol===		===Apoferritin: complex with 2,6-diethylphenol===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19605349}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19605349 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19605349}}		{{ABSTRACT_PUBMED_19605349}}

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	==See Also==		==See Also==
-	*[[Ferritin]]	+	*[[Ferritin\|Ferritin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19605349~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019605349</ref><references group="xtra"/>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Eckenhoff, R G.]]		[[Category: Eckenhoff, R G.]]
Line 34:		Line 23:
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: 6-diethylphenol]]		[[Category: 6-diethylphenol]]
-	[[Category: Acetylation]]
	[[Category: Anesthetic]]		[[Category: Anesthetic]]
	[[Category: Iron]]		[[Category: Iron]]

OCA: Protected "3f34" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 23:35:09 GMT

Protected "3f34" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:35, 26 December 2010

OCA at 23:35, 26 December 2010

OCA — Sun, 26 Dec 2010 23:35:08 GMT

←Older revision		Revision as of 23:35, 26 December 2010
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-	{{Seed}}
	[[Image:3f34.png\|left\|200px]]		[[Image:3f34.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3F34~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA].	+	[[3f34]] is a 1 chain structure of [[Ferritin]] with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F34 OCA].
		+
		+	==See Also==
		+	*[[Ferritin]]

	==Reference==		==Reference==
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	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Propofol analogue]]		[[Category: Propofol analogue]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 12:38:33 2009''