3f4i - Revision history

OCA at 06:41, 6 September 2023

OCA — Wed, 06 Sep 2023 06:41:59 GMT

←Older revision		Revision as of 06:41, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3f4i' size='340' side='right'caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3f4i' size='340' side='right'caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex~~ aeolicus~~" huber and stetter 2001~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F4I FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BOG:B~~-~~OCTYLGLUCOSIDE'>BOG</scene>~~, ~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2a65\|2a65]], [[2qei\|2qei]], [[3f3a\|3f3a]], [[3f3c\|3f3c]], [[3f3d\|3f3d]], [[3f3e\|3f3e]], [[3f48\|3f48]], [[3f4j\|3f4j]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">snf, aq_2077 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4i OCA], [https://pdbe.org/3f4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f4i RCSB], [https://www.ebi.ac.uk/pdbsum/3f4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4i OCA], [https://pdbe.org/3f4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f4i RCSB], [https://www.ebi.ac.uk/pdbsum/3f4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O67854_AQUAE O67854_AQUAE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus ~~huber and stetter 2001~~]]	+	[[Category: Aquifex aeolicus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gouaux, E]]	+	[[Category: Gouaux E]]
-	[[Category: Piscitelli~~, C L~~]]	+	[[Category: Piscitelli CL]]
-	[[Category: Singh~~, S K~~]]	+	[[Category: Singh SK]]
-	[[Category: Yamashita, A]]	+	[[Category: Yamashita A]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Neurotransmitter]]~~	+
-	~~[[Category: Nss]]~~	+
-	~~[[Category: Slc6]]~~	+
-	~~[[Category: Sodium-couple]]~~	+
-	~~[[Category: Symport]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 09:23, 23 February 2022

OCA — Wed, 23 Feb 2022 09:23:34 GMT

←Older revision		Revision as of 09:23, 23 February 2022
Line 3:		Line 3:
	<StructureSection load='3f4i' size='340' side='right'caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3f4i' size='340' side='right'caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F4I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a65\|2a65]], [[2qei\|2qei]], [[3f3a\|3f3a]], [[3f3c\|3f3c]], [[3f3d\|3f3d]], [[3f3e\|3f3e]], [[3f48\|3f48]], [[3f4j\|3f4j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a65\|2a65]], [[2qei\|2qei]], [[3f3a\|3f3a]], [[3f3c\|3f3c]], [[3f3d\|3f3d]], [[3f3e\|3f3e]], [[3f48\|3f48]], [[3f4j\|3f4j]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">snf, aq_2077 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">snf, aq_2077 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4i OCA], [~~http~~://pdbe.org/3f4i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f4i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f4i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4i OCA], [https://pdbe.org/3f4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f4i RCSB], [https://www.ebi.ac.uk/pdbsum/3f4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	==See Also==		==See Also==
	*[[Leucine transporter\|Leucine transporter]]		*[[Leucine transporter\|Leucine transporter]]
-	*[[Symporter\|Symporter]]	+	*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:05, 24 July 2019

OCA — Wed, 24 Jul 2019 08:05:30 GMT

←Older revision		Revision as of 08:05, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure of LeuT bound to L-selenomethionine and sodium==		==Crystal Structure of LeuT bound to L-selenomethionine and sodium==
-	<StructureSection load='3f4i' size='340' side='right' caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3f4i' size='340' side='right'caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F4I FirstGlance]. <br>		<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F4I FirstGlance]. <br>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Aquifex aeolicus huber and stetter 2001]]		[[Category: Aquifex aeolicus huber and stetter 2001]]
		+	[[Category: Large Structures]]
	[[Category: Gouaux, E]]		[[Category: Gouaux, E]]
	[[Category: Piscitelli, C L]]		[[Category: Piscitelli, C L]]

OCA at 21:59, 2 December 2018

OCA — Sun, 02 Dec 2018 21:59:16 GMT

←Older revision		Revision as of 21:59, 2 December 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/3f4i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/3f4i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	==See Also==		==See Also==
	*[[Leucine transporter\|Leucine transporter]]		*[[Leucine transporter\|Leucine transporter]]
		+	*[[Symporter\|Symporter]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:10, 11 August 2016

OCA — Thu, 11 Aug 2016 20:10:48 GMT

←Older revision		Revision as of 20:10, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of LeuT bound to L-selenomethionine and sodium==		==Crystal Structure of LeuT bound to L-selenomethionine and sodium==
	<StructureSection load='3f4i' size='340' side='right' caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3f4i' size='340' side='right' caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus Aquifex~~ aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F4I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a65\|2a65]], [[2qei\|2qei]], [[3f3a\|3f3a]], [[3f3c\|3f3c]], [[3f3d\|3f3d]], [[3f3e\|3f3e]], [[3f48\|3f48]], [[3f4j\|3f4j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a65\|2a65]], [[2qei\|2qei]], [[3f3a\|3f3a]], [[3f3c\|3f3c]], [[3f3d\|3f3d]], [[3f3e\|3f3e]], [[3f48\|3f48]], [[3f4j\|3f4j]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">snf, aq_2077 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">snf, aq_2077 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f4i RCSB], [http://www.ebi.ac.uk/pdbsum/3f4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4i OCA], [http://pdbe.org/3f4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f4i RCSB], [http://www.ebi.ac.uk/pdbsum/3f4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f4i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f4i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus]]	+	[[Category: Aquifex aeolicus huber and stetter 2001]]
	[[Category: Gouaux, E]]		[[Category: Gouaux, E]]
	[[Category: Piscitelli, C L]]		[[Category: Piscitelli, C L]]

OCA at 08:44, 26 November 2014

OCA — Wed, 26 Nov 2014 08:44:07 GMT

←Older revision		Revision as of 08:44, 26 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3f4i.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of LeuT bound to L-selenomethionine and sodium==
		+	<StructureSection load='3f4i' size='340' side='right' caption='[[3f4i]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F4I FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a65\|2a65]], [[2qei\|2qei]], [[3f3a\|3f3a]], [[3f3c\|3f3c]], [[3f3d\|3f3d]], [[3f3e\|3f3e]], [[3f48\|3f48]], [[3f4j\|3f4j]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">snf, aq_2077 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f4i RCSB], [http://www.ebi.ac.uk/pdbsum/3f4i PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/3f4i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Secondary transporters are workhorses of cellular membranes, catalyzing the movement of small molecules and ions across the bilayer and coupling substrate passage to ion gradients. However, the conformational changes that accompany substrate transport, the mechanism by which a substrate moves through the transporter, and principles of competitive inhibition remain unclear. We used crystallographic and functional studies on the leucine transporter (LeuT), a model for neurotransmitter sodium symporters, to show that various amino acid substrates induce the same occluded conformational state and that a competitive inhibitor, tryptophan (Trp), traps LeuT in an open-to-out conformation. In the Trp complex, the extracellular gate residues arginine 30 and aspartic acid 404 define a second weak binding site for substrates or inhibitors as they permeate from the extracellular solution to the primary substrate site, which demonstrates how residues that participate in gating also mediate permeation.

-	~~{{STRUCTURE_3f4i\| PDB=3f4i \| SCENE= }}~~	+	A competitive inhibitor traps LeuT in an open-to-out conformation.,Singh SK, Piscitelli CL, Yamashita A, Gouaux E Science. 2008 Dec 12;322(5908):1655-61. PMID:19074341<ref>PMID:19074341</ref>

-	~~===Crystal Structure~~ of ~~LeuT bound to L-selenomethionine and sodium===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19074341}}~~	+	==See Also==
-		+	*[[Leucine transporter\|Leucine transporter]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3f4i~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019074341<~~/~~ref~~><~~ref group="xtra">PMID:017687333</ref><ref group="xtra">PMID:016041361</ref><references group="xtra"~~/>	+
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: Gouaux, E.]]	+	[[Category: Gouaux, E]]
-	[[Category: Piscitelli, C L.]]	+	[[Category: Piscitelli, C L]]
-	[[Category: Singh, S K.]]	+	[[Category: Singh, S K]]
-	[[Category: Yamashita, A.]]	+	[[Category: Yamashita, A]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Neurotransmitter]]		[[Category: Neurotransmitter]]

OCA at 11:04, 13 February 2013

OCA — Wed, 13 Feb 2013 11:04:05 GMT

←Older revision		Revision as of 11:04, 13 February 2013
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	[[Image:3f4i.png\|left\|200px]]		[[Image:3f4i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3f4i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_3f4i\| PDB=3f4i \| SCENE= }}		{{STRUCTURE_3f4i\| PDB=3f4i \| SCENE= }}

	===Crystal Structure of LeuT bound to L-selenomethionine and sodium===		===Crystal Structure of LeuT bound to L-selenomethionine and sodium===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19074341}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19074341 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19074341}}		{{ABSTRACT_PUBMED_19074341}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19074341~~</ref><ref group="xtra">PMID:~~17687333~~</ref><ref group="xtra">PMID:~~16041361~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019074341</ref><ref group="xtra">PMID:017687333</ref><ref group="xtra">PMID:016041361</ref><references group="xtra"/>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
	[[Category: Gouaux, E.]]		[[Category: Gouaux, E.]]

OCA: Protected "3f4i" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 22:29:19 GMT

Protected "3f4i" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:29, 14 March 2011

OCA at 22:29, 14 March 2011

OCA — Mon, 14 Mar 2011 22:29:18 GMT

←Older revision		Revision as of 22:29, 14 March 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3f4i.png\|left\|200px]]		[[Image:3f4i.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3F4I~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA].	+	[[3f4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA].

	==Reference==		==Reference==
Line 39:		Line 38:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Transporter]]		[[Category: Transporter]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:54:42 2010''

OCA at 08:45, 22 September 2010

OCA — Wed, 22 Sep 2010 08:45:43 GMT

←Older revision		Revision as of 08:45, 22 September 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3F4I is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA].	+	3F4I is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4I OCA].

	==Reference==		==Reference==
-	~~A competitive inhibitor traps LeuT in an open-to-out conformation., Singh SK, Piscitelli CL, Yamashita A, Gouaux E, Science. 2008 Dec 12;322(5908):1655-61.~~ PMID:~~[http:~~/~~/www.ncbi.nlm.nih.gov/pubmed/19074341 19074341]~~	+	<ref group="xtra">PMID:19074341</ref><ref group="xtra">PMID:17687333</ref><ref group="xtra">PMID:16041361</ref><references group="xtra"/>
-		+
-	~~Antidepressant binding site in a bacterial homologue of neurotransmitter transporters., Singh SK, Yamashita A, Gouaux E, Nature. 2007 Aug 23;448(7156):952-6. Epub 2007 Aug 8.~~ PMID:~~[http://www.ncbi.nlm.nih.gov/pubmed/~~17687333 ~~17687333]~~	+
-		+
-	~~Crystal structure of a bacterial homologue of Na+~~/~~Cl--dependent neurotransmitter transporters., Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E, Nature. 2005 Sep 8;437(7056):215-23. Epub 2005 Jul 24.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16041361 16041361]~~	+
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Gouaux, E.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Piscitelli, C L.]]
		+	[[Category: Singh, S K.]]
		+	[[Category: Yamashita, A.]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Neurotransmitter]]		[[Category: Neurotransmitter]]
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	[[Category: Transporter]]		[[Category: Transporter]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar~~ 11 20:14:~~07 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:54:42 2010''