3f5n - Revision history

OCA at 15:26, 1 November 2023

OCA — Wed, 01 Nov 2023 15:26:40 GMT

←Older revision		Revision as of 15:26, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3f5n' size='340' side='right'caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='3f5n' size='340' side='right'caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5N FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3f02\|3f02]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.15Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SERPINI1, PI12 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [https://pdbe.org/3f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [https://www.ebi.ac.uk/pdbsum/3f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [https://pdbe.org/3f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [https://www.ebi.ac.uk/pdbsum/3f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5n ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.	+	[https://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bolognesi, M]]	+	[[Category: Bolognesi M]]
-	[[Category: Caccia, S]]	+	[[Category: Caccia S]]
-	[[Category: Ricagno, S]]	+	[[Category: Ricagno S]]
-	[[Category: Sorrentino, G]]	+	[[Category: Sorrentino G]]
-	~~[[Category: Cleaved form]]~~	+
-	~~[[Category: Fenib]]~~	+
-	~~[[Category: Hydrolase inhibitor]]~~	+
-	~~[[Category: Neuroserpin]]~~	+
-	~~[[Category: Serpin]]~~	+
-	~~[[Category: Tissue plasminogen activator~~]]	+

OCA at 09:24, 23 February 2022

OCA — Wed, 23 Feb 2022 09:24:18 GMT

←Older revision		Revision as of 09:24, 23 February 2022
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	==Structure of native human neuroserpin==		==Structure of native human neuroserpin==
-	<StructureSection load='3f5n' size='340' side='right' caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>	+	<StructureSection load='3f5n' size='340' side='right'caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5N FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f02\|3f02]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [~~http~~://pdbe.org/3f5n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f5n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [https://pdbe.org/3f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [https://www.ebi.ac.uk/pdbsum/3f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5n ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.	+	[[https://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Serpin\|Serpin]]	+	*[[Serpin 3D structures\|Serpin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]
	[[Category: Caccia, S]]		[[Category: Caccia, S]]

OCA at 22:01, 2 December 2018

OCA — Sun, 02 Dec 2018 22:01:40 GMT

←Older revision		Revision as of 22:01, 2 December 2018
Line 1:		Line 1:
		+
	==Structure of native human neuroserpin==		==Structure of native human neuroserpin==
	<StructureSection load='3f5n' size='340' side='right' caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='3f5n' size='340' side='right' caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [http://pdbe.org/3f5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [http://www.ebi.ac.uk/pdbsum/3f5n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [http://pdbe.org/3f5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [http://www.ebi.ac.uk/pdbsum/3f5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5n ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/3f5n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/3f5n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:05, 8 February 2016

OCA — Mon, 08 Feb 2016 03:05:33 GMT

←Older revision		Revision as of 03:05, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3f5n' size='340' side='right' caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='3f5n' size='340' side='right' caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5N FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [http://www.ebi.ac.uk/pdbsum/3f5n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [http://pdbe.org/3f5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [http://www.ebi.ac.uk/pdbsum/3f5n PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f5n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f5n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]
	[[Category: Caccia, S]]		[[Category: Caccia, S]]
Line 43:		Line 44:
	[[Category: Cleaved form]]		[[Category: Cleaved form]]
	[[Category: Fenib]]		[[Category: Fenib]]
-	[[Category: Human]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]
	[[Category: Neuroserpin]]		[[Category: Neuroserpin]]
	[[Category: Serpin]]		[[Category: Serpin]]
	[[Category: Tissue plasminogen activator]]		[[Category: Tissue plasminogen activator]]

OCA at 08:29, 20 January 2015

OCA — Tue, 20 Jan 2015 08:29:21 GMT

←Older revision		Revision as of 08:29, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5N FirstGlance]. <br>		<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [http://www.ebi.ac.uk/pdbsum/3f5n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [http://www.ebi.ac.uk/pdbsum/3f5n PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bolognesi, M.]]	+	[[Category: Bolognesi, M]]
-	[[Category: Caccia, S.]]	+	[[Category: Caccia, S]]
-	[[Category: Ricagno, S.]]	+	[[Category: Ricagno, S]]
-	[[Category: Sorrentino, G.]]	+	[[Category: Sorrentino, G]]
	[[Category: Cleaved form]]		[[Category: Cleaved form]]
	[[Category: Fenib]]		[[Category: Fenib]]

OCA at 11:15, 29 September 2014

OCA — Mon, 29 Sep 2014 11:15:07 GMT

←Older revision		Revision as of 11:15, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3f5n.~~png~~\|~~left~~\|200px]]	+	==Structure of native human neuroserpin==
		+	<StructureSection load='3f5n' size='340' side='right' caption='[[3f5n]], [[Resolution\|resolution]] 3.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f5n]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f02\|3f02]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINI1, PI12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5n RCSB], [http://www.ebi.ac.uk/pdbsum/3f5n PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/3f5n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human neuroserpin (hNS) is a protein serine protease inhibitor expressed mainly in the nervous system, where it plays key roles in neural development and plasticity by primarily targeting tissue plasminogen activator (tPA). Four hNS mutations are associated to a form of autosomal dominant dementia, known as familial encephalopathy with neuroserpin inclusion bodies. The medical interest in and the lack of structural information on hNS prompted us to study the crystal structure of native and cleaved hNS, reported here at 3.15 and 1.85 A resolution, respectively. In the light of the three-dimensional structures, we focus on the hNS reactive centre loop in its intact and cleaved conformations relative to the current serpin polymerization models and discuss the protein sites hosting neurodegenerative mutations. On the basis of homologous serpin structures, we suggest the location of a protein surface site that may stabilize the hNS native (metastable) form. In parallel, we present the results of kinetic studies on hNS inhibition of tPA. Our data analysis stresses the instability of the hNS-tPA complex with a dissociation half-life of minutes compared to a half-life of weeks observed for other serpin-cognate protease complexes.

-	~~{{STRUCTURE_3f5n\| PDB=3f5n \| SCENE= }}~~	+	Human neuroserpin: structure and time-dependent inhibition.,Ricagno S, Caccia S, Sorrentino G, Antonini G, Bolognesi M J Mol Biol. 2009 Apr 24;388(1):109-21. Epub 2009 Mar 2. PMID:19265707<ref>PMID:19265707</ref>

-	~~===Structure~~ of ~~native human neuroserpin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19265707}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3f5n]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA].~~	+

	==See Also==		==See Also==
	*[[Serpin\|Serpin]]		*[[Serpin\|Serpin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019265707<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bolognesi, M.]]		[[Category: Bolognesi, M.]]

OCA: Protected "3f5n" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 08:42:10 GMT

Protected "3f5n" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:42, 20 October 2012

OCA at 08:42, 20 October 2012

OCA — Sat, 20 Oct 2012 08:42:07 GMT

←Older revision		Revision as of 08:42, 20 October 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3f5n.png\|left\|200px]]
-	[[Image:3f5n.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3f5n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3f5n\| PDB=3f5n \| SCENE= }}		{{STRUCTURE_3f5n\| PDB=3f5n \| SCENE= }}

	===Structure of native human neuroserpin===		===Structure of native human neuroserpin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19265707}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19265707 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19265707}}		{{ABSTRACT_PUBMED_19265707}}

	==About this Structure==		==About this Structure==
-	~~3F5N~~ is a 5 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA].	+	[[3f5n]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA].
		+
		+	==See Also==
		+	*[[Serpin\|Serpin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19265707~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019265707</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bolognesi, M.]]		[[Category: Bolognesi, M.]]
Line 36:		Line 27:
	[[Category: Serpin]]		[[Category: Serpin]]
	[[Category: Tissue plasminogen activator]]		[[Category: Tissue plasminogen activator]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 15:20:38 2009''

OCA at 12:20, 27 May 2009

OCA — Wed, 27 May 2009 12:20:41 GMT

←Older revision		Revision as of 12:20, 27 May 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3f5n.jpg\|left\|200px]]

-	The ~~entry 3f5n~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3f5n", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3f5n\| PDB=3f5n \| SCENE= }}

-	~~Authors: Ricagno, S., Caccia, S., Sorrentino, G., Bolognesi, M.~~	+	===Structure of native human neuroserpin===

-	Description: Structure of native human neuroserpin

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Nov 20 07~~:43:~~09 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19265707}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19265707 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19265707}}
		+
		+	==About this Structure==
		+	3F5N is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5N OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19265707</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bolognesi, M.]]
		+	[[Category: Caccia, S.]]
		+	[[Category: Ricagno, S.]]
		+	[[Category: Sorrentino, G.]]
		+	[[Category: Cleaved form]]
		+	[[Category: Fenib]]
		+	[[Category: Human]]
		+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Neuroserpin]]
		+	[[Category: Serpin]]
		+	[[Category: Tissue plasminogen activator]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 15:20:38 2009''

OCA: New page: '''Unreleased structure''' The entry 3f5n is ON HOLD until Paper Publication Authors: Ricagno, S., Caccia, S., Sorrentino, G., Bolognesi, M. Description: Structure of native human neur...

OCA — Thu, 20 Nov 2008 05:43:09 GMT

New page: '''Unreleased structure''' The entry 3f5n is ON HOLD until Paper Publication Authors: Ricagno, S., Caccia, S., Sorrentino, G., Bolognesi, M. Description: Structure of native human neur...

New page

'''Unreleased structure'''

The entry 3f5n is ON HOLD until Paper Publication

Authors: Ricagno, S., Caccia, S., Sorrentino, G., Bolognesi, M.

Description: Structure of native human neuroserpin

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:43:09 2008''